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Research Article
Analysis of the reciprocating kinematics of the VDW Silver Reciproc, E-Connect Pro, Ecom, and Endopen endodontic motors: an in vitro experimental study
Cristielly França, Juliana D. Bronzato, Dieimes Braambati, Adriana de-Jesus-Soares, Carla C. R. B. Félix, Michelle A. N. S. Ferreira, Marcos Frozoni
Received August 18, 2025  Accepted October 12, 2025  Published online January 20, 2026  
DOI: https://doi.org/10.5395/rde.2026.51.e5    [Epub ahead of print]
AbstractAbstract PDFPubReaderePub
Objectives
This study aimed to evaluate the actual parameters of four endodontic motors, each adjusted for reciprocating motion, and compare them to the manufacturers’ declared values.
Methods
The motors used were the VDW Silver Reciproc (VDW GmbH), E-Connect Pro (MK Life), Ecom (Woodpecker), and Endopen (Schuster Woodpecker). A custom optical target was attached to the motor contra-angle, the movements were recorded with a high-resolution camera, and the images were analyzed. Engagement, disengagement, net angles, and speed for each operation cycle, duration of clockwise (CW) and counter-clockwise (CCW) movement, duration of standstill after CW and CCW movement, and the number of cycles to complete a full rotation were analyzed. The data were statistically analyzed at a significance level of 5%. The replicability of all reciprocal parameters analyzed was statistically different from that reported by the manufacturers.
Results
There was no statistically significant difference between the VDW Silver Reciproc, Ecom, and Endopen for the engagement angle. The E-Connect Pro was the least reliable at the 150°/30° settings for both angle parameters. There was no significant difference between the set and actual cycle net angles for the VDW Silver Reciproc (p = 0.493). While the actual values for the Ecom and E-Connect Pro were significantly higher than the set (p < 0.001), the actual values for the Endopen were significantly lower than the set (p < 0.001).
Conclusions
Experiments on four commercially available reciprocating endodontic motors revealed that the actual motor values differed significantly from the set values.
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Review Article
Influence of disinfecting solutions on the surface topography of gutta-percha cones: a systematic review of in vitro studies
Lora Mishra, Gathani Dash, Naomi Ranjan Singh, Manoj Kumar, Saurav Panda, Franck Diemer, Monika Lukomska-Szymanska, Barbara Lapinska, Abdul Samad Khan
Restor Dent Endod 2024;49(4):e42.   Published online November 1, 2024
DOI: https://doi.org/10.5395/rde.2024.49.e42
AbstractAbstract PDFSupplementary MaterialPubReaderePub

The surface integrity of gutta-percha cones is a crucial factor in the success of endodontic procedures. Disinfecting solutions play a pivotal role in sterilizing gutta-percha cones, but their influence on gutta-percha surface topography remains a subject of concern. This systematic review aimed to present a qualitative synthesis of available laboratory studies assessing the influence of disinfecting solutions on the surface topography of gutta-percha and offers insights into the implications for clinical practice. The present review followed PRISMA 2020 guidelines. An advanced database search was performed in PubMed, Google Scholar, Embase, Scopus, LILAC, non-indexed citations and reference lists of eligible studies in May 2024. Laboratory studies, in English language, were considered for inclusion. The quality (risk of bias) of the included studies was assessed using parameters for in vitro studies. A total of 28 studies were included in the qualitative synthesis. Based on the included in vitro studies, surface deposits and alterations in the physical properties of gutta-percha cones were observed after the disinfection protocol. A comprehensive review of the available literature indicates that the choice of disinfecting solution, its concentration, and immersion time significantly affect the surface topography of gutta-percha cones.

Citations

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  • In Vitro Evaluation of Disinfectants on Gutta-Percha Cones: Antimicrobial Efficacy Against Enterococcus faecalis and Candida albicans
    Tringa Kelmendi, Donika Bajrami Shabani, Aida Meto, Hani Ounsi
    Journal of Clinical Medicine.2025; 14(19): 6846.     CrossRef
  • 3,664 View
  • 189 Download
  • 1 Web of Science
  • 1 Crossref
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Research Articles
Can discolored dental composites be bleached in depth?
Luca Giachetti, Daniele Scaminaci Russo, Michele Nieri, Francesca Cinelli
Restor Dent Endod 2024;49(3):e23.   Published online June 11, 2024
DOI: https://doi.org/10.5395/rde.2024.49.e23
AbstractAbstract PDFPubReaderePub
Objectives

Previous in vitro studies determined the whitening effects of bleaching products on stained resin composite surfaces. This in vitro study aimed to verify the effectiveness of a whitening system on composite resin previously subjected to pigmentation, specifically examining the depth of whitening effectiveness within the material structure.

Materials and Methods

A commercially available nano-filled composite resin was used. Specimens were stained using a coffee-based solution and a 10% carbamide peroxide-based gel was employed as the whitening agent. The pigment’s penetration and the effect of the bleaching gel were evaluated by measuring color (CieLab values) from the outer edge to the inner part of the specimens. Color measurements were taken at 14 points, starting from 0.1 mm from the external perimeter up to 3.0 mm.

Results

Analysis of variance tests showed a statistically significant difference between the Control Group (CG), Pigmentation Group, and Whitening Group. The whitening agent was effective up to 1.5 mm in depth, with Whiteness index (W) values not statistically different from those of CG up to 0.5 mm in depth.

Conclusions

Whitening agents on nano-filled resin composite previously pigmented appear effective in restoring the W to values similar to the original, particularly in the superficial layers of the sample.

Citations

Citations to this article as recorded by  
  • Color Stability of Tooth-Colored Restorative Materials After Exposure to Arabic Coffee and Black Tea: A Systematic Review
    Abdulrhman Y Alenezi, Abdulwahab M AlEyada, Yousef H Aldhafiri, Mohammed S Alsubaie, Mohammed S Alshahrani, Mahesh Shenoy
    Cureus.2025;[Epub]     CrossRef
  • Comparative evaluation to composite resin bleaching using ozone-enhanced low-concentration hydrogen peroxide
    Mahmoud K. AL-Omiri, Dania Sa’ed Hussam Abuherra, Khaled M. AL-Omiri, Ali Y. Alsaeed, Mohammad Alamri, Ali M. Alqahtani, Saleh Ali Alqahtani, Ghadeer Saleh Alwadai, Naif Abogazalah, Edward Lynch
    Scientific Reports.2025;[Epub]     CrossRef
  • The effects of mechanical and chemical degradation on the surface roughness, gloss, and color stability of bulk-fill resin composites
    Merve Nezir, Hanife Altınışık, Esra Özyurt, Naz Bayar, Mediha Büyükgöze Dindar
    BMC Oral Health.2025;[Epub]     CrossRef
  • 3,388 View
  • 133 Download
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Pomegranate extract on eroded dentin: antioxidant action, bond strength and morphology of the adhesive interface after aging
Thiago Vinícius Cortez, Nathália Mancioppi Cerqueira, Julia Adornes Gallas, Wanderley Pereira Oliveira, Silmara Aparecida Milori Corona, Aline Evangelista Souza-Gabriel
Restor Dent Endod 2024;49(1):e9.   Published online January 26, 2024
DOI: https://doi.org/10.5395/rde.2024.49.e9
AbstractAbstract PDFPubReaderePub
Objectives

This study aimed to evaluate the effect of pomegranate solution (Punica granatum) on eroded dentin through antioxidant action, shear bond strength (SBS) and interface morphology.

Materials and Methods

The 10% pomegranate peel extract was prepared by the lyophilization method. Punicalagin polyphenol was confirmed by high-performance liquid chromatography. Antioxidant activity was evaluated by capturing the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. For the SBS, 48 dentin fragments were divided into sound or eroded, and subdivided according to the pretreatment (n = 12): water or P. granatum. The surfaces were restored with self-etch adhesive and a bulk-fill resin (Ecosite; DMG). The SBS was done immediately (24 hours) and after thermal cycling + water storage (12 months). For scanning electron microscopy, 48 dentin fragments (24 sound and 24 eroded) received the same treatments as for SBS (n = 6), and they were analyzed after 24 hours and 12 months.

Results

The P. granatum had antioxidant action similar (p = 0.246) to the phenolic standard antioxidants. After 24 hours, eroded dentin had lower SBS than sound dentin (p < 0.001), regardless of the pretreatment. After 12 months, P. granatum maintained the SBS of sound dentin (13.46 ± 3.42 MPa) and eroded dentin (10.96 ± 1.90 MPa) statistically similar. The lowest values were found on eroded dentin treated with water (5.75 ± 1.65 MPa) (p < 0.001). P. granatum on eroded dentin caused peritubular demineralization and hybrid layer with resin tags.

Conclusions

The pomegranate extract had antioxidant action and preserved the adhesive interface of the eroded dentin.

Citations

Citations to this article as recorded by  
  • Antibacterial Effects of Ethanolic Extractions of Aloe Vera, Black Tea, Pomegranate and Orange on Streptococcus mutans: An In-vitro Study
    Bardia Vadiati Saberi, Soheil Taghavi Namin, Dina Maleki
    Nutrition And Food In Health And Disease.2025; 12(2): 29.     CrossRef
  • Protective effect of a novel antioxidant gel containing resveratrol and sodium fluoride on dentin erosion in the presence of acquired salivary pellicle: An in vitro study
    Loraine Perez Manzoli, Luan Júlio Ruiz da Silva, George Clay dos Santos Caracas, Kalinca Furtado de Oliveira, Walessa Alana Braganca Aragão, Rafael Rodrigues Lima, Milton Carlos Kuga, Cristiane de Melo Alencar
    Archives of Oral Biology.2025; 179: 106395.     CrossRef
  • Effect of pomegranate solution alone or combined with chlorhexidine against oral multispecies biofilm
    J. A. Gallas, L. L. Pelozo, S. A. M. Corona, Y. Shen, M. Haapasalo, M. D. Sousa‐Neto, A. E. Souza‐Gabriel
    International Endodontic Journal.2024; 57(12): 1819.     CrossRef
  • The effect of resveratrol application on the micro-shear bond strength of adhesive to bleached enamel
    Esra Cengiz-Yanardag, Izgen Karakaya
    Scientific Reports.2024;[Epub]     CrossRef
  • 2,362 View
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  • 3 Web of Science
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Investigation of fracture prevalence of instruments used in root canal treatments at a faculty of dentistry: a prospective study
Mehmet Eskibağlar, Merve Yeniçeri Özata, Mevlüt Sinan Ocak, Faruk Öztekin
Restor Dent Endod 2023;48(4):e38.   Published online November 1, 2023
DOI: https://doi.org/10.5395/rde.2023.48.e38
AbstractAbstract PDFPubReaderePub
Objectives

The aim of this study was to examine the use of hand or rotary files by pre-graduation (fourth- and fifth-year) and postgraduate students in endodontic treatments and to determine the incidence of file fracture and the management of cases with broken instruments.

Materials and Methods

A total of 2,168 teeth undergoing primary endodontic treatment were included in this study. It was determined that 79 of these teeth resulted in broken tools. In the case of broken tools, the education level of the treating clinician, the tooth that was being treated, the canal and fracture level, the curvature of the tooth and the management of the broken instrument were recorded. Periapical radiographs of the patients were used to calculate curvature following the Schneider method.

Results

There was no significant difference in the incidence of broken tools according to education level (p > 0.05). The incidence of file fracture in molar teeth (73.4%) was higher than in other teeth (p < 0.05). More files were broken in the mandibular molar MB canal (20.25%) and in the apical third of the canals (72.1%). The risk of instrument fracture was high in teeth with moderate (44.3%) and severe (38%) curvature canals. The management of apically broken (80%) files mostly involved lefting (p < 0.05).

Conclusions

There was no statistically significant difference between fourth-year students, fifth-year students and postgraduate students in terms of instrument fracture.

Citations

Citations to this article as recorded by  
  • Assessment of Techniques of Surpassing Ledges in Curved Canals and Its Effect on File: An In Vitro Study
    Nezar Boreak, Abdulrahman Ali Sawadi, Yahya Yaqoup Hazazi, Sameer J Oqayshi, Wed AY Ayash, Essa Ibrahim Al Essa, Abdulaziz Ismail Shafei, Amjad Hassan Khawaji
    World Journal of Dentistry.2026; 16(11): 1032.     CrossRef
  • Case Study of a Broken Instrument in a Primary Tooth and Literature Review
    Masashi Nakano, Tatsuya Akitomo, Masashi Ogawa, Mariko Kametani, Momoko Usuda, Satoru Kusaka, Chieko Mitsuhata, Ryota Nomura
    Children.2025; 12(2): 149.     CrossRef
  • Neodymium-Doped Yttrium Aluminum Perovskite (Nd:YAP) Laser in the Elimination of Endodontic Nickel-Titanium Files Fractured in Rooted Canals (Part 2: Teeth With Significant Root Curvature)
    Amaury Namour, Marwan El Mobadder, Clément Cerfontaine, Patrick Matamba, Lucia Misoaga, Delphine Magnin , Praveen Arany, Samir Nammour
    Cureus.2025;[Epub]     CrossRef
  • Pattern of endodontic instrument separation and factors affecting its retrieval: a 10-year retrospective observational study in a postgraduate institute
    Velmurugan Natanasabapathy, Aswathi Varghese, Paul Kevin Abishek Karthikeyan, Srinivasan Narasimhan
    Restorative Dentistry & Endodontics.2025; 50(1): e7.     CrossRef
  • Remoção de instrumentos fraturados nos canais radiculares: Desafios, estratégias e perspectivas clínicas
    João Victor da Fonseca Barbosa, Eduardo Kitto Miranda Teixeira , Laura Rodrigues Barbosa, Martinelle Ferreira da Rocha Taranto, Jáder Camilo Pinto
    Research, Society and Development.2025; 14(10): e98141049749.     CrossRef
  • Comparative evaluation of curvature severity of mesiobuccal canals in permanent maxillary 1st molar using multiple complexity risk criteria: A cone-beam computed tomography-based cross-sectional study of central Indian subpopulation
    Mahima Mathur, Suparna Ganguly Saha, Rolly S. Agarwal, Shakti Singh, Manasi Kewlani, Shaurya Sahu
    Endodontology.2025; 37(4): 393.     CrossRef
  • Methods for preventing fragmentation of endodontic instruments: a systematic review
    A. V. Mitronin, D. A. Ostanina, K. A. Archakov, Yu. A. Mitronin
    Endodontics Today.2025; 23(4): 672.     CrossRef
  • Perception of Dental Interns About Intracanal Fracture of Endodontic Instruments in the Central Region of Saudi Arabia: A Cross-Sectional Study
    Abdullah Ahmad A. Aloyouni, Muhammad Atif Saleem Agwan, Saleh Suliman S. Almuzaini, Faris Saleh A. Alqazlan, Abdulaziz Abdulrhman A. Alshumaym, Khalid Abdullah G. Alfuryah
    Journal of Pharmacy and Bioallied Sciences.2024; 16(Suppl 4): S3890.     CrossRef
  • Predictive factors in the retrieval of endodontic instruments: the relationship between the fragment length and location
    Ricardo Portigliatti, Eugenia Pilar Consoli Lizzi, Pablo Alejandro Rodríguez
    Restorative Dentistry & Endodontics.2024;[Epub]     CrossRef
  • Causes and prevention of endodontic file fractures: a review of the literature
    Erkal Damla, Er Kürşat
    Acta Stomatologica Marisiensis Journal.2024; 7(2): 33.     CrossRef
  • PREVALENCE AND ENDODONTIC MANAGEMENT OF SEPARATED INSTRUMENTS INSIDE THE ROOT CANAL
    Cristina Coralia Nistor, Ana Maria Țâncu , Elena Claudia Coculescu , Albu Cristina Crenguta , Stefan Milicescu , Bogdan Dimitriu
    Romanian Journal of Oral Rehabilitation.2024; 16(1): 96.     CrossRef
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Effect of irrigation protocols on smear layer removal, bond strength and nanoleakage of fiber posts using a self-adhesive resin cement
Rodrigo Stadler Alessi, Renata Terumi Jitumori, Bruna Fortes Bittencourt, Giovana Mongruel Gomes, João Carlos Gomes
Restor Dent Endod 2023;48(3):e28.   Published online July 27, 2023
DOI: https://doi.org/10.5395/rde.2023.48.e28
AbstractAbstract PDFPubReaderePub
Objectives

This study aimed to investigate the effect of the application method of 2% chlorhexidine (CHX) and its influence on the adhesion of fiberglass posts cemented with a self-adhesive resin cement.

Materials and Methods

Sixty human mandibular premolars were endodontically treated and divided into 5 groups (n = 12), according to the canal irrigant and its application method: 2 groups with conventional syringe irrigation (CSI)—2.5% sodium hypochlorite (NaOCl) (control) and 2% CHX— and 3 groups with 2% CHX irrigation/activation—by passive ultrasonic irrigation (PUI), Easy Clean file, and XP-Endo Finisher file. Two roots per group were evaluated for smear layer (SL) removal by scanning electron microscopy. For other roots, fiber posts were luted using a self-adhesive resin cement. The roots were sectioned into 6 slices for push-out bond strength (BS) (7/group) and nanoleakage (NL) (3/group). Data from SL removal were submitted to Kruskal-Wallis and Student-Newman-Keuls tests (α = 0.05). Data from BS and NL were evaluated by 2-way analysis of variance and Tukey’s test (α = 0.05).

Results

For SL removal and BS, the CHX irrigation/activation promoted better values than CSI with CHX (p < 0.05), but it was not significantly different from CSI with NaOCl (p > 0.05). For NL, the lowest values were obtained by the chlorhexidine irrigation/activation groups (p < 0.05).

Conclusions

Active 2% CHX irrigation can be used to improve the post space cleaning and adhesion before fiber post cementation with self-adhesive resin cements.

Citations

Citations to this article as recorded by  
  • Effects of radiotherapy dose and endodontic irrigants on universal resin cement bonding to root dentin: mechanical and interfacial analyses
    Lívia Ribeiro, Luíz Carlos de Lima Dias-Júnior, Paulo Henrique dos Santos, Mariana Comparotto Minamisako, Paulo Marcelo Rodrigues, Vicente Ribeiro Netto, Bruno Alexandre Pacheco de Castro Henriques, Renata Gondo Machado, Cleonice da Silveira Teixeira, Luc
    International Journal of Adhesion and Adhesives.2026; 146: 104252.     CrossRef
  • Laser‐Activated Irrigation via Photon‐Induced Photoacoustic Streaming and Shock Wave Enhanced Emission on Smear Layer Removal Efficacy, Pushout Bond Strength, and Sealer Adaptation: A SEM Assessment
    Basil Almutairi, Fahad Alkhudhairy
    Microscopy Research and Technique.2025; 88(6): 1806.     CrossRef
  • The impact of passive ultrasonic irrigation on the bond strength of two different self-etch adhesives to human pulp chamber dentine: a laboratory investigation
    Mohammed Turky, Jukka Matinlinna, Monika Lukomska-Szymanska, Venkateshbabu Nagendrababu, Paul M. H. Dummer, Ahmad Abdel Hamid Elheeny, Nermin Alsayed Mahmoud
    BMC Oral Health.2025;[Epub]     CrossRef
  • The effect of nanoparticles incorporation titanium dioxide and zirconium oxide within self-adhesive resin cement on the push-out bond strength of the fiber post to the radicular dentin: An in vitro study
    Sawsan Hameed Al-Jubori, Maha Anwer AL-Murad
    Saudi Endodontic Journal.2025; 15(2): 162.     CrossRef
  • The Effects of Different Post Space Conditioning Procedures and Different Endodontic Sealers on the Push-Out Bond Strengths of Fiber Posts
    Leyla Ayranci, Ahmet Serkan Küçükekenci, Fatih Sarı, Ahmet Çetinkaya
    Clinical and Experimental Health Sciences.2025; 15(3): 620.     CrossRef
  • Evaluation of Microleakage Using Different Luting Cements in Kedo Zirconia Crowns: An In Vitro Assessment
    Guru Vishnu, Ganesh Jeevanandan
    Cureus.2024;[Epub]     CrossRef
  • 3,222 View
  • 68 Download
  • 6 Web of Science
  • 6 Crossref
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Effects of CTHRC1 on odontogenic differentiation and angiogenesis in human dental pulp stem cells
Jong-soon Kim, Bin-Na Lee, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Yun-Chan Hwang
Restor Dent Endod 2023;48(2):e18.   Published online April 28, 2023
DOI: https://doi.org/10.5395/rde.2023.48.e18
AbstractAbstract PDFPubReaderePub
Objectives

This study aimed to determine whether collagen triple helix repeat containing-1 (CTHRC1), which is involved in vascular remodeling and bone formation, can stimulate odontogenic differentiation and angiogenesis when administered to human dental pulp stem cells (hDPSCs).

Materials and Methods

The viability of hDPSCs upon exposure to CTHRC1 was assessed with the WST-1 assay. CTHRC1 doses of 5, 10, and 20 µg/mL were administered to hDPSCs. Reverse-transcription polymerase reaction was used to detect dentin sialophosphoprotein, dentin matrix protein 1, vascular endothelial growth factor, and fibroblast growth factor 2. The formation of mineralization nodules was evaluated using Alizarin red. A scratch wound assay was conducted to evaluate the effect of CTHRC1 on cell migration. Data were analyzed using 1-way analysis of variance followed by the Tukey post hoc test. The threshold for statistical significance was set at p < 0.05.

Results

CTHRC1 doses of 5, 10, and 20 µg/mL had no significant effect on the viability of hDPSCs. Mineralized nodules were formed and odontogenic markers were upregulated, indicating that CTHRC1 promoted odontogenic differentiation. Scratch wound assays demonstrated that CTHRC1 significantly enhanced the migration of hDPSCs.

Conclusions

CTHRC1 promoted odontogenic differentiation and mineralization in hDPSCs.

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High-plasticity mineral trioxide aggregate and its effects on M1 and M2 macrophage viability and adherence, phagocyte activity, production of reactive oxygen species, and cytokines
Betânia Canal Vasconcellos, Layara Cristine Tomaz Tavares, Danilo Couto da Silva, Francielen Oliveira Fonseca, Francine Benetti, Antônio Paulino Ribeiro Sobrinho, Warley Luciano Fonseca Tavares
Restor Dent Endod 2023;48(1):e6.   Published online December 29, 2022
DOI: https://doi.org/10.5395/rde.2023.48.e6
AbstractAbstract PDFPubReaderePub
Objectives

This study evaluated the effects of high-plasticity mineral trioxide aggregate (MTA-HP) on the activity of M1 and M2 macrophages, compared to white MTA (Angelus).

Materials and Methods

Peritoneal inflammatory M1 (from C57BL/6 mice) and M2 (from BALB/c mice) macrophages were cultured in the presence of the tested materials. Cell viability (MTT and trypan blue assays), adhesion, phagocytosis, reactive oxygen species (ROS) production, and tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β production were evaluated. Parametric analysis of variance and the non-parametric Kruskal-Wallis test were used. Results were considered significant when p < 0.05.

Results

The MTT assay revealed a significant decrease in M1 metabolism with MTA-HP at 24 hours, and with MTA and MTA-HP later. The trypan blue assay showed significantly fewer live M1 at 48 hours and live M2 at 48 and 72 hours with MTA-HP, compared to MTA. M1 and M2 adherence and phagocytosis showed no significant differences compared to control for both materials. Zymosan A stimulated ROS production by macrophages. In the absence of interferon-γ, TNF-α production by M1 did not significantly differ between groups. For M2, both materials showed higher TNF-α production in the presence of the stimulus, but without significant between-group differences. Likewise, TGF-β production by M1 and M2 macrophages was not significantly different between the groups.

Conclusions

M1 and M2 macrophages presented different viability in response to MTA and MTA-HP at different time points. Introducing a plasticizer into the MTA vehicle did not interfere with the activity of M1 and M2 macrophages.

Citations

Citations to this article as recorded by  
  • Local Immune Response to Mineral Trioxide Aggregate: A Narrative Review
    Shankargouda Patil, Shilpa Bhandi, Oladapo T Okareh
    World Journal of Dentistry.2023; 14(4): 382.     CrossRef
  • 1,952 View
  • 28 Download
  • 1 Crossref
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Cytotoxicity of two self-adhesive resin cements and their interference in the phagocytic activity of murine macrophages
Danilo Couto da Silva, Leonardo Gomes Vaz, Warley Luciano Fonseca Tavares, Leda Quercia Vieira, Ricardo Reis de Oliveira, Antônio Paulino Ribeiro Sobrinho
Restor Dent Endod 2022;47(3):e31.   Published online July 14, 2022
DOI: https://doi.org/10.5395/rde.2022.47.e31
AbstractAbstract PDFPubReaderePub
Objectives

This study aimed to evaluate in vitro the effects of the self-adhesive resin cements RelyX U200 (3M ESPE) and seT PP (SDI Limited) on murine macrophages and the interference of the photoactivation.

Materials and Methods

Cell viability assays, cell adherence, yeast phagocytosis of Saccharomyces boulardii and production of reactive oxygen species (ROS) were performed in the presence of capillaries containing the respective self-adhesive cement when photoactivated or not.

Results

After long periods of contact, both types of cements, when not photoactivated, are more cytotoxic for macrophages. The seT PP cement when only chemically activated seems to interfere more negatively in the process of phagocytosis of yeasts S. boulardii. Both types of cements interfere in the cell adhesion process, independent of photoactivation. None of the types of cements tested was able to induce the production of ROS.

Conclusions

Our results highlight the great importance of the photoactivation of self-adhesive resin cements in the dental clinic, since RelyX U200, when photoactivated, presented the best results within the evaluated parameters.

Citations

Citations to this article as recorded by  
  • Influence of Preheating Self-Adhesive Cements on the Degree of Conversion, Cell Migration, and Cell Viability
    Henrique Cantarelli, Fernando Antonio Costa Xavier, Fernando Freitas Portella, Keiichi Hosaka, Eduardo Galia Reston, Louis Hardan, Rim Bourgi, Celso Afonso Klein-Junior
    Applied Mechanics.2024; 5(3): 553.     CrossRef
  • Dental Luting Cements: An Updated Comprehensive Review
    Artak Heboyan, Anna Vardanyan, Mohmed Isaqali Karobari, Anand Marya, Tatevik Avagyan, Hamid Tebyaniyan, Mohammed Mustafa, Dinesh Rokaya, Anna Avetisyan
    Molecules.2023; 28(4): 1619.     CrossRef
  • 1,768 View
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  • 4 Web of Science
  • 2 Crossref
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Is dentin biomodification with collagen cross-linking agents effective for improving dentin adhesion? A systematic review and meta-analysis
Julianne Coelho Silva, Edson Luiz Cetira Filho, Paulo Goberlânio de Barros Silva, Fábio Wildson Gurgel Costa, Vicente de Paulo Aragão Saboia
Restor Dent Endod 2022;47(2):e23.   Published online May 6, 2022
DOI: https://doi.org/10.5395/rde.2022.47.e23
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Objectives

The aim of this investigation was to evaluate the effectiveness of collagen cross-linking agents (CCLAs) used in combination with the adhesive technique in restorative procedures.

Materials and Methods

In this systematic review, the authors followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. An electronic search was performed using PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and DOSS, up to October 2020. The gray literature was also researched. Only randomized clinical trials were selected.

Results

The selection process yielded 3 studies from the 838 retrieved. The addition of CCLAs in the retention of restorations increased the number of events. The postoperative sensitivity scores and marginal adaptation scores showed no significant difference between the CCLA and control groups, and the marginal pigmentation scores showed a significant increase in the CCLA group. There were no caries events in any group throughout the evaluation period.

Conclusions

This systematic review showed that there is no clinical efficacy to justify the use of CCLAs in the protocols performed.

Citations

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  • Riboflavin-ultraviolet-A collagen crosslinking treatments in improving dentin bonding and resistance to enzymatic digestion
    Yung-Show Chiang, Ping-Ju Chen, Chun-Chan Ting, Yuh-Ling Chen, Shu-Fen Chuang
    Journal of Dental Sciences.2025; 20(1): 109.     CrossRef
  • Effect of dentin bio modifications and matrix metalloproteinase activity on bond strength – A systematic review and meta-analysis
    D. Agarwal, S. R. Srinidhi, S. D. Aggarwal, P. Ingle, S. Tandon
    Endodontics Today.2025; 23(1): 71.     CrossRef
  • O USO DE ADESIVO AUTOCONDICIONANTE E RESINA FLOW COMO INTERFACE ADESIVA PROTETORA DA DENTINA FRENTE À IRRIGAÇÃO COM NaClO NO TRATAMENTO ENDODÔNTICO: ESTUDO IN-VITRO
    Luís Daniel Ramos de Oliveira, Leandro Botelho Hanna, José Augusto Rodrigues
    RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218.2025; 6(12): e6127063.     CrossRef
  • Stability of dentin matrix treated with caffeic acid phenethyl ester at different concentrations
    Aline Honorato Damázio, Rosanna Tarkany Basting, Enrico Coser Bridi, Fabiana Mantovani Gomes França, Flávia Lucisano Botelho do Amaral, Cecilia Pedroso Turssi, Waldemir Francisco Vieira Junior, Roberta Tarkany Basting
    Brazilian Journal of Oral Sciences.2024; 23: e244006.     CrossRef
  • Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis
    Louis Hardan, Umer Daood, Rim Bourgi, Carlos Enrique Cuevas-Suárez, Walter Devoto, Maciej Zarow, Natalia Jakubowicz, Juan Eliezer Zamarripa-Calderón, Mateusz Radwanski, Giovana Orsini, Monika Lukomska-Szymanska
    Cells.2022; 11(15): 2417.     CrossRef
  • 2,005 View
  • 47 Download
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Interplay of collagen and mast cells in periapical granulomas and periapical cysts: a comparative polarizing microscopic and immunohistochemical study
Deepty Bansal, Mala Kamboj, Anjali Narwal, Anju Devi, Nisha Marwah
Restor Dent Endod 2022;47(1):e12.   Published online February 14, 2022
DOI: https://doi.org/10.5395/rde.2022.47.e12
AbstractAbstract PDFPubReaderePub
Objectives

This pilot study aimed to establish the interrelationship between collagen and mast cells in periapical granulomas and periapical cysts.

Materials and Methods

An observational cross-sectional study was conducted on the paraffin-embedded tissue sections of 68 specimens (34 periapical granulomas and 34 periapical cysts). The specimens were stained with picrosirius to observe collagen fiber birefringence and anti-tryptase antibody to evaluate the mast cell count immunohistochemically. The mean number and birefringence of collagen fibers, as well as the mean number of mast cells (total, granulated, and degranulated), and the mean inflammatory cell density were calculated. The data obtained were analyzed using the Kruskal Wallis test, Mann Whitney U test, and Spearman correlation test (p < 0.05).

Results

The mean number of thick collagen fibers was higher in periapical cysts, while that of thin fibers was higher in granulomas (p = 0.00). Cysts emitted orange-yellow to red birefringence, whereas periapical granulomas had predominantly green fibers (p = 0.00). The mean inflammatory cell density was comparable in all groups (p = 0.129). The number of total, degranulated, and granulated mast cells exhibited significant results (p = 0.00) in both groups. Thick cyst fibers showed significant inverse correlations with inflammation and degranulated mast cells (p = 0.041, 0.04 respectively).

Conclusions

Mast cells and inflammatory cells influenced the nature of collagen fiber formation and its birefringence. This finding may assist in the prediction of the nature, pathogenesis, and biological behavior of periapical lesions.

Citations

Citations to this article as recorded by  
  • The Mystifying Role of Mast Cells in the Pathogenesis of Periapical Pathologies - A Systematic Review
    Mala Kamboj, Shashibala Malik, R. Keerthika, Anjali Narwal, Anju Devi, Gopikrishnan Vijayakumar, Adarsh Kumar
    Journal of Endodontics.2025; 51(7): 845.     CrossRef
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    Sujatha Varma, Shameena PM, Plakkil Viswanathan Deepthi, Indu G
    Cureus.2024;[Epub]     CrossRef
  • Immunohistochemical evaluation of cyclooxygenase‐2 and mast cell density in periapical lesions
    Shashibala Malik, Mala Kamboj, Anjali Narwal, Anju Devi
    International Endodontic Journal.2023; 56(8): 980.     CrossRef
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  • 21 Download
  • 2 Web of Science
  • 3 Crossref
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Comparison of instrumental methods for color change assessment of Giomer resins
Luiza de Almeida Queiroz Ferreira, Rogéli Tibúrcio Ribeiro da Cunha Peixoto, Cláudia Silami de Magalhães, Tassiana Melo Sá, Monica Yamauti, Francisca Daniele Moreira Jardilino
Restor Dent Endod 2022;47(1):e8.   Published online February 3, 2022
DOI: https://doi.org/10.5395/rde.2022.47.e8
AbstractAbstract PDFPubReaderePub
Objectives

The aim of this study was to compare the color change of the Giomer resin composite (Beautifil-Bulk) by using photographs obtained with a smartphone (iPhone 6S) associated with Adobe Photoshop software (digital method), with the spectrophotometric method (Vita Easyshade) after immersion in different pigment solutions.

Materials and Methods

Twenty resin composite samples with a diameter of 15.0 mm and thickness of 1.0 mm were confectioned in A2 color (n = 5). Photographs and initial color readings were performed with a smartphone and spectrophotometer, respectively. Then, samples were randomly divided and subjected to cycles of immersion in distilled water (control), açai, Coke, and tomato sauce, 3 times a day, 20 minutes for 7 days. Later, new photographs and color readings were taken.

Results

The analysis (2-way analysis of variance, Holm-Sidak, p < 0.05) demonstrated no statistical difference (p < 0.005) between the methods in all groups. Similar color changes were observed for all pigment solutions when using the spectrophotometric method. For the digital method, all color changes were clinically unacceptable, with distilled water and tomato sauce similar to each other and with statistical differences (p < 0.005) for Coke and açai.

Conclusions

Only the tomato sauce produced a color change above the acceptability threshold using both methods of color assessment. The spectrophotometric and digital methods produce different patterns of color change. According to our results, the spectrophotometric method is more recommended in color change assessment.

Citations

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  • The effects of mechanical and chemical degradation on the surface roughness, gloss, and color stability of bulk-fill resin composites
    Merve Nezir, Hanife Altınışık, Esra Özyurt, Naz Bayar, Mediha Büyükgöze Dindar
    BMC Oral Health.2025;[Epub]     CrossRef
  • Are Sculptable Bulk‐Fill Composites Susceptible to Color Change: A Systematic Review
    Jamieson Wong, Constance Yeo, Michelle The, Filip Taneski, Uros Josic, Lorenzo Breschi, Vesna Miletic
    Journal of Esthetic and Restorative Dentistry.2025;[Epub]     CrossRef
  • Color Image Expression through CIE L*a*b* System in Foods
    Hyun-Woong Choi, Seong-Eun Park, Hong-Seok Son
    Journal of the Korean Society of Food Science and Nutrition.2023; 52(2): 223.     CrossRef
  • 2,507 View
  • 36 Download
  • 3 Web of Science
  • 3 Crossref
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In-office dental bleaching with violet light emitting diode: bleaching efficacy and pulpal temperature rise
Brunna Katyuscia de Almeida Guanaes, Talyta Neves Duarte, Gisele Maria Correr, Marina da Rosa Kaizer, Carla Castiglia Gonzaga
Restor Dent Endod 2022;47(1):e7.   Published online February 3, 2022
DOI: https://doi.org/10.5395/rde.2022.47.e7
AbstractAbstract PDFPubReaderePub
Objectives

This study evaluated the bleaching efficacy of different in-office protocols associated with violet light emitting diode (V-LED), and measured the pulpal temperature rise caused by V-LED with or without gel application.

Materials and Methods

Bovine incisors were distributed in 4 groups (n = 10): VL – V-LED; HP – 35% hydrogen peroxide (control); HYB – hybrid protocol, V-LED applied without gel for 10 irradiation cycles followed by V-LED applied with gel for another 10 irradiation cycles; and HPVL – gel and V-LED applied for 20 irradiation cycles. Three bleaching sessions were performed with 7-day intervals. Bleaching efficacy was evaluated with ΔEab*, ΔE00 and ΔWID. Data were recorded at baseline, 7, 14, 21 and 70 days. For pulpal temperature rise, thermocouples were placed inside the pulp chamber of human incisors. To determine intrapulpal temperature, the teeth were irradiated with V-LED with or without application of bleaching gel. Color difference data were analyzed by 2-way repeated measures ANOVA and Tukey’s test. Pulpal temperature was analyzed by t-test (α = 5%).

Results

VL exhibited lower color (ΔEab* and ΔE00) and whiteness changes (ΔWID) than the other groups. HPVL presented higher color change values than HYB. HYB and HPVL showed not different ΔWID values; and HP showed the highest whiteness changes at all times. There were significant differences comparing ΔT with gel (8.9°C) and without gel application (7.2°C).

Conclusions

HPLV was more efficient than HYB. The 2 protocols with VL showed similar results to control. Gel application combined with VL promoted higher pulpal temperature than to the no gel group.

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    Mohamed Nabil, Mostafa Mohamed Hasan, Eman Abd Elghany Shebl
    Journal of Esthetic and Restorative Dentistry.2024; 36(3): 429.     CrossRef
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    NR Carlos, RT Basting, KR Kantovitz, ES Bronze-Uhle, PN Lisboa Filho, V Cavalli, RT Basting
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    Isabela Souza Vardasca, Michael Willian Favoreto, Mylena de Araujo Regis, Taynara de Souza Carneiro, Emanuel Adriano Hul, Christiane Philippini Ferreira Borges, Alessandra Reis, Alessandro D. Loguercio, Carlos Francci
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    Gustavo Garcia Castro, Palena Araújo Pinto, Michael Willian Favoreto, Alessandra Reis, Maria Viviana-Mora, Rita de Cássia Mendonça de Miranda, Andres Felipe Milan Cardenas, Alessandro D. Loguercio, Rudys Rodolfo de Jesus Tavarez
    Photodiagnosis and Photodynamic Therapy.2024; 50: 104410.     CrossRef
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    Mandana Karimi, Elmira Ataee, Ladan Ranjbar Omrani, Mahdi Abbasi, Elham Ahmadi
    Avicenna Journal of Dental Research.2024; 16(4): 225.     CrossRef
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    Mayanna Pacheco Trindade Najar, Luciana Hilel Rangel Barbosa, Natália Russo Carlos, Fabiana Mantovani Gomes França, Cecilia Pedroso Turssi, Waldemir Francisco Vieira-Junior, Roberta Tarkany Basting
    Photodiagnosis and Photodynamic Therapy.2023; 42: 103631.     CrossRef
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    Marlon Ferreira Dias, Beatriz Voss Martins, Rafael Antonio de Oliveira Ribeiro, Josimeri Hebling, Carlos Alberto de Souza Costa
    Lasers in Medical Science.2022;[Epub]     CrossRef
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  • 7 Web of Science
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Review Article
Silver nanoparticles in endodontics: recent developments and applications
Aysenur Oncu, Yan Huang, Gulin Amasya, Fatma Semra Sevimay, Kaan Orhan, Berkan Celikten
Restor Dent Endod 2021;46(3):e38.   Published online July 1, 2021
DOI: https://doi.org/10.5395/rde.2021.46.e38
AbstractAbstract PDFPubReaderePub

The elimination of endodontic biofilms and the maintenance of a leak-proof canal filling are key aspects of successful root canal treatment. Several materials have been introduced to treat endodontic disease, although treatment success is limited by the features of the biomaterials used. Silver nanoparticles (AgNPs) have been increasingly considered in dental applications, especially endodontics, due to their high antimicrobial activity. For the present study, an electronic search was conducted using MEDLINE (PubMed), the Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and EMBASE. This review provides insights into the unique characteristics of AgNPs, including their chemical, physical, and antimicrobial properties; limitations; and potential uses. Various studies involving different application methods of AgNPs were carefully examined. Based on previous clinical studies, the synthesis, means of obtaining, usage conditions, and potential cytotoxicity of AgNPs were evaluated. The findings indicate that AgNPs are effective antimicrobial agents for the elimination of endodontic biofilms.

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    Selvam Manoj, Radhakrishnan Sreena, Rajkumar Divya, Starlin Ebinesh, Shenbagaraman Akshaya, Srikumar Sugantha Angel, Arputharaj Joseph Nathanael
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    Laila Mohamed Mohamed Kenawi, Mohamed Fattouh, Khaled Abid Althaqafi, Abla Arafa
    The Open Dentistry Journal.2025;[Epub]     CrossRef
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    Seema H Bukhari, Dax Abraham, Shakila Mahesh
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    Karla Navarrete-Olvera, Nereyda Niño-Martínez, Idania De Alba-Montero, Nuria Patiño-Marín, Facundo Ruiz, Horacio Bach, Gabriel-Alejandro Martínez-Castañón
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    Abbas Abbaszadegan, Elham Tayebikhorami, Ahmad Gholami, Nazanin Bonyanpour, Bahar Asheghi, Sara Nikmanesh
    Journal of Ionic Liquids.2024; 4(2): 100117.     CrossRef
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    Célia Marques, Liliana Grenho, Maria Helena Fernandes, Sofia A. Costa Lima
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    Roohollah Sharifi, Ahmad Vatani, Amir Sabzi, Mohsen Safaei
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    Gustavo Adolfo Tovar Rangel , Fanny Mildred González Sáenz , Ingrid Ximena Zamora Córdoba , Lina María García Zapata
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Research Articles
Microleakage and characteristics of resin-tooth tissues interface of a self-etch and an etch-and-rinse adhesive systems
Xuan Vinh Tran, Khanh Quang Tran
Restor Dent Endod 2021;46(2):e30.   Published online May 18, 2021
DOI: https://doi.org/10.5395/rde.2021.46.e30
AbstractAbstract PDFPubReaderePub
Objectives

This study was conducted to compare the microleakage and characteristics of the resin-tooth tissue interface between self-etch and etch-and-rinse adhesive systems after 48 hours and 3 months.

Materials and Methods

40 extracted premolar teeth were randomly divided into 2 groups: 1-step self-etch adhesive system – Optibond™ All-In-One, and 2-step etch-and-rinse adhesive system - Adper™ Single Bond 2. Both groups were subjected to 500 thermocycles (5°C–55°C) before scanning electron microscope (SEM) analysis or microleakage trial at 48-hour and 3-month time periods.

Results

SEM images showed the hybrid layer thickness, diameter, and length of resin tags of the self-etch adhesive (0.42 ± 0.14 µm; 1.49 ± 0.45 µm; 16.35 ± 14.26 µm) were smaller than those of the etch-and-rinse adhesive (4.39 ± 1.52 µm; 3.49 ± 1 µm; 52.81 ± 35.81 µm). In dentin, the microleakage scores of the 2 adhesives were not different in both time periods (48 hours/3 months). However, the microleakage score of etch-and-rinse adhesive increased significantly after 3 months (0.8 ± 0.63 and 1.9 ± 0.88, p < 0.05).

Conclusions

The self-etch adhesive exhibited better long-term sealing ability in dentin when compared to that of the etch-and-rinse adhesive. The greater hybrid layer thickness and dimensions of resin tags did not guarantee reliable, long-lasting sealing in the bonding area.

Citations

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  • Efficacy of different adhesive systems in bonding direct resin composite restorations: a systematic review and meta-analysis
    Ravinder S. Saini, Rajesh Vyas, Sunil Kumar Vaddamanu, Syed Altafuddin Quadri, Seyed Ali Mosaddad, Artak Heboyan
    Evidence-Based Dentistry.2025; 26(2): 115.     CrossRef
  • Characterisation of universal adhesive bonded resin-dentin interface after focused ultrasound smear layer conditioning
    Cheryl Fu, Peta L. Clode, Amr S. Fawzy
    International Journal of Adhesion and Adhesives.2025; 142: 104115.     CrossRef
  • Effect of Dentin Pretreatment With Dimethyl Sulfoxide Solution on Interfacial Fracture Toughness of Composite Resin to Wet and Dry Dentin
    Fatemeh Molaei, Mehrsima Ghavami-Lahiji, Seyedeh Maryam Tavangar, Hannah Wesley
    International Journal of Dentistry.2025;[Epub]     CrossRef
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    Nabih Alkhouri, Wendy Xia, Paul Ashley, Anne Young
    Frontiers in Oral Health.2024;[Epub]     CrossRef
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    Lucineide Silva da Rocha, Daniela Ferreira de Oliveira, Cinthya Luna Veloso de Lima, Ticiano Gomes do Nascimento, Johnnatan Duarte de Freitas, Jeniffer Mclaine Duarte de Freitas, Isabel Cristina Celerino de Moraes Porto
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    Xiangqin Xu, Jiansheng Zhu, May Lei Mei, Huaying Wu, Kaipeng Xie, Shoulin Wang, Yaming Chen
    The Journal of Biomedical Research.2023; 37(2): 138.     CrossRef
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    Rana Alkattan
    Primary Dental Journal.2023; 12(3): 33.     CrossRef
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    Xiaoxiao You, Long Chen, Jie Xu, Sihui Li, Zhenghao Zhang, Ling Guo
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    Nojoud Alshehri, Abdullah Aljamhan, Mohammed Bin-Shuwaish
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    Zonghua Wang, Xiaoran Zhang, Shuo Yao, Jiaxin Zhao, Chuanjian Zhou, Junling Wu
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    Jia Wang, Wei Jiang, Jingping Liang, Shujun Ran
    The Journal of Prosthetic Dentistry.2022; 128(6): 1363.e1.     CrossRef
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  • 36 Download
  • 10 Web of Science
  • 11 Crossref
Close layer
A novel antimicrobial-containing nanocellulose scaffold for regenerative endodontics
Victoria Kichler, Lucas Soares Teixeira, Maick Meneguzzo Prado, Guilherme Colla, Daniela Peressoni Vieira Schuldt, Beatriz Serrato Coelho, Luismar Marques Porto, Josiane de Almeida
Restor Dent Endod 2021;46(2):e20.   Published online March 16, 2021
DOI: https://doi.org/10.5395/rde.2021.46.e20
AbstractAbstract PDFPubReaderePub
Objectives

The aim of this study was to evaluate bacterial nanocellulose (BNC) membranes incorporated with antimicrobial agents regarding cytotoxicity in fibroblasts of the periodontal ligament (PDLF), antimicrobial activity, and inhibition of multispecies biofilm formation.

Materials and Methods

The tested BNC membranes were BNC + 1% clindamycin (BNC/CLI); BNC + 0.12% chlorhexidine (BNC/CHX); BNC + nitric oxide (BNC/NO); and conventional BNC (BNC; control). After PDLF culture, the BNC membranes were positioned in the wells and maintained for 24 hours. Cell viability was then evaluated using the MTS calorimetric test. Antimicrobial activity against Enterococcus faecalis, Actinomyces naeslundii, and Streptococcus sanguinis (S. sanguinis) was evaluated using the agar diffusion test. To assess the antibiofilm activity, BNC membranes were exposed for 24 hours to the mixed culture. After sonicating the BNC membranes to remove the remaining biofilm and plating the suspension on agar, the number of colony-forming units (CFU)/mL was determined. Data were analyzed by 1-way analysis of variance and the Tukey, Kruskal-Wallis, and Dunn tests (α = 5%).

Results

PDLF metabolic activity after contact with BNC/CHX, BNC/CLI, and BNC/NO was 35%, 61% and 97%, respectively, compared to BNC. BNC/NO showed biocompatibility similar to that of BNC (p = 0.78). BNC/CLI showed the largest inhibition halos, and was superior to the other BNC membranes against S. sanguinis (p < 0.05). The experimental BNC membranes inhibited biofilm formation, with about a 3-fold log CFU reduction compared to BNC (p < 0.05).

Conclusions

BNC/NO showed excellent biocompatibility and inhibited multispecies biofilm formation, similarly to BNC/CLI and BNC/CHX.

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    Prachi Shrivastav, Sheersha Pramanik, Gayatri Vaidya, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Ajeet Singh, Bassam M. Abualsoud, Larissa Souza Amaral, Mohammed A. S. Abourehab
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    Peyman Esmaeili Fard Barzegar, Reza Ranjbar, Mohsen Yazdanian, Elahe Tahmasebi, Mostafa Alam, Kamyar Abbasi, Hamid Tebyaniyan, Keyvan Esmaeili Fard Barzegar
    Materials Today Communications.2022; 32: 104099.     CrossRef
  • 1,988 View
  • 30 Download
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Can silver diamine fluoride or silver nanoparticle-based anticaries agents to affect enamel bond strength?
Jaqueline Costa Favaro, Yana Cosendey Toledo de Mello Peixoto, Omar Geha, Flaviana Alves Dias, Ricardo Danil Guiraldo, Murilo Baena Lopes, Sandrine Bittencourt Berger
Restor Dent Endod 2021;46(1):e7.   Published online January 12, 2021
DOI: https://doi.org/10.5395/rde.2021.46.e7
AbstractAbstract PDFPubReaderePub
Objectives

The aim of the current study is to investigate the effect of different anticaries agents, such as experimental agents based on silver nanoparticles (SNPs) and silver diamine fluoride (SDF), on the micro-shear bond strength (μ-SBS) of composite resin applied to intact enamel (IE) or demineralized enamel (DE).

Materials and Methods

Sixty dental enamel fragments were collected from human third molars and categorized into 6 groups (n = 10): positive control (IE), negative control (DE), IE + SDF, DE + SDF, IE + SNP and DE + SNP. Samples from DE, DE + SDF and DE + SNP groups were subjected to pH cycling; superficial microhardness test was performed to confirm demineralization. Resin composite build-ups were applied to the samples (0.75-mm diameter and 1-mm height) after the treatments (except for IE and DE groups); μ-SBS was also evaluated. Samples were analyzed under a stereomicroscope at 40× magnification to identify failure patterns. Data were subjected to one-way analysis of variance, followed by Tukey's and Dunnett's tests (p < 0.05).

Results

There was no significant difference among the IE, IE + SNP, DE + SDF, and DE + SNP groups. The IE + SDF and DE groups recorded the highest and the lowest μ-SBS values, respectively. Adhesive-type failures were the most frequent for all treatments.

Conclusions

Anticaries agents did not have a negative effect on the μ-SBS of composite resin when it was used on IE or DE.

Citations

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  • Impact of Incorporating Nanoparticles to Adhesive Resin on the Demineralization of Enamel: A Systematic Review
    Naif Almosa
    Dentistry Journal.2025; 13(3): 89.     CrossRef
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    Yanyan Guo, Xiaomei Hou, Sanjun Fan, Chanyuan Jin
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    Rasha N. AlSheikh
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    Zaher Jabbour, Mijoo Kim, Marc Hayashi, Reuben Kim
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    Aya Anwar Alsherif, Mohamed Ali Farag, Mai Badreldin Helal
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    Amjad Almuqrin, Inder Preet Kaur, Laurence J. Walsh, Chaminda Jayampath Seneviratne, Sobia Zafar
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    Mohammed M Aldosari, Fares S Al-Sehaibany
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  • 22 Download
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Close layer
Interface between calcium silicate cement and adhesive systems according to adhesive families and cement maturation
Nelly Pradelle-Plasse, Caroline Mocquot, Katherine Semennikova, Pierre Colon, Brigitte Grosgogeat
Restor Dent Endod 2021;46(1):e3.   Published online December 9, 2020
DOI: https://doi.org/10.5395/rde.2021.46.e3
AbstractAbstract PDFPubReaderePub
Objectives

This study aimed to evaluate the interface between a calcium silicate cement (CSC), Biodentine and dental adhesives in terms of sealing ability.

Materials and Methods

Microleakage test: 160 standardized class II cavities were prepared on 80 extracted human molars. The cavities were filled with Biodentine and then divided into 2 experimental groups according to the time of restoration: composite resin obturation 15 minutes after Biodentine handling (D0); restoration after 7 days (D7). Each group was then divided into 8 subgroups (n = 5) according to the adhesive system used: etch-and-rinse adhesive (Prime & Bond); self-etch adhesive 2 steps (Optibond XTR and Clearfil SE Bond); self-etch adhesive 1 step (Xeno III, G-aenial Bond, and Clearfil Tri-S Bond); and universal used as etch-and-rinse or self-etch (ScotchBond Universal ER or SE). After thermocycling, the teeth were immersed in a silver nitrate solution, stained, longitudinally sectioned, and the Biodentine/adhesive percolation was quantified. Scanning electron microscopic observations: Biodentine/adhesive interfaces were observed.

Results

A tendency towards less microleakage was observed when Biodentine was etched (2.47%) and when restorations were done without delay (D0: 4.31%, D7: 6.78%), but this was not significant. The adhesives containing 10-methacryloyloxydecyl dihydrogen phosphate monomer showed the most stable results at both times studied. All Biodentine/adhesive interfaces were homogeneous and regular.

Conclusions

The good sealing of the CSC/adhesive interface is not a function of the system adhesive family used or the cement maturation before restoration. Biodentine can be used as a dentine substitute.

Citations

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    Zeynep Hale Keleş, Vasfiye Işık, Soner Sismanoglu
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    Abidin Talha Mutluay, Merve Mutluay
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Close layer
Physicochemical properties, cytotoxicity and penetration into dentinal tubules of sodium hypochlorite with and without surfactants
Hernán Coaguila-Llerena, Isadora Barbieri, Mário Tanomaru-Filho, Renato de Toledo Leonardo, Ana Paula Ramos, Gisele Faria
Restor Dent Endod 2020;45(4):e47.   Published online September 10, 2020
DOI: https://doi.org/10.5395/rde.2020.45.e47
AbstractAbstract PDFPubReaderePub
Objectives

The aim of this study was to assess the physicochemical properties, cytotoxicity and penetration into dentinal tubules of ChlorCid™ Surf (3% sodium hypochlorite [NaOCl] with surfactant) in comparison to ChlorCid™ (3% NaOCl without surfactant).

Materials and Methods

The physicochemical properties evaluated were pH, surface tension, free available chlorine (FAC) and contact angle. Cytotoxicity was evaluated in L929 fibroblasts exposed to the solutions by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and neutral red assays. Assessment of penetration into dentinal tubules was performed by staining single-rooted permanent human teeth with crystal violet (n = 9), which were irrigated with the solutions and analyzed in cervical, middle and apical segments. Data were analyzed by one-way analysis of variance (ANOVA) and Tukey's post-test, 2-way ANOVA and Bonferroni's post-test or t-test (α = 0.05).

Results

ChlorCid™ Surf and ChlorCid™ FAC values were close to those indicated by the manufacturer. ChlorCid™ Surf showed lower surface tension and contact angle on dentin, and higher pH than ChlorCid™ (p < 0.05). The penetration of ChlorCid™ Surf was higher in cervical and middle segments, compared with ChlorCid™ (p < 0.05). There was no difference in irrigant cytotoxicity (p > 0.05).

Conclusions

ChlorCid™ Surf showed lower surface tension, lower contact angle on root canal dentin, higher penetration into dentinal tubules and more alkaline pH, compared with ChlorCid™. However, both solutions showed similar cytotoxicity and FAC content.

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    Hernán Coaguila-Llerena, Luana Raphael da Silva, Gisele Faria
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    Preety Sehrawat
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    Joatan Lucas de Sousa Gomes COSTA, Tatiane Miranda MANZOLI, João Felipe BESEGATO, Joissi Ferrari ZANIBONI, Eliane Cristina Gulin DE OLIVEIRA, Lucas David GALVANI, Andréa Abi Rached DANTAS, Luis Geraldo VAZ, Milton Carlos KUGA
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    Hernán Coaguila-Llerena, Julia da Silva Toledo, Ana Paula Ramos, Gisele Faria
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Close layer
Review Articles
Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion
Izadora Quintela Souza de Moraes, Ticiano Gomes do Nascimento, Antonio Thomás da Silva, Lilian Maria Santos Silva de Lira, Abhishek Parolia, Isabel Cristina Celerino de Moraes Porto
Restor Dent Endod 2020;45(3):e31.   Published online May 22, 2020
DOI: https://doi.org/10.5395/rde.2020.45.e31
AbstractAbstract PDFPubReaderePub

Matrix metalloproteinases (MMPs) are enzymes that can degrade collagen in hybrid layer and reduce the longevity of adhesive restorations. As scientific understanding of the MMPs has advanced, useful strategies focusing on preventing these enzymes' actions by MMP inhibitors have quickly developed in many medical fields. However, in restorative dentistry, it is still not well established. This paper is an overview of the strategies to inhibit MMPs that can achieve a long-lasting material-tooth adhesion. Literature search was performed comprehensively using the electronic databases: PubMed, ScienceDirect and Scopus including articles from May 2007 to December 2019 and the main search terms were “matrix metalloproteinases”, “collagen”, and “dentin” and “hybrid layer”. MMPs typical structure consists of several distinct domains. MMP inhibitors can be divided into 2 main groups: synthetic (synthetic-peptides, non-peptide molecules and compounds, tetracyclines, metallic ions, and others) and natural bioactive inhibitors mainly flavonoids. Selective inhibitors of MMPs promise to be the future for specific targeting of preventing dentin proteolysis. The knowledge about MMPs functionality should be considered to synthesize drugs capable to efficiently and selectively block MMPs chemical routes targeting their inactivation in order to overcome the current limitations of the therapeutic use of MMPs inhibitors, i.e., easy clinical application and long-lasting effect.

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    Dalia A. Abuelenain, Ensanya A. Abou Neel, Tariq S. Abuhaimed, Amal M. Alamri, Hanan S. Ammar, Sahar M. N. Bukhary
    The Open Dentistry Journal.2021; 15(1): 540.     CrossRef
  • Reinforced Universal Adhesive by Ribose Crosslinker: A Novel Strategy in Adhesive Dentistry
    Rim Bourgi, Umer Daood, Mohammed Nadeem Bijle, Amr Fawzy, Maroun Ghaleb, Louis Hardan
    Polymers.2021; 13(5): 704.     CrossRef
  • 6,949 View
  • 155 Download
  • 40 Crossref
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Age-dependent root canal instrumentation techniques: a comprehensive narrative review
Michael Solomonov, Hyeon-Cheol Kim, Avi Hadad, Dan Henry Levy, Joe Ben Itzhak, Oleg Levinson, Hadas Azizi
Restor Dent Endod 2020;45(2):e21.   Published online March 4, 2020
DOI: https://doi.org/10.5395/rde.2020.45.e21
AbstractAbstract PDFPubReaderePub

The aim of this article was to review age-dependent clinical recommendations for appropriate root canal instrumentation techniques. A comprehensive narrative review of canal morphology, the structural characteristics of dentin, and endodontic outcomes at different ages was undertaken instead of a systematic review. An electronic literature search was carried out, including the Medline (Ovid), PubMed, and Web of Science databases. The searches used controlled vocabulary and free-text terms, as follows: ‘age-related root canal treatment,’ ‘age-related instrumentation,’ ‘age-related chemo-mechanical preparation,’ ‘age-related endodontic clinical recommendations,’ ‘root canal instrumentation at different ages,’ ‘geriatric root canal treatment,’ and ‘pediatric root canal treatment.’ Due to the lack of literature with practical age-based clinical recommendations for an appropriate root canal instrumentation technique, a narrative review was conducted to suggest a clinical algorithm for choosing the most appropriate instrumentation technique during root canal treatment. Based on the evidence found through the narrative review, an age-related clinical algorithm for choosing appropriate instrumentation during root canal treatment was proposed. Age affects the morphology of the root canal system and the structural characteristics of dentin. The clinician’s awareness of root canal morphology and dentin characteristics can influence the choice of instruments for root canal treatment.

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Research Articles
Influence of modeling agents on the surface properties of an esthetic nano-hybrid composite
Zeynep Bilge Kutuk, Ecem Erden, Damla Lara Aksahin, Zeynep Elif Durak, Alp Can Dulda
Restor Dent Endod 2020;45(2):e13.   Published online January 29, 2020
DOI: https://doi.org/10.5395/rde.2020.45.e13
AbstractAbstract PDFPubReaderePub
Objective

The aim of this study was to evaluate the influence of different modeling agents on the surface microhardness (Vickers hardness number; VHN), roughness (Ra), and color change (ΔE) of a nano-hybrid composite with or without exposure to discoloration by coffee.

Materials and Methods

Sixty-four cylinder-shaped nano-hybrid composite specimens were prepared using a Teflon mold. The specimens' surfaces were prepared according to the following groups: group 1, no modeling agent; group 2, Modeling Liquid; group 3, a universal adhesive (G-Premio Bond); and group 4, the first step of a 2-step self-adhesive system (OptiBond XTR). Specimens were randomly allocated into 2 groups (n = 8) according to the storage medium (distilled water or coffee). VHN, Ra, and ΔE were measured at 24 hours, 1 week, and 6 weeks. The Kruskal-Wallis test followed by the Bonferroni correction for pairwise comparisons was used for statistical analysis (α = 0.05).

Results

Storage time did not influence the VHN of the nano-hybrid composite in any group (p > 0.05). OptiBond XTR Primer application affected the VHN negatively in all investigated storage medium and time conditions (p < 0.05). Modeling Liquid application yielded improved Ra values for the specimens stored in coffee at each time point (p < 0.05). Modeling Liquid application was associated with the lowest ΔE values in all investigated storage medium and time conditions (p < 0.05).

Conclusion

Different types of modeling agents could affect the surface properties and discoloration of nano-hybrid composites.

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    Ezgi Erden Kayalidere, Merve Sahin
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    Journal of Esthetic and Restorative Dentistry.2025; 37(2): 514.     CrossRef
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    FR Hojo, TC Martins, WF Vieira-Junior, FMG França, CP Turssi, RT Basting
    Operative Dentistry.2025; 50(1): 101.     CrossRef
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    Melek Güven Bekdaş, Ihsan Hubbezoglu
    BMC Oral Health.2025;[Epub]     CrossRef
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    Bengü Doğu Kaya, Mehmet Buldur, Burcu Gözetici-Çil
    Odontology.2025;[Epub]     CrossRef
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    Ahmed Alshawi, Benin Dikmen, Sevda Ozel Yildiz, Ugur Erdemir
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    Murat Can Ersen, Nevin Cobanoglu
    BMC Oral Health.2025;[Epub]     CrossRef
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    Abdulrahman A Balhaddad, Faisal Alharamlah, Alhanoof Aldossary, Wejdan Almutairi, Turki Alshehri, Mary Anne S Melo, Afnan O Al-Zain, Eman H Ismail
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    Musa Kazim Ucuncu, Ozge Celiksoz, Emine Sen, Yasemin Yucel Yucel, Bircan Dinc
    Applied Sciences.2024; 14(11): 4406.     CrossRef
  • EFEITO DOS LÍQUIDOS MODELADORES NA SUPERFÍCIE DA RESINA COMPOSTA – UMA REVISÃO DE LITERATURA
    Samuel Silva Dias, Matheus Fernando Lopes, Jeffison Teles Dias, Caio Junji Tanaka, Jose Augusto Rodrigues
    RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218.2024; 5(2): e524899.     CrossRef
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    G Pippin, D Tantbirojn, M Wolfgang, JS Nordin, A Versluis
    Operative Dentistry.2024; 49(4): 475.     CrossRef
  • Full analysis of the effects of modeler liquids on the properties of direct resin-based composites: a meta-analysis review of in vitro studies
    Eduardo Trota Chaves, Lisia Lorea Valente, Eliseu Aldrighi Münchow
    Clinical Oral Investigations.2023; 27(7): 3289.     CrossRef
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    Gaetano Paolone, Claudia Mazzitelli, Giacomo Zechini, Salvatore Scolavino, Cecilia Goracci, Nicola Scotti, Giuseppe Cantatore, Enrico Gherlone, Alessandro Vichi
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    Juliusz Kosewski, Przemysław Kosewski, Agnieszka Mielczarek
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    Numan AYDIN, Serpil KARAOĞLANOĞLU, Bilge ERSÖZ
    Cumhuriyet Dental Journal.2022; 25(Supplement): 119.     CrossRef
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    Nantawan Krajangta, Supissara Ninbanjong, Sunisa Khosook, Kanjana Chaitontuak, Awiruth Klaisiri
    European Journal of Dentistry.2022; 16(04): 828.     CrossRef
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    Gaetano Paolone, Claudia Mazzitelli, Uros Josic, Nicola Scotti, Enrico Gherlone, Giuseppe Cantatore, Lorenzo Breschi
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  • Shear Bond Strength of Composite Diluted with Composite-Handling Agents on Dentin and Enamel
    Mijoo Kim, Deuk-Won Jo, Shahed Al Khalifah, Bo Yu, Marc Hayashi, Reuben H. Kim
    Polymers.2022; 14(13): 2665.     CrossRef
  • Effect of Modeling Resins on Microhardness of Resin Composites
    Ezgi T. Bayraktar, Pinar Y. Atali, Bora Korkut, Ezgi G. Kesimli, Bilge Tarcin, Cafer Turkmen
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The influence of nanofillers on the properties of ethanol-solvated and non-solvated dental adhesives
Leonardo Bairrada Tavares da Cruz, Marcelo Tavares Oliveira, Cintia Helena Coury Saraceni, Adriano Fonseca Lima
Restor Dent Endod 2019;44(3):e28.   Published online July 24, 2019
DOI: https://doi.org/10.5395/rde.2019.44.e28
AbstractAbstract PDFPubReaderePub
Objectives

The aim of this study was to evaluate the influence of different concentrations of nanofillers on the chemical and physical properties of ethanol-solvated and non-solvated dental adhesives.

Materials and Methods

Eight experimental adhesives were prepared with different nanofiller concentrations (0, 1, 2, and 4 wt%) and 2 solvent concentrations (0% and 10% ethanol). Several properties of the experimental adhesives were evaluated, such as water sorption and solubility (n = 5, 20 seconds light activation), real-time degree of conversion (DC; n = 3, 20 and 40 seconds light activation), and stability of cohesive strength at 6 months (CS; n = 20, 20 seconds light activation) using the microtensile test. A light-emitting diode (Bluephase 20i, Ivoclar Vivadent) with an average light emittance of 1,200 mW/cm2 was used.

Results

The presence of solvent reduced the DC after 20 seconds of curing, but increased the final DC, water sorption, and solubility of the adhesives. Storage in water reduced the strength of the adhesives. The addition of 1 wt% and 2 wt% nanofillers increased the polymerization rate of the adhesives.

Conclusions

The presence of nanofillers and ethanol improved the final DC, although the DC of the solvated adhesives at 20 seconds was lower than that of the non-solvated adhesives. The presence of ethanol reduced the strength of the adhesives and increased their water sorption and solubility. However, nanofillers did not affect the water sorption and strength of the tested adhesives.

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    Dalndushe Abdulai, Rafat Sasany, Raghib Suradi, Mehran Moghbel, Seyed Ali Mosaddad
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    Senthilguru Kulanthaivel, Jeremiah Poppen, Sandra Ribeiro Cunha, Benjamin Furman, Kyumin Whang, Erica C. Teixeira
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    Abdul Khan, Yasmin Alhamdan, Hala Alibrahim, Khalid Almulhim, Muhammad Nawaz, Syed Ahmed, Khalid Aljuaid, Ijlal Ateeq, Sultan Akhtar, Mohammad Ansari, Intisar Siddiqui
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    Camila Sabatini, Russell J. Aguilar, Ziwen Zhang, Steven Makowka, Abhishek Kumar, Megan M. Jones, Michelle B. Visser, Mark Swihart, Chong Cheng
    Journal of the Mechanical Behavior of Biomedical Materials.2022; 129: 105153.     CrossRef
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  • 8 Download
  • 4 Crossref
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In vitro evaluation of octenidine as an antimicrobial agent against Staphylococcus epidermidis in disinfecting the root canal system
Jia Da Chum, Darryl Jun Zhi Lim, Sultan Omer Sheriff, Shaju Jacob Pulikkotil, Anand Suresh, Fabian Davamani
Restor Dent Endod 2019;44(1):e8.   Published online February 8, 2019
DOI: https://doi.org/10.5395/rde.2019.44.e8
AbstractAbstract PDFPubReaderePub
Objectives

Irrigants are imperative in endodontic therapy for the elimination of pathogens from the infected root canal. The present study compared the antimicrobial efficacy of octenidine dihydrochloride (OCT) with chlorhexidine (CHX) and sodium hypochlorite (NaOCl) against Staphylococcus epidermidis (S. epidermidis) for root canal disinfection.

Materials and Methods

The minimum inhibitory concentration (MIC) was obtained using serial dilution method. The agar diffusion method was then used to determine the zones of inhibition for each irrigant. Lastly, forty 6-mm dentin blocks were prepared from human mandibular premolars and inoculated with S. epidermidis. Samples were randomly divided into 4 groups of 10 blocks and irrigated for 3 minutes with saline (control), 2% CHX, 3% NaOCl, or 0.1% OCT. Dentin samples were then collected immediately for microbial analysis, including an analysis of colony-forming units (CFUs).

Results

The MICs of each tested irrigant were 0.05% for CHX, 0.25% for NaOCl, and 0.0125% for OCT. All tested irrigants showed concentration-dependent increase in zones of inhibition, and 3% NaOCl showed the largest zone of inhibition amongst all tested irrigants (p < 0.05). There were no significant differences among the CFU measurements of 2% CHX, 3% NaOCl, and 0.1% OCT showing complete elimination of S. epidermidis in all samples.

Conclusions

This study showed that OCT was comparable to or even more effective than CHX and NaOCl, demonstrating antimicrobial activity at low concentrations against S. epidermidis.

Citations

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    Sevinc Askerbeyli Örs, Gülgün Atay Yılmaz, Nihan Şengül, Ahmet Keleş, Selen Küçükkaya Eren
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    Nirit Tagger Green, Roni Kolerman, Carlos Nemcovsky, Shlomo Matalon, Dan Gaukhman, Liat Chaushu
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    Ihsan Hakki Ciftci, Asuman Deveci Ozkan, Gulay Erman, Elmas Pinar Kahraman Kilbas, Mehmet Koroglu
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    Journal of Conservative Dentistry and Endodontics.2024; 27(6): 654.     CrossRef
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    Zongxia Zhu, Guangli Fu
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    Huili Wu, Lijuan Wang, Chenjie Qiu
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    Yuqiang Wang, Jiakang Zhu, Ying Tang, Cui Huang
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    Stefania-Irina Dumitrel, Anamaria Matichescu, Stefania Dinu, Roxana Buzatu, Ramona Popovici, Dorin Dinu, Dana Bratu
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    Omer Sheriff Sultan, Haresh Kumar A/L Kantilal, Khoo Suan Phaik, Hira Choudhury, Fabian Davamani
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    Shadab Ahmed, Kamil Shahnawaz, Tapan Kumar Mandal, Mamnoon Ghafir, Shiva Shankar Gummaluri, Gaurav Vishal
    Contemporary Clinical Dentistry.2022; 13(4): 383.     CrossRef
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    B. Reda, J. Dudek, M. Martínez-Hernández, M. Hannig
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  • Does Cavity Disinfectant Affect Sealing Ability of Universal Self-etch Adhesive?
    S Lata, Prasanti Kumari Pradhan, Gaurav Patri, Subhasmita Bhol, Kanhu C Sahoo, Khushboo Ghosh
    The Journal of Contemporary Dental Practice.2021; 22(3): 273.     CrossRef
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    VinayaSusan Varghese, Nirmal Kurian
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Evaluation of the effects of whitening mouth rinses combined with conventional tooth bleaching treatments
Jaqueline Costa Favaro, Omar Geha, Ricardo Danil Guiraldo, Murilo Baena Lopes, Andreza Maria Fábio Aranha, Sandrine Bittencourt Berger
Restor Dent Endod 2019;44(1):e6.   Published online January 30, 2019
DOI: https://doi.org/10.5395/rde.2019.44.e6
AbstractAbstract PDFPubReaderePub
Objectives

The aim of the present study was to evaluate the effect of whitening mouth rinses alone and in combination with conventional whitening treatments on color, microhardness, and surface roughness changes in enamel specimens.

Materials and Methods

A total of 108 enamel specimens were collected from human third molars and divided into 9 groups (n = 12): 38% hydrogen peroxide (HP), 10% carbamide peroxide (CP), 38% HP + Listerine Whitening (LW), 10% CP + LW, 38% HP + Colgate Plax Whitening (CPW), 10% CP + CPW, LW, CPW, and the control group (CG). The initial color of the specimens was measured, followed by microhardness and roughness tests. Next, the samples were bleached, and their color, microhardness, and roughness were assessed. Data were analyzed through 2-way analysis of variance (ANOVA; microhardness and roughness) and 1-way ANOVA (color change), followed by the Tukey post hoc test. The Dunnett test was used to compare the roughness and microhardness data of the CG to those of the treated groups.

Results

Statistically significant color change was observed in all groups compared to the CG. All groups, except the LW group, showed statistically significant decreases in microhardness. Roughness showed a statistically significant increase after the treatments, except for the 38% HP group.

Conclusions

Whitening mouth rinses led to a whitening effect when they were used after conventional treatments; however, this process caused major changes on the surface of the enamel specimens.

Citations

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    Elif Varli Tekingur, Fatih Bedir, Muhammet Karadas, Rahime Zeynep Erdem
    Journal of Esthetic and Restorative Dentistry.2025; 37(4): 960.     CrossRef
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    Hamideh Sadat Mohammadipour, Parnian Shokrollahi, Sima Gholami, Hosein Bagheri, Fatemeh Namdar, Salehe Sekandari, Cesar Rogério Pucci
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    Mayada S. Sultan
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    Radhika Agarwal, Nikki Vasani, Urmila Sachin Mense, Niharika Prasad, Aditya Shetty, Srikant Natarajan, Arindam Dutta, Manuel S. Thomas
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    Rosa Josefina Roncal Espinoza, José Alberto Castañeda Vía, Alexandra Mena-Serrano, Lidia Yileng Tay
    World Journal of Dentistry.2023; 14(9): 739.     CrossRef
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    Maiara Rodrigues de Freitas, Marynara Mathias de Carvalho, Priscila Christiane Suzy Liporoni, Ana Clara Borges Fort, Rodrigo de Morais e Moura, Rayssa Ferreira Zanatta
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  • Renklendirilmiş kompozit rezinin renk değişimine ve yüzey pürüzlülüğüne beyazlatıcı ağız gargarasının etkisi
    Şeref Nur MUTLU, Makbule Tuğba TUNCDEMIR
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Effects of a bleaching agent on properties of commercial glass-ionomer cements
Fernanda Lúcia Lago de Camargo, Ailla Carla Lancellotti, Adriano Fonseca de Lima, Vinícius Rangel Geraldo Martins, Luciano de Souza Gonçalves
Restor Dent Endod 2018;43(3):e32.   Published online July 5, 2018
DOI: https://doi.org/10.5395/rde.2018.43.e32
AbstractAbstract PDFPubReaderePub
Objectives

This study evaluated the effects of a bleaching agent on the composition, mechanical properties, and surface topography of 6 conventional glass-ionomer cements (GICs) and one resin-modified GIC.

Materials and Methods

For 3 days, the specimens were subjected to three 20-minute applications of a 37% H2O2-based bleaching agent and evaluated for water uptake (WTK), weight loss (WL), compressive strength (CS), and Knoop hardness number (KHN). Changes in surface topography and chemical element distribution were also analyzed by energy-dispersive X-ray spectroscopy and scanning electron microscopy. For statistical evaluation, the Kruskal-Wallis and Wilcoxon paired tests (α = 0.05) were used to evaluate WTK and WL. CS specimens were subjected to 2-way analysis of variance (ANOVA) and the Tukey post hoc test (α = 0.05), and KH was evaluated by one-way ANOVA, the Holm-Sidak post hoc test (α = 0.05), and the t-test for independent samples (α = 0.05).

Results

The bleaching agent increased the WTK of Maxxion R, but did not affect the WL of any GICs. It had various effects on the CS, KHN, surface topography, and the chemical element distribution of the GICs.

Conclusions

The bleaching agent with 37% H2O2 affected the mechanical and surface properties of GICs. The extent of the changes seemed to be dependent on exposure time and cement composition.

Citations

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Bacterial leakage and micro-computed tomography evaluation in round-shaped canals obturated with bioceramic cone and sealer using matched single cone technique
Kallaya Yanpiset, Danuchit Banomyong, Kanet Chotvorrarak, Ratchapin Laovanitch Srisatjaluk
Restor Dent Endod 2018;43(3):e30.   Published online July 5, 2018
DOI: https://doi.org/10.5395/rde.2018.43.e30
AbstractAbstract PDFPubReaderePub
Objectives

To evaluate sealing ability of root canals obturated with bioceramic-impregnated gutta percha cone (BCC) or gutta percha (GP), with bioceramic sealer (BCS) or AH Plus (AH; Dentsply-Maillefer), in roundly-prepared canals using matched single-cone technique, based on bacterial leakage test, and to analyze obturation quality using micro-computed tomography (CT) analysis.

Materials and Methods

Ninety-two distobuccal roots of maxillary molars were prepared using nickel-titanium files to apical size 40/0.06. The roots were divided into 4 groups (n = 20) that were obturated with a master cone and sealer: GP/AH, BCC/AH, GP/BCS, and BCC/BCS. Bacterial leakage model using Enterococcus faecalis was used to evaluate sealing ability for 60-day period. Obturated samples from each group (n = 4) were analyzed using micro-CT.

Results

All groups showed bacterial leakage at 20%–45% of samples with mean leakage times of 42–52 days. There were no significant differences in bacterial leakage among the groups. Micro-CT showed minimal gaps and voids in all groups at less than 1%.

Conclusions

In roundly-prepared canals, the single cone obturation with BCC/BCS was comparable to GP/AH for bacterial leakage at 60 days.

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Do universal adhesives promote bonding to dentin? A systematic review and meta-analysis
Ali A. Elkaffas, Hamdi H. H. Hamama, Salah H. Mahmoud
Restor Dent Endod 2018;43(3):e29.   Published online June 18, 2018
DOI: https://doi.org/10.5395/rde.2018.43.e29
AbstractAbstract PDFPubReaderePub
Objectives

The aims of this study were to conduct a systematic review of the microtensile bond strength (µTBS) of multi-mode adhesives to dentin and to perform a meta-analysis to assess the significance of differences in the µTBS of one of the most commonly used universal adhesives (Scotchbond Universal, 3M ESPE) depending on whether the etch-and-rinse or self-etch mode was used.

Materials and Methods

An electronic search was performed of MEDLINE/PubMed, ScienceDirect, and EBSCOhost. Laboratory studies that evaluated the µTBS of multi-mode adhesives to dentin using either the etch-and-rinse or self-etch mode were selected. A meta-analysis was conducted of the reviewed studies to quantify the differences in the µTBS of Scotchbond Universal adhesive.

Results

Only 10 studies fulfilled the inclusion criteria for the systematic review. Extensive variation was found in the restorative materials, testing methodologies, and failure mode in the reviewed articles. Furthermore, variation was also observed in the dimensions of the microtensile testing beams. The meta-analysis showed no statistically significant difference between the etch-and-rinse and self-etch modes for Scotchbond Universal adhesive (p > 0.05).

Conclusions

Multi-mode ‘universal’ adhesives can achieve substantial bonding to dentin, regardless of the used modes (either etch-and-rinse or self-etch).

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Effect of smear layer deproteinization on bonding of self-etch adhesives to dentin: a systematic review and meta-analysis
Khaldoan H. Alshaikh, Hamdi H. H. Hamama, Salah H. Mahmoud
Restor Dent Endod 2018;43(2):e14.   Published online March 6, 2018
DOI: https://doi.org/10.5395/rde.2018.43.e14
AbstractAbstract PDFPubReaderePub
Objectives

The aim of this systematic review was to critically analyze previously published studies of the effects of dentin surface pretreatment with deproteinizing agents on the bonding of self-etch (SE) adhesives to dentin. Additionally, a meta-analysis was conducted to quantify the effects of the above-mentioned surface pretreatment methods on the bonding of SE adhesives to dentin.

Materials and Methods

An electronic search was performed using the following databases: Scopus, PubMed and ScienceDirect. The online search was performed using the following keywords: ‘dentin’ or ‘hypochlorous acid’ or ‘sodium hypochlorite’ and ‘self-etch adhesive.’ The following categories were excluded during the assessment process: non-English articles, randomized clinical trials, case reports, animal studies, and review articles. The reviewed studies were subjected to meta-analysis to quantify the effect of the application time and concentration of sodium hypochlorite (NaOCl) and hypochlorous acid (HOCl) deproteinizing agents on bonding to dentin.

Results

Only 9 laboratory studies fit the inclusion criteria of this systematic review. The results of the meta-analysis revealed that the pooled average microtensile bond strength values to dentin pre-treated with deproteinizing agents (15.71 MPa) was significantly lower than those of the non-treated control group (20.94 MPa).

Conclusions

In light of the currently available scientific evidence, dentin surface pretreatment with deproteinizing agents does not enhance the bonding of SE adhesives to dentin. The HOCl deproteinizing agent exhibited minimal adverse effects on bonding to dentin in comparison with NaOCl solutions.

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    Fahad Alkhudhairy
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Close layer
The effect of root canal preparation on the surface roughness of WaveOne and WaveOne Gold files: atomic force microscopy study
Taha Özyürek, Koray Yılmaz, Gülşah Uslu, Gianluca Plotino
Restor Dent Endod 2018;43(1):e10.   Published online February 2, 2018
DOI: https://doi.org/10.5395/rde.2018.43.e10
AbstractAbstract PDFPubReaderePub
Objectives

To examine the surface topography of intact WaveOne (WO; Dentsply Sirona Endodontics) and WaveOne Gold (WOG; Dentsply Sirona Endodontics) nickel-titanium rotary files and to evaluate the presence of alterations to the surface topography after root canal preparations of severely curved root canals in molar teeth.

Materials and Methods

Forty-eight severely curved canals of extracted molar teeth were divided into 2 groups (n = 24/each group). In group 1, the canals were prepared using WO and in group 2, the canals were prepared using WOG files. After the preparation of 3 root canals, instruments were subjected to atomic force microscopy analysis. Average roughness and root mean square values were chosen to investigate the surface features of endodontic files. The data was analyzed using one-way analysis of variance and post hoc Tamhane's tests at 5% significant level.

Results

The surface roughness values of WO and WOG files significantly changed after use in root canals (p < 0.05). The used WOG files exhibited higher surface roughness change when compared with the used WO files (p < 0.05).

Conclusions

Using WO and WOG Primary files in 3 root canals affected the surface topography of the files. After being used in root canals, the WOG files showed a higher level of surface porosity value than the WO files.

Citations

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  • Comparative Analysis of Surface Roughness and Plastic Deformation of Reciprocating Instruments after Clinical Use
    Ángel Herrera, Magdalena Azabal, Jesús R. Jimenez-Octavio, Juan C. del Real-Romero, Sara López de Armentia, Juan M. Asensio-Gil, Ana Arias
    Materials.2024; 17(16): 3978.     CrossRef
  • Comparative Evaluation of Surface Roughness of Different Rotary Nickel-Titanium (NiTi) Files After Autoclaving: An Atomic Force Microscopic Study
    Angela Alex, Ranjith Kumar Sivarajan, Vijay Venkatesh
    Cureus.2024;[Epub]     CrossRef
  • Impact of endodontic irrigants on surface roughness of various nickel-titanium rotary endodontic instruments
    Tamer M. Hamdy, Yasmine Mohsen Alkabani, Amira Galal Ismail, Manar M. Galal
    BMC Oral Health.2023;[Epub]     CrossRef
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    Alessio Zanza, Marco Seracchiani, Rodolfo Reda, Gabriele Miccoli, Luca Testarelli, Dario Di Nardo
    Bioengineering.2022; 9(1): 30.     CrossRef
  • Cyclic Fatigue Resistance and Surface Roughness of Rotary NiTi Instruments after Simulated Clinical Use in Curved Root Canals – An Atomic Force Microscopy Study
    Raksha Bhat, Arjun Kini, Preethesh Shetty, Payalben Kansara, Bapanaiah Penugonda
    Pesquisa Brasileira em Odontopediatria e Clínica Integrada.2022;[Epub]     CrossRef
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    Imelda Darmawi, Trimurni Abidin, Harry Agusnar, Basri A. Gani
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    Khoa Van Pham
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    Iandara de Lima Scardini, Denise Maria Zezell, Juliana Lisboa Couto Marques, Laila Gonzales Freire, Marcelo dos Santos
    Brazilian Dental Journal.2021; 32(6): 8.     CrossRef
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    Muhammad Sohail Zafar
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    Khoa Van Pham, Canh Quang Vo
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    Mario Dioguardi, Vito Crincoli, Luigi Laino, Mario Alovisi, Enrica Laneve, Diego Sovereto, Bruna Raddato, Khrystyna Zhurakivska, Filiberto Mastrangelo, Domenico Ciavarella, Lucio Lo Russo, Lorenzo Lo Muzio
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  • Atomic force microscopy and energy dispersive X‐ray spectrophotometry analysis of reciprocating and continuous rotary nickel‐titanium instruments following root canal retreatment
    Bulem Üreyen Kaya, Cevat Emre Erik, Gülsen Kiraz
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    E. J. N. L. Silva, J. F. N. Giraldes, C. O. de Lima, V. T. L. Vieira, C. N. Elias, H. S. Antunes
    International Endodontic Journal.2019; 52(11): 1645.     CrossRef
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Close layer
Effect of water storage on flexural strength of silorane and methacrylate-based composite resins
Narges Panahandeh, Hassan Torabzadeh, Hani Naderi, Seyedeh Mahsa Sheikh-Al-Eslamian
Restor Dent Endod 2017;42(4):309-315.   Published online November 6, 2017
DOI: https://doi.org/10.5395/rde.2017.42.4.309
AbstractAbstract PDFPubReaderePub
Objectives

This study assessed the effect of water storage on the flexural strength (FS) of low shrinkage composites.

Materials and Methods

A total of 165 bar-shaped specimens (2 × 2 × 25 mm) were fabricated of 2 low shrinkage composites (Filtek P90 [3M ESPE], GC Kalore [GC International]) and a conventional methacrylate-based composite (Filtek Z250 [3M ESPE]). The specimens were subjected to 3-point bending test at 6 time intervals, namely: immediately after curing, at 24 hours, 1 week, 1 month, 6 months, and 1 year following storage in wet and dry conditions. The FS of the specimens were measured by applying compressive load at a crosshead speed of 1.0 mm/min. Data was analyzed using 3-way analysis of variance (ANOVA) and Tukey's test.

Results

Three-way ANOVA revealed significant interactions between time, type of composite, and storage condition (p = 0.001). Tukey's multiple comparison test revealed significant reductions in FS of all composites after 6 months and 1 year of storage in distilled water compared to dry condition.

Conclusions

Filtek P90 showed the highest and GC Kalore showed the lowest FS after 1 year storage in distilled water. The immediate high strength of Filtek Z250 significantly decreased at 1 year and its final value was lower than that of Filtek P90.

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    Renata Pereira, Flávio H. B. Aguiar, Rodrigo B. E. Lins, Maria C. A. J. Mainairdi, Bruna G. Silva, Marcela A. Ferretti, Klaus Rischka
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    Marlus da Silva Pedrosa, Fernando Neves Nogueira, Vitor de Oliveira Baldo, Igor Studart Medeiros
    The Saudi Dental Journal.2021; 33(8): 1160.     CrossRef
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    Agata Szczesio-Wlodarczyk, Jerzy Sokolowski, Joanna Kleczewska, Kinga Bociong
    Polymers.2020; 12(4): 882.     CrossRef
  • Color stability of nanohybrid composite resins in drinks
    Juliana Jendiroba Faraoni, Isabela Barbosa Quero, Lívia Semedo Schiavuzzo, Regina Guenka Palma-Dibb
    Brazilian Journal of Oral Sciences.2019; 18: e191601.     CrossRef
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    Weber Adad Ricci, Priscila Alfano, Saulo Pamato, Carlos Alberto dos Santos Cruz, Jefferson Ricardo Pereira
    BioMed Research International.2019; 2019: 1.     CrossRef
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    Xinxuan Zhou, Suping Wang, Xian Peng, Yao Hu, Biao Ren, Mingyun Li, Liying Hao, Mingye Feng, Lei Cheng, Xuedong Zhou
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  • 5 Download
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Close layer
Comparing the effect of a desensitizing material and a self-etch adhesive on dentin sensitivity after periodontal surgery: a randomized clinical trial
Hila Hajizadeh, Atefeh Nemati-Karimooy, Sara Majidinia, Amir Moeintaghavi, Marjaneh Ghavamnasiri
Restor Dent Endod 2017;42(3):168-175.   Published online July 21, 2017
DOI: https://doi.org/10.5395/rde.2017.42.3.168
AbstractAbstract PDFPubReaderePub
Objectives

This double-blind randomized placebo-controlled clinical trial evaluated the ability of a desensitizing agent and a self-etch adhesive on cervical dentin sensitivity (CDS) after periodontal surgery.

Materials and Methods

Ninety hypersensitive teeth of 13 subjects were included in the study. After periodontal surgery, the teeth of each posterior sextant treated with one of the following materials: G1: Clearfil S3 Bond (Kuraray Dental), G2: Gluma Desensitizer (Heraeus Kulzer), and G3: placebo (water). The sensitivity was assessed using evaporative stimuli before treatment (baseline, T0), 1 day after treatment (T1), after 1 week (T2), and after 1 month (T3) according to visual analog scale (VAS).

Results

Following the treatment, all the 3 groups showed significant reduction of CDS in T1 compared to T0. Reduction of CDS between T1 and T2 was observed only in G1 but there was no significant difference between T2 and T3 in this group. Although we observed a significant difference in T3 compared to T1 and T2 in G2 and G3, comparison of treatment groups in each assessment time showed a significant difference only in T3. According to paired comparison, this was due to the difference between G2 and G3.

Conclusions

Dentin sensitivity following periodontal surgery will decrease spontaneously over time, but treating the sensitive teeth with Gluma Desensitizer and Clearfil S3 Bond can have some benefits.

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  • Biomineralization reaction from nanosized calcium silicate: A new method for reducing dentin hypersensitivity
    Mi-Jeong Jeon, Yu-Sung Choi, Jeong-Kil Park, Jin-Soo Ahn, Yu-Chih Chiang, Deog-Gyu Seo
    Journal of Dental Sciences.2025; 20(1): 428.     CrossRef
  • Effectiveness of Self-etching Adhesive Only Versus in Combination with Gluma Desensitizer for Preventing Post-composite Sensitivity - A Prospective Study
    Hemamalini Rath, Shilpa Mahapatra, Sri Priya Narayanan
    Indian Journal of Dental Research.2025; 36(1): 32.     CrossRef
  • Efficacy of seventh generation bonding agents as desensitizers in patients with dentin hypersensitivity: a randomized clinical trial
    Sumaiya Shabbir, Shahbaz Ahmed, Syed Jaffar Abbas Zaidi, Sania Riaz, Huma Sarwar, Muhammad Taqi, Zia ur Rahman Khan
    BMC Oral Health.2024;[Epub]     CrossRef
  • Investigation of the crystal formation from calcium silicate in human dentinal tubules and the effect of phosphate buffer saline concentration
    Mi-Jeong Jeon, Jin-Soo Ahn, Jeong-Kil Park, Deog-Gyu Seo
    Journal of Dental Sciences.2024; 19(4): 2278.     CrossRef
  • The effect of fluoride iontophoresis on seal ability of self-etch adhesive in human dentin in vitro
    Kanittha Kijsamanmith, Parintorn Wallanon, Chanya Pitchayasatit, Poonnapha Kittiratanaviwat
    BMC Oral Health.2022;[Epub]     CrossRef
  • The study of toothpaste desensitizing properties
    S. B. Ulitovskiy, O. V. Kalinina, A. A. Leontev, O. V. Khabarova, L. I. Pankrateva, E. S. Soloveva, N. K. Fok
    Parodontologiya.2022; 27(1): 81.     CrossRef
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    Ruodan Jiang, Yongxiang Xu, Feilong Wang, Hong Lin
    BMC Oral Health.2022;[Epub]     CrossRef
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    Samar Hatem Abuzinadah, Abdulrahman Jafar Alhaddad
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    Muhammad Zohaib Younus, Muhammad Adeel Ahmed, Azeem Ul Yaqin Syed, Jiand Malik Baloch, Muhammad Ali, Abubakar Sheikh
    Technology and Health Care.2021; 29(6): 1153.     CrossRef
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    Alexia da Mata Galvão, Livia Fávaro Zeola, Guilherme Faria Moura, Daniela Navarro Ribeiro Teixeira, Ramon Corrêa de Queiroz Gonzaga, Gisele Rodrigues da Silva, Paulo Vinícius Soares
    Journal of Dentistry.2019; 89: 103180.     CrossRef
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Close layer
Differential diagnosis of periapical cyst using collagen birefringence pattern of the cyst wall
Hyo Jin Ji, Se-Hee Park, Kyung-Mo Cho, Suk Keun Lee, Jin Woo Kim
Restor Dent Endod 2017;42(2):111-117.   Published online February 9, 2017
DOI: https://doi.org/10.5395/rde.2017.42.2.111
AbstractAbstract PDFPubReaderePub
Objectives

Periapical lesions, including periapical cyst (PC), periapical granuloma (PG), and periapical abscess (PA), are frequently affected by chemical/physical damage during root canal treatment or severe bacterial infection, and thus, the differential diagnosis of periapical lesions may be difficult due to the presence of severe inflammatory reaction. The aim of this study was to make differential diagnosis among PC, PG, and PA under polarizing microscope.

Materials and Methods

The collagen birefringence patterns of 319 cases of PC (n = 122), PG (n = 158), and PA (n = 39) obtained using a polarizing microscope were compared. In addition, 6 cases of periodontal fibroma (PF) were used as positive controls.

Results

Collagen birefringence was condensed with a thick, linear band-like pattern in PC, but was short and irregularly scattered in PG, and scarce or absent in PA. PF showed intense collagen birefringence with a short, palisading pattern but no continuous band-like pattern. The linear band-like birefringence in PC was ascribed to pre-existing expansile tensile stress of the cyst wall.

Conclusions

In this study all PCs (n = 122) were distinguishable from PGs and PAs by their characteristic birefringence, despite the absence of lining epithelium (n = 20). Therefore, the authors suggest that the presence of linear band-like collagen birefringence of the cyst wall aids the diagnostic differentiation of PC from PG and PA.

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  • Interplay of collagen and mast cells in periapical granulomas and periapical cysts: a comparative polarizing microscopic and immunohistochemical study
    Deepty Bansal, Mala Kamboj, Anjali Narwal, Anju Devi, Nisha Marwah
    Restorative Dentistry & Endodontics.2022;[Epub]     CrossRef
  • 1,819 View
  • 6 Download
  • 1 Crossref
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Case Report
Dental management of patients with X-linked hypophosphatemia
Bin-Na Lee, Hye-Yoon Jung, Hoon-Sang Chang, Yun-Chan Hwang, Won-Mann Oh
Restor Dent Endod 2017;42(2):146-151.   Published online January 6, 2017
DOI: https://doi.org/10.5395/rde.2017.42.2.146
AbstractAbstract PDFPubReaderePub

X-linked hypophosphatemia (XLH) is a hereditary metabolic disease caused by the loss of phosphate through the renal tubules into the urine, and an associated decrease in serum calcium and potassium phosphate. Its dental features include spontaneous dental abscesses that occur in the absence of trauma or dental caries. The aim of this case report was to describe the dental problems of XLH patients and to evaluate limitations in their treatment. A 14 year old male and a 38 year old female with XLH were referred to the Department of Conservative Dentistry for endodontic treatment. The dental findings were periapical abscesses without obvious trauma or caries. Conservative endodontic treatment was performed in teeth with pulp necrosis and abscess. In case 1, the treated teeth showed improvements in bone healing, without clinical symptoms. However, in case 2, the implants and the treated tooth showed hypermobility, and the final restoration was therefore postponed. Early diagnosis, periodic examinations, and communication with the patient's pediatrician are important in the dental management of patients with XLH.

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    Aonjittra Phanrungsuwan, Bella Donnelly, José Luis Millán, Brian L. Foster
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    Seyed Ali Mosaddad, Sahar Talebi, Seied Omid Keyhan, Hamid Reza Fallahi, Mohammad Darvishi, Seyedeh Sara Aghili, Narges Tavahodi, Reza Abdollahi Namanloo, Artak Heboyan, Amirhossein Fathi
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    Kripa Elizabeth Cherian, Thomas Vizhalil Paul
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    Eiji Iwata, Shyam Kishor Sah, I‐Ping Chen, Ernst Reichenberger
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    Iris Alla, Felice Lorusso, Sergio Alexandre Gehrke, Francesco Inchingolo, Maristella Di Carmine, Antonio Scarano
    International Journal of Environmental Research and Public Health.2023; 20(3): 2401.     CrossRef
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    Clara Gibson, Suhaym Mubeen, Robert Evans
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    Adalbert Raimann, Roland Kocijan, Gabriel T. Mindler
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    Rena Okawa, Kazuhiko Nakano
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Research Articles
Effects of proanthocyanidin, a crosslinking agent, on physical and biological properties of collagen hydrogel scaffold
Yoorina Choi, Hee-Jin Kim, Kyung-San Min
Restor Dent Endod 2016;41(4):296-303.   Published online October 4, 2016
DOI: https://doi.org/10.5395/rde.2016.41.4.296
AbstractAbstract PDFPubReaderePub
Objectives

The purpose of the present study was to evaluate the effects of proanthocyanidin (PAC), a crosslinking agent, on the physical properties of a collagen hydrogel and the behavior of human periodontal ligament cells (hPDLCs) cultured in the scaffold.

Materials and Methods

Viability of hPDLCs treated with PAC was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The physical properties of PAC treated collagen hydrogel scaffold were evaluated by the measurement of setting time, surface roughness, and differential scanning calorimetry (DSC). The behavior of the hPDLCs in the collagen scaffold was evaluated by cell morphology observation and cell numbers counting.

Results

The setting time of the collagen scaffold was shortened in the presence of PAC (p < 0.05). The surface roughness of the PAC-treated collagen was higher compared to the untreated control group (p < 0.05). The thermogram of the crosslinked collagen exhibited a higher endothermic peak compared to the uncrosslinked one. Cells in the PAC-treated collagen were observed to attach in closer proximity to one another with more cytoplasmic extensions compared to cells in the untreated control group. The number of cells cultured in the PAC-treated collagen scaffolds was significantly increased compared to the untreated control (p < 0.05).

Conclusions

Our results showed that PAC enhanced the physical properties of the collagen scaffold. Furthermore, the proliferation of hPDLCs cultured in the collagen scaffold crosslinked with PAC was facilitated. Conclusively, the application of PAC to the collagen scaffold may be beneficial for engineering-based periodontal ligament regeneration in delayed replantation.

Citations

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Close layer
In vitro evaluation of a newly produced resin-based endodontic sealer
Yoo-Seok Song, Yoorina Choi, Myung-Jin Lim, Mi-Kyung Yu, Chan-Ui Hong, Kwang-Won Lee, Kyung-San Min
Restor Dent Endod 2016;41(3):189-195.   Published online July 26, 2016
DOI: https://doi.org/10.5395/rde.2016.41.3.189
AbstractAbstract PDFPubReaderePub
Objectives

A variety of root canal sealers were recently launched to the market. This study evaluated physicochemical properties, biocompatibility, and sealing ability of a newly launched resin-based sealer (Dia-Proseal, Diadent) compared to the existing root canal sealers (AHplus, Dentsply DeTrey and ADseal, Metabiomed).

Materials and Methods

The physicochemical properties of the tested sealers including pH, solubility, dimensional change, and radiopacity were evaluated. Biocompatibility was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. For microleakage test, single-rooted teeth were instrumented, and obturated with gutta-percha and one of the sealers (n = 10). After immersion in 1% methylene blue solution for 2 weeks, the specimens were split longitudinally. Then, the maximum length of staining was measured. Statistical analysis was performed by one-way analysis of variance followed by Tukey test (p = 0.05).

Results

Dia-Proseal showed the highest pH value among the tested sealers (p < 0.05). ADseal showed higher dimensional change compared to AHplus and Dia-Proseal (p < 0.05). The solubility values of AHplus and Dia-Proseal were similar, whereas ADseal had the lowest solubility value (p < 0.05). The flow values of sealer in increasing order were AHplus, DiaProseal, and ADseal (p < 0.05). The radiopacity of AHplus was higher than those of ADseal and Dia-Proseal (p < 0.05). The cell viability of the tested materials was statistically similar throughout the experimental period. There were no significant differences in microleakage values among the tested samples.

Conclusions

The present study indicates that Dia-Proseal has acceptable physicochemical properties, biocompatibility, and sealing ability.

Citations

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Close layer
Marginal microleakage of cervical composite resin restorations bonded using etch-and-rinse and self-etch adhesives: two dimensional vs. three dimensional methods
Maryam Khoroushi, Ailin Ehteshami
Restor Dent Endod 2016;41(2):83-90.   Published online April 18, 2016
DOI: https://doi.org/10.5395/rde.2016.41.2.83
AbstractAbstract PDFPubReaderePub
Objectives

This study was evaluated the marginal microleakage of two different adhesive systems before and after aging with two different dye penetration techniques.

Materials and Methods

Class V cavities were prepared on the buccal and lingual surfaces of 48 human molars. Clearfil SE Bond and Single Bond (self-etching and etch-and-rinse systems, respectively) were applied, each to half of the prepared cavities, which were restored with composite resin. Half of the specimens in each group underwent 10,000 cycles of thermocycling. Microleakage was evaluated using two dimensional (2D) and three dimensional (3D) dye penetration techniques separately for each half of each specimen. Data were analyzed with SPSS 11.5 (SPSS Inc.), using the Kruskal-Wallis and Mann-Whitney U tests (α = 0.05).

Results

The difference between the 2D and 3D microleakage evaluation techniques was significant at the occlusal margins of Single bond groups (p = 0.002). The differences between 2D and 3D microleakage evaluation techniques were significant at both the occlusal and cervical margins of Clearfil SE Bond groups (p = 0.017 and p = 0.002, respectively). The difference between the 2D and 3D techniques was significant at the occlusal margins of non-aged groups (p = 0.003). The difference between these two techniques was significant at the occlusal margins of the aged groups (p = 0.001). The Mann-Whitney test showed significant differences between the two techniques only at the occlusal margins in all specimens.

Conclusions

Under the limitations of the present study, it can be concluded that the 3D technique has the capacity to detect occlusal microleakage more precisely than the 2D technique.

Citations

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  • A comparison of the marginal and internal fit of porcelain laminate veneers fabricated by pressing and CAD-CAM milling and cemented with 2 different resin cements
    Ziad N. Al-Dwairi, Rana M. Alkhatatbeh, Nadim Z. Baba, Charles J. Goodacre
    The Journal of Prosthetic Dentistry.2019; 121(3): 470.     CrossRef
  • Microleakage in class V cavities prepared using conventional method versus Er:YAG laser restored with glass ionomer cement or resin composite
    Sertac Peker, Figen Eren Giray, Basak Durmus, Nural Bekiroglu, Betül Kargül, Mutlu Özcan
    Journal of Adhesion Science and Technology.2017; 31(5): 509.     CrossRef
  • 1,403 View
  • 8 Download
  • 9 Crossref
Close layer
Influence of a glide path on the dentinal crack formation of ProTaper Next system
Sevinç Aktemur Türker, Emel Uzunoğlu
Restor Dent Endod 2015;40(4):286-289.   Published online September 2, 2015
DOI: https://doi.org/10.5395/rde.2015.40.4.286
AbstractAbstract PDFPubReaderePub
Objectives

The aim was to evaluate dentinal crack formation after root canal preparation with ProTaper Next system (PTN) with and without a glide path.

Materials and Methods

Forty-five mesial roots of mandibular first molars were selected. Fifteen teeth were left unprepared and served as controls. The experimental groups consist of mesiobuccal and mesiolingual root canals of remaining 30 teeth, which were divided into 2 groups (n = 15): Group PG/PTN, glide path was created with ProGlider (PG) and then canals were shaped with PTN system; Group PTN, glide path was not prepared and canals were shaped with PTN system only. All roots were sectioned perpendicular to the long axis at 1, 2, 3, 4, 6, and 8 mm from the apex, and the sections were observed under a stereomicroscope. The presence/absence of cracks was recorded. Data were analyzed with chi-square tests with Yates correction.

Results

There were no significant differences in crack formation between the PTN with and without glide path preparation. The incidence of cracks observed in PG/PTN and PTN groups was 17.8% and 28.9%, respectively.

Conclusions

The creation of a glide path with ProGlider before ProTaper Next rotary system did not influence dentinal crack formation in root canals.

Citations

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    Prajna Pattanaik, Akilan Balasubramanian, P. Veeralakshmi, Gautam Singh, Vandana Sadananda, Hina Ahmed, J. Suresh Babu, C. Swarnalatha, Abhishek Singh Nayyar
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    Vlad Mircea Lup, Giulia Malvicini, Carlo Gaeta, Simone Grandini, Gabriela Ciavoi
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    Takhellambam Premlata Devi, Amandeep Kaur, Shamurailatpam Priyadarshini, B. S. Deepak, Sumita Banerjee, Ng Sanjeeta
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    Gianluca Plotino, Venkateshbabu Nagendrababu, Frederic Bukiet, Nicola M. Grande, Sajesh K. Veettil, Gustavo De-Deus, Hany Mohamed Aly Ahmed
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  • 1,398 View
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  • 4 Crossref
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Effects of solvent volatilization time on the bond strength of etch-and-rinse adhesive to dentin using conventional or deproteinization bonding techniques
José Aginaldo de Sousa Júnior, Márcia Luciana Carregosa Santana, Fabricio Eneas Diniz de Figueiredo, André Luis Faria-e-Silva
Restor Dent Endod 2015;40(3):202-208.   Published online March 17, 2015
DOI: https://doi.org/10.5395/rde.2015.40.3.202
AbstractAbstract PDFPubReaderePub
Objectives

This study determined the effect of the air-stream application time and the bonding technique on the dentin bond strength of adhesives with different solvents. Furthermore, the content and volatilization rate of the solvents contained in the adhesives were also evaluated.

Materials and Methods

Three adhesive systems with different solvents (Stae, SDI, acetone; XP Bond, Dentsply De Trey, butanol; Ambar, FGM, ethanol) were evaluated. The concentrations and evaporation rates of each adhesive were measured using an analytical balance. After acid-etching and rinsing, medium occlusal dentin surfaces of human molars were kept moist (conventional) or were treated with 10% sodium hypochlorite for deproteinization. After applying adhesives over the dentin, slight air-stream was applied for 10, 30 or 60 sec. Composite cylinders were built up and submitted to shear testing. The data were submitted to ANOVA and Tukey's test (α = 0.05).

Results

Stae showed the highest solvent content and Ambar the lowest. Acetone presented the highest evaporation rate, followed by butanol. Shear bond strengths were significantly affected only by the factors of 'adhesive' and 'bonding technique' (p < 0.05), while the factor 'duration of air-stream' was not significant. Deproteinization of dentin increased the bond strength (p < 0.05). Stae showed the lowest bond strength values (p < 0.05), while no significant difference was observed between XP Bond and Ambar.

Conclusions

Despite the differences in content and evaporation rate of the solvents, the duration of air-stream application did not affect the bond strength to dentin irrespective of the bonding technique.

Citations

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  • Effect of solvent evaporation and photo-irradiation strategy of contact-cure adhesive system on bonding to root canal
    Wahyuni Suci Dwiandhany, Kittisak Sanon, Yasushi Shimada, Ahmed Abdou
    Odontology.2025;[Epub]     CrossRef
  • Effect of adhesive air-drying time on bond strength to dentin: A systematic review and meta-analysis
    Mohamed M. Awad, Ali Alrahlah, Jukka P. Matinlinna, Hamdi Hosni Hamama
    International Journal of Adhesion and Adhesives.2019; 90: 154.     CrossRef
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  • 6 Download
  • 2 Crossref
Close layer
Review Article
Current perspectives of bio-ceramic technology in endodontics: calcium enriched mixture cement - review of its composition, properties and applications
Shivani Utneja, Ruchika Roongta Nawal, Sangeeta Talwar, Mahesh Verma
Restor Dent Endod 2015;40(1):1-13.   Published online November 3, 2014
DOI: https://doi.org/10.5395/rde.2015.40.1.1
AbstractAbstract PDFPubReaderePub

Advancements in bio-ceramic technology has revolutionised endodontic material science by enhancing the treatment outcome for patients. This class of dental materials conciliates excellent biocompatibility with high osseoconductivity that render them ideal for endodontic care. Few recently introduced bio-ceramic materials have shown considerable clinical success over their early generations in terms of good handling characteristics. Calcium enriched mixture (CEM) cement, Endosequence sealer, and root repair materials, Biodentine and BioAggregate are the new classes of bio-ceramic materials. The aim of this literature review is to present investigations regarding properties and applications of CEM cement in endodontics. A review of the existing literature was performed by using electronic and hand searching methods for CEM cement from January 2006 to December 2013. CEM cement has a different chemical composition from that of mineral trioxide aggregate (MTA) but has similar clinical applications. It combines the biocompatibility of MTA with more efficient characteristics, such as significantly shorter setting time, good handling characteristics, no staining of tooth and effective seal against bacterial leakage.

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    S. Nagarajan M. P. Sockalingam, Katherine Kong Loh Seu, Halimah Mohamed Noor, Ahmad Shuhud Irfani Zakaria
    Case Reports in Dentistry.2018; 2018: 1.     CrossRef
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    Aline Teixeira Mendes, Paula Barcellos da Silva, Bruna Barcelos Só, Lina Naomi Hashizume, Rodrigo Ricci Vivan, Ricardo Abreu da Rosa, Marco Antonio Húngaro Duarte, Marcus Vinícius Reis Só
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  • Comparison of mineral trioxide aggregate and calcium hydroxide for apexification of immature permanent teeth: A systematic review and meta-analysis
    Jia-Cheng Lin, Jia-Xuan Lu, Qian Zeng, Wei Zhao, Wen-Qing Li, Jun-Qi Ling
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  • Cytotoxic effects of mineral trioxide aggregate, calcium enrichedmixture cement, Biodentine and octacalcium pohosphate onhuman gingival fibroblasts
    Eshagh A. Saberi, Narges Farhadmollashahi, Faroogh Ghotbi, Hamed Karkeabadi, Roholla Havaei
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  • Influence of Biodentine® - A Dentine Substitute - On Collagen Type I Synthesis in Pulp Fibroblasts In Vitro
    Frangis Nikfarjam, Kim Beyer, Anke König, Matthias Hofmann, Manuel Butting, Eva Valesky, Stefan Kippenberger, Roland Kaufmann, Detlef Heidemann, August Bernd, Nadja Nicole Zöller, Dimitrios Karamichos
    PLOS ONE.2016; 11(12): e0167633.     CrossRef
  • Challenges in developing valid techniques for equine endodontic treatment of apically infected cheek teeth
    R. M. Baratt
    Equine Veterinary Education.2016; 28(11): 609.     CrossRef
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    So-Youn An, Jin-Kyoung Kim, Youn-Soo Shim
    Journal of dental hygiene science.2016; 16(4): 317.     CrossRef
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Research Articles
Microtensile bond strength of silorane-based composite specific adhesive system using different bonding strategies
Laura Alves Bastos, Ana Beatriz Silva Sousa, Brahim Drubi-Filho, Fernanda de Carvalho Panzeri Pires-de-Souza, Lucas da Fonseca Roberti Garcia
Restor Dent Endod 2015;40(1):23-29.   Published online August 25, 2014
DOI: https://doi.org/10.5395/rde.2015.40.1.23
AbstractAbstract PDFPubReaderePub
Objectives

The aim of this study was to evaluate the effect of pre-etching on the bond strength of silorane-based composite specific adhesive system to dentin.

Materials and Methods

Thirty human molars were randomly divided into 5 groups according to the different bonding strategies. For teeth restored with silorane-based composite (Filtek Silorane, 3M ESPE), the specific self-etching adhesive system (Adhesive System P90, 3M ESPE) was used with and without pre-etching (Pre-etching/Silorane and Silorane groups). Teeth restored with methacrylate based-composite (Filtek Z250, 3M ESPE) were hybridized with the two-step self-etching system (Clearfil SE Bond, Kuraray), with and without pre-etching (Pre-etching/Methacrylate and Methacrylate groups), or three-step adhesive system (Adper Scotchbond Multi-Purpose, 3M ESPE) (Three-step/Methacrylate group) (n = 6). The restored teeth were sectioned into stick-shaped test specimens (1.0 × 1.0 mm), and coupled to a universal test machine (0.5 mm/min) to perform microtensile testing.

Results

Pre-etching/Methacrylate group presented the highest bond strength values, with significant difference from Silorane and Three-step/Methacrylate groups (p < 0.05). However, it was not significantly different from Preetching/Silorane and Methacrylate groups.

Conclusions

Pre-etching increased bond strength of silorane-based composite specific adhesive system to dentin.

Citations

Citations to this article as recorded by  
  • Is the presence of 10-MDP associated to higher bonding performance for self-etching adhesive systems? A meta-analysis of in vitro studies
    Julia Fehrenbach, Cristina Pereira Isolan, Eliseu Aldrighi Münchow
    Dental Materials.2021; 37(10): 1463.     CrossRef
  • 1,287 View
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  • 1 Crossref
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Effect of 38% carbamide peroxide on the microleakage of silorane-based versus methacrylate-based composite restorations
Sedighe Sadat Hashemi Kamangar, Maryam Ghavam, Nazanin Mahinfar, Seyed Jalal Pourhashemi
Restor Dent Endod 2014;39(3):172-179.   Published online May 13, 2014
DOI: https://doi.org/10.5395/rde.2014.39.3.172
AbstractAbstract PDFPubReaderePub
Objectives

This study aimed to assess the effect of 38% carbamide peroxide on the microleakage of class V cavities restored with either a silorane-based composite or two methacrylate-based composites.

Materials and Methods

A total of 96 class V cavities were prepared on the buccal surface of extracted human teeth with both enamel and dentin margins and were randomly assigned into three groups of Filtek P90 (3M-ESPE) + P90 system adhesive (3M-ESPE)(group A), Filtek Z250 (3M-ESPE) + Adper Prompt L-Pop (3M-ESPE)(group B) and Filtek Z350XT (3M-ESPE) + Adper Prompt L-Pop (group C). Half of the teeth were randomly underwent bleaching (38% carbamide peroxide, Day White, Discus Dental, applying for 15 min, twice a day for 14 day) while the remaining half (control) were not bleached. Dye penetration was measured following immersion in basic fuchsine. Data were statistically analyzed using Kruskal-Wallis and Mann-Whitney U tests at a level of 0.05.

Results

No significant differences were found between composites in the control groups in enamel (p = 0.171) or dentin (p = 0.094) margins. After bleaching, microleakage of Z250 (in enamel [p = 0.867] or dentin [p = 0.590] margins) and Z350 (in enamel [p = 0.445] or dentin [p = 0.591] margins) did not change significantly, but the microleakage of P90 significantly increased in both enamel (p = 0.042) and dentin (p = 0.002) margins.

Conclusions

No significant differences were noted between the bleached and control subgroups of two methacrylate-based composites in enamel or dentin margins. Microleakage of silorane-based composite significantly increased after bleaching.

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Review Article
Biologic response of local hemostatic agents used in endodontic microsurgery
Youngjune Jang, Hyeon Kim, Byoung-Duck Roh, Euiseong Kim
Restor Dent Endod 2014;39(2):79-88.   Published online March 21, 2014
DOI: https://doi.org/10.5395/rde.2014.39.2.79
AbstractAbstract PDFPubReaderePub

Appropriate use of local hemostatic agent is one of the important factors on the prognosis of endodontic microsurgery. However, most investigations to date focus on the hemostatic efficacy of the agents, whereas their biologic characteristics have not received enough attention. The purpose of this paper was to review the biologic response of local hemostatic agents, and to provide clinical guidelines on their use during endodontic microsurgery. Electronic database (PUBMED) was screened to search related studies from 1980 to 2013, and 8 clinical studies and 18 animal studies were identified. Among the materials used in these studies, most widely-investigated and used materials, epinephrine, ferric sulfate (FS) and calcium sulfate (CS), were thoroughly discussed. Influence of these materials on local tissue and systemic condition, such as inflammatory and foreign body reaction, local ischemia, dyspigmentation, delayed or enhanced bone and soft tissue healing, and potential cardiovascular complications were assessed. Additionally, biological property of their carrier materials, cotton pellet and absorbable collagen, were also discussed. Clinicians should be aware of the biologic properties of local hemostatic agents and their carrier materials, and should pay attention to the potential complications when using them in endodontic microsurgery.

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    Hanguo Wang, Xin Xu, Zhuan Bian, Jingping Liang, Zhi Chen, Benxiang Hou, Lihong Qiu, Wenxia Chen, Xi Wei, Kaijin Hu, Qintao Wang, Zuhua Wang, Jiyao Li, Dingming Huang, Xiaoyan Wang, Zhengwei Huang, Liuyan Meng, Chen Zhang, Fangfang Xie, Di Yang, Jinhua Yu
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    Ramazan Üstün, Elif Oğuz, Ayşe Şeker, Filiz Taspinar
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    Bardia Jamali, Saeed Nouri, Salimeh Amidi
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    VELLORE KANNAN GOPINATH, SHAJU JACOB PULIKKOTIL, SAJESH K VEETTIL, LALLI DHARMARAJAN, PONNUDURAI SAMUEL GNANA PRAKASH, VINEET DHAR, JAYAKUMAR JAYARAMAN
    Journal of Evidence-Based Dental Practice.2022; 22(4): 101770.     CrossRef
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    Anita Aminoshariae, Mark Donaldson, Michael Horan, James C. Kulild, Dale Baur
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    Talal Al-Nahlawi, Maisour Ala Rachi, Amjad Abu Hasna, Zohaib Khurshid
    International Journal of Dentistry.2021; 2021: 1.     CrossRef
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    Z. S. Khabadze, D. A. Nazarova, E. S. Shilyaeva, A. P. Kotelnikova, Yu. A. Bakayev, S. M. Abdulkerimova, Kh. O. Omarova
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    Syamsiah Syam, Yung-Chieh Cho, Chung-Ming Liu, Mao-Suan Huang, Wen-Chien Lan, Bai-Hung Huang, Takaaki Ueno, Chi-Hsun Tsai, Takashi Saito, May-Show Chen, Keng-Liang Ou
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    Mohammad Reza Nabavizadeh, Arman Zargaran, Fariborz Moazami, Fatemeh Askari, Safoora Sahebi, Alireza Farhadpoor, Pouya Faridi
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    BMC Oral Health.2016;[Epub]     CrossRef
  • 2,509 View
  • 14 Download
  • 15 Crossref
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Case Report
Biodentine-a novel dentinal substitute for single visit apexification
Gurudutt Nayak, Mohammad Faiz Hasan
Restor Dent Endod 2014;39(2):120-125.   Published online March 21, 2014
DOI: https://doi.org/10.5395/rde.2014.39.2.120
AbstractAbstract PDFPubReaderePub

Use of an apical plug in management of cases with open apices has gained popularity in recent years. Biodentine, a new calcium silicate-based material has recently been introduced as a dentine substitute, whenever original dentine is damaged. This case report describes single visit apexification in a maxillary central incisor with necrotic pulp and open apex using Biodentine as an apical barrier, and a synthetic collagen material as an internal matrix. Following canal cleaning and shaping, calcium hydroxide was placed as an intracanal medicament for 1 mon. This was followed by placement of small piece of absorbable collagen membrane beyond the root apex to serve as matrix. An apical plug of Biodentine of 5 mm thickness was placed against the matrix using pre-fitted hand pluggers. The remainder of canal was back-filled with thermoplasticized gutta-percha and access cavity was restored with composite resin followed by all-ceramic crown. One year follow-up revealed restored aesthetics and function, absence of clinical signs and symptoms, resolution of periapical rarefaction, and a thin layer of calcific tissue formed apical to the Biodentine barrier. The positive clinical outcome in this case is encouraging for the use of Biodentine as an apical plug in single visit apexification procedures.

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  • Influence of Biodentine® - A Dentine Substitute - On Collagen Type I Synthesis in Pulp Fibroblasts In Vitro
    Frangis Nikfarjam, Kim Beyer, Anke König, Matthias Hofmann, Manuel Butting, Eva Valesky, Stefan Kippenberger, Roland Kaufmann, Detlef Heidemann, August Bernd, Nadja Nicole Zöller, Dimitrios Karamichos
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  • 33 Crossref
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Research Articles
Antibacterial properties of composite resins incorporating silver and zinc oxide nanoparticles on Streptococcus mutans and Lactobacillus
Shahin Kasraei, Lida Sami, Sareh Hendi, Mohammad-Yousef AliKhani, Loghman Rezaei-Soufi, Zahra Khamverdi
Restor Dent Endod 2014;39(2):109-114.   Published online March 21, 2014
DOI: https://doi.org/10.5395/rde.2014.39.2.109
AbstractAbstract PDFPubReaderePub
Objectives

Recurrent caries was partly ascribed to lack of antibacterial properties in composite resin. Silver and zinc nanoparticles are considered to be broad-spectrum antibacterial agents. The aim of the present study was to evaluate the antibacterial properties of composite resins containing 1% silver and zinc-oxide nanoparticles on Streptococcus mutans and Lactobacillus.

Materials and Methods

Ninety discoid tablets containing 0%, 1% nano-silver and 1% nano zinc-oxide particles were prepared from flowable composite resin (n = 30). The antibacterial properties of composite resin discs were evaluated by direct contact test. Diluted solutions of Streptococcus mutans (PTCC 1683) and Lactobacillus (PTCC 1643) were prepared. 0.01 mL of each bacterial species was separately placed on the discs. The discs were transferred to liquid culture media and were incubated at 37℃ for 8 hr. 0.01 mL of each solution was cultured on blood agar and the colonies were counted. Data was analyzed with Kruskall-Wallis and Mann-Whitney U tests.

Results

Composites containing nano zinc-oxide particles or silver nanoparticles exhibited higher antibacterial activity against Streptococcus mutans and Lactobacillus compared to the control group (p < 0.05). The effect of zinc-oxide on Streptococcus mutans was significantly higher than that of silver (p < 0.05). There were no significant differences in the antibacterial activity against Lactobacillus between composites containing silver nanoparticles and those containing zinc-oxide nanoparticles.

Conclusions

Composite resins containing silver or zinc-oxide nanoparticles exhibited antibacterial activity against Streptococcus mutans and Lactobacillus.

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Micro-CT evaluation of internal adaptation in resin fillings with different dentin adhesives
Seung-Hoon Han, Sung-Ho Park
Restor Dent Endod 2014;39(1):24-31.   Published online January 20, 2014
DOI: https://doi.org/10.5395/rde.2014.39.1.24
AbstractAbstract PDFPubReaderePub
Objectives

The purpose of present study was to evaluate the internal adaptation of composite restorations using different adhesive systems.

Materials and Methods

Typical class I cavities were prepared in 32 human third molars. The teeth were divided into the following four groups: 3-step etch-and-rinse, 2-step etch-and-rinse, 2-step self-etch and 1-step self-etch system were used. After the dentin adhesives were applied, composite resins were filled and light-cured in two layers. Then, silver nitrate solution was infiltrated, and all of the samples were scanned by micro-CT before and after thermo-mechanical load cycling. For each image, the length to which silver nitrate infiltrated, as a percentage of the whole pulpal floor length, was calculated (%SP). To evaluate the internal adaptation using conventional method, the samples were cut into 3 pieces by two sectioning at an interval of 1 mm in the middle of the cavity and they were dyed with Rhodamine-B. The cross sections of the specimens were examined by stereomicroscope. The lengths of the parts where actual leakage was shown were measured and calculated as a percentage of real leakage (%RP). The values for %SP and %RP were compared.

Results

After thermo-mechanical loading, all specimens showed significantly increased %SP compared to before thermo-mechanical loading and 1-step self-etch system had the highest %SP (p < 0.05). There was a tendency for %SP and %RP to show similar microleakage percentage depending on its sectioning.

Conclusions

After thermo-mechanical load cycling, there were differences in internal adaptation among the groups using different adhesive systems.

Citations

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  • Effect of different factors on microleakage and fracture strength of CAD‐CAM produced inlays
    Meryem Gülce Subaşı, Gürel Pekkan, Meral Arslan Malkoç, Hilal Ekşi Özsoy
    Journal of Prosthodontics.2025;[Epub]     CrossRef
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    Ahmed Y. Alzahrani, Amani A. Al Tuwirqi, Nada O. Bamashmous, Turki A. Bakhsh, Eman A. El Ashiry
    Children.2023; 10(8): 1318.     CrossRef
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    DH Floriani, RN Rached, SA Ignácio, EM Souza
    Operative Dentistry.2022; 47(5): 527.     CrossRef
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    Priyanka Angadala, Jyothi Mandava, Ravichandra Ravi, KoteswarRao Hanumanthu, Prasanthi Penmatsa, Hema Pulidindi
    Dental Research Journal.2022; 19(1): 56.     CrossRef
  • Tomographic Evaluation of the Internal Adaptation for Recent Calcium Silicate‐Based Pulp Capping Materials in Primary Teeth
    A. A. Al Tuwirqi, E. A. El Ashiry, A. Y. Alzahrani, N. Bamashmous, T. A. Bakhsh, Iole Vozza
    BioMed Research International.2021;[Epub]     CrossRef
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    Imaging Science in Dentistry.2021; 51(4): 341.     CrossRef
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Review Article
Cardiovascular effect of epinephrine in endodontic microsurgery: a review
Youngjune Jang, Euiseong Kim
Restor Dent Endod 2013;38(4):187-193.   Published online November 12, 2013
DOI: https://doi.org/10.5395/rde.2013.38.4.187
AbstractAbstract PDFPubReaderePub

Epinephrine is one of the most widely-used vasoconstrictors in dental treatment including endodontic microsurgery. However, the systemic safety of epinephrine has been in debate for many years because of its potential risk to cause cardiovascular complications. The purpose of this review was to assess the cardiovascular effect of epinephrine use in endodontic microsurgery. Endodontic microsurgery directly applies epinephrine into the bone cavity, and the amount is reported to be much larger than other dental surgeries. Moreover, when considering that systemic potency of intraosseous application is reported to be comparable to intravenous application, the systemic influence of epinephrine could be increased in endodontic microsurgery. Besides, pre-existing cardiovascular complications or drug interactions can enhance its systemic influence, resulting in increased susceptibility to cardiovascular complications. Although clinical studies have not reported significant complications for patients without severe systemic complications, many epinephrine-induced emergency cases are warning the cardiovascular risk related with pre-existing systemic disease or drug interactions. Epinephrine is a dose-sensitive drug, and its hypersensitivity reaction can be fatal to patients when it is related to cardiovascular complications. Therefore, clinicians should recognize the risk, and the usage of pre-operative patient evaluation, dose control and patient monitoring are required to ensure patient's safety during endodontic microsurgery.

Citations

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  • Expert consensus on apical microsurgery
    Hanguo Wang, Xin Xu, Zhuan Bian, Jingping Liang, Zhi Chen, Benxiang Hou, Lihong Qiu, Wenxia Chen, Xi Wei, Kaijin Hu, Qintao Wang, Zuhua Wang, Jiyao Li, Dingming Huang, Xiaoyan Wang, Zhengwei Huang, Liuyan Meng, Chen Zhang, Fangfang Xie, Di Yang, Jinhua Yu
    International Journal of Oral Science.2025;[Epub]     CrossRef
  • Comparative Evaluation of Local Hemostatic Agents in Minor Oral Surgical Procedures: A Randomized Clinical Trial
    Kshitija Patil, Jay N Goyal, Saurabh Dudhe, Janice John, Simona Joseph, Sanchi Kadbe, Seema Gupta
    Cureus.2025;[Epub]     CrossRef
  • Pharmacological Interactions of Epinephrine at Concentrations Used in Dental Anesthesiology: An Updated Narrative Review
    Maria Aikaterini Saraga, Ioannis Fotopoulos, Vasileios Zisis, Athanasios Poulopoulos, Nikolaos Dabarakis, Theodoros Lillis
    Reports.2025; 8(4): 224.     CrossRef
  • Effects of nasal desmopressin spray versus topical epinephrine on surgical field clarity and hemodynamics in endonasal dacryocystorhinostomy: a randomized clinical study
    Mohamed G.M. El Sayed, Marwa M. Medhat, Dina A.E. Salem, Marwa A.M. Khedr, Alshaimaa A.F. Kamel
    Research and Opinion in Anesthesia & Intensive Care.2024; 11(1): 1.     CrossRef
  • Is 1:1000 adrenaline as a topical haemostat an effective alternative to control bleeding in dentistry and oral surgery?
    Raj D. Aslam, Jonathan Liew, Eleni Besi
    British Dental Journal.2023; 235(1): 29.     CrossRef
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    Journal of Personalized Medicine.2022; 12(3): 416.     CrossRef
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    Z. S. Khabadze, D. A. Nazarova, E. S. Shilyaeva, A. P. Kotelnikova, Yu. A. Bakayev, S. M. Abdulkerimova, Kh. O. Omarova
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    S. Shkurashivska, H. Ersteniuk
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  • Biologic response of local hemostatic agents used in endodontic microsurgery
    Youngjune Jang, Hyeon Kim, Byoung-Duck Roh, Euiseong Kim
    Restorative Dentistry & Endodontics.2014; 39(2): 79.     CrossRef
  • 1,801 View
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  • 10 Crossref
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Research Article
The effects of image acquisition control of digital X-ray system on radiodensity quantification
Wook-Jin Seong, Hyeon-Cheol Kim, Soocheol Jeong, Youngcheul Heo, Woo-Bin Song, Mansur Ahmad
Restor Dent Endod 2013;38(3):146-153.   Published online August 23, 2013
DOI: https://doi.org/10.5395/rde.2013.38.3.146
AbstractAbstract PDFPubReaderePub
Objectives

Aluminum step wedge (ASW) equivalent radiodensity (eRD) has been used to quantify restorative material's radiodensity. The aim of this study was to evaluate the effects of image acquisition control (IAC) of a digital X-ray system on the radiodensity quantification under different exposure time settings.

Materials and Methods

Three 1-mm thick restorative material samples with various opacities were prepared. Samples were radiographed alongside an ASW using one of three digital radiographic modes (linear mapping (L), nonlinear mapping (N), and nonlinear mapping and automatic exposure control activated (E)) under 3 exposure time settings (underexposure, normal-exposure, and overexposure). The ASW eRD of restorative materials, attenuation coefficients and contrasts of ASW, and the correlation coefficient of linear relationship between logarithms of gray-scale value and thicknesses of ASW were compared under 9 conditions.

Results

The ASW eRD measurements of restorative materials by three digital radiographic modes were statistically different (p = 0.049) but clinically similar. The relationship between logarithms of background corrected grey scale value and thickness of ASW was highly linear but attenuation coefficients and contrasts varied significantly among 3 radiographic modes. Varying exposure times did not affect ASW eRD significantly.

Conclusions

Even though different digital radiographic modes induced large variation on attenuation of coefficient and contrast of ASW, E mode improved diagnostic quality of the image significantly under the under-exposure condition by improving contrasts, while maintaining ASW eRDs of restorative materials similar. Under the condition of this study, underexposure time may be acceptable clinically with digital X-ray system using automatic gain control that reduces radiation exposure for patient.

Citations

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  • Is the radiopacity of CAD/CAM aesthetic materials sufficient?
    Rua S. Babaier, Modi S. Aldeeb, Nick Silikas, David C. Watts
    Dental Materials.2022; 38(6): 1072.     CrossRef
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  • 1 Crossref
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Review Article
Is stopping of anticoagulant therapy really required in a minor dental surgery? - How about in an endodontic microsurgery?
Yong-Wook Cho, Euiseong Kim
Restor Dent Endod 2013;38(3):113-118.   Published online August 23, 2013
DOI: https://doi.org/10.5395/rde.2013.38.3.113
AbstractAbstract PDFPubReaderePub

Nowadays, oral anticoagulants are commonly prescribed to numerous patients for preventing cardiovascular accident such as thromboembolism. An important side effect of anticoagulant is anti-hemostasis. In a major surgery, the oral anticoagulant therapy (OAT) regimen must be changed before the surgery for proper post-operative bleeding control. However, in a minor dental surgery and endodontic surgery, the necessity for changing or discontinuing the OAT is open to debate. In this study, risks of the consequences were weighed and analyzed. In patients who stop the OAT, the occurrence of thromboembolic complication is rare but the result is fatal. In patients who continuing the OAT, post-operative bleeding can be controlled well with the local hemostatic measures. In the endodontic surgery, there are almost no studies about this issue. The intra-operative bleeding control is particularly important in the endodontic surgery because of its delicate and sensitive procedures such as inspection of resected root surface using dental microscope and retrograde filling. Further studies are necessary about this issue in the viewpoint of endodontic surgery.

Citations

Citations to this article as recorded by  
  • Expert consensus on apical microsurgery
    Hanguo Wang, Xin Xu, Zhuan Bian, Jingping Liang, Zhi Chen, Benxiang Hou, Lihong Qiu, Wenxia Chen, Xi Wei, Kaijin Hu, Qintao Wang, Zuhua Wang, Jiyao Li, Dingming Huang, Xiaoyan Wang, Zhengwei Huang, Liuyan Meng, Chen Zhang, Fangfang Xie, Di Yang, Jinhua Yu
    International Journal of Oral Science.2025;[Epub]     CrossRef
  • Management of Patients Receiving Anticoagulation Therapy in Dental Practice: A Systematic Review
    Francesco Inchingolo, Angelo Michele Inchingolo, Fabio Piras, Laura Ferrante, Antonio Mancini, Andrea Palermo, Alessio Danilo Inchingolo, Gianna Dipalma
    Healthcare.2024; 12(15): 1537.     CrossRef
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    Mai El Halawany, Randa Latif, Mohamed H. H. AbouGhaly
    Pharmaceutics.2022; 14(10): 2255.     CrossRef
  • Perioperative Antiplatelet and Anticoagulant Management with Endodontic Microsurgical Techniques
    Anita Aminoshariae, Mark Donaldson, Michael Horan, James C. Kulild, Dale Baur
    Journal of Endodontics.2021; 47(10): 1557.     CrossRef
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    Thomas M. Halaszynski
    Oral and Maxillofacial Surgery Clinics of North America.2016; 28(4): 443.     CrossRef
  • Biologic response of local hemostatic agents used in endodontic microsurgery
    Youngjune Jang, Hyeon Kim, Byoung-Duck Roh, Euiseong Kim
    Restorative Dentistry & Endodontics.2014; 39(2): 79.     CrossRef
  • Cardiovascular effect of epinephrine in endodontic microsurgery: a review
    Youngjune Jang, Euiseong Kim
    Restorative Dentistry & Endodontics.2013; 38(4): 187.     CrossRef
  • 1,989 View
  • 5 Download
  • 7 Crossref
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Research Article
Effect of different air-drying time on the microleakage of single-step self-etch adhesives
Horieh Moosavi, Maryam Forghani, Esmatsadat Managhebi
Restor Dent Endod 2013;38(2):73-78.   Published online May 28, 2013
DOI: https://doi.org/10.5395/rde.2013.38.2.73
AbstractAbstract PDFPubReaderePub
Objectives

This study evaluated the effect of three different air-drying times on microleakage of three self-etch adhesive systems.

Materials and Methods

Class I cavities were prepared for 108 extracted sound human premolars. The teeth were divided into three main groups based on three different adhesives: Opti Bond All in One (OBAO), Clearfil S3 Bond (CSB), Bond Force (BF). Each main group divided into three subgroups regarding the air-drying time: without application of air stream, following the manufacturer's instruction, for 10 sec more than manufacturer's instruction. After completion of restorations, specimens were thermocycled and then connected to a fluid filtration system to evaluate microleakage. The data were statistically analyzed using two-way ANOVA and Tukey-test (α = 0.05).

Results

The microleakage of all adhesives decreased when the air-drying time increased from 0 sec to manufacturer's instruction (p < 0.001). The microleakage of BF reached its lowest values after increasing the drying time to 10 sec more than the manufacturer's instruction (p < 0.001). Microleakage of OBAO and CSB was significantly lower compared to BF in all three drying time (p < 0.001).

Conclusions

Increasing in air-drying time of adhesive layer in one-step self-etch adhesives caused reduction of microleakage, but the amount of this reduction may be dependent on the adhesive components of self-etch adhesives.

Citations

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    Science of The Total Environment.2024; 918: 170734.     CrossRef
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    Seo-Young Park, Jin-Hyun Kim
    Biotechnology and Bioprocess Engineering.2021; 26(5): 814.     CrossRef
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    Frontiers in Dental Medicine.2021;[Epub]     CrossRef
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    Tae-Hun Yoon, Jin-Hyun Kim
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    Photomedicine and Laser Surgery.2018; 36(11): 589.     CrossRef
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    Chung-Gi Lee, Jin-Hyun Kim
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