Restorative Dentistry & Endodontics

Review Article

Success rate of direct pulp capping on permanent teeth using bioactive materials: a systematic review and meta-analysis of randomized clinical trials: Karem Paula Pinto, Gabriela Ribeiro da Silva, Cláudio Malizia Alves Ferreira, Luciana Moura Sassone, Emmanuel João Nogueira Leal da Silva; Restor Dent Endod 2024;49(4):e34. Published online September 6, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e34

Abstract PDF Supplementary Material PubReader ePub: This systematic review and meta-analysis aimed to evaluate the success rate of direct pulp capping (DPC) on permanent teeth, comparing the use of MTA with calcium hydroxide and calcium silicate-based cements. A systematic search was carried out in 4 databases until July 2023. The selection was based on PICOS criteria and only randomized clinical trials were included. The risk of bias was assessed using RoB-2 tool, and meta-analyses were performed using RevMan 5.3 software. The overall quality of evidence was determined using the GRADE tool. Thirteen studies were included. Meta-analyses indicated significantly higher success rate for DPC using MTA compared to calcium hydroxide, while no significant difference was observed between MTA and Biodentine, showing a success rate from 80% to 100% even after 3 years of follow-up. Five studies were classified as having high risk of bias and the GRADE assessment revealed low certainty of evidence. DPC is highly effective for permanent teeth when using MTA or Biodentine. There is a need for future well-designed randomized clinical trials to evaluate the efficacy of DPC using newer bioceramic materials.

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Research Articles

High-plasticity mineral trioxide aggregate and its effects on M1 and M2 macrophage viability and adherence, phagocyte activity, production of reactive oxygen species, and cytokines: Betânia Canal Vasconcellos, Layara Cristine Tomaz Tavares, Danilo Couto da Silva, Francielen Oliveira Fonseca, Francine Benetti, Antônio Paulino Ribeiro Sobrinho, Warley Luciano Fonseca Tavares; Restor Dent Endod 2023;48(1):e6. Published online December 29, 2022; DOI: https://doi.org/10.5395/rde.2023.48.e6

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Objectives

This study evaluated the effects of high-plasticity mineral trioxide aggregate (MTA-HP) on the activity of M1 and M2 macrophages, compared to white MTA (Angelus).

Materials and Methods

Peritoneal inflammatory M1 (from C57BL/6 mice) and M2 (from BALB/c mice) macrophages were cultured in the presence of the tested materials. Cell viability (MTT and trypan blue assays), adhesion, phagocytosis, reactive oxygen species (ROS) production, and tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β production were evaluated. Parametric analysis of variance and the non-parametric Kruskal-Wallis test were used. Results were considered significant when p < 0.05.

Results

The MTT assay revealed a significant decrease in M1 metabolism with MTA-HP at 24 hours, and with MTA and MTA-HP later. The trypan blue assay showed significantly fewer live M1 at 48 hours and live M2 at 48 and 72 hours with MTA-HP, compared to MTA. M1 and M2 adherence and phagocytosis showed no significant differences compared to control for both materials. Zymosan A stimulated ROS production by macrophages. In the absence of interferon-γ, TNF-α production by M1 did not significantly differ between groups. For M2, both materials showed higher TNF-α production in the presence of the stimulus, but without significant between-group differences. Likewise, TGF-β production by M1 and M2 macrophages was not significantly different between the groups.

Conclusions

M1 and M2 macrophages presented different viability in response to MTA and MTA-HP at different time points. Introducing a plasticizer into the MTA vehicle did not interfere with the activity of M1 and M2 macrophages.

Citations

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Local Immune Response to Mineral Trioxide Aggregate: A Narrative Review
Shankargouda Patil, Shilpa Bhandi, Oladapo T Okareh
World Journal of Dentistry.2023; 14(4): 382. CrossRef

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Push-out bond strength and marginal adaptation of apical plugs with bioactive endodontic cements in simulated immature teeth: Maria Aparecida Barbosa de Sá, Eduardo Nunes, Alberto Nogueira da Gama Antunes, Manoel Brito Júnior, Martinho Campolina Rebello Horta, Rodrigo Rodrigues Amaral, Stephen Cohen, Frank Ferreira Silveira; Restor Dent Endod 2021;46(4):e53. Published online October 20, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e53

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Objectives

This study evaluates the bond strength and marginal adaptation of mineral trioxide aggregate (MTA) Repair HP and Biodentine used as apical plugs; MTA was used as reference material for comparison.

Materials and Methods

A total of 30 single-rooted teeth with standardized, artificially created open apices were randomly divided into 3 groups (n = 10 per group), according to the material used to form 6-mm-thick apical plugs: group 1 (MTA Repair HP); group 2 (Biodentine); and group 3 (white MTA). Subsequently, the specimens were transversely sectioned to obtain 2 (cervical and apical) 2.5-mm-thick slices per root. Epoxy resin replicas were observed under a scanning electron microscope to measure the gap size at the material/dentin interface (the largest and smaller gaps were recorded for each replica). The bond strength of the investigated materials to dentin was determined using the push-out test. The variable bond strengths and gap sizes were evaluated independently at the apical and cervical root dentin slices. Data were analyzed using descriptive and analytic statistics.

Results

The comparison between the groups regarding the variables' bond strengths and gap sizes showed no statistical difference (p > 0.05) except for a single difference in the smallest gap at the cervical root dentin slice, which was higher in group 3 than in group 1 (p < 0.05).

Conclusions

The bond strength and marginal adaptation to root canal walls of MTA HP and Biodentine cement were comparable to white MTA.

Citations

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Evaluation of the root dentin bond strength and intratubular biomineralization of a premixed calcium aluminate-based hydraulic bioceramic endodontic sealer
Yu-Na Lee, Min-Kyeong Kim, Hee-Jin Kim, Mi-Kyung Yu, Kwang-Won Lee, Kyung-San Min
Journal of Oral Science.2024; 66(2): 96. CrossRef
Managing Cracked Teeth with Root Extension: A Prospective Preliminary Study Using Biodentine™ Material
Kênia Maria Soares de Toubes, Isabella Sousa Corrêa, Regina Célia Lopes Valadares, Stephanie Quadros Tonelli, Fábio Fernandes Borém Bruzinga, Frank Ferreira Silveira, Dr Karthikeyan Ramalingam
International Journal of Dentistry.2024;[Epub] CrossRef
Marginal adaptation of customized gutta percha cone with calcium silicate based sealer versus MTA and biodentine apical plugs in simulated immature permanent teeth (an in vitro study)
Mary M. Mina, Sybel M. Moussa, Mahmoud R. Aboelseoud
BMC Oral Health.2024;[Epub] CrossRef
Comparative Evaluation of Push-Out Bond Strength of Conventional Mineral Trioxide Aggregate, Biodentine, a Modified Mineral Trioxide Aggregate, and Two Novel Antibacterial-Enhanced Mineral Trioxide Aggregates
Arokia Rajkumar Shancy Merlin, Vignesh Ravindran, Ganesh Jeevanandan, Rajalakshmanan Eswaramoorthy, Abirami Arthanari
Cureus.2024;[Epub] CrossRef
Push out bond strength of hydraulic cements used at different thicknesses
C. Ruiz Durán, Dra L. Gancedo-Caravia, V. Vera González, C. González Losada
BMC Oral Health.2023;[Epub] CrossRef
Effects of different calcium-silicate based materials on fracture resistance of immature permanent teeth with replacement root resorption and osteoclastogenesis
Gabriela Leite de Souza, Gabrielle Alves Nunes Freitas, Maria Tereza Hordones Ribeiro, Nelly Xiomara Alvarado Lemus, Carlos José Soares, Camilla Christian Gomes Moura
Restorative Dentistry & Endodontics.2023;[Epub] CrossRef

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Bone repair in defects filled with AH Plus sealer and different concentrations of MTA: a study in rat tibiae: Jessica Emanuella Rocha Paz, Priscila Oliveira Costa, Albert Alexandre Costa Souza, Ingrid Macedo de Oliveira, Lucas Fernandes Falcão, Carlos Alberto Monteiro Falcão, Maria Ângela Area Leão Ferraz, Lucielma Salmito Soares Pinto; Restor Dent Endod 2021;46(4):e48. Published online September 2, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e48

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Objectives

This study aimed to evaluate the effects on bone repair of different concentrations of mineral trioxide aggregate (MTA) added to AH Plus.

Materials and Methods

Bone tissue reactions were evaluated in 30 rats (Rattus norvegicus) after 7 and 30 days. In the AH + MTA10, AH + MTA20, and AH + MTA30 groups, defects in the tibiae were filled with AH Plus with MTA in proportions of 10%, 20% and 30%, respectively; in the MTA-FILL group, MTA Fillapex was used; and in the control group, no sealer was used. The samples were histologically analyzed to assess bone union and maturation. The Kruskal-Wallis and Mann-Whitney tests were performed for multiple pairwise comparisons (p ≤ 0.05).

Results

At the 7-day time point, AH + MTA10 was superior to MTA-FILL with respect to bone union, and AH + MTA20 was superior to MTA-FILL with respect to bone maturity (p < 0.05). At the 30-day time point, both the AH + MTA10 and AH + MTA20 experimental sealers were superior not only to MTA-FILL, but also to AH + MTA30 with respect to both parameters (p < 0.05). The results of the AH + MTA10 and AH + MTA20 groups were superior to those of the control group for both parameters and experimental time points (p < 0.05).

Conclusions

The results suggest the potential benefit of using a combination of these materials in situations requiring bone repair.

Citations

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Analysis of the cytotoxicity and bioactivity of CeraSeal, BioRoot™ and AH Plus® sealers in pre-osteoblast lineage cells
Luciano Aparecido de Almeida-Junior, Giuliana de Campos Chaves Lamarque, Henry Herrera, Maya Fernanda Manfrin Arnez, Francine Lorencetti-Silva, Raquel Assed Bezerra Silva, Léa Assed Bezerra Silva, Francisco Wanderley Garcia Paula-Silva
BMC Oral Health.2024;[Epub] CrossRef
A Review of the research methods and progress of biocompatibility evaluation of root canal sealers
Xiliang Yang, Tianxia Zheng, Nuoya Yang, Zihan Yin, Wuliang Wang, Yuhong Bai
Australian Endodontic Journal.2023; 49(S1): 508. CrossRef
Effect of Vitapex Combined with AH-Plus Paste on Inflammation in Middle-Aged and Elderly Patients with Periodontal-Endodontic Disease
Rong Hu, Fulan Zhang, Xiangyu Guo, Youren Jing, Xiaowan Lin, Liping Tian, Min Tang
Computational and Mathematical Methods in Medicine.2022; 2022: 1. CrossRef

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Comparison of the sealing ability of various bioceramic materials for endodontic surgery: Benjamin Rencher, Ana M. Chang, Hanson Fong, James D. Johnson, Avina Paranjpe; Restor Dent Endod 2021;46(3):e35. Published online June 8, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e35

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Objectives

Endosequence Bioceramic Root Repair Material (BC-RRM) is used in endodontic microsurgery. It is available as a paste and a putty. However, no studies to date have examined the sealing ability of these forms alone or in combination as root-end filling materials. Hence, this study aimed to compare the sealing properties of these 2 forms of BC-RRM.

Materials and Methods

Forty-two extracted upper anterior teeth were divided into 3 experimental groups, a positive and negative control. After the root canal treatment, the root ends were resected, retroprepared and retrofilled with either putty, paste + putty or mineral trioxide aggregate (MTA). The teeth were mounted in tubes so the apical 3 mm was submerged in Brain Heart Infusion (BHI) broth. The coronal portions of the canals were inoculated with Enterococcus faecalis and BHI broth and incubated for 30 days. The broth in the tubes was analyzed for colony forming units to check for leakage of bacteria from the canal. The teeth from the groups were sectioned and analyzed using scanning electron microscopy (SEM). The Kruskal-Wallis test and analysis of variance were used to analyze the data with a significance level p < 0.05.

Results

The BC-RRM and MTA groups showed similar sealing ability. The positive control showed leakage in all samples. The SEM imaging showed the presence of bacteria in all experimental groups at the material-tooth interface.

Conclusions

No significant differences were noted in the experimental groups, providing sufficient evidence that any combination could be effectively used during endodontic microsurgery.

Citations

Citations to this article as recorded by

An Ex-vivo Evaluation of Sealability of Three Bioceramic Physical Variants in Coronal and Apical Thirds of Root Canals
Murali H Rao, Rajkumar Krishnan, Pavithra Gopal, Elizabeth Thomas
The Journal of Contemporary Dental Practice.2025; 25(11): 1022. CrossRef
Clinical applications and classification of calcium silicate-based cements based on their history and evolution: a narrative review
Kenta Tsuchiya, Salvatore Sauro, Hidehiko Sano, Jukka P. Matinlinna, Monica Yamauti, Shuhei Hoshika, Yu Toida, Rafiqul Islam, Atsushi Tomokiyo
Clinical Oral Investigations.2025;[Epub] CrossRef
Evaluation of the Marginal Adaptation of Two Hydraulic Calcium Silicate Cements Used in Apical Plugs: An In Vitro Study
Sara Filipe, José Pedro Martinho, Siri Paulo, Catarina Carvalho, Ana Coelho, Inês Amaro, Eunice Carrilho, Anabela Paula, Carlos Miguel Marto, Henrique Girão, Mónica Zuzarte, Ana S. Pires, Manuel Marques Ferreira
Applied Sciences.2024; 14(2): 480. CrossRef
A Study on Nanoleakage of Apical Retrograde Filling of Premixed Calcium Silicate-Based Cement Using a Lid Technique
Nyamsuren Enkhbileg, Jin Woo Kim, Seok Woo Chang, Se-Hee Park, Kyung Mo Cho, Yoon Lee
Materials.2024; 17(10): 2366. CrossRef
The outcome of combined use of iRoot BP Plus and iRoot SP for root-end filling in endodontic microsurgery: a randomized controlled trial
Xu Dong, Qin Su, Wen Li, Jinbo Yang, Dongzhe Song, Jing Yang, Xin Xu
Clinical Oral Investigations.2024;[Epub] CrossRef
Bacterial sealing ability of calcium silicate-based sealer for endodontic surgery: an in-vitro study
Mai M. Mansour, Sybel M. Moussa, Marwa A. Meheissen, Mahmoud R. Aboelseoud
BMC Oral Health.2024;[Epub] CrossRef
Evaluation of Marginal Adaptation of Three Biomaterials as Apical Barrier in Experimental Apexification Model
Nagehan Aktaş, Didem Sakaryalı Uyar, Didem Atabek
ADO Klinik Bilimler Dergisi.2024; 13(3): 409. CrossRef
In vitro evaluation of the sealing ability of combined use of iRoot BP Plus and iRoot SP for root-end filling
Xu Dong, Qian Xie, Xin Xu
Clinical Oral Investigations.2023; 27(6): 2969. CrossRef
Outcomes of endodontic microsurgery using different calcium silicate–based retrograde filling materials: a cohort retrospective cone-beam computed tomographic analysis
Rawan F. Eskandar, Mey A. Al-Habib, Mohammed A. Barayan, Hadeel Y. Edrees
BMC Oral Health.2023;[Epub] CrossRef
Bioceramics in Endodontics: Updates and Future Perspectives
Xu Dong, Xin Xu
Bioengineering.2023; 10(3): 354. CrossRef
Biological properties of Ceraputty as a retrograde filling material: an in vitro study on hPDLSCs
Sergio López-García, Francisco J. Rodríguez-Lozano, José Luis Sanz, Leopoldo Forner, María Pilar Pecci-Lloret, Adrián Lozano, Laura Murcia, Sonia Sánchez-Bautista, Ricardo E. Oñate-Sánchez
Clinical Oral Investigations.2023; 27(8): 4233. CrossRef
Bone Window Technique in Endodontic Microsurgery – Report of Two Cases
Spyros Floratos, Vasileios Molonis, Apostolos Tsolakis, Stylianos Kykalos, Konstantinos Kontzoglou
Journal of Endodontic Microsurgery.2022; 2: 24. CrossRef

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Biological assessment of a new ready-to-use hydraulic sealer: Francine Benetti, João Eduardo Gomes-Filho, India Olinta de Azevedo-Queiroz, Marina Carminatti, Letícia Citelli Conti, Alexandre Henrique dos Reis-Prado, Sandra Helena Penha de Oliveira, Edilson Ervolino, Elói Dezan-Júnior, Luciano Tavares Angelo Cintra; Restor Dent Endod 2021;46(2):e21. Published online March 24, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e21

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Objectives

This study compared the cytotoxicity, biocompatibility, and tenascin immunolabeling of a new ready-to-use hydraulic sealer (Bio-C Sealer) with MTA-Fillapex and white MTA-Angelus.

Materials and Methods

L929 fibroblasts were cultivated and exposed to undiluted and diluted material extracts. Polyethylene tubes with or without (the control) the materials were implanted into the dorsa of rats. At 7 days and 30 days, the rats were euthanized, and the specimens were prepared for analysis; inflammation and immunolabeling were measured, and statistical analysis was performed (p < 0.05).

Results

MTA-Fillapex exhibited greater cytotoxicity than the other materials at all time points (p < 0.05). The undiluted Bio-C Sealer exhibited greater cytocompatibility at 6 and 48 hours than white MTA-Angelus, with higher cell viability than in the control (p < 0.05). White MTA-Angelus displayed higher cell viability than the control at 24 hours, and the one-half dilution displayed similar results at both 6 and 48 hours (p < 0.05). At 7 days and 30 days, the groups exhibited moderate inflammation with thick fibrous capsules and mild inflammation with thin fibrous capsules, respectively (p > 0.05). At 7 days, moderate to strong immunolabeling was observed (p > 0.05). After 30 days, the control and MTA-Fillapex groups exhibited strong immunolabeling, the white MTA-Angelus group exhibited moderate immunolabeling (p > 0.05), and the Bio-C Sealer group exhibited low-to-moderate immunolabeling, differing significantly from the control (p < 0.05).

Conclusions

Bio-C Sealer and white MTA-Angelus exhibited greater cytocompatibility than MTA-Fillapex; all materials displayed adequate biocompatibility and induced tenascin immunolabeling.

Citations

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Influence of photoactivation on tissue response to different dyes used in photodynamic therapy and laser ablation therapy
Luciano Tavares Angelo Cintra, Cristiane Cantiga-Silva, Henrique Augusto Banci, Flávio Duarte Faria, Nathália Evelyn da Silva Machado, Carolina de Barros Morais Cardoso, Pedro Henrique Chaves de Oliveira, Lucas Rodrigues de Araújo Estrela, Gustavo Sivieri
Journal of Photochemistry and Photobiology B: Biology.2024; 251: 112843. CrossRef
Bleaching effectiveness and cytotoxicity of new experimental formulation of niobium-based bleaching gel
Camila de Sousa Caneschi, Francine Benetti, Luiz Carlos Alves de Oliveira, Jadson Cláudio Belchior, Raquel Conceição Ferreira, Allyson Nogueira Moreira, Luís Fernando dos Santos Alves Morgan
Clinical Oral Investigations.2023; 27(4): 1613. CrossRef
Biological investigation of resinous endodontic sealers containing calcium hydroxide
Carlos Roberto Emerenciano Bueno, Francine Benetti, Marina Tolomei Sandoval Cury, Ana Maria Veiga Vasques, Leopoldo Cosme-Silva, Índia Olinta de Azevedo Queiroz, Ana Cláudia Rodrigues da Silva, Rogério de Castilho Jacinto, Luciano Tavares Angelo Cintra, E
PLOS ONE.2023; 18(7): e0287890. CrossRef
Tricalcium silicate cement sealers
Anita Aminoshariae, Carolyn Primus, James C. Kulild
The Journal of the American Dental Association.2022; 153(8): 750. CrossRef
Comparative evaluation of push-out bond strength of bioceramic and epoxy sealers after using various final irrigants: An in vitro study
Chandrasekhar Veeramachaneni, Swathi Aravelli, Sreeja Dundigalla
Journal of Conservative Dentistry.2022; 25(2): 145. CrossRef

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Case Report

Bioblock technique to treat severe internal resorption with subsequent periapical pathology: a case report: Márk Fráter, Tekla Sáry, Sufyan Garoushi; Restor Dent Endod 2020;45(4):e43. Published online August 18, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e43

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A variety of therapeutic modalities can be used for the endodontic treatment of a traumatized tooth with internal root resorption (IRR). The authors present a case report of the successful restoration of a traumatized upper central incisor that was weakened due to severe IRR and subsequent periapical lesion formation. A 20-year-old female patient was referred to our clinic with severe internal resorption and subsequent periapical pathosis destroying the buccal bone wall. Root canal treatment had been initiated previously at another dental practice, but at that time, the patient's condition could not be managed even with several treatments. After cone-beam computed tomography imaging and proper chemomechanical cleaning, the tooth was managed with a mineral trioxide aggregate plug followed by root canal filling using short fiber-reinforced composite, known as the Bioblock technique. This report is the first documentation of the use of the Bioblock technique in the restoration of a traumatized tooth. The Bioblock technique appears to be ideal for restoring wide irregular root canals, as in cases of severe internal resorption, because it can uniquely fill out the hollow irregularities of the canal. However, further long-term clinical investigations are required to provide additional information about this new technique.

Citations

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Üvegszálas fogászati kompozit tömőanyag keménysége a gyökércsatornában: nanoindentációs vizsgálat
András Jakab, Kata Lilla Vánkay, Tamás Tarjányi, Gábor Gulyás, Krisztián Bali, Pál Patrik Dézsi, Márton Sámi, Márk Fráter
Fogorvosi Szemle.2024; 117(2): 47. CrossRef
Evaluation of microhardness of short fiber-reinforced composites inside the root canal after different light curing methods – An in vitro study
Márk Fráter, János Grosz, András Jakab, Gábor Braunitzer, Tamás Tarjányi, Gábor Gulyás, Krisztián Bali, Paula Andrea Villa-Machado, Sufyan Garoushi, András Forster
Journal of the Mechanical Behavior of Biomedical Materials.2024; 150: 106324. CrossRef
Imaging techniques and various treatment modalities used in the management of internal root resorption: A systematic review
R. S Digholkar, S D Aggarwal, P S Kurtarkar, P. B Dhatavkar, V L Neil, D N Agarwal
Endodontology.2023; 35(2): 85. CrossRef
The Impact of the Preferred Reporting Items for Case Reports in Endodontics (PRICE) 2020 Guidelines on the Reporting of Endodontic Case Reports
Sofian Youssef, Phillip Tomson, Amir Reza Akbari, Natalie Archer, Fayjel Shah, Jasmeet Heran, Sunmeet Kandhari, Sandeep Pai, Shivakar Mehrotra, Joanna M Batt
Cureus.2023;[Epub] CrossRef
Fatigue performance of endodontically treated premolars restored with direct and indirect cuspal coverage restorations utilizing fiber-reinforced cores
Márk Fráter, Tekla Sáry, Janka Molnár, Gábor Braunitzer, Lippo Lassila, Pekka K. Vallittu, Sufyan Garoushi
Clinical Oral Investigations.2022; 26(4): 3501. CrossRef

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Research Article

Comparative evaluation of the bond strength of self-adhering and bulk-fill flowable composites to MTA Plus, Dycal, Biodentine, and TheraCal: an in vitro study: Aakrati Raina, Asheesh Sawhny, Saurav Paul, Sridevi Nandamuri; Restor Dent Endod 2020;45(1):e10. Published online January 8, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e10

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Objectives

This study aimed to compare the shear bond strength (SBS) of a self-adhering flowable composite (Dyad Flow) and a bulk-fill flowable composite (Smart Dentin Replacement [SDR]) to several pulp-capping materials, including MTA Plus, Dycal, Biodentine, and TheraCal.

Materials and Methods

Eighty acrylic blocks with 2-mm-deep central holes that were 4 mm in diameter were prepared and divided into 2 groups (n = 40 each) according to the composite used (Dyad Flow or SDR). They were further divided into 4 sub-groups (n = 10 each) according to the pulp-capping agent used. SBS was tested using a universal testing machine at a crosshead speed of 1 mm/min. Data were analyzed using 2-way analysis of variance. A p value of < 0.05 was considered to indicate statistical significance.

Results

A statistically significant difference (p = 0.040) was found between Dyad Flow and SDR in terms of bond strength to MTA Plus, Dycal, Biodentine, and TheraCal.

Conclusions

Among the 8 sub-groups, the combination of TheraCal and SDR exhibited the highest SBS.

Citations

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Hygroscopic bioactive light-cured composite promoting dentine bridge formation
Yunzi Long, Guibin Huang, Siyi Liu, Liju Xu, Ailing Li, Dong Qiu, Yanmei Dong
Regenerative Biomaterials.2024;[Epub] CrossRef
Comparative evaluation of shear bond strength and modes of failure of five different reinforced glass ionomer restorative cements to TheraCal LC: An in vitro study
Kalyani Gajanan Umale, Vandana Jaykumar Gade, Ambar W. Raut
Journal of Conservative Dentistry and Endodontics.2024; 27(2): 200. CrossRef
Evaluation of the Effect of Chitosan-Based Irrigation Solutions on the Bond Strength of Mineral Trioxide Aggregate to Bulk-Fill Composite
Arzu Şahin Mantı, Bağdagül Helvacıoğlu Kıvanç
Journal of Functional Biomaterials.2024; 15(12): 370. CrossRef
Radiopacity evaluations of the novel calcium-silicate and glass-Ionomer-based materials
Yeşim Şeşen Uslu, Elif Çelebi, Meriç Berkman
Journal of Health Sciences and Medicine.2024; 7(2): 192. CrossRef
Effect of Er Cr YSGG laser etching procedure on the bond strength of different calcium silicate cements
Yesim Sesen Uslu, Hakan Yasin Gönder, Pinar Sesen, Gizem Gunduz Bektaş
Lasers in Dental Science.2024;[Epub] CrossRef
The micro‐shear bond strength of new endodontic tricalcium silicate‐based putty: An in vitro study
Merve Yeniçeri Özata, Seda Falakaloğlu, Gianluca Plotino, Özkan Adıgüzel
Australian Endodontic Journal.2023; 49(1): 124. CrossRef
Analysis of the bond strength between conventional, putty or resin‐modified calcium silicate cement and bulk fill composites
İ Ipek, B Karaağaç Eskibağlar, Ş Yildiz, O Ataş, M Ünal
Australian Dental Journal.2023; 68(4): 265. CrossRef
Effect of Different Adhesive Strategies on the Microshear Bond Strength of Calcium-Silicate-Based Materials
Aliye Tuğçe Gürcan, Soner Şişmanoğlu, Görkem Sengez
Journal of Advanced Oral Research.2022; 13(2): 191. CrossRef
BULK FİLL KOMPOZİT REZİN RESTORATİF MATERYALLER
Merve NEZİR, Suat ÖZCAN
Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi.2022; : 1. CrossRef
Effect of Bioinductive Cavity Liners on Shear Bond Strength of Dental Composite to Dentin
Saba Tohidkhah, Elham Ahmadi, Mahdi Abbasi, Reza Morvaridi Farimani, Ladan Ranjbar Omrani, Victor Feitosa
BioMed Research International.2022;[Epub] CrossRef
Bond Strength of Adhesive Systems to Calcium Silicate-Based Materials: A Systematic Review and Meta-Analysis of In Vitro Studies
Louis Hardan, Davide Mancino, Rim Bourgi, Alejandra Alvarado-Orozco, Laura Emma Rodríguez-Vilchis, Abigailt Flores-Ledesma, Carlos Enrique Cuevas-Suárez, Monika Lukomska-Szymanska, Ammar Eid, Maya-Line Danhache, Maryline Minoux, Youssef Haïkel, Naji Kharo
Gels.2022; 8(5): 311. CrossRef
How do imaging protocols affect the assessment of root-end fillings?
Fernanda Ferrari Esteves Torres, Reinhilde Jacobs, Mostafa EzEldeen, Karla de Faria-Vasconcelos, Juliane Maria Guerreiro-Tanomaru, Bernardo Camargo dos Santos, Mário Tanomaru-Filho
Restorative Dentistry & Endodontics.2022;[Epub] CrossRef
Evaluation of Shear Bond Strength of Resin-Based Composites to Biodentine with Three Types of Seventh-Generation Bonding Agents: An In Vitro Study
Huda Abbas Abdullah, Zahraa Abdulaali Al-Ibraheemi, Zanbaq Azeez Hanoon, Julfikar Haider, Boonlert Kukiattrakoon
International Journal of Dentistry.2022; 2022: 1. CrossRef
Evaluation of the Bond Strength of Different Pulp Capping Materials to Dental Adhesive Systems: An In Vitro Study
Sema Yazici Akbiyik, Elif Pınar Bakir, S¸eyhmus Bakir
Journal of Advanced Oral Research.2021; 12(2): 286. CrossRef
Differential Gene Expression Changes in Human Primary Dental Pulp Cells Treated with Biodentine and TheraCal LC Compared to MTA
Ok Hyung Nam, Ho Sun Lee, Jae-Hwan Kim, Yong Kwon Chae, Seoung-Jin Hong, Sang Wook Kang, Hyo-Seol Lee, Sung Chul Choi, Young Kim
Biomedicines.2020; 8(11): 445. CrossRef

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15 Crossref

Case Report

Observation of an extracted premolar 2.5 years after mineral trioxide aggregate apexification using micro-computed tomography: Gayeon Lee, Chooryung Chung, Sunil Kim, Su-Jung Shin; Restor Dent Endod 2020;45(2):e4. Published online November 22, 2019; DOI: https://doi.org/10.5395/rde.2020.45.e4

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Although numerous studies have been conducted on apexification using mineral trioxide aggregate (MTA), direct observation of extracted human teeth after the procedure has been rarely reported. This case report describes a mandibular premolar treated 2.5 years ago and extracted recently for orthodontic treatment. The tubercle of the right mandibular premolar of a 12-year-old boy with dens evaginatus was fractured and the pulp was exposed. The tooth was diagnosed with pulp necrosis and asymptomatic periapical abscess. During the first visit, copious irrigation was performed with 2.5% sodium hypochlorite. Calcium hydroxide paste was placed as an intracanal medicament. The sinus tract had disappeared at the second visit after 3 weeks. MTA was applied on to the bleeding point as a 4-mm-thick layer, followed by a 3-mm-thick gutta-percha filling and resin core build-up. After 2.5 years, the tooth and three other premolars were extracted for orthodontic treatment. The right and left mandibular premolars were scanned with micro-computed tomography to determine the root shape and canal anatomy. Irregular root growth was observed and the root outline of the right mandibular premolar differed from that of the contralateral tooth. Apexification with MTA leads to the formation of roots with irregular morphology, without any pulpal space.

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Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an in vitro study
Fábio Rocha Bohns, Vicente Castelo Branco Leitune, Isadora Martini Garcia, Bruna Genari, Nélio Bairros Dornelles, Silvia Stanisçuaski Guterres, Fabrício Aulo Ogliari, Mary Anne Sampaio de Melo, Fabrício Mezzomo Collares
Restorative Dentistry & Endodontics.2020;[Epub] CrossRef

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Research Article

Bioactivity of endodontic biomaterials on dental pulp stem cells through dentin: Bahar Javid, Narges Panahandeh, Hassan Torabzadeh, Hamid Nazarian, Ardavan Parhizkar, Saeed Asgary; Restor Dent Endod 2020;45(1):e3. Published online November 4, 2019; DOI: https://doi.org/10.5395/rde.2020.45.e3

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Objectives

This study investigated the indirect effect of calcium-enriched mixture (CEM) cement and mineral trioxide aggregate (MTA), as 2 calcium silicate-based hydraulic cements, on human dental pulp stem cells (hDPSCs) through different dentin thicknesses.

Materials and Methods

Two-chamber setups were designed to simulate indirect pulp capping (IPC). Human molars were sectioned to obtain 0.1-, 0.3-, and 0.5-mm-thick dentin discs, which were placed between the 2 chambers to simulate an IPC procedure. Then, MTA and CEM were applied on one side of the discs, while hDPSCs were cultured on the other side. After 2 weeks of incubation, the cells were removed, and cell proliferation, morphology, and attachment to the discs were evaluated under scanning electron microscopy (SEM). Energy-dispersive X-ray (EDXA) spectroscopy was performed for elemental analysis. Alkaline phosphatase (ALP) activity was assessed quantitatively. The data were analyzed using the Kruskal-Wallis and Mann-Whitney tests.

Results

SEM micrographs revealed elongated cells, collagen fibers, and calcified nucleations in all samples. EDXA verified that the calcified nucleations consisted of calcium phosphate. The largest calcifications were seen in the 0.1-mm-thick dentin subgroups. There was no significant difference in ALP activity across the CEM subgroups; however, ALP activity was significantly lower in the 0.1-mm-thick dentin subgroup than in the other MTA subgroups (p < 0.05).

Conclusions

The employed capping biomaterials exerted biological activity on hDPSCs, as shown by cell proliferation, morphology, and attachment and calcific precipitations, through 0.1- to 0.5-mm-thick layers of dentin. In IPC, the bioactivity of these endodontic biomaterials is probably beneficial.

Citations

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Effect of pulp capping materials on odontogenic differentiation of human dental pulp stem cells: An in vitro study
Mahmoud M. Bakr, Mohamed Shamel, Shereen N. Raafat, Robert M. Love, Mahmoud M. Al‐Ankily
Clinical and Experimental Dental Research.2024;[Epub] CrossRef
Effects of Growth Factors on the Differentiation of Dental Stem Cells: A Systematic Review and Meta-analysis (Part I)
Sayna Shamszadeh, Armin Shirvani, Hassan Torabzadeh, Saeed Asgary
Current Stem Cell Research & Therapy.2024; 19(4): 523. CrossRef
The Role of Growth Factor Delivery Systems on Cellular Activities of Dental Stem Cells: A Systematic Review (Part II)
Sayna Shamszadeh, Armin Shirvani, Saeed Asgary
Current Stem Cell Research & Therapy.2024; 19(4): 587. CrossRef
Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis
Saeed Asgary, Mahtab Aram, Mahta Fazlyab
BioMedical Engineering OnLine.2024;[Epub] CrossRef
Evaluation of dental pulp stem cells behavior after odontogenic differentiation induction by three different bioactive materials on two different scaffolds
Basma Ahmed, Mai H. Ragab, Rania A. Galhom, Hayam Y. Hassan
BMC Oral Health.2023;[Epub] CrossRef
Characterization of Dental Pulp Stem Cell Responses to Functional Biomaterials Including Mineralized Trioxide Aggregates
Sejin Bae, Bueonguk Kang, Hyungbin Lee, Harrison Luu, Eric Mullins, Karl Kingsley
Journal of Functional Biomaterials.2021; 12(1): 15. CrossRef
Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an in vitro study
Fábio Rocha Bohns, Vicente Castelo Branco Leitune, Isadora Martini Garcia, Bruna Genari, Nélio Bairros Dornelles, Silvia Stanisçuaski Guterres, Fabrício Aulo Ogliari, Mary Anne Sampaio de Melo, Fabrício Mezzomo Collares
Restorative Dentistry & Endodontics.2020;[Epub] CrossRef

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Case Report

Pulp revascularization with and without platelet-rich plasma in two anterior teeth with horizontal radicular fractures: a case report: Edison Arango-Gómez, Javier Laureano Nino-Barrera, Gustavo Nino, Freddy Jordan, Henry Sossa-Rojas; Restor Dent Endod 2019;44(4):e35. Published online August 20, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e35

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Pulp revascularization is an alternative treatment in immature traumatized teeth with necrotic pulp. However, this procedure has not been reported in horizontal root fractures. This is a case report of a 9-year-old patient with multiple horizontal root fractures in 2 upper central incisors that were successfully treated with pulp revascularization. The patient presented for treatment 2 years after the initial trauma, and revascularization was attempted after the initial treatment with calcium hydroxide had failed. Prior to pulp revascularization, cone-beam computed tomography and autoradiograms demonstrated multiple horizontal fractures in the middle and apical thirds of the roots of the 2 affected teeth. Revascularization was performed in both teeth; platelet-rich plasma (PRP) was used in one tooth (#11) and the conventional method (blood clot) was used in the other tooth (#21). Clinical and radiographic follow-up over 4 years demonstrated pulp calcification in the PRP-treated tooth. Neither of the 2 teeth were lost, and the root canal calcification of tooth #11 was greater than that of tooth #21. This case suggests that PRP-based pulp revascularization may be an alternative for horizontal root fractures.

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Dental pulp mesenchymal stem cells-response to fibrin hydrogel reveals ITGA2 and MMPs expression
David Tong, Stéphanie Gobert, Alicia Reuzeau, Jean-Christophe Farges, Marianne Leveque, Marie Bolon, Arthur Costantini, Marielle Pasdeloup, Jérôme Lafont, Maxime Ducret, Mourad Bekhouche
Heliyon.2024; 10(13): e32891. CrossRef
Pulp regeneration treatment using different bioactive materials in permanent teeth of pediatric subjects
Dina Abdellatif, Alfredo Iandolo, Giuseppina De Benedetto, Francesco Giordano, Davide Mancino, Edouard Euvrard, Massimo Pisano
Journal of Conservative Dentistry and Endodontics.2024; 27(5): 458. CrossRef
Retreatment of a Failed Regenerative Endodontic Treatment in an Immature Tooth with a Horizontal Root Fracture: A Case Report
Zaher Marjy, Iris Slutzky-Goldberg
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The Impact of the Preferred Reporting Items for Case Reports in Endodontics (PRICE) 2020 Guidelines on the Reporting of Endodontic Case Reports
Sofian Youssef, Phillip Tomson, Amir Reza Akbari, Natalie Archer, Fayjel Shah, Jasmeet Heran, Sunmeet Kandhari, Sandeep Pai, Shivakar Mehrotra, Joanna M Batt
Cureus.2023;[Epub] CrossRef
Evaluation of postoperative pain and healing following regenerative endodontics using platelet‐rich plasma versus conventional endodontic treatment in necrotic mature mandibular molars with chronic periapical periodontitis. A randomized clinical trial
Yassmin Elsayed Ahmed, Geraldine Mohamed Ahmed, Angie Galal Ghoneim
International Endodontic Journal.2023; 56(4): 404. CrossRef
Regenerative endodontic procedures for two traumatized mature anterior teeth with transverse root fractures
Jing Lu, Bill Kahler
BMC Oral Health.2022;[Epub] CrossRef
Are platelet concentrate scaffolds superior to traditional blood clot scaffolds in regeneration therapy of necrotic immature permanent teeth? A systematic review and meta-analysis
Qianwei Tang, Hua Jin, Song Lin, Long Ma, Tingyu Tian, Xiurong Qin
BMC Oral Health.2022;[Epub] CrossRef
Platelet-Rich Fibrin Used as a Scaffold in Pulp Regeneration: Case Series
Ceren ÇİMEN, Selin ŞEN, Elif ŞENAY, Tuğba BEZGİN
Cumhuriyet Dental Journal.2021; 24(1): 113. CrossRef
Plasma rico en plaquetas en Odontología: Revisión de la literatura
Hugo Anthony Rosas Rozas, Hugo Leoncio Rosas Cisneros
Yachay - Revista Científico Cultural.2021; 10(1): 536. CrossRef

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Research Articles

Coronal tooth discoloration induced by regenerative endodontic treatment using different scaffolds and intracanal coronal barriers: a 6-month ex vivo study: Noushin Shokouhinejad, Hassan Razmi, Maryam Farbod, Marzieh Alikhasi, Josette Camilleri; Restor Dent Endod 2019;44(3):e25. Published online July 16, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e25

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Objective

The aim of this study was to evaluate discoloration of teeth undergoing regenerative endodontic procedures (REPs) using blood clot or platelet-rich fibrin (PRF) as the scaffolds and different calcium silicate-based materials as the intracanal coronal barriers in an ex vivo model.

Materials and Methods

Forty-eight bovine incisors were prepared and disinfected using 1 mg/mL double antibiotic paste (DAP). The specimens were then randomly divided into 2 groups (n = 24) according to the scaffolds (blood or PRF). After placement of scaffolds each group was divided into 2 subgroups (n = 12) according to the intracanal coronal barriers (ProRoot MTA or Biodentine). The pulp chamber walls were sealed with dentin bonding agent before placement of DAP and before placement of scaffolds. The color changes (∆E) were measured at different steps. The data were analyzed using 2-way analysis of variance.

Results

Coronal discoloration induced by DAP was not clinically perceptible (ΔE ≤ 3.3). Regarding the type of the scaffold, coronal discoloration was significantly higher in blood groups compared with PRF groups at the end of REP and after 1 month (p < 0.05). However, no significant difference was found between PRF and blood clot after 6 months (p > 0.05). Considering the type of intracanal coronal barrier, no significant difference existed between ProRoot MTA and Biodentine (p > 0.05).

Conclusions

With sealing the dentinal tubules of pulp chamber with a dentin bonding agent and application of DAP as an intracanal medicament, coronal color change of the teeth following the use of PRF and blood sealed with either ProRoot MTA or Biodentine was not different at 6-month follow-up.

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Effect of pH on the solubility and volumetric change of ready-to-use Bio-C Repair bioceramic material
Luana Raphael da SILVA, Jader Camilo PINTO, Juliane Maria GUERREIRO-TANOMARU, Mário TANOMARU-FILHO
Brazilian Oral Research.2024;[Epub] CrossRef
Efficacy of Potassium Iodide and Glutathione for Correlation of Dentin Discoloration Caused by Silver Diamine Fluoride
Mahsa Samani, Hamid Majzoub, Faramarz Zakavi, Ayyub Mojaddami
Cureus.2024;[Epub] CrossRef
Intracanal medicaments and coronal sealing materials influence on root fracture resistance and coronal discoloration: An in vitro study
Rasoul Sahebalam, Marzie Boskabady, Maryam Naghavi, Samira Dehghanitafti
Saudi Endodontic Journal.2024; 14(2): 199. CrossRef
Potential Crown Discoloration Induced by the Combination of Various Intracanal Medicaments and Scaffolds Applied in Regenerative Endodontic Therapy
NB Altun, A Turkyilmaz
Nigerian Journal of Clinical Practice.2024; 27(7): 897. CrossRef
Evaluation of the effectiveness of different treatment approaches in preventing coronal discoloration caused by regenerative endodontic treatment
Melis Oya Ateş, Zeliha Uğur Aydın
Clinical Oral Investigations.2023; 27(8): 4595. CrossRef
Evaluation of the Effectiveness of Laser-Assisted Bleaching of the Teeth Discolored due to Regenerative Endodontic Treatment
Noushin Shokouhinejad, Mehrfam Khoshkhounejad, Fatemeh Hamidzadeh, Murilo Baena Lopes
International Journal of Dentistry.2022; 2022: 1. CrossRef
Effectiveness of Teeth Whitening after Regenerative Endodontics Procedures: An In Vitro Study
Irini Fagogeni, Joanna Metlerska, Tomasz Falgowski, Maciej Górski, Mariusz Lipski, Alicja Nowicka
Journal of Clinical Medicine.2022; 11(23): 7016. CrossRef
Microstructure and color stability of calcium silicate-based dental materials exposed to blood or platelet-rich fibrin
Noushin Shokouhinejad, Ibrahim Abu Tahun, Shima Saber Tahan, Fatemeh Mohandes, Mohammad H. Nekoofar, Paul M. H. Dummer
Clinical Oral Investigations.2022; 27(3): 1193. CrossRef
Spectrophotometric analysis of internal bleaching of traumatized teeth with coronal discoloration following regenerative endodontic procedures
Jaqueline Lazzari, Walbert Vieira, Vanessa Pecorari, Brenda Paula Figueiredo de Almeida Gomes, José Flávio Affonso de Almeida, Adriana De-Jesus-Soares
Brazilian Journal of Oral Sciences.2021;[Epub] CrossRef
Biological parameters, discolouration and radiopacity of calcium silicate‐based materials in a simulated model of partial pulpotomy
Lilian Vieira Oliveira, Gabriela Leite de Souza, Gisele Rodrigues da Silva, Thamara Eduarda Alves Magalhães, Gabrielle Alves Nunes Freitas, Ana Paula Turrioni, Gabriella Lopes de Rezende Barbosa, Camilla Christian Gomes Moura
International Endodontic Journal.2021; 54(11): 2133. CrossRef
Effect of hydrogel-based antibiotic intracanal medicaments on crown discoloration
Rayan B. Yaghmoor, Jeffrey A. Platt, Kenneth J. Spolnik, Tien Min Gabriel Chu, Ghaeth H. Yassen
Restorative Dentistry & Endodontics.2021;[Epub] CrossRef
The effect of different calcium silicate-based pulp capping materials on tooth discoloration: an in vitro study
Ahmad S. Al-Hiyasat, Dana M. Ahmad, Yousef S. Khader
BMC Oral Health.2021;[Epub] CrossRef
Knowledge, attitudes, and practices of undergraduate students concerning Regenerative Endodontics
Ligia B. da Silva, Mariana Gabriel, Márcia M. Marques, Fernanda C. Carrer, Flávia Gonçalves, Giovanna Sarra, Giovanna L. Carvalho, Ana Armas-Vega, Maria S. Moreira
Minerva Stomatologica.2020;[Epub] CrossRef
Coronal Discoloration Related to Bioceramic and Mineral Trioxide Aggregate Coronal Barrier in Non-vital Mature Teeth Undergoing Regenerative Endodontic Procedures
Mazen Doumani, Mohammad Yaman Seirawan, Kinda Layous, Mohammad Kinan Seirawan
World Journal of Dentistry.2020; 11(1): 52. CrossRef

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The push-out bond strength of BIOfactor mineral trioxide aggregate, a novel root repair material: Makbule Bilge Akbulut, Durmus Alperen Bozkurt, Arslan Terlemez, Melek Akman; Restor Dent Endod 2019;44(1):e5. Published online January 28, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e5

Abstract PDF PubReader ePub

Objectives

The aim of this in vitro study was to evaluate the push-out bond strength of a novel calcium silicate-based root repair material-BIOfactor MTA to root canal dentin in comparison with white MTA-Angelus (Angelus) and Biodentine (Septodont).

Materials and Methods

The coronal parts of 12 central incisors were removed and the roots were embedded in acrylic resin blocks. Midroot dentin of each sample was horizontally sectioned into 1.1 mm slices and 3 slices were obtained from each root. Three canal-like standardized holes having 1 mm in diameter were created parallel to the root canal on each dentin slice with a diamond bur. The holes were filled with MTA-Angelus, Biodentine, or BIOfactor MTA. Wet gauze was placed over the specimens and samples were stored in an incubator at 37°C for 7 days to allow complete setting. Then samples were subjected to the push-out test method using a universal test machine with the loading speed of 1 mm/min. Data was statistically analyzed using Friedman test and post hoc Wilcoxon signed rank test with Bonferroni correction.

Results

There were no significant differences among the push-out bond strength values of MTA-Angelus, Biodentine, and BIOfactor MTA (p > 0.017). Most of the specimens exhibited cohesive failure in all groups, with the highest rate found in Biodentine group.

Conclusions

Based on the results of this study, MTA-Angelus, Biodentine, and BIOfactor MTA showed similar resistances to the push-out testing.

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Sevda Tok, Leyla Benan Ayranci
Applied Sciences.2025; 15(7): 3441. CrossRef
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Sanjeev Khanagar, Suman Panda, Prabhadevi C Maganur, Ganesh Jeevanandan, Satish Vishwanathaiah, Ather A Syed, Sara Kalagi, Arokia RS Merlin, Vignesh Ravindran, Aram AlShehri
The Journal of Contemporary Dental Practice.2024; 25(2): 168. CrossRef
Influence of Phase Composition and Morphology on the Calcium Ion Release of Several Classical and Hybrid Endodontic Cements
Ivanka Dimitrova, Galia Gentscheva, Ivanka Spassova, Daniela Kovacheva
Materials.2024; 17(22): 5568. CrossRef
The Effect of Two Different MTA (Mineral Trioxide Aggregate) On Thermal Insulation
Gizem Akkus, Ecem Salmaz, Didem Oner Ozdas
The Open Dentistry Journal.2024;[Epub] CrossRef
Comparison of push‐out bond strength and apical microleakage of different calcium silicate‐based cements after using EDTA, chitosan and phytic acid irrigations
Tutku Koçak Şahin, Murat Ünal
Microscopy Research and Technique.2024; 87(9): 2072. CrossRef
In vitro evaluation of the physical characteristics and push-out bond strength of new experimental nano-MTA
Nada Omar, Yousra Aly, Haidy N. Salem
Bulletin of the National Research Centre.2024;[Epub] CrossRef
Interfacial characteristics of BIOfactor MTA and Biodentine with dentin
Makbule Bilge Akbulut, Şeref Nur Mutlu, Mehmet Ali Soylu, Emine Şimşek
Microscopy Research and Technique.2023; 86(2): 258. CrossRef
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Osman Ataş, Kubra Bılge, Semsettin Yıldız, Serkan Dundar, Ilknur Calik, Asime Gezer Ataş, Alihan Bozoglan
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Hazal Özer, Merve Abaklı İnci, Sevcihan Açar Tuzluca
Frontiers in Dental Medicine.2023;[Epub] CrossRef
Effects of different irrigation protocols on push-out bond strength of pre-mixed calcium silicate-based cements
Sabiha Ceren İlisulu, Aliye Tugce Gürcan, Soner Sismanoglu
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Taibe Tokgöz Kaplan, Murat Selim Botsalı
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Şeref Nur Mutlu, Makbule Bilge Akbulut
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Pelin Tüfenkçi, Sevinç Sevgi, Ayşenur Öncü, Fatma Semra Sevimay, Berkan Çelikten
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Aliye Tuğçe Gürcan, Soner Şişmanoğlu, Görkem Sengez
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Şeref Nur MUTLU, Makbule Bilge AKBULUT
Selcuk Dental Journal.2022; 9(2): 520. CrossRef
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Okba Mahmoud, Nashwan Abdullah Al-Afifi, Mohideen Salihu Farook, Maysara Adnan Ibrahim, Saaid Al Shehadat, Mohammed Amjed Alsaegh, Sandrine Bittencourt Berger
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Cristina Rodrigues Paulo, Joana A. Marques, Diana B. Sequeira, Patrícia Diogo, Rui Paiva, Paulo J. Palma, João Miguel Santos
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VandanaJ Gade, Aparajita Gangrade, JaykumarR Gade, Neelam Rahul
Journal of the International Clinical Dental Research Organization.2021; 13(2): 124. CrossRef
A micro-computed tomographic study using a novel test model to assess the filling ability and volumetric changes of bioceramic root repair materials
Fernanda Ferrari Esteves Torres, Jader Camilo Pinto, Gabriella Oliveira Figueira, Juliane Maria Guerreiro-Tanomaru, Mario Tanomaru-Filho
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Micro-computed tomographic evaluation of the flow and filling ability of endodontic materials using different test models
Fernanda Ferrari Esteves Torres, Juliane Maria Guerreiro-Tanomaru, Gisselle Moraima Chavez-Andrade, Jader Camilo Pinto, Fábio Luiz Camargo Villela Berbert, Mario Tanomaru-Filho
Restorative Dentistry & Endodontics.2020;[Epub] CrossRef

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21 Crossref

Case Report

Endodontic management of central incisor associated with large periapical lesion and fused supernumerary root: a conservative approach: Gautam P. Badole, Pratima R. Shenoi, Ameya Parlikar; Restor Dent Endod 2018;43(4):e44. Published online October 26, 2018; DOI: https://doi.org/10.5395/rde.2018.43.e44

Abstract PDF PubReader ePub

Fusion and gemination are developmental anomalies of teeth that may require endodontic treatment. Fusion may cause various clinical problems related to esthetics, tooth spacing, and other periodontal complications. Additional diagnostic tools are required for the diagnosis and the treatment planning of fused tooth. The present case report describes a case of unilateral fusion of a supernumerary root to an upper permanent central incisor with large periapical lesion in which a conservative approach was used without extraction of supernumerary tooth and obturated with mineral trioxide aggregate to reach a favorable outcome.

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Fusion of a Tooth with a Supernumerary Tooth: A Case Report and Literature Review of 35 Cases
Tatsuya Akitomo, Satoru Kusaka, Momoko Usuda, Mariko Kametani, Ami Kaneki, Taku Nishimura, Masashi Ogawa, Chieko Mitsuhata, Ryota Nomura
Children.2023; 11(1): 6. CrossRef
Approche multidisciplinaire d’un cas de fusion incisive centrale maxillaire avec un « talon cusp »
Sonia Terbeche, Kheira Yousfi, Samia Saddat, Souad Larbi Messaoudi, Noureddine Ahmed Fouatih, G. Mer, O. Weissenbach
Revue d'Orthopédie Dento-Faciale.2022; 56(2): 205. CrossRef

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Research Articles

Effects of the exposure site on histological pulpal responses after direct capping with 2 calcium-silicate based cements in a rat model: Panruethai Trongkij, Supachai Sutimuntanakul, Puangwan Lapthanasupkul, Chitpol Chaimanakarn, Rebecca Wong, Danuchit Banomyong; Restor Dent Endod 2018;43(4):e36. Published online August 22, 2018; DOI: https://doi.org/10.5395/rde.2018.43.e36

Abstract PDF PubReader ePub

Objectives

Direct pulp capping is a treatment for mechanically exposed pulp in which a biocompatible capping material is used to preserve pulpal vitality. Biocompatibility tests in animal studies have used a variety of experimental protocols, particularly with regard to the exposure site. In this study, pulp exposure on the occlusal and mesial surfaces of molar teeth was investigated in a rat model.

Materials and Methods

A total of 58 maxillary first molars of Wistar rats were used. Forty molars were mechanically exposed and randomly assigned according to 3 factors: 1) the exposure site (occlusal or mesial), 2) the pulp-capping material (ProRoot White MTA or Bio-MA), and 3) 2 follow-up periods (1 day or 7 days) (n = 5 each). The pulp of 6 intact molars served as negative controls. The pulp of 12 molars was exposed without a capping material (n = 3 per exposure site for each period) and served as positive controls. Inflammatory cell infiltration and reparative dentin formation were histologically evaluated at 1 and 7 days using grading scores.

Results

At 1 day, localized mild inflammation was detected in most teeth in all experimental groups. At 7 days, continuous/discontinuous calcified bridges were formed at exposure sites with no or few inflammatory cells. No significant differences in pulpal response according to the exposure site or calcium-silicate cement were observed.

Conclusions

The location of the exposure site had no effect on rat pulpal healing. However, mesial exposures could be performed easily, with more consistent results. The pulpal responses were not significantly different between the 2 capping materials.

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Nuha A Elmubarak
International Dental Journal of Student's Research.2024; 11(4): 163. CrossRef
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Kanyarat Tungputsa, Danuchit Banomyong, Sittichoke Osiri, Supachai Sutimuntanakul
Endodontology.2024; 36(4): 315. CrossRef
Biological evaluation of novel phosphorylated pullulan‐based calcium hydroxide formulations as direct pulp capping materials: An in vivo study on a rat model
Md Refat Readul Islam, Rafiqul Islam, Yunqing Liu, Yu Toida, Yasuhiro Yoshida, Hidehiko Sano, Hany Mohamed Aly Ahmed, Atsushi Tomokiyo
International Endodontic Journal.2024; 57(9): 1247. CrossRef
3D-printed microgels supplemented with dentin matrix molecules as a novel biomaterial for direct pulp capping
Diana Cunha, Nayara Souza, Manuela Moreira, Nara Rodrigues, Paulo Silva, Cristiane Franca, Sivaporn Horsophonphong, Ashley Sercia, Ramesh Subbiah, Anthony Tahayeri, Jack Ferracane, Pamela Yelick, Vicente Saboia, Luiz Bertassoni
Clinical Oral Investigations.2022; 27(3): 1215. CrossRef
Calcium silicate and calcium aluminate cements for dentistry reviewed
Carolyn Primus, James L. Gutmann, Franklin R. Tay, Anna B. Fuks
Journal of the American Ceramic Society.2022; 105(3): 1841. CrossRef
Pulpal response to mineral trioxide aggregate containing phosphorylated pullulan-based capping material
Yu TOIDA, Shimpei KAWANO, Rafiqul ISLAM, Fu JIALE, AFM A CHOWDHURY, Shuhei HOSHIKA, Yasushi SHIMADA, Junji TAGAMI, Masahiro YOSHIYAMA, Satoshi INOUE, Ricardo M. CARVALHO, Yasuhiro YOSHIDA, Hidehiko SANO
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The Effect of Calcium-Silicate Cements on Reparative Dentinogenesis Following Direct Pulp Capping on Animal Models
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Ermin Nie, Jiali Yu, Rui Jiang, Xiangzhen Liu, Xiang Li, Rafiqul Islam, Mohammad Khursheed Alam
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Carolyn M. Primus, Franklin R. Tay, Li-na Niu
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Retention of BioAggregate and MTA as coronal plugs after intracanal medication for regenerative endodontic procedures: an ex vivo study: Suzan Abdul Wanees Amin, Shaimaa Ismail Gawdat; Restor Dent Endod 2018;43(3):e18. Published online April 26, 2018; DOI: https://doi.org/10.5395/rde.2018.43.e18

Abstract PDF PubReader ePub

Objectives

This study compared the retention of BioAggregate (BA; Innovative BioCeramix) and mineral trioxide aggregate (MTA; Angelus) as coronal plugs after applying different intracanal medications (ICMs) used in regenerative endodontics.

Materials and Methods

One-hundred human maxillary central incisors were used. The canals were enlarged to a diameter of 1.7 mm. Specimens were divided into 5 groups (n = 20) according to the ICM used: calcium hydroxide (CH), 2% chlorhexidine (CHX), triple-antibiotic paste (TAP), double-antibiotic paste (DAP), and no ICM (control; CON). After 3 weeks of application, ICMs were removed and BA or MTA were placed as the plug material (n = 10). The push-out bond strength and the mode of failure were assessed. The data were analyzed using 2-way analysis of variance, the Tukey's test, and the χ² test; p values < 0.05 indicated statistical significance.

Results

The type of ICM and the type of plug material significantly affected bond strength (p < 0.01). Regardless of the type of ICM, BA showed a lower bond strength than MTA (p < 0.05). For MTA, CH showed a higher bond strength than CON, TAP and DAP; CHX showed a higher bond strength than DAP (p < 0.01). For BA, CH showed a higher bond strength than DAP (p < 0.05). The mode of failure was predominantly cohesive for BA (p < 0.05).

Conclusions

MTA may show better retention than BA. The mode of bond failure with BA can be predominantly cohesive. BA retention may be less affected by ICM type than MTA retention.

Citations

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An in vitro comparative evaluation of the effect of three intracanal medicaments – chlorhexidine gel, triple antibiotic paste, and calcium hydroxide paste on the push-out bond strength of MTA Plus, Biodentine, and calcium-enriched mixture
Gouthami Datta, Ramya Raghu, Ashish Shetty, Gautham P Manjunath, Dishant Patel, Subhashini Rajasekhara
Endodontology.2023; 35(1): 60. CrossRef
Effects of calcium hydroxide intracanal medicament on push‐out bond strength of endodontic sealers: A systematic review and meta‐analysis
Mohammed Nasser Alhajj, Fadhilah Daud, Sadeq Ali Al‐Maweri, Yanti Johari, Zuryati Ab‐Ghani, Mariatti Jaafar, Yoshihito Naito, Widyasri Prananingrum, Zaihan Ariffin
Journal of Esthetic and Restorative Dentistry.2022; 34(8): 1166. CrossRef
A Breakthrough in the Era of Calcium Silicate-Based Cements: A Critical Review
Payal S Chaudhari, Manoj G Chandak, Akshay A Jaiswal, Nikhil P Mankar, Priyanka Paul
Cureus.2022;[Epub] CrossRef
Modern Medicaments for Endodontic Treatment in Children
Н.В. Шаковец, О.С. Романова
Стоматология. Эстетика. Инновации.2021; (4): 408. CrossRef
Do intracanal medications used in regenerative endodontics affect the bond strength of powder-to-liquid and ready-to-use cervical sealing materials?
MarinaCarvalho Prado, Kevillin Martiniano, AndreaCardoso Pereira, KarineL Cortellazzi, MarinaA Marciano, Gabriel Abuna, Adriana de-Jesus-Soares
Journal of Conservative Dentistry.2021; 24(5): 464. CrossRef
In vivo Biocompatibility and Bioactivity of Calcium Silicate-Based Bioceramics in Endodontics
Wencheng Song, Wei Sun, Lili Chen, Zhenglin Yuan
Frontiers in Bioengineering and Biotechnology.2020;[Epub] CrossRef
Effect of Hydrogel-Based Antibiotic Intracanal Medicaments on Push-Out Bond Strength
Rayan B. Yaghmoor, Jeffrey A. Platt, Kenneth J. Spolnik, Tien Min Gabriel Chu, Ghaeth H. Yassen
European Journal of Dentistry.2020; 14(04): 575. CrossRef
Regenerative Endodontic Procedures, Disinfectants and Outcomes: A Systematic Review
Adam S. Kharchi, Nara Tagiyeva-Milne, Shalini Kanagasingam
Primary Dental Journal.2020; 9(4): 65. CrossRef

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White mineral trioxide aggregate mixed with calcium chloride dihydrate: chemical analysis and biological properties: Hany Mohamed Aly Ahmed, Norhayati Luddin, Thirumulu Ponnuraj Kannan, Khairani Idah Mokhtar, Azlina Ahmad; Restor Dent Endod 2017;42(3):176-187. Published online April 17, 2017; DOI: https://doi.org/10.5395/rde.2017.42.3.176

Abstract PDF PubReader ePub

Objectives

This study aimed to evaluate the chemical and biological properties of fast-set white mineral trioxide aggregate (FS WMTA), which was WMTA combined with calcium chloride dihydrate (CaCl₂·2H₂O), compared to that of WMTA.

Materials and Methods

Surface morphology, elemental, and phase analysis were examined using scanning electron microscope (SEM), energy dispersive X-ray microanalysis (EDX), and X-ray diffraction (XRD), respectively. The cytotoxicity and cell attachment properties were evaluated on human periodontal ligament fibroblasts (HPLFs) using methyl-thiazol-diphenyltetrazolium (MTT) assay and under SEM after 24 and 72 hours, respectively.

Results

Results showed that the addition of CaCl₂·2H₂O to WMTA affected the surface morphology and chemical composition. Although FS WMTA exhibited a non-cytotoxic profile, the cell viability values of this combination were lesser than WMTA, and the difference was significant in 7 out of 10 concentrations at the 2 time intervals (p < 0.05). HPLFs adhered over the surface of WMTA and at the interface, after 24 hours of incubation. After 72 hours, there were increased numbers of HPLFs with prominent cytoplasmic processes. Similar findings were observed with FS WMTA, but the cells were not as confluent as with WMTA.

Conclusions

The addition of CaCl₂·2H₂O to WMTA affected its chemical properties. The favorable biological profile of FS WMTA towards HPLFs may have a potential impact on its clinical application for repair of perforation defects.

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Behnam Bolhari, Faranak Noori, Hadi Assadian, Amir Raee, Sholeh Ghabraei, Ahmad-Reza Shamshiri, Artak Heboyan
BMC Oral Health.2024;[Epub] CrossRef
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Renata Josipovic, Violeta Petrovic, Marijana Popovic-Bajic, Irena Kuzmanovic-Radman, Mirjana Umicevic-Davidovic, Aleksandra Djeri, Slavoljub Zivkovic
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Hasan Subhi, Adam Husein, Dasmawati Mohamad, Nik Rozainah Nik Abdul Ghani, Asma-Abdullah Nurul
Polymers.2021; 13(19): 3358. CrossRef
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Faeze Jamali Zavare, Hanieh Nojehdehian, Maryam Moezizadeh, Mehdi Daneshpooya
Journal of Dental Research, Dental Clinics, Dental Prospects.2020; 14(1): 1. CrossRef
Biological effects of acid-eroded MTA Repair HP and ProRoot MTA on human periodontal ligament stem cells
Mar Collado-González, Sergio López-García, David García-Bernal, Ricardo E. Oñate-Sánchez, Christopher J. Tomás-Catalá, Jose M. Moraleda, Adrián Lozano, Leopoldo Forner, Francisco J. Rodríguez-Lozano
Clinical Oral Investigations.2019; 23(10): 3915. CrossRef
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Sergio López-García, Miguel R. Pecci-Lloret, Julia Guerrero-Gironés, María P. Pecci-Lloret, Adrián Lozano, Carmen Llena, Francisco Javier Rodríguez-Lozano, Leopoldo Forner
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International Endodontic Journal.2019; 52(8): 1196. CrossRef

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Case Report

Retreatment of failed regenerative endodontic of orthodontically treated immature permanent maxillary central incisor: a case report: Musaed Fahad Al-Tammami, Saad A. Al-Nazhan; Restor Dent Endod 2017;42(1):65-71. Published online October 28, 2016; DOI: https://doi.org/10.5395/rde.2017.42.1.65

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A revascularization procedure was shown to be the best alternative therapy for immature teeth with necrotic pulp and apical infection. A 12 year old female with a history of trauma to her upper central incisor and a sinus tract was referred for endodontic treatment. She was an active orthodontic patient and had undergone regenerative endodontic treatment for the past 2 years. Clinical examination revealed no response to sensibility, percussion, and palpation tests. The preoperative radiograph showed an open apex and apical rarefaction. The case was diagnosed as previously treated tooth with asymptomatic apical periodontitis. Regenerative endodontic retreatment was performed, and the case was followed for 3 years. Clinical, radiographic, and cone-beam computed tomography follow-up examination revealed an asymptomatic tooth, with evidence of periapical healing and root maturation.

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Alaa Shaker, Mohamed Salem Rekab, Mohammad Alharissy, Naji Kharouf
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Luciane Geanini Pena dos Santos, Luiz Alexandre Chisini, Camila Guerner Springmann, Beatriz Dulcineia Mendes de Souza, Fernanda Geraldo Pappen, Flávio Fernando Demarco, Mara Cristina Santos Felippe, Wilson Tadeu Felippe
Brazilian Dental Journal.2018; 29(5): 409. CrossRef

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Research Articles

Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth: Bharti Kusum, Kumar Rakesh, Khanna Richa; Restor Dent Endod 2015;40(4):276-285. Published online September 9, 2015; DOI: https://doi.org/10.5395/rde.2015.40.4.276

Abstract PDF PubReader ePub

Objectives

The purpose of this study was to evaluate the efficacy of mineral trioxide aggregate (MTA), Biodentine and Propolis as pulpotomy medicaments in primary dentition, both clinically and radiographically.

Materials and Methods

A total of 75 healthy 3 to 10 yr old children each having at least one carious primary molar tooth were selected. Random assignment of the pulpotomy medicaments was done as follows: Group I, MTA; Group II, Biodentine; Group III, Propolis. All the pulpotomized teeth were evaluated at 3, 6, and 9 mon clinically and radiographically, based on the scoring criteria system.

Results

The clinical success rates were found to be similar among the three groups at 3 and 6 mon where as a significant decrease in success rate was observed in Group III (84%) compared to both Group I (100%) and Group II (100%) at 9 mon. Radiographic success rates over a period of 9 mon in Groups I, II, and III were 92, 80, and 72%, respectively.

Conclusions

Teeth treated with MTA and Biodentine showed more favorable clinical and radiographic success as compared to Propolis at 9 mon follow-up.

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Nancy M. Metwally, Amina M. El Hosary, Gamal M. El Maghraby, Maha A. El Demellawy, Mohamed Nabil, Elsayed M. Deraz
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Fouad Ayoub, Hitaf Nasrallah, Balsam El Noueiri, Charles Pilipili
International Journal of Clinical Pediatric Dentistry.2018; 11(5): 393. CrossRef
Clinical and radiographic comparison of biodentine, mineral trioxide aggregate and formocresol as pulpotomy agents in primary molars
P. Juneja, S. Kulkarni
European Archives of Paediatric Dentistry.2017; 18(4): 271. CrossRef
Success Rates of Pulpotomies in Primary Molars Using Calcium Silicate-Based Materials: A Randomized Control Trial
Yeliz Guven, Sermin Dicle Aksakal, Nilufer Avcu, Gulcan Unsal, Elif Bahar Tuna, Oya Aktoren
BioMed Research International.2017; 2017: 1. CrossRef
Biodentine: from biochemical and bioactive properties to clinical applications
Imad About
Giornale Italiano di Endodonzia.2016; 30(2): 81. CrossRef

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Surface microhardness of three thicknesses of mineral trioxide aggregate in different setting conditions: Noushin Shokouhinejad, Leila Jafargholizadeh, Mehrfam Khoshkhounejad, Mohammad Hossein Nekoofar, Maryam Raoof; Restor Dent Endod 2014;39(4):253-257. Published online August 20, 2014; DOI: https://doi.org/10.5395/rde.2014.39.4.253

Abstract PDF PubReader ePub

Objectives

This study aimed to compare the surface microhardness of mineral trioxide aggregate (MTA) samples having different thicknesses and exposed to human blood from one side and with or without a moist cotton pellet on the other side.

Materials and Methods

Ninety cylindrical molds with three heights of 2, 4, and 6 mm were fabricated. In group 1 (dry condition), molds with heights of 2, 4, and 6 mm (10 molds of each) were filled with ProRoot MTA (Dentsply Tulsa Dental), and the upper surface of the material was not exposed to any additional moisture. In groups 2 and 3, a distilled water- or phosphate-buffered saline (PBS)-moistened cotton pellet was placed on the upper side of MTA, respectively. The lower side of the molds in all the groups was in contact with human blood-wetted foams. After 4 day, the Vickers microhardness of the upper surface of MTA was measured.

Results

In the dry condition, the 4 and 6 mm-thick MTA samples showed significantly lower microhardness than the 2 mm-thick samples (p = 0.003 and p = 0.001, respectively). However, when a distilled water- or PBS-moistened cotton pellet was placed over the MTA, no significant difference was found between the surface microhardness of samples having the abovementioned three thicknesses of the material (p = 0.210 and p = 0.112, respectively).

Conclusions

It could be concluded that a moist cotton pellet must be placed over the 4 to 6 mm-thick MTA for better hydration of the material. However, this might not be necessary when 2 mm-thick MTA is used.

Citations

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MTA as modulator of periapical tissue healing in rat molar: A histological study
Christian Khoswanto, Ira Kusuma Dewi
Journal of Oral Biology and Craniofacial Research.2024; 14(2): 201. CrossRef
An Update on Endodontic Microsurgery of Mandibular Molars: A Focused Review
Sun Mi Jang, Euiseong Kim, Kyung-San Min
Medicina.2021; 57(3): 270. CrossRef
Assessment of Mineral Trioxide Aggregate Setting in Simulated Root Canal with Different Root Canal Wall Thickness: In Vitro Study
Radovan Žižka, Radim Čtvrtlík, Jan Tomáštík, Kamila Fačevicová, Ondřej Vencálek, Jiří Šedý, David Marinčák
Applied Sciences.2021; 11(4): 1727. CrossRef
Evaluation of the bioactivity of fluoride‐enriched mineral trioxide aggregate on osteoblasts
S. Proksch, J. Brossart, K. Vach, E. Hellwig, M. J. Altenburger, L. Karygianni
International Endodontic Journal.2018; 51(8): 912. CrossRef
Antimicrobial and antibiofilm activities of MTA supplemented with bismuth lipophilic nanoparticles
Rene HERNANDEZ-DELGADILLO, Casiano DEL ANGEL-MOSQUEDA, Juan Manuel SOLÍS-SOTO, Silvia MUNGUIA-MORENO, Nayely PINEDA-AGUILAR, Rosa Isela SÁNCHEZ-NÁJERA, Shankararaman CHELLAM, Claudio CABRAL-ROMERO
Dental Materials Journal.2017; 36(4): 503. CrossRef
Carbohydrate-electrolyte drinks exhibit risks for human enamel surface loss
Mary Anne Sampaio de Melo, Vanara Florêncio Passos, Juliana Paiva Marques Lima, Sérgio Lima Santiago, Lidiany Karla Azevedo Rodrigues
Restorative Dentistry & Endodontics.2016; 41(4): 246. CrossRef

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The effects of bone morphogenetic protein-2 and enamel matrix derivative on the bioactivity of mineral trioxide aggregate in MC3T3-E1cells: Youngdan Jeong, Wonkyung Yang, Hyunjung Ko, Miri Kim; Restor Dent Endod 2014;39(3):187-194. Published online June 19, 2014; DOI: https://doi.org/10.5395/rde.2014.39.3.187

Abstract PDF PubReader ePub

Objectives

The effects of bone morphogenetic protein-2 (BMP-2) and enamel matrix derivative (EMD) respectively with mineral trioxide aggregate (MTA) on hard tissue regeneration have been investigated in previous studies. This study aimed to compare the osteogenic effects of MTA/BMP-2 and MTA/EMD treatment in MC3T3-E1 cells.

Materials and Methods

MC3T3-E1 cells were treated with MTA (ProRoot, Dentsply), BMP-2 (R&D Systems), EMD (Emdogain, Straumann) separately and MTA/BMP-2 or MTA/EMD combination. Mineralization was evaluated by staining the calcium deposits with alkaline phosphatase (ALP, Sigma-Aldrich) and Alizarin red (Sigma-Aldrich). The effects on the osteoblast differentiation were evaluated by the expressions of osteogenic markers, including ALP, bone sialoprotein (BSP), osteocalcin (OCN), osteopontin (OPN) and osteonectin (OSN), as determined by reverse-transcription polymerase chain reaction analysis (RT-PCR, AccuPower PCR, Bioneer).

Results

Mineralization increased in the BMP-2 and MTA/BMP-2 groups and increased to a lesser extent in the MTA/EMD group but appeared to decrease in the MTA-only group based on Alizarin red staining. ALP expression largely decreased in the EMD and MTA/EMD groups based on ALP staining. In the MTA/BMP-2 group, mRNA expression of OPN on day 3 and BSP and OCN on day 7 significantly increased. In the MTA/EMD group, OSN and OCN gene expression significantly increased on day 7, whereas ALP expression decreased on days 3 and 7 (p < 0.05).

Conclusions

These results suggest the MTA/BMP-2 combination promoted more rapid differentiation in MC3T3-E1 cells than did MTA/EMD during the early mineralization period.

Citations

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Lei Huang, Xuan Chen, Xiaoxia Yang, Yinchun Zhang, Yiyun Liang, Xiaoling Qiu
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Evaluation of the genotoxicity, cytotoxicity, and bioactivity of calcium silicate-based cements
Merve Esen, Yeliz Guven, Mehmet Fatih Seyhan, Handan Ersev, Elif Bahar Tuna-Ince
BMC Oral Health.2024;[Epub] CrossRef
GelMA‐based hydrogel biomaterial scaffold: A versatile platform for regenerative endodontics
Lei Huang, Xuan Chen, XiaoXia Yang, Yinchun Zhang, Xiaoling Qiu
Journal of Biomedical Materials Research Part B: Applied Biomaterials.2024;[Epub] CrossRef
Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways
Md. Niaj Morshed, Reshmi Akter, Imran Mahmud, Ah-Yeong Gwon, Jin Woo Jeang, Yeong-Geun Lee, Dae Won Park, Deok Chun Yang, Yeon Ju Kim, Se-Chan Kang
Life.2024; 15(1): 41. CrossRef
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2
Da Eun Lee, Kun Hee Park, Joo-Hyun Hong, Seon Hee Kim, Ki-Moon Park, Ki Hyun Kim
Archives of Pharmacal Research.2023; 46(9-10): 771. CrossRef
In Silico and In Vitro Evaluation of Antiobesogenic and Osteoprotective Effect of Pomegranate Juice Fermented by Tannin Acyl Hydrolase and Lactobacillus vespulae DCY75 via the Wnt/β-Catenin Pathway
Reshmi Akter, Vinothini Boopathi, Muhammad Awais, Juha Park, Byoung Man Kong, Se-Woung Oh, Ji-Hyung Oh, Jong Chan Ahn, Deok Chun Yang
ACS Food Science & Technology.2023; 3(11): 1975. CrossRef
Early induction of Hes1 by bone morphogenetic protein 9 plays a regulatory role in osteoblastic differentiation of a mesenchymal stem cell line
Chang‐Hwan Seong, Norika Chiba, Mardiyantoro Fredy, Joji Kusuyama, Kiyohide Ishihata, Toshiro Kibe, Muhammad Subhan Amir, Ryohei Tada, Tomokazu Ohnishi, Norifumi Nakamura, Tetsuya Matsuguchi
Journal of Cellular Biochemistry.2023; 124(9): 1366. CrossRef
Effects of Fucoidan Powder Combined with Mineral Trioxide Aggregate as a Direct Pulp-Capping Material
Mijoo Kim, Marc Hayashi, Bo Yu, Thomas K. Lee, Reuben H. Kim, Deuk-Won Jo
Polymers.2022; 14(12): 2315. CrossRef
Nerve growth factor promotes osteogenic differentiation of MC3T3-E1 cells via BMP-2/Smads pathway
Xuming Yang, Donggang Mou, Qunying Yu, Jimei Zhang, Ying Xiong, Zhimin Zhang, Shan Xing
Annals of Anatomy - Anatomischer Anzeiger.2022; 239: 151819. CrossRef
Anti-Osteoporosis Effects of the Fruit of Sea Buckthorn (Hippophae rhamnoides) through Promotion of Osteogenic Differentiation in Ovariectomized Mice
Kun Hee Park, Joo-Hyun Hong, Seon-Hee Kim, Jin-Chul Kim, Ki Hyun Kim, Ki-Moon Park
Nutrients.2022; 14(17): 3604. CrossRef
Oroactive dental biomaterials and their use in endodontic therapy
Ebrahim Patel, Priyamvada Pradeep, Pradeep Kumar, Yahya E. Choonara, Viness Pillay
Journal of Biomedical Materials Research Part B: Applied Biomaterials.2020; 108(1): 201. CrossRef
BMP-2 and type I collagen preservation in human deciduous teeth after demineralization
Nina Bono, Paolo Tarsini, Gabriele Candiani
Journal of Applied Biomaterials & Functional Materials.2019;[Epub] CrossRef
An assessment of the overexpression of BMP‐2 in transfected human osteoblast cells stimulated by mineral trioxide aggregate and Biodentine
E. M. Rodrigues, A. L. Gomes‐Cornélio, A. Soares‐Costa, L. P. Salles, M. Velayutham, C. Rossa‐Junior, J. M. Guerreiro‐Tanomaru, M. Tanomaru‐Filho
International Endodontic Journal.2017;[Epub] CrossRef
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Samdharu Pramono, Kamolparn Pugdee, Jintamai Suwanprateep, Sittichai Koontongkaew
Journal of Dental Sciences.2016; 11(4): 427. CrossRef
Combined Effects of Growth Hormone and Mineral Trioxide Aggregate on Growth, Differentiation, and Angiogenesis in Human Dental Pulp Cells
Hyung-Mun Yun, Seok-Woo Chang, Kyung-Ran Park, Lan Herr, Eun-Cheol Kim
Journal of Endodontics.2016; 42(2): 269. CrossRef
Combined effects of mineral trioxide aggregate and human placental extract on rat pulp tissue and growth, differentiation and angiogenesis in human dental pulp cells
Seok-Woo Chang, Ji-Youn Kim, Mi-Joo Kim, Ga-Hyun Kim, Jin-Kyu Yi, Deok-Won Lee, Kee-Yeon Kum, Eun-Cheol Kim
Acta Odontologica Scandinavica.2016; 74(4): 298. CrossRef
Mineral trioxide aggregate induces osteoblastogenesis via Atf6
Toyonobu Maeda, Atsuko Suzuki, Satoshi Yuzawa, Yuh Baba, Yuichi Kimura, Yasumasa Kato
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Qi Wang, Hao Li, Yu Xiao, Shuan Li, Bo Li, Xiaowen Zhao, Lin Ye, Bin Guo, Xinmin Chen, Yi Ding, Chongyun Bao
Journal of Controlled Release.2015; 206: 232. CrossRef

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In vitro cytotoxicity of four calcium silicate-based endodontic cements on human monocytes, a colorimetric MTT assay: Sedigheh Khedmat, Somayyeh Dehghan, Jamshid Hadjati, Farimah Masoumi, Mohammad Hossein Nekoofar, Paul Michael Howell Dummer; Restor Dent Endod 2014;39(3):149-154. Published online April 30, 2014; DOI: https://doi.org/10.5395/rde.2014.39.3.149

Abstract PDF PubReader ePub

Objectives

This study was performed to evaluate the cytotoxicity of four calcium silicate-based endodontic cements at different storage times after mixing.

Materials and Methods

Capillary tubes were filled with Biodentine (Septodont), Calcium Enriched Mixture (CEM cement, BioniqueDent), Tech Biosealer Endo (Tech Biosealer) and ProRoot MTA (Dentsply Tulsa Dental). Empty tubes and tubes containing Dycal were used as negative and positive control groups respectively. Filled capillary tubes were kept in 0.2 mL microtubes and incubated at 37℃. Each material was divided into 3 groups for testing at intervals of 24 hr, 7 day and 28 day after mixing. Human monocytes were isolated from peripheral blood mononuclear cells and cocultered with 24 hr, 7 day and 28 day samples of different materials for 24 and 48 hr. Cell viability was evaluated using an MTT assay.

Results

In all groups, the viability of monocytes significantly improved with increasing storage time regardless of the incubation time (p < 0.001). After 24 hr of incubation, there was no significant difference between the materials regarding monocyte viability. However, at 48 hr of incubation, ProRoot MTA and Biodentine were less cytotoxic than CEM cement and Biosealer (p < 0.01).

Conclusions

Biodentine and ProRoot MTA had similar biocompatibility. Mixing ProRoot MTA with PBS in place of distilled water had no effect on its biocompatibility. Biosealer and CEM cement after 48 hr of incubation were significantly more cytotoxic to on monocyte cells compared to ProRoot MTA and Biodentine.

Citations

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Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis
Saeed Asgary, Mahtab Aram, Mahta Fazlyab
BioMedical Engineering OnLine.2024;[Epub] CrossRef
Biocompatibility of mineral trioxide aggregate and biodentine as root-end filling materials: an in vivo study
Mohamed Nabeel, Ashraf M. Abu-Seida, Abeer A. Elgendy, Hossam M. Tawfik
Scientific Reports.2024;[Epub] CrossRef
Apoptotic effects of biodentine, calcium-enriched mixture (CEM) cement, ferric sulfate, and mineral trioxide aggregate (MTA) on human mesenchymal stem cells isolated from the human pulp of exfoliated deciduous teeth
Bahareh NAZEMI SALMAN, Mahshid MOHEBBI RAD, Ehsan SABURI
Minerva Dental and Oral Science.2024;[Epub] CrossRef
Evaluation of the Effects of Retro-Cavity Preconditioning with or Without Ethylenediaminetetraacetic Acid on Root Surface pH and Dislodgement Resistance of NeoMTA2 and Mineral Trioxide Aggregate Flow Retro-Fills: An Ex Vivo Investigation
Sedigheh Khedmat, Seyyed Ali Abaee, Hadi Assadian, Antonio Signore, Stefano Benedicenti
Journal of Functional Biomaterials.2024; 16(1): 3. CrossRef
Bone morphogenetic proteins in biomineralization of two endodontic restorative cements
Tamara A. Souza, Mirna M. Bezerra, Paulo G. B. Silva, José J. N. Costa, Rayssa F. L. A. Carneiro, Janice O. F. Barcelos, Bruno C. Vasconcelos, Hellíada V. Chaves
Journal of Biomedical Materials Research Part B: Applied Biomaterials.2021; 109(3): 348. CrossRef
Cytotoxicity and Bioactivity of Mineral Trioxide Aggregate and Bioactive Endodontic Type Cements: A Systematic Review
Uma Dixit, Rucha Shivajirao Bhise Patil, Rupanshi Parekh
International Journal of Clinical Pediatric Dentistry.2021; 14(1): 30. CrossRef
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Kyung-Hyeon Yoo, Yong-Il Kim, Seog-Young Yoon
Materials.2021; 14(8): 1843. CrossRef
Comparative evaluation of the effect of cold ceramic and MTA-Angelus on cell viability, attachment and differentiation of dental pulp stem cells and periodontal ligament fibroblasts: an in vitro study
Sedigheh Khedmat, Pegah Sarraf, Ehsan Seyedjafari, Parisa Sanaei-rad, Faranak Noori
BMC Oral Health.2021;[Epub] CrossRef
Cytotoxicity of universal dental adhesive systems: Assessment in vitro assays on human gingival fibroblasts
Stefano Pagano, Guido Lombardo, Stefania Balloni, Maria Bodo, Stefano Cianetti, Antonella Barbati, Azadeh Montaseri, Lorella Marinucci
Toxicology in Vitro.2019; 60: 252. CrossRef
The effect of desiccation on water sorption, solubility and hygroscopic volumetric expansion of dentine replacement materials
Ruba Mustafa, Ruwaida Z. Alshali, Nick Silikas
Dental Materials.2018; 34(8): e205. CrossRef
Evaluation of the Viability of Rat Periodontal Ligament Cells after Storing at 0℃/2 MPa Condition up to One Week: In Vivo MTT Method
Sun Mi Jang, Sin-Yeon Cho, Eui-Seong Kim, Il-Young Jung, Seung Jong Lee
Journal of Korean Dental Science.2016; 9(1): 1. CrossRef
Cytotoxic effects of one‐step self‐etching adhesives on an odontoblast cell line
Yoon Lee, So‐Youn An, Yoon‐Jung Park, Frank H. Yu, Joo‐Cheol Park, Deog‐Gyu Seo
Scanning.2016; 38(1): 36. CrossRef
Influence of Biodentine® - A Dentine Substitute - On Collagen Type I Synthesis in Pulp Fibroblasts In Vitro
Frangis Nikfarjam, Kim Beyer, Anke König, Matthias Hofmann, Manuel Butting, Eva Valesky, Stefan Kippenberger, Roland Kaufmann, Detlef Heidemann, August Bernd, Nadja Nicole Zöller, Dimitrios Karamichos
PLOS ONE.2016; 11(12): e0167633. CrossRef
Evaluation of cytotoxicity and gelatinases activity in 3T3 fibroblast cell by root repair materials
Varol Basak, Tuna Elif Bahar, Karsli Emine, Kasimoglu Yelda, Koruyucu Mine, Seymen Figen, Nurten Rustem
Biotechnology & Biotechnological Equipment.2016; 30(5): 984. CrossRef
In VitroCytotoxicity of Calcium Silicate-Based Endodontic Cement as Root-End Filling Materials
Selen Küçükkaya, Mehmet Ömer Görduysus, Naciye Dilara Zeybek, Sevda Fatma Müftüoğlu
Scientifica.2016; 2016: 1. CrossRef
Cytotoxic effects of mineral trioxide aggregate, calcium enrichedmixture cement, Biodentine and octacalcium pohosphate onhuman gingival fibroblasts
Eshagh A. Saberi, Narges Farhadmollashahi, Faroogh Ghotbi, Hamed Karkeabadi, Roholla Havaei
Journal of Dental Research, Dental Clinics, Dental Prospects.2016; 10(2): 75. CrossRef
Cytotoxicity and Initial Biocompatibility of Endodontic Biomaterials (MTA and Biodentine™) Used as Root-End Filling Materials
Diana María Escobar-García, Eva Aguirre-López, Verónica Méndez-González, Amaury Pozos-Guillén
BioMed Research International.2016; 2016: 1. CrossRef
Cytotoxicity and osteogenic potential of silicate calcium cements as potential protective materials for pulpal revascularization
Eduardo A. Bortoluzzi, Li-na Niu, Chithra D. Palani, Ahmed R. El-Awady, Barry D. Hammond, Dan-dan Pei, Fu-cong Tian, Christopher W. Cutler, David H. Pashley, Franklin R. Tay
Dental Materials.2015; 31(12): 1510. CrossRef

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Case Reports

Surgical management of a failed internal root resorption treatment: a histological and clinical report: Saeed Asgary, Mohammad Jafar Eghbal, Leili Mehrdad, Sanam Kheirieh, Ali Nosrat; Restor Dent Endod 2014;39(2):137-142. Published online March 21, 2014; DOI: https://doi.org/10.5395/rde.2014.39.2.137

Abstract PDF PubReader ePub

This article presents the successful surgical management of a failed mineral trioxide aggregate (MTA) orthograde obturation of a tooth with a history of impact trauma and perforated internal root resorption. A symptomatic maxillary lateral incisor with a history of perforation due to internal root resorption and nonsurgical repair using MTA was referred. Unintentional overfill of the defect with MTA had occurred 4 yr before the initial visit. The excess MTA had since disappeared, and a radiolucent lesion adjacent to the perforation site was evident radiographically. Surgical endodontic retreatment was performed using calcium enriched mixture (CEM) cement as a repair material. Histological examination of the lesion revealed granulation tissue with chronic inflammation, and small fragments of MTA encapsulated within fibroconnective tissue. At the one and two year follow up exams, all signs and symptoms of disease had resolved and the tooth was functional. Complete radiographic healing of the lesion was observed two years after the initial visit. This case report illustrates how the selection of an appropriate approach to treatment of a perforation can affect the long term prognosis of a tooth. In addition, extrusion of MTA into a periradicular lesion should be avoided.

Citations

Citations to this article as recorded by

Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis
Saeed Asgary, Mahtab Aram, Mahta Fazlyab
BioMedical Engineering OnLine.2024;[Epub] CrossRef
The various forms of tooth resorption
Jordan Samuel Blum
Australian Endodontic Journal.2024; 50(2): 191. CrossRef
Bioceramics in Endodontics: Updates and Future Perspectives
Xu Dong, Xin Xu
Bioengineering.2023; 10(3): 354. CrossRef
Imaging techniques and various treatment modalities used in the management of internal root resorption: A systematic review
R. S Digholkar, S D Aggarwal, P S Kurtarkar, P. B Dhatavkar, V L Neil, D N Agarwal
Endodontology.2023; 35(2): 85. CrossRef
Treatment of Teeth with Root Resorptions: A Case Report and Systematic Review
Damla Erkal, Abdullah Başoğlu, Damla Kırıcı, Nezahat Arzu Kayar, Simay Koç, Kürşat Er
Galician Medical Journal.2023;[Epub] CrossRef
Effects of calcium silicate cements on neuronal conductivity
Derya Deniz-Sungur, Mehmet Ali Onur, Esin Akbay, Gamze Tan, Fügen Daglı-Comert, Taner Cem Sayın
Restorative Dentistry & Endodontics.2022;[Epub] CrossRef
Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part II: other clinical applications and complications
M. Torabinejad, M. Parirokh, P. M. H. Dummer
International Endodontic Journal.2018; 51(3): 284. CrossRef
Periodontal healing following non-surgical repair of an old perforation with pocket formation and oral communication
Saeed Asgary, Prashant Verma, Ali Nosrat
Restorative Dentistry & Endodontics.2018;[Epub] CrossRef
Conservative Management of Class 4 Invasive Cervical Root Resorption Using Calcium-enriched Mixture Cement
Saeed Asgary, Ali Nosrat
Journal of Endodontics.2016; 42(8): 1291. CrossRef
Importance of CBCT in the management plan of upper canine with internal resorption
Roberto Fornara, Dario Re Cecconi
Giornale Italiano di Endodonzia.2015; 29(2): 70. CrossRef

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Healing after horizontal root fractures: 3 cases with 2-year follow-up: Yoorina Choi, Sung-Ok Hong, Seok-Ryun Lee, Kyung-San Min, Su-Jung Park; Restor Dent Endod 2014;39(2):126-131. Published online March 21, 2014; DOI: https://doi.org/10.5395/rde.2014.39.2.126

Abstract PDF PubReader ePub

Among dental traumas, horizontal root fractures are relatively uncommon injuries. Proper initial management and periodical evaluation is essential for the successful treatment of a root-fractured tooth. If pulpal necrosis develops, endodontic treatment is indicated, exclusively for the coronal fragment. Fragment diastases exert a great influence on healing at the fracture line and on pulpal necrosis. An adequately treated root-fractured tooth has a good prognosis. This case report describes the treatment and 2-yr follow up of 3 maxillary central incisors, first with horizontal root fracture, second with horizontal root fracture and avulsion, and third with horizontal root fracture and lateral luxation. All three cases were treated with mineral trioxide aggregate (ProRoot, Dentsply). During 2 yr of follow-up evaluation, the root-fractured teeth of the present patients were well retained in the arch, showing periodontal healing, even after endodontic treatment.

Citations

Citations to this article as recorded by

Clinical applications of calcium silicate‐based materials: a narrative review
S Küçükkaya Eren
Australian Dental Journal.2023;[Epub] CrossRef
A three-dimensional finite element analysis of stress distribution in maxillary central incisor with a horizontal mid root fracture after various management protocols
Kavitha Anantula, Bhavana Vankayala, SarjeevSingh Yadav
Journal of Conservative Dentistry.2021; 24(5): 470. CrossRef
: The Use of Mineral Trioxide Aggregate in The Treatment of Horizontal Root Fractures: A Case Presentation and Literature Update
Elif BALLIKAYA, Hamdi GÜNGÖR
Selcuk Dental Journal.2021; 8(3): 850. CrossRef
Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part II: other clinical applications and complications
M. Torabinejad, M. Parirokh, P. M. H. Dummer
International Endodontic Journal.2018; 51(3): 284. CrossRef

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4 Crossref

Research Articles

Washout resistance of fast-setting pozzolan cement under various root canal irrigants: Ga-Yeon Jang, Su-Jung Park, Seok-Mo Heo, Mi-Kyung Yu, Kwang-Won Lee, Kyung-San Min; Restor Dent Endod 2013;38(4):248-252. Published online November 12, 2013; DOI: https://doi.org/10.5395/rde.2013.38.4.248

Abstract PDF PubReader ePub

Objectives

Fast-setting pozzolan cement (Endocem, Maruchi) was recently developed. The aim of this study was to investigate the effects of various root canal irrigants on the washout of Endocem in comparison to the previously marketed mineral trioxide aggregate (ProRoot; Dentsply) in a furcal perforation model.

Materials and Methods

ProRoot and Endocem were placed into acrylic molds on moist Oasis. Each mold was then immediately exposed to either physiologic saline, 2.5% sodium hypochlorite (NaOCl), or 2% chlorhexidine (CHX) under gentle shaking for five minutes. Washout testing was performed by scoring scanning electron microscope (SEM) images.

Results

Endocem exhibited higher washout resistance compared to ProRoot, especially in the NaOCl group.

Conclusions

These results suggest that Endocem can be considered a useful repair material for furcal perforation, especially in a single-visit scenario.

Citations

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Stereomicroscopic Evaluation of Sealing Ability of Three Different Furcal Perforation Repair Materials: An In vitro Study
Sriparna De, N Sathyajith Naik, Shivangi Sharma, Pallavi Vashisth, Rasleen Dua, Priya Maheshwari
Contemporary Clinical Dentistry.2024; 15(4): 259. CrossRef
Chemical and physical properties of radiopaque Portland cement formulation with reduced particle size
Hoda Mohamed ELNAWAWY, Muralithran Govindan KUTTY, Noor Azlin YAHYA, Noor Hayaty ABU KASIM, Paul Roy COOPER, Josette CAMILLERI, Hany Mohamed Aly AHMED
Dental Materials Journal.2024; 43(5): 672. CrossRef
The Washout Resistance of Bioactive Root-End Filling Materials
Joanna Falkowska, Tomasz Chady, Włodzimierz Dura, Agnieszka Droździk, Małgorzata Tomasik, Ewa Marek, Krzysztof Safranow, Mariusz Lipski
Materials.2023; 16(17): 5757. CrossRef
Effects of fast- and slow-setting calcium silicate–based root-end filling materials on the outcome of endodontic microsurgery: a retrospective study up to 6 years
Dohyun Kim, Hyunjung Lee, Minsun Chung, Sunil Kim, Minju Song, Euiseong Kim
Clinical Oral Investigations.2020; 24(1): 247. CrossRef
Novel anti-biofouling bioactive calcium silicate-based cement containing 2-methacryloyloxyethyl phosphorylcholine
Jae-Sung Kwon, Myung-Jin Lee, Ji-Young Kim, Dohyun Kim, Jeong-Hyun Ryu, Sungil Jang, Kwang-Mahn Kim, Chung-Ju Hwang, Sung-Hwan Choi, Jinkee Hong
PLOS ONE.2019; 14(1): e0211007. CrossRef
Surface and vertical dimensional changes of mineral trioxide aggregate and biodentine in different environmental conditions
Hacer Aksel, Selen Küçükkaya Eren, Sevinc Askerbeyli Õrs, Eda Karaismailoğlu
Journal of Applied Oral Science.2018;[Epub] CrossRef
Push-out Bond Strength of Fast-setting Mineral Trioxide Aggregate and Pozzolan-based Cements: ENDOCEM MTA and ENDOCEM Zr
Emmanuel João Nogueira Leal Silva, Nancy Kudsi Carvalho, Marta Reis da Costa Labanca Guberman, Marina Prado, Plinio Mendes Senna, Erick M. Souza, Gustavo De-Deus
Journal of Endodontics.2017; 43(5): 801. CrossRef
Dynamic intratubular biomineralization following root canal obturation with pozzolan‐based mineral trioxide aggregate sealer cement
Yeon‐Jee Yoo, Seung‐Ho Baek, Kee‐Yeon Kum, Won‐Jun Shon, Kyung‐Mi Woo, WooCheol Lee
Scanning.2016; 38(1): 50. CrossRef
Comparison of Setting Time, Compressive Strength, Solubility, and pH of Four Kinds of MTA
Jing-Ling Che, Jae-Hwan Kim, Seon-Mi Kim, Nam-ki Choi, Hyun-Joo Moon, Moon-Jin Hwang, Ho-Jun Song, Yeong-Joon Park
Korean Journal of Dental Materials.2016; 43(1): 61. CrossRef
A Randomized Controlled Study of the Use of ProRoot Mineral Trioxide Aggregate and Endocem as Direct Pulp Capping Materials: 3-month versus 1-year Outcomes
Youngjune Jang, Minju Song, Il-Sang Yoo, Yunjung Song, Byoung-Duck Roh, Euiseong Kim
Journal of Endodontics.2015; 41(8): 1201. CrossRef
Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide
Kyoung-A KIM, Yeon-Mi YANG, Young-Sun KWON, Yun-Chan HWANG, Mi-Kyung YU, Kyung-San MIN
Dental Materials Journal.2015; 34(4): 432. CrossRef
D90: The Strongest Contributor to Setting Time in Mineral Trioxide Aggregate and Portland Cement
William N. Ha, Dale P. Bentz, Bill Kahler, Laurence J. Walsh
Journal of Endodontics.2015; 41(7): 1146. CrossRef
A Randomized Controlled Study of the Use of ProRoot Mineral Trioxide Aggregate and Endocem as Direct Pulp Capping Materials
Minju Song, Minji Kang, Hyeon-Cheol Kim, Euiseong Kim
Journal of Endodontics.2015; 41(1): 11. CrossRef
Physical properties and biological/odontogenic effects of an experimentally developed fast-setting α-tricalcium phosphate-based pulp capping material
Jun-Bong Lee, Su-Jung Park, Hyun-Ha Kim, Young-Sun Kwon, Kwang-Won Lee, Kyung-San Min
BMC Oral Health.2014;[Epub] CrossRef
Effect of Mineral Trioxide Aggregate Surface Treatments on Morphology and Bond Strength to Composite Resin
Joo-Hee Shin, Ji-Hyun Jang, Sang Hyuk Park, Euiseong Kim
Journal of Endodontics.2014; 40(8): 1210. CrossRef

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Evaluation of the effect of blood contamination on the compressive strength of MTA modified with hydration accelerators: Kaveh Oloomi, Eshaghali Saberi, Hadi Mokhtari, Hamid Reza Mokhtari Zonouzi, Ali Nosrat, Mohammad Hossein Nekoofar, Paul Michael Howell Dummer; Restor Dent Endod 2013;38(3):128-133. Published online August 23, 2013; DOI: https://doi.org/10.5395/rde.2013.38.3.128

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Objectives

This study was performed to evaluate the effect of blood contamination on the compressive strength (CS) of Root MTA (RMTA) modified with Calcium chloride (CaCl₂) and Disodium hydrogen phosphate (Na₂HPO₄) as setting accelerators over time.

Materials and Methods

A total of 110 cylindrical specimens of RMTA were divided into 6 experimental groups as follows: Group1, RMTA; Group 2, RMTA modified with CaCl₂ (RMTA-C); Group 3, RMTA modified with Na₂HPO₄ (RMTA-N); Group 4, RMTA contaminated with blood; Group 5, RMTA-C contaminated with blood; Group 6, RMTA-N contaminated with blood. The CS of specimens in all groups was evaluated after 3 hr, 24 hr, and 1 wk. In the modified groups (groups 2, 3, 5, and 6) the CS of five specimens per group was also evaluated after 1 hr.

Results

Blood contamination significantly reduced the CS of all materials at all time intervals (p < 0.05). After 3 hr, the CS of specimens in the RMTA groups (with and without blood contamination) was significantly lower than those in the RMTA-C and RMTA-N groups (p < 0.05). The CS values were not significantly different at the other time intervals. In all groups, the CS of specimens significantly increased over time (p < 0.05).

Conclusions

Blood contamination decreased the CS of both original and accelerated RMTA.

Citations

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The effect of three additives on properties of mineral trioxide aggregate cements: a systematic review and meta-analysis of in vitro studies
Behnam Bolhari, Faranak Noori, Hadi Assadian, Amir Raee, Sholeh Ghabraei, Ahmad-Reza Shamshiri, Artak Heboyan
BMC Oral Health.2024;[Epub] CrossRef
Push‐out bond strength of the calcium silicate‐based endodontic cements in the presence of blood: A systematic review and meta‐analysis of in vitro studies
Mahdieh Alipour, Leili Faraji Gavgani, Negin Ghasemi
Clinical and Experimental Dental Research.2022; 8(2): 571. CrossRef
Effect of bioactive glass addition on the physical properties of mineral trioxide aggregate
Jei Kim, Hyun-Jung Kim, Seok Woo Chang, Soram Oh, Sun-Young Kim, Kyoung-Kyu Choi, Duck-Su Kim, Ji-Hyun Jang
Biomaterials Research.2021;[Epub] CrossRef
Effect of the addition of nanoparticles of CaCO3 and different water‐to‐powder ratios on the physicochemical properties of white Portland cement
Cleonice da Silveira Teixeira, Jessica Coelho Wasielewsky, Giovanna Slongo dos Santos, Anarela Bernardi, Eduardo Antunes Bortoluzzi, Lucas da Fonseca Roberti Garcia
Microscopy Research and Technique.2021; 84(4): 592. CrossRef
Assessment of the interaction of Portland cement-based materials with blood and tissue fluids using an animal model
P. Schembri Wismayer, C. Y. K. Lung, F. Rappa, F. Cappello, J. Camilleri
Scientific Reports.2016;[Epub] CrossRef
Effect of the plant-based hemostatic agent Ankaferd Blood Stopper® on the biocompatibility of mineral trioxide aggregate
Muzaffer Emir Dinçol, Hakan Ozbas, Bulent Yılmaz, Handan Ersev, Selcuk Gokyay, Vakur Olgac
BMC Oral Health.2016;[Epub] CrossRef
Surface microhardness of three thicknesses of mineral trioxide aggregate in different setting conditions
Noushin Shokouhinejad, Leila Jafargholizadeh, Mehrfam Khoshkhounejad, Mohammad Hossein Nekoofar, Maryam Raoof
Restorative Dentistry & Endodontics.2014; 39(4): 253. CrossRef
Surgical management of a failed internal root resorption treatment: a histological and clinical report
Saeed Asgary, Mohammad Jafar Eghbal, Leili Mehrdad, Sanam Kheirieh, Ali Nosrat
Restorative Dentistry & Endodontics.2014; 39(2): 137. CrossRef

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Evaluation of the rat tissue reaction to experimental new resin cement and mineral trioxide aggregate cement: Won-Kyung Yang, Hyun-Jung Ko, Mi-Ri Kim; Restor Dent Endod 2012;37(4):194-200. Published online November 21, 2012; DOI: https://doi.org/10.5395/rde.2012.37.4.194

Abstract PDF PubReader ePub

Objectives

New resin cement (NRC) has been developed as a root repairing material and the material is composed of organic resin matrix and inorganic powders. The aim of this study was to compare the rat subcutaneous tissue response to NRC and mineral trioxide aggregate (MTA) cement and to investigate the tissue toxicity of both materials.

Materials and Methods

Sixty rats received two polyethylene tube-implants in dorsal subcutaneous regions, MTA and NRC specimens. Twenty rats were sacrificed respectively at 1, 4 and 8 wk after implantation and sectioned to 5 µm thickness and stained with Hematoxylin-Eosin (H-E) or von-Kossa staining. The condition of tissue adjacent to the implanted materials and the extent of inflammation to each implant were evaluated by two examiners who were unaware of the type of implanted materials in the tissues. Data were statistically analyzed with paired t-test (p < 0.05).

Results

In specimens implanted with both NRC and MTA, severe inflammatory reactions were present at one wk, which decreased with time. At eighth wk, MTA implanted tissue showed mild inflammatory reaction, while there were moderate inflammatory reactions in NRC implanted tissue, respectively. In NRC group, von-Kossa staining showed more calcification materials than MTA group at eighth wk.

Conclusions

It was concluded that the calcium reservoir capability of NRC may contribute to mineralization of the tissues.

Citations

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Biomineralization of three calcium silicate-based cements after implantation in rat subcutaneous tissue
Ranjdar Mahmood Talabani, Balkees Taha Garib, Reza Masaeli, Kavosh Zandsalimi, Farinaz Ketabat
Restorative Dentistry & Endodontics.2021;[Epub] CrossRef
Genotoxicity of root canal sealers: a literature review
Fábio Miguel dos Santos Costa, Maria Helena Fernandes, Silvia Regina Batistuzzo de Medeiros
Clinical Oral Investigations.2020; 24(10): 3347. CrossRef
Marginal adaptation, solubility and biocompatibility of TheraCal LC compared with MTA-angelus and biodentine as a furcation perforation repair material
M. A. Alazrag, A. M. Abu-Seida, K. M. El-Batouty, S. H. El Ashry
BMC Oral Health.2020;[Epub] CrossRef
Evaluation in vivo of biocompatibility of differents resin-modified cements for bonding orthodontic bands
JANAINA A. MESQUITA, ROGÉRIO LACERDA-SANTOS, GÊISA A.M. SAMPAIO, GUSTAVO P. GODOY, CASSIANO F.W. NONAKA, POLLIANNA M. ALVES
Anais da Academia Brasileira de Ciências.2017; 89(3 suppl): 2433. CrossRef
A preliminary report on histological outcome of pulpotomy with endodontic biomaterials vs calcium hydroxide
Ali Nosrat, Ali Peimani, Saeed Asgary
Restorative Dentistry & Endodontics.2013; 38(4): 227. CrossRef
Biocompatibility of root-end filling materials: recent update
Payal Saxena, Saurabh Kumar Gupta, Vilas Newaskar
Restorative Dentistry & Endodontics.2013; 38(3): 119. CrossRef

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6 Crossref

Review Article

Chemical characteristics of mineral trioxide aggregate and its hydration reaction: Seok-Woo Chang; Restor Dent Endod 2012;37(4):188-193. Published online November 21, 2012; DOI: https://doi.org/10.5395/rde.2012.37.4.188

Abstract PDF PubReader ePub

Mineral trioxide aggregate (MTA) was developed in early 1990s and has been successfully used for root perforation repair, root end filling, and one-visit apexification. MTA is composed mainly of tricalcium silicate and dicalcium silicate. When MTA is hydrated, calcium silicate hydrate (CSH) and calcium hydroxide is formed. Formed calcium hydroxide interacts with the phosphate ion in body fluid and form amorphous calcium phosphate (ACP) which finally transforms into calcium deficient hydroxyapatite (CDHA). These mineral precipitate were reported to form the MTA-dentin interfacial layer which enhances the sealing ability of MTA. Clinically, the use of zinc oxide euginol (ZOE) based materials may retard the setting of MTA. Also, the use of acids or contact with excessive blood should be avoided before complete set of MTA, because these conditions could adversely affect the hydration reaction of MTA. Further studies on the chemical nature of MTA hydration reaction are needed.

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Basic Researchs

Comparison of gene expression profiles of human dental pulp cells treated with mineral trioxide aggregate and calcium hydroxide: Yong-Beom Kim, Won-Jun Shon, Woocheol Lee, Kee-Yeon Kum, Seung-Ho Baek, Kwang-Shik Bae; J Korean Acad Conserv Dent 2011;36(5):397-408. Published online September 14, 2011; DOI: https://doi.org/10.5395/JKACD.2011.36.5.397

Abstract PDF PubReader ePub

Abstract Objectives:

This study investigated changes in gene expressions concerning of differentiation, proliferation, mineralization and inflammation using Human-8 expression bead arrays when white Mineral Trioxide Aggregate and calcium hydroxide-containing cement were applied in vitro to human dental pulp cells (HDPCs).

Materials and Methods:

wMTA (white ProRoot MTA, Dentsply) and Dycal (Dentsply Caulk) in a Teflon tube (inner diameter 10 mm, height 1 mm) were applied to HDPCs. Empty tube-applied HDPCs were used as negative control. Total RNA was extracted at 3, 6, 9 and 24 hr after wMTA and Dycal application. The results of microarray were confirmed by reverse transcriptase polymerase chain reaction.

Results:

Out of the 24,546 genes, 43 genes (e.g., BMP2, FOSB, THBS1, EDN1, IL11, COL10A1, TUFT1, HMOX1) were up-regulated greater than two-fold and 25 genes (e.g., SMAD6, TIMP2, DCN, SOCS2, CEBPD, KIAA1199) were down-regulated below 50% by wMTA. Two hundred thirty nine genes (e.g., BMP2, BMP6, SMAD6, IL11, FOS, VEGFA, PlGF, HMOX1, SOCS2, CEBPD, KIAA1199) were up-regulated greater than two-fold and 358 genes (e.g., EDN1, FGF) were down-regulated below 50% by Dycal.

Conclusions:

Both wMTA and Dycal induced changes in gene expressions related with differentiation and proliferation of pulp cells. wMTA induced changes in gene expressions related with mineralization, and Dycal induced those related with angiogenesis. The genes related with inflammation were more expressed by Dycal than by wMTA. It was confirmed that both wMTA and Dycal were able to induce gene expression changes concerned with the pulp repair in different ways.

Citations

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Analysis of gene expression during odontogenic differentiation of cultured human dental pulp cells
Min-Seock Seo, Kyung-Gyun Hwang, Hyongbum Kim, Seung-Ho Baek
Restorative Dentistry & Endodontics.2012; 37(3): 142. CrossRef

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Biocompatibility of experimental mixture of mineral trioxide aggregate and glass ionomer cement: Min-Jae Oh, Yu-Na Jeong, In-Ho Bae, So-Young Yang, Bum-Jun Park, Jeong-Tae Koh, Yun-Chan Hwang, In-Nam Hwang, Won-Mann Oh; J Korean Acad Conserv Dent 2010;35(5):359-367. Published online September 30, 2010; DOI: https://doi.org/10.5395/JKACD.2010.35.5.359

Abstract PDF PubReader ePub

Objectives

The purpose of the present in vitro study was to evaluate the biocompatibility of mineral trioxide aggregate (MTA) mixed with glass ionomer cement (GIC), and to compare it with that of MTA, GIC, IRM and SuperEBA.

Materials and Methods

Experimental groups were divided into 3 groups such as 1 : 1, 2 : 1, and 1 : 2 groups depending on the mixing ratios of MTA powder and GIC powder. Instead of distilled water, GIC liquid was mixed with the powder. This study was carried out using MG-63 cells derived from human osteosarcoma. They were incubated for 1 day on the surfaces of disc samples and examined by scanning electron microscopy. To evaluate the cytotoxicity of test materials quantitatively, XTT assay was used. The cells were exposed to the extracts and incubated. Cell viability was recorded by measuring the optical density of each test well in reference to controls.

Results

The SEM revealed that elongated, dense, and almost confluent cells were observed in the cultures of MTA mixed with GIC, MTA and GIC. On the contrary, cells on the surface of IRM or SuperEBA were round in shape. In XTT assay, cell viability of MTA mixed with GIC group was similar to that of MTA or GIC at all time points. IRM and SuperEBA showed significantly lower cell viability than other groups at all time points (p < 0.05).

Conclusions

In this research MTA mixed with GIC showed similar cellular responses as MTA and GIC. It suggests that MTA mixed with GIC has good biocompatibility like MTA and GIC.

Citations

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In vitrocytotoxicity of four calcium silicate-based endodontic cements on human monocytes, a colorimetric MTT assay
Sedigheh Khedmat, Somayyeh Dehghan, Jamshid Hadjati, Farimah Masoumi, Mohammad Hossein Nekoofar, Paul Michael Howell Dummer
Restorative Dentistry & Endodontics.2014; 39(3): 149. CrossRef
Endodontic management of a maxillary lateral incisor with dens invaginatus and external root irregularity using cone-beam computed tomography
Young-Jun Lim, Sook-Hyun Nam, Sung-Ho Jung, Dong-Ryul Shin, Su-Jung Shin, Kyung-San Min
Restorative Dentistry & Endodontics.2012; 37(1): 50. CrossRef

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