Restorative Dentistry & Endodontics

Research Articles

Success rates comparison of endodontic microsurgery and single implants with comprehensive and explicit criteria: a systematic review and meta-analysis: Min Jung Ko, Ju Hyun Park, Na Rae Lee, Joon-Ho Yoon, Young-Taek Kim, Sin-Yeon Cho; Restor Dent Endod 2025;50(1):e8. Published online February 19, 2025; DOI: https://doi.org/10.5395/rde.2025.50.e8

Abstract PDF Supplementary Material PubReader ePub: Objectives
While the success criteria of endodontic microsurgery (EMS) have been consistently defined and widely accepted, the success criteria of dental implants are outdated and focus only on the implant fixture and surrounding bone. This study aimed to evaluate the outcomes of EMS and single implants (SIs) with explicit criteria.
Methods
We searched for articles published from January 2010 to February 2022 and discussed them and consulted with a clinical advisory committee composed of four dental specialists and one epidemiologist during article selection and data extraction.
Results
Twenty-two EMS studies and six SI studies were included in the meta-analysis. Teeth treated using EMS had a pooled success rate of 89% (90% at <5-year follow-up and 80% at ≥5-year follow-up) and the pooled success rate of SI was 78%.
Conclusions
The success rates of the two procedures with similar follow-up periods were comparable. Subgroup analysis found no other variable that significantly influenced study heterogeneity. Considering the treatment sequence and the similar success rates, it would be advantageous to consider EMS, rather than implants, first in a situation where both procedures are applicable.

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Fracture resistance and failure modes of endodontically-treated permanent teeth restored with Ribbond posts vs other post systems: a systematic review and meta-analysis of in vitro studies: Meghana Aditya Vartak, Vibha Rahul Hegde, Sanitra Rahul Hegde, Ushaina Fanibunda; Restor Dent Endod 2025;50(1):e5. Published online February 17, 2025; DOI: https://doi.org/10.5395/rde.2025.50.e5

Abstract PDF PubReader ePub: Objectives
This systematic review aimed to investigate the fracture resistance and mode of failure of endodontically-treated permanent teeth restored with Ribbond posts (Ribbond, Inc.) compared with endodontically-treated permanent teeth restored with other post systems.
Methods
A comprehensive, systematic literature search was carried out using several electronic databases: MEDLINE/PubMed, Google Scholar, and Cochrane Library. Two separate researchers were appointed to identify the studies meeting the eligibility criteria, and to perform the data extraction, risk of bias, and quality assessment.
Results
Twelve studies were included in the quantitative analysis. Meta-analysis was performed with 11 of the 12 included articles. The meta-analysis showed that Ribbond posts have a fracture strength less than prefabricated metal posts, cast metal posts, and prefabricated fiber posts and greater than custom e-glass fiber posts. Mode of failure analysis revealed that Ribbond posts have the most favorable non-catastrophic fractures.
Conclusions
Although Ribbond posts have lower fracture resistance, their favorable mode of failure makes them potentially the most biomimetic post system.

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Review Articles

The prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation: a systematic review: Letícia Tainá de Oliveira Lemes, Carolina Horn Troian-Michel, Theodoro Weissheimer, Marcus Vinicius Reis Só; Restor Dent Endod 2024;49(2):e22. Published online May 9, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e22

Abstract PDF Supplementary Material PubReader ePub: Objectives
This systematic review addressed the question: “What is the prevalence of apical periodontitis in patients prior to hematopoietic cell transplantation?”
Materials and Methods
A systematic search was conducted in MEDLINE/PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Grey Literature Report. Eligibility criteria were based on the condition, content, and population strategy: the condition was the radiographic prevalence of apical periodontitis, the content comprised patients scheduled for hematopoietic stem cell transplantation, and the population consisted of adult and pediatric patients. The revised Risk of Bias in Nonrandomized Studies of Exposure tool was used to assess the quality of studies. The Grading Recommendations Assessments, Development, and Evaluation (GRADE) tool was used to assess the quality of evidence.
Results
Eight studies were included in this review. The average number of patients with apical periodontitis was 15.65% (range, 2.1%–43.34%). One study was classified as having a very high risk of bias, 1 with a high risk of bias, and 6 with some concern for bias. GRADE analysis showed a very low certainty of evidence. Significant limitations concerning the absence of control over confounding variables were identified.
Conclusions
With the caveat of the very low quality of evidence in the studies reviewed, there was a low to moderate prevalence of apical periodontitis in patients prior to undergoing hematopoietic cell transplantation.

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Can carbamide peroxide be as effective as hydrogen peroxide for in-office tooth bleaching and cause less sensitivity? A systematic review: Patrick Wesley Marques de Boa, Kaiza de Sousa Santos, Francisca Jennifer Duarte de Oliveira, Boniek Castillo Dutra Borges; Restor Dent Endod 2024;49(2):e14. Published online March 20, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e14

Abstract PDF PubReader ePub

This study aimed to answer the question through a systematic review: Can carbamide peroxide be as effective as hydrogen peroxide and cause less in-office bleaching sensitivity? A literature survey was performed in PubMed/MEDLINE, Embase, Scopus, ISI Web of Science, and gray literature. Primary clinical trials that compared the efficacy or the in-office bleaching sensitivity between carbamide and hydrogen peroxides were included. The risk of bias was evaluated using the RoB2. The certainty of the evidence was assessed using the GRADE approach. DPI training significantly improved the mean scores of the dental undergraduates from 7.53 in the pre-DPI-training test to 9.01 in the post-DPI-training test (p < 0.001). After 6 weeks, the mean scores decreased marginally to 8.87 in the retention test (p = 0.563). DPI training increased their confidence level from 5.68 pre-DPI training to 7.09 post-DPI training. The limited evidence suggests that the 37% carbamide peroxide may be similarly effective to the 35% hydrogen peroxide for bleaching teeth in-office and causes less bleaching sensitivity. However, more well-designed split-mouth clinical trials are necessary to strengthen the evidence.

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Impact of nanostructured additives in tooth bleaching agents on enhancing color change and reducing side effects: a scoping review
Patrick Wesley Marques de Boa, Kaiza de Sousa Santos, Aleph Matthews da Silva Souza, Arnóbio Antônio da Silva-Júnior, Boniek Castillo Dutra Borges
Clinical Oral Investigations.2025;[Epub] CrossRef

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Cone-beam computed tomography in endodontics: from the specific technical considerations of acquisition parameters and interpretation to advanced clinical applications: Néstor Ríos-Osorio, Sara Quijano-Guauque, Sandra Briñez-Rodríguez, Gustavo Velasco-Flechas, Antonieta Muñoz-Solís, Carlos Chávez, Rafael Fernandez-Grisales; Restor Dent Endod 2024;49(1):e1. Published online December 11, 2023; DOI: https://doi.org/10.5395/rde.2024.49.e1

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The implementation of imaging methods that enable sensitive and specific observation of anatomical structures has been a constant in the evolution of endodontic therapy. Cone-beam computed tomography (CBCT) enables 3-dimensional (3D) spatial anatomical navigation in the 3 volumetric planes (sagittal, coronal and axial) which translates into great accuracy for the identification of endodontic pathologies/conditions. CBCT interpretation consists of 2 main components: (i) the generation of specific tasks of the image and (ii) the subsequent interpretation report. A systematic and reproducible method to review CBCT scans can improve the accuracy of the interpretation process, translating into greater precision in terms of diagnosis and planning of endodontic clinical procedures. MEDLINE (PubMed), Web of Science, Google Scholar, Embase and Scopus were searched from inception to March 2023. This narrative review addresses the theoretical concepts, elements of interpretation and applications of the CBCT scan in endodontics. In addition, the contents and rationale for reporting 3D endodontic imaging are discussed.

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Evaluation of Maxillary Sinus Pathologies in Children and Adolescents with Cleft Lip and Palate Using Cone Beam Computed Tomography: A Retrospective Study
Ayşe Çelik, Nilüfer Ersan, Senem Selvi-Kuvvetli
The Cleft Palate Craniofacial Journal.2025;[Epub] CrossRef
Machine Learning Models in the Detection of MB2 Canal Orifice in CBCT Images
Shishir Shetty, Meliz Yuvali, Ilker Ozsahin, Saad Al-Bayatti, Sangeetha Narasimhan, Mohammed Alsaegh, Hiba Al-Daghestani, Raghavendra Shetty, Renita Castelino, Leena R David, Dilber Uzun Ozsahin
International Dental Journal.2025; 75(3): 1640. CrossRef
Bildgebung im ZMK-Bereich – aber in welcher Reihenfolge?
Rainer Lutz
Zahnmedizin up2date.2024; 18(04): 297. CrossRef
Cone-beam computed tomography evaluation of shaping ability of kedo-S square and fanta AF™ baby rotary files compared to manual K-files in root canal preparation of primary anterior teeth
Shaimaa S. El-Desouky, Bassem N. El Fahl, Ibrahim A. Kabbash, Shimaa M. Hadwa
Clinical Oral Investigations.2024;[Epub] CrossRef
Analysis of Endodontic Successes and Failures in the Removal of Fractured Endodontic Instruments during Retreatment: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis
Mario Dioguardi, Corrado Dello Russo, Filippo Scarano, Fariba Esperouz, Andrea Ballini, Diego Sovereto, Mario Alovisi, Angelo Martella, Lorenzo Lo Muzio
Healthcare.2024; 12(14): 1390. CrossRef

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Research Article

Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research: Letícia Aparecida Silva Batista, Alexandre Henrique dos Reis-Prado, Hebertt Gonzaga dos Santos Chaves, Lara Cancella de Arantes, Luís Fernando Santos Alves Morgan, Carolina Bosso André, Thaís Yumi Suzuki, Francine Benetti; Restor Dent Endod 2023;48(4):e39. Published online November 6, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e39

Abstract PDF Supplementary Material PubReader ePub

Objectives

This study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells.

Materials and Methods

Electronic searches were performed in July 2023. In vivo and in vitro studies evaluating the effects of different topical or systemic agents on pulp inflammation or cytotoxicity after exposure to bleaching agents were included. The risk of bias was assessed.

Results

Out of 1,112 articles, 27 were included. Nine animal studies evaluated remineralizing/anti-inflammatories agents in rat molars subjected to bleaching with 35%–38% hydrogen peroxide (HP). Five of these studies demonstrated a significant reduction in inflammation caused by HP when combined with bioglass or MI Paste Plus (GC America), or following KF-desensitizing or Otosporin treatment (n = 3). However, orally administered drugs did not reduce pulp inflammation (n = 4). Cytotoxicity (n = 17) was primarily assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on human dental pulp cells and mouse dental papilla Cell-23 cells. Certain substances, including sodium ascorbate, butein, manganese chloride, and peroxidase, were found to reduce cytotoxicity, particularly when applied prior to bleaching. The risk of bias was high in animal studies and low in laboratory studies.

Conclusions

Few in vivo studies have evaluated agents to reduce the damage caused by bleaching gel to pulp tissue. Within the limitations of these studies, it was found that topical agents were effective in reducing pulp inflammation in animals and cytotoxicity. Further analyses with human pulp are required to substantiate these findings.

Trial Registration

PROSPERO Identifier: CRD42022337192

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Cytotoxicity of Bleaching Products: A Systematic Review
Mireia Montaner, José Luis Sanz, Carmen Llena, María Melo, Clara Puig-Herreros, James Ghilotti
Applied Sciences.2024; 14(9): 3680. CrossRef

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Review Articles

Disinfectant effectiveness of chlorhexidine gel compared to sodium hypochlorite: a systematic review with meta-analysis: Theodoro Weissheimer, Karem Paula Pinto, Emmanuel João Nogueira Leal da Silva, Lina Naomi Hashizume, Ricardo Abreu da Rosa, Marcus Vinicius Reis Só; Restor Dent Endod 2023;48(4):e37. Published online October 26, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e37

Abstract PDF Supplementary Material PubReader ePub

This study aimed to compare the disinfectant ability of chlorhexidine (CHX) gel and sodium hypochlorite (NaOCl). Systematic searches were conducted from inception until December 8th, 2022 (MEDLINE/PubMed, Cochrane Library, Web of Science, Scopus, Embase, and Grey Literature databases). Only randomized clinical trials were included. The revised Cochrane risk of bias tools for randomized trials were used to assess the quality of studies. Meta-analyses were performed. The overall quality of evidence was assessed through the Grading of Recommendations Assessment, Development, and Evaluation tool. Six studies were included. Five had a low risk of bias and 1 had some concerns. Three studies assessed bacterial reduction. Two were included in the meta-analysis for bacterial reduction (mean difference, 75.03 [confidence interval, CI, −271.15, 421.22], p = 0.67; I² = 74%); and 3 in the meta-analysis for cultivable bacteria after chemomechanical preparation (odds ratio, 1.03 [CI, 0.20, 5.31], P = 0.98; I² = 49%). Five studies assessed endotoxin reduction. Three were included in a meta-analysis (mean difference, 20.59 [CI, −36.41, 77.59], p = 0.48; I² = 74%). There seems to be no difference in the disinfectant ability of CHX gel and NaOCl, but further research is necessary.

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Preparing porcine lens to mimic human lens capsule
Yajing Pei, Shaofeng Han, Mingfeng Lu, Yang Yang, Ke Ma
Journal of Cataract & Refractive Surgery.2024; 50(9): 963. CrossRef
Comparative Evaluation of Disinfection Protocols for Dental Impressions in Prosthodontics
Subhash Sonkesriya, Ghanshyam Gaur, Akanksha Maheshwari, Arun Kumar Ashahiya, Simran Kaur Aulakh, Amit Kumar, Bhumika Kamal Badiyani
Cureus.2024;[Epub] CrossRef

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Does minimally invasive canal preparation provide higher fracture resistance of endodontically treated teeth? A systematic review of in vitro studies: Sıla Nur Usta, Emmanuel João Nogueira Leal Silva, Seda Falakaloğlu, Mustafa Gündoğar; Restor Dent Endod 2023;48(4):e34. Published online October 17, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e34

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This systematic review aimed to investigate whether minimally invasive root canal preparation ensures higher fracture resistance compared to conventional root canal preparation in endodontically treated teeth (ETT). A comprehensive search strategy was conducted on the “PubMed, Web of Science, and Scopus” databases, alongside reference and hand searches, with language restrictions applied. Two independent reviews selected pertinent laboratory studies that explored the effect of minimally invasive root canal preparation on fracture resistance, in comparison to larger preparation counterparts. The quality of the studies was assessed, and the risk of bias was categorized as low, moderate, or high. The electronic search yielded a total of 1,767 articles. After applying eligibility criteria, 8 studies were included. Given the low methodological quality of these studies and the large variability of fracture resistance values, the impact of reduced apical size and/or taper on the fracture resistance of the ETT can be considered uncertain. This systematic review could not reveal sufficient evidence regarding the effect of minimally invasive preparation on increasing fracture resistance of ETT, primarily due to the inherent limitations of the studies and the moderate risk of bias.

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Impact of conservative versus conventional instrumentation on the release of inflammatory mediators and post‐operative pain in mandibular molars with asymptomatic irreversible pulpitis: A randomized clinical trial
Sıla Nur Usta, Ana Arias, Emre Avcı, Emmanuel João Nogueira Leal Silva
International Endodontic Journal.2025;[Epub] CrossRef
Micro‐computed tomography evaluation of minimally invasive root canal preparation in 3D‐printed C‐shaped canal
Nutcha Supavititpattana, Siriwan Suebnukarn, Panupat Phumpatrakom, Kamon Budsaba
Australian Endodontic Journal.2024; 50(3): 621. CrossRef
Ex vivo investigation on the effect of minimally invasive endodontic treatment on vertical root fracture resistance and crack formation
Andreas Rathke, Henry Frehse, Maria Bechtold
Scientific Reports.2024;[Epub] CrossRef

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Effect of endodontic sealer on postoperative pain: a network meta-analysis: Cynthia Maria Chaves Monteiro, Ana Cristina Rodrigues Martins, Alessandra Reis, Juliana Larocca de Geus; Restor Dent Endod 2023;48(1):e5. Published online December 29, 2022; DOI: https://doi.org/10.5395/rde.2023.48.e5

Abstract PDF PubReader ePub

This systematic review and network meta-analysis aimed to answer the following focused research question: “Does the type of endodontic sealer affect the postoperative pain in patients who received endodontic treatment?” Different databases and grey literature were surveyed. Only one randomized controlled trial were included. The risk of bias in the studies was evaluated by using the Cochrane Collaboration’s tool. A random-effects meta-analysis was conducted to compare the risk and intensity of postoperative pain. The quality of the body of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Out of 11,601 studies, 15 remained for qualitative analyses and 12 for meta-analysis. Seven studies were classified at high risk of bias, and 8 studies raised some concerns. No significant differences between the endodontic materials were observed in the direct comparisons, both in risk and in intensity of postoperative pain (pairwise comparisons with 2 studies: I² = 0%; p > 0.05 and 8 studies: I² = 23%; p > 0.05, respectively). The certainty of the evidence was graded as low or moderate. There was no difference in the risk and intensity of postoperative pain after filling with different endodontic sealers. Further systematic reviews should be conducted.

Trial Registration

PROSPERO Identifier: CRD42020215314

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Comparative evaluation of postoperative pain and periapical healing after root canal treatment using three different endodontic sealers: A randomized controlled clinical trial
Ruchika Pandey, Nitin Kararia, Deepak Kumar Sharma, Vishal Rathod, Anand Vilas Bansod, Dhaval Desai
Journal of Conservative Dentistry and Endodontics.2024; 27(9): 962. CrossRef
Effect of bioceramic-based and resin-based sealers on postoperative discomfort following root canal therapy: a systematic review and meta-analysis
Mansi Supare, Ajinkya M. Pawar, Kashmira Sawant, Dian Agustin Wahjuningrum, Suraj Arora, Firas Elmsmari, Mohmed Isaqali Karobari, Bhagyashree Thakur
PeerJ.2024; 12: e18198. CrossRef
Comparative Evaluation of Incidences of Post Operative Pain in Patient Treated in Single Visit Root Canal Treatment by Using Different Sealers: - An in-Vivo Study
Sadashiv Daokar, Aishwarya Ranjalkar, Kalpana Pawar, Komal Potfode, Dhanashri Padwal, Sana Khan
International Journal of Innovative Science and Research Technology (IJISRT).2024; : 2743. CrossRef

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Influence of the root canal filling technique on the success rate of primary endodontic treatments: a systematic review: Daniel Feijolo Marconi, Giovana Siocheta da Silva, Theodoro Weissheimer, Isadora Ames Silva, Gabriel Barcelos Só, Leonardo Thomasi Jahnke, Jovito Adiel Skupien, Marcus Vinicius Reis Só, Ricardo Abreu da Rosa; Restor Dent Endod 2022;47(4):e40. Published online October 11, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e40

Abstract PDF Supplementary Material PubReader ePub

Objectives

This study aimed to investigate the influence of different obturation techniques compared to cold lateral compaction on the success rate of primary non-surgical endodontic treatments.

Materials and Methods

Systematic searches were performed for studies published up to May 17^th, 2022 in MEDLINE/PubMed, Cochrane Library, Web of Science, Scopus, EMBASE, and Grey Literature Reports. Randomized clinical trials and nonrandomized (nonrandomized clinical trials, prospective or retrospective) studies that evaluated the success rate of primary non-surgical endodontic treatments obturated with the cold lateral compaction (control) and other obturation techniques were included. The revised Cochrane risk of bias tools for randomized trials (RoB 2) and nonrandomized studies of interventions (ROBINS-I) were used to evaluate the risk of bias. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool was used to evaluate the certainty of evidence.

Results

Eleven studies (4 randomized clinical trials (RCTs), 4 prospective, and 3 retrospectives) were included. Two RCTs were classified as having some concerns risk of bias and 2 as a low risk of bias. Two nonrandomized studies were classified as having a critical risk of bias and 5 as having a moderate risk of bias. The GRADE analysis demonstrated a very low to moderate certainty of evidence.

Conclusions

This systematic review generally evidenced no differences in the success rate of primary non-surgical endodontic treatments when the cold lateral compaction technique and other obturation techniques are performed. Further well-designed studies are still necessary.

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Comparative Analysis Of Obturation Techniques In Endodontics: Lateral Vs. Thermoplasticized. Thermoplasticized
Juan Esteban Díaz Pacheco , Rómulo Guillermo López Torres , Verónica Alejandra Salame Ortíz
Salud, Ciencia y Tecnología.2025; 5: 1626. CrossRef
Clinical and Radiographic Failure of Nonsurgical Endodontic Treatment and Retreatment Using Single-cone Technique With Calcium Silicate-based Sealers: A Systematic Review and Meta-analysis
Mohammad A. Sabeti, Negah Karimpourtalebi, Arash Shahravan, Omid Dianat
Journal of Endodontics.2024; 50(6): 735. CrossRef
Method of microbial decontamination of endodontic absorbent paper points: a randomised experimental study
O. A. Pavlovskaya, O. A. Kachanova, V. V. Volobuev, M. N. Mitropanova, A. R. Gazarova, V. Y. Zobenko, A. G. Uvarova
Pediatric dentistry and dental prophylaxis.2024; 24(2): 157. CrossRef
The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles
Karla Navarrete-Olvera, Nereyda Niño-Martínez, Idania De Alba-Montero, Nuria Patiño-Marín, Facundo Ruiz, Horacio Bach, Gabriel-Alejandro Martínez-Castañón
Molecules.2024; 29(18): 4422. CrossRef
Clinical outcome of non-surgical root canal treatment using different sealers and techniques of obturation in 237 patients: A retrospective study
Mateusz Radwanski, Krystyna Pietrzycka, Tan Fırat Eyüboğlu, Mutlu Özcan, Monika Lukomska-Szymanska
Clinical Oral Investigations.2024;[Epub] CrossRef

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Research Articles

Effect of intracanal cryotherapy on postoperative pain after endodontic treatment: systematic review with meta-analysis: Fernanda Garcias Hespanhol, Ludmila Silva Guimarães, Lívia Azeredo Alves Antunes, Leonardo Santos Antunes; Restor Dent Endod 2022;47(3):e30. Published online July 4, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e30

Abstract PDF PubReader ePub

Objectives

This study aimed to evaluate the effectiveness of final irrigation with cold saline solution after endodontic treatment compared with saline solution at room temperature against postoperative pain following endodontic treatment.

Materials and Methods

A broad search was performed in the PubMed, Web of Science, Scopus, Cochrane Library, Virtual Health Library (LILACS), and Grey Literature databases. Two independent reviewers performed data extraction, risk of bias using the Cochrane methodology, and certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.

Results

Eight studies were included in qualitative synthesis. Intracanal cryotherapy favored the reduction of postoperative pain in the systematic review. Four studies were included in meta-analyses. The meta-analysis showed that intracanal cryotherapy reduced postoperative pain in teeth with symptomatic apical periodontitis (SAP) at 24 hours. There was no association between intracanal cryotherapy and control (room temperature) groups in teeth with normal periapical tissue with respect to postoperative pain at 24 hours and 48 hours.

Conclusions

Intracanal cryotherapy was effective in reducing postoperative pain after endodontic treatment in teeth with SAP.

Citations

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Determining Efficacy of Intracanal Cryotherapy on Post Endodontic Pain in Irreversible Pulpitis
Anam Fayyaz Bashir, Ussamah Waheed Jatala, Moeen ud din Ahmad, Muhammad Talha Khan, Saima Razzaq Khan, Aisha Arshad Butt
Pakistan Journal of Health Sciences.2024; : 68. CrossRef
The effect of intracanal cryotherapy with and without foraminal enlargement on pain prevention after endodontic treatment: a randomized clinical trial
Marcos Felipe Iparraguirre Nuñovero, Marco Antonio Hungaro Duarte, André Vinícius Kaled Segato, Ulisses Xavier da Silva Neto, Vania Portela Ditzel Westphalen, Everdan Carneiro
Scientific Reports.2024;[Epub] CrossRef
Effect of cryotherapy duration on experimentally induced connective tissue inflammationin vivo
Jorge Vera, Mayra Alejandra Castro-Nuñez, María Fernanda Troncoso-Cibrian, Ana Gabriela Carrillo-Varguez, Edgar Ramiro Méndez Sánchez, Viviana Sarmiento, Lourdes Lanzagorta-Rebollo, Prasanna Neelakantan, Monica Romero, Ana Arias
Restorative Dentistry & Endodontics.2023;[Epub] CrossRef
Evaluation of knowledge and awareness of pediatric oral health among school teachers of Hazaribag before and after oral health education.
Vipin Ahuja, Annapurna Ahuja, Nilima Thosar
F1000Research.2023; 12: 1292. CrossRef

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Association between cigarette smoking and the prevalence of post-endodontic periapical pathology: a systematic review and meta-analysis: Néstor Ríos-Osorio, Hernan Darío Muñoz-Alvear, Fabio Andrés Jiménez-Castellanos, Sara Quijano-Guauque, Oscar Jiménez-Peña, Herney Andrés García-Perdomo, Javier Caviedes-Bucheli; Restor Dent Endod 2022;47(3):e27. Published online June 13, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e27

Abstract PDF PubReader ePub: Objectives
This systematic review and meta-analysis aimed to assess the association of cigarette smoking with the prevalence of post-endodontic apical periodontitis in humans.
Materials and Methods
We searched through PubMed/Medline, Web of Science, and Scopus from inception to December 2020. Risk of bias was performed by using the Newcastle-Ottawa Scale for cross-sectional, cohort, and case-control studies. We performed the statistical analysis in Review Manager 5.3 (RevMan 5.3).
Results
6 studies met the inclusion criteria for qualitative and quantitative synthesis. Statistical analysis of these studies suggests that there were no differences in the prevalence of post endodontic apical periodontitis (AP) when comparing non-smokers vs smoker subjects regarding patients (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.31–1.49; I2 = 58%) and teeth (OR, 1.71; 95% CI, 0.99–2.93; I2 = 72%).
Conclusions
Our findings suggest that there was no association between cigarette smoking and post-endodontic apical periodontitis, as we did not find statistical differences in the prevalence of post-endodontic AP when comparing non-smokers vs smoker subjects. Therefore, smoking should not be considered a risk factor associated with endodontic failure.

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Anesthetic efficacy in vital asymptomatic teeth using different local anesthetics: a systematic review with network meta-analysis: Amy Kia Cheen Liew, Yi-Chun Yeh, Dalia Abdullah, Yu-Kang Tu; Restor Dent Endod 2021;46(3):e41. Published online July 21, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e41

Abstract PDF Supplementary Material PubReader ePub

Objectives

This study aimed to evaluate the efficacy of various local anesthesia (LA) in vital asymptomatic teeth.

Materials and Methods

Randomized controlled trials comparing pulpal anesthesia of various LA on vital asymptomatic teeth were included in this review. Searches were conducted in the Cochrane CENTRAL, MEDLINE (via PubMed), EMBASE, ClinicalTrials.gov, Google Scholar and 3 field-specific journals from inception to May 3, 2019. Study selection, data extraction, and risk of bias assessment using Cochrane Risk of Bias Tool were done by 2 independent reviewers in duplicate. Network meta-analysis (NMA) was performed within the frequentist setting using STATA 15.0. The LA was ranked, and the surface under the cumulative ranking (SUCRA) line was plotted. The confidence of the NMA estimates was assessed using the CINeMA web application.

Results

The literature search yielded 1,678 potentially eligible reports, but only 42 were included in this review. For maxillary buccal infiltration, articaine 4% with epinephrine 1:100,000 was more efficacious than lidocaine 2% with epinephrine 1:100,000 (odds ratio, 2.11; 95% confidence interval, 1.14–3.89). For mandibular buccal infiltration, articaine 4% with epinephrine 1:100,000 was more efficacious than various lidocaine solutions. The SUCRA ranking was highest for articaine 4% with epinephrine when used as maxillary and mandibular buccal infiltrations, and lidocaine 2% with epinephrine 1:80,000 when used as inferior alveolar nerve block. Inconsistency and imprecision were detected in some of the NMA estimates.

Conclusions

Articaine 4% with epinephrine is superior when maxillary or mandibular infiltration is required in vital asymptomatic teeth.

Citations

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Adrenaline in pulp capping treatment of reversible pulpitis
Si-Yun Yang, Jin-Zhu Wang, Hao Fan, Min Chen
World Journal of Clinical Cases.2024; 12(22): 5024. CrossRef
Effect of 810 nm Diode Laser Irradiation on the Time of Initiation and Depth of Anesthesia for Endodontic Treatment of Mandibular First Molars with Symptomatic Irreversible Pulpitis: A Clinical Trial
Elham Khoshbin, Leila Ghasemi, Rooholah Behroozi, Zahra Khosravi, Afsaneh Rahmati, Loghman Rezaeisoufi, Hamed Karkehabadi
Photobiomodulation, Photomedicine, and Laser Surgery.2023; 41(9): 475. CrossRef
The potential of articaine as new generation of local anesthesia in dental clinics: A review
Wen Luo, Kaiyue Zheng, Huifang Kuang, Zhixin Li, Jinrong Wang, Jie Mei
Medicine.2022; 101(48): e32089. CrossRef

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The effectiveness of the supplementary use of the XP-endo Finisher on bacteria content reduction: a systematic review and meta-analysis: Ludmila Smith de Jesus Oliveira, Rafaella Mariana Fontes de Bragança, Rafael Sarkis-Onofre, André Luis Faria-e-Silva; Restor Dent Endod 2021;46(3):e37. Published online June 18, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e37

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Objectives

This systematic review evaluated the efficacy of the supplementary use of the XP-endo Finisher on bacteria content reduction in the root canal system.

Materials and Methods

In-vitro studies evaluating the use of the XP-endo Finisher on bacteria content were searched in four databases in July 2020. Two authors independently screened the studies for eligibility. Data were extracted, and risk of bias was assessed. Data were meta-analyzed by using random-effects model to compare the effect of the supplementary use (experimental) or not (control) of the XP-endo Finisher on bacteria counting reduction, and results from different endodontic protocols were combined. Four studies met the inclusion criteria while 1 study was excluded from the meta-analysis due to its high risk of bias and outlier data. The 3 studies that made it to the meta-analysis had an unclear risk of bias for at least one criterion.

Results

No heterogeneity was observed among the results of the studies included in the meta-analysis. The study excluded from the meta-analysis assessing the bacteria counting deep in the dentin demonstrated further bacteria reduction upon the use of the XP-endo Finisher.

Conclusions

This systematic review found no evidence supporting the supplementary use of the XP-endo Finisher on further bacteria counting the reduction in the root canal.

Citations

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Characteristics and Effectiveness of XP‐Endo Files and Systems: A Narrative Review
Sarah M. Alkahtany, Rana Alfadhel, Aseel AlOmair, Sarah Bin Durayhim, Kee Y. Kum
International Journal of Dentistry.2024;[Epub] CrossRef
Impact XP-endo finisher on the 1-year follow-up success of posterior root canal treatments: a randomized clinical trial
Ludmila Smith de Jesus Oliveira, Fabricio Eneas Diniz de Figueiredo, Janaina Araújo Dantas, Maria Amália Gonzaga Ribeiro, Carlos Estrela, Manoel Damião Sousa-Neto, André Luis Faria-e-Silva
Clinical Oral Investigations.2023; 27(12): 7595. CrossRef
Comparative analysis of the effectiveness of modern irrigants activation techniques in the process of mechanical root canal system treatment (Literature review)
Anatoliy Potapchuk, Vasyl Almashi, Arsenii Horzov, Victor Buleza
InterConf.2023; (34(159)): 200. CrossRef
Methodological quality assessment criteria for the evaluation of laboratory‐based studies included in systematic reviews within the specialty of Endodontology: A development protocol
Venkateshbabu Nagendrababu, Paul V. Abbott, Christos Boutsioukis, Henry F. Duncan, Clovis M. Faggion, Anil Kishen, Peter E. Murray, Shaju Jacob Pulikkotil, Paul M. H. Dummer
International Endodontic Journal.2022; 55(4): 326. CrossRef

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Influence of reciprocating and rotary instrumentation on microbial reduction: a systematic review and meta-analysis of in vitro studies: Selen Küçükkaya Eren, Emel Uzunoğlu-Özyürek, Sevilay Karahan; Restor Dent Endod 2021;46(2):e19. Published online March 10, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e19

Abstract PDF PubReader ePub

Objectives

The purpose of this study was to conduct a systematic review and meta-analysis of in vitro studies regarding the effectiveness of reciprocating and rotary instrumentation on microbial reduction in root canals.

Materials and Methods

PubMed, Scopus, Web of Science, the Cochrane Library, and the gray literature were searched through December 2019. Studies comparing the influence of reciprocating and rotary instrumentation on the removal of microorganisms from root canals that quantified the antimicrobial effect were included. Data extraction was completed using a systematic form for data collection. The risk of bias of the studies was evaluated. Standardized mean differences (SMDs) and confidence intervals (CIs) were calculated using a random effects meta-analysis.

Results

Seventeen in vitro studies were included in this systematic review, of which 7 provided adequate data for inclusion in the meta-analysis. Both reciprocating and rotary systems were similarly effective in reducing the microbial load in infected root canals (SMD [95% CI], 0.0481 [−0.271, 0.367]). Three studies showed a low risk of bias, whereas most of the studies (82%) presented a medium risk.

Conclusions

Although both techniques decrease the microbial content (with reductions of 23.32%–88.47% and 23.33%–89.86% for reciprocating and rotary instrumentation, respectively), they are not able to provide complete disinfection of root canals.

Citations

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Fifteen years of engine‐driven nickel–titanium reciprocating instruments, what do we know so far? An umbrella review
Felipe Immich, Lucas Peixoto de Araújo, Rafaella Rodrigues da Gama, Wellington Luiz de Oliveira da Rosa, Evandro Piva, Giampiero Rossi‐Fedele
Australian Endodontic Journal.2024; 50(2): 409. CrossRef
Does minimally invasive canal preparation provide higher fracture resistance of endodontically treated teeth? A systematic review ofin vitrostudies
Sıla Nur Usta, Emmanuel João Nogueira Leal Silva, Seda Falakaloğlu, Mustafa Gündoğar
Restorative Dentistry & Endodontics.2023;[Epub] CrossRef
The Effect of Combined Ultrasonic Tip and Mechanized Instrumentation on the Reduction of the Percentage of Non-Instrumented Surfaces in Oval/Flat Root Canals: A Systematic Review and Meta-Analysis
Marcella Dewes Cassal, Pedro Cardoso Soares, Marcelo dos Santos
Cureus.2023;[Epub] CrossRef
Impact of Different Access Cavity Designs and Ni–Ti Files on the Elimination of Enterococcus faecalis from the Root Canal System: An In Vitro Study
Gizem Andac, Atakan Kalender, Buket Baddal, Fatma Basmaci
Applied Sciences.2022; 12(4): 2049. CrossRef
Shaping Properties and Outcomes of Nickel-Titanium Reciprocation Systems in Primary Teeth: A Systematic Review and Meta-Analysis of In Vitro Studies
SelvaKumar Haridoss, Bhavyaa R, Kavitha Swaminathan, Aruna P
Cureus.2022;[Epub] CrossRef
Influence of Root Canal Sealers and Obturation Techniques on Vertical Root Fracture Resistance. An In Vitro Experiment
Mazen F. Alkahtany, Khalid H. Almadi, Fahad A. Alahmad, Abdullah M. Alshehri, Abdulrahman A. AlSwayyed, Omar M. AlZahran, Ali AlHadan, Abdulaziz S. Almustafa, Fahim Vohra, Tariq Abduljabbar
Applied Sciences.2021; 11(17): 8022. CrossRef

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Reference values for pulp oxygen saturation as a diagnostic tool in endodontics: a systematic review and meta-analysis: Paula Lambert, Sergio Augusto Quevedo Miguens, Caroline Solda, Juliana Tomaz Sganzerla, Leandro Azambuja Reichert, Carlos Estrela, Fernando Branco Barletta; Restor Dent Endod 2020;45(4):e48. Published online October 5, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e48

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Objectives

This systematic review aimed to identify mean oxygen saturation values (SpO₂) using pulse oximetry in permanent maxillary anterior teeth.

Materials and Methods

The MEDLINE, Scientific Electronic Library Online, Cochrane Central Register of Controlled Trials, EMBASE, and Literatura Latino Americana em Ciências da Saúde electronic databases were searched. Combinations and variations of “oximetry” AND “dental pulp test” were used as search terms. Studies reporting means and standard deviations of SpO₂ values were included. Two reviewers independently extracted data following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Heterogeneity was assessed using the I² statistic, and all analyses were performed using R software. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool and the Newcastle-Ottawa scale.

Results

Of the 251 studies identified, 19 met the eligibility criteria and were included (total sample, 4,541 teeth). In the meta-analysis, the mean SpO₂ values were 84.94% (95% confidence interval [CI], 84.85%–85.04%) for the central incisors, 89.29% (95% CI, 89.22%–89.35%) for the lateral incisors, and 89.20% (95% CI, 89.05%–89.34%) for the canines. The studies were predominantly low-quality due to the high risk of bias associated with the index test, unclear risk regarding patient selection, and concerns about outcome assessment.

Conclusions

Although most studies were low-quality, the oxygen saturation levels in normal pulp could be established (minimum saturation, 77.52%). Despite the risk of bias of the included studies, the reference values reported herein are clinically relevant for assessments of changes in pulp status.

Trial Registration

International Prospective Register of Systematic Reviews Identifier: CRD42018085598

Citations

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Foo Suanhow, Tawil Bill
Journal of Applied Biotechnology & Bioengineering.2024; 11(1): 1. CrossRef
Assessment of Pulpal Oxygen Saturation in Caries-free and Carious Maxillary Primary Central Incisors Using a Customized Dental Pulse Oximeter
Shankar Paulindraraj, Hemalatha Ramkumar, Trophimus Gnanabagyan Jayakaran, Kranthi Reddy Kanumuru, Nancy Solomon, Senthil Dakshinamoorthy
International Journal of Clinical Pediatric Dentistry.2023; 16(4): 560. CrossRef
Age-Related Variation of Pulpal Oxygen Saturation in Healthy Primary and Permanent Teeth in Children: A Clinical Study
Andreea Igna, Darian Rusu, Emilia Ogodescu, Ștefania Dinu, Marius Boariu, Adrian Voicu, Ștefan-Ioan Stratul
Journal of Clinical Medicine.2022; 12(1): 170. CrossRef
Pulp oxygen saturation measurement as a diagnostic tool for assessing pulp status in primary teeth
Kanamarlapudi Venkata Saikiran, Deepa Gurunathan, Sainath Reddy Elicherla, Sreekanth Kumar Mallineni, Sivakumar Nuvvula
Journal of Indian Society of Pedodontics and Preventive Dentistry.2022; 40(4): 349. CrossRef
Diagnostic Value of Serum Chitinase‐3‐Like Protein 1 for Liver Fibrosis: A Meta‐analysis
Xiaoting Huang, Jialing Zhuang, Yongqiang Yang, Jiaxin Jian, Wen Ai, Chunyong Liu, Wenzhi Tang, Changyu Jiang, Yongshen He, Lesheng Huang, Se Peng, Jin Shui Pan
BioMed Research International.2022;[Epub] CrossRef
Assessment of Pulpal Status in Primary Teeth Following Direct Pulp Capping in an Experimental Canine Model
Andreea Igna, Cornel Igna, Mariana Ioana Miron, Larisa Schuszler, Roxana Dascălu, Mihaela Moldovan, Adrian Aristide Voicu, Carmen Darinca Todea, Marius Boariu, Maria-Alexandra Mârțu, Ștefan-Ioan Stratul
Diagnostics.2022; 12(8): 2022. CrossRef

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Calcium hydroxide intracanal medication effects on pain and flare-up: a systematic review and meta-analysis: Ahmed Mohamed Ibrahim, Siza Yacoub Zakhary, Suzan Abdul Wanees Amin; Restor Dent Endod 2020;45(3):e26. Published online May 22, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e26

Abstract PDF Supplementary Material PubReader ePub

Objectives

This study aimed to systematically review the pain and flare-up effects of calcium hydroxide (CH) as intracanal medication (ICM) in non-vital mature teeth.

Materials and Methods

Electronic-databases searching for published and grey literature and manual searching were conducted. Only randomized clinical trials (RCTs) were included comparing CH to other ICMs in non-vital mature teeth. The risk of bias was assessed using the RoB 2.0 Cochrane tool. The main outcomes were pain and flare-up. Qualitative and quantitative analysis, wherever applicable, was performed. The certainty of evidence (CoE) was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE).

Results

Sixteen articles were included in 6 comparisons at different time points for different outcomes. CH reduced pain risk than no ICM within the 1–14-days interval (p < 0.05) and than triple-antibiotic paste within the first day (p < 0.05) and was similar to corticosteroid/antibiotics combination (p > 0.05). Chlorhexidine (CHX) or CH/CHX, however, reduced pain levels than CH alone (p < 0.05). CH showed higher flare-up risk than CHX (p < 0.05). CoE, however, ranged from very low to moderate.

Conclusion

Most comparisons for different outcomes are based on very few studies, mostly low-powered, with an overall low CoE. Thus, the available evidence is considered insufficient to either support or refute CH effectiveness or to recommend one ICM over another. Therefore, further well-designed, larger RCTs are required.

Trial Registration

PROSPERO database Identifier: CRD42016041953

Citations

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Garre’s osteomyelitis of the mandible managed by nonsurgical re-endodontic treatment
Heegyun Kim, Jiyoung Kwon, Hyun-Jung Kim, Soram Oh, Duck-Su Kim, Ji-Hyun Jang
Restorative Dentistry & Endodontics.2024;[Epub] CrossRef
Interpretation by literature review of the use of calcium hydroxide as an intra-ductal medication
María Belén Muñoz Padilla, Verónica Alicia Vega Martínez, Camila Alejandra Villafuerte Moya
Salud, Ciencia y Tecnología.2024; 4: 924. CrossRef
ProTaper Ultimate: The Evolution of Rotary Systems and Their Clinical Applicability
Mateo-Castillo JF, Siqueira-Sandrin VDS, Moreira RA, Brandelero Junior S, Olano-Dextre TL, Claudia R Pinheiro
Journal of Operative Dentistry & Endodontics.2024; 9(1): 16. CrossRef
Comparative Evaluation of Bacterial Reduction by Laser-Activated Irrigation Technique (LAI) With Conventional Needle Irrigation (CNI) in Single-Rooted Teeth With Pulpal Necrosis: A Single-Blinded Randomized Controlled Trial
Keerthika Rajamanickam, Sandhya Raghu, J Vijayashree Priyadharsini, Delphine Priscilla Antony, Nivedhitha Malli Sureshbabu
Cureus.2023;[Epub] CrossRef
Post-Operative Endodontic Pain Management: An Overview of Systematic Reviews on Post-Operatively Administered Oral Medications and Integrated Evidence-Based Clinical Recommendations
Federica Di Spirito, Giuseppe Scelza, Roberto Fornara, Francesco Giordano, Donato Rosa, Alessandra Amato
Healthcare.2022; 10(5): 760. CrossRef
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Saeed Asgary, Ardavan Parhizkar, Paulo J. Palma
Case Reports in Dentistry.2022; 2022: 1. CrossRef
Calcium hydroxide as an intracanal medication for postoperative pain during primary root canal therapy: A systematic review and meta-analysis with trial sequential analysis of randomised controlled trials
Muhammad Zubair Ahmad, Durre Sadaf, Khalid A Merdad, Amani Almohaimeed, Igho J. Onakpoya
Journal of Evidence-Based Dental Practice.2022; 22(1): 101680. CrossRef
Post-operative Pain and Antibacterial Efficacy of Silver Nanoparticles Formulations Intracanal Medication: A Randomized Controlled Clinical Study
Nermine Hassan, Alaa Diab, Geraldine Ahmed
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Effect of QMix irrigant in removal of smear layer in root canal system: a systematic review of in vitro studies: Margaret Soo Yee Chia, Abhishek Parolia, Benjamin Syek Hur Lim, Jayakumar Jayaraman, Isabel Cristina Celerino de Moraes Porto; Restor Dent Endod 2020;45(3):e28. Published online May 21, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e28

Abstract PDF PubReader ePub

Objectives

To evaluate the outcome of in vitro studies comparing the effectiveness of QMix irrigant in removing the smear layer in the root canal system compared with other irrigants.

Materials and Methods

The research question was developed by using Population, Intervention, Comparison, Outcome and Study design framework. Literature search was performed using 3 electronic databases PubMed, Scopus, and EBSCOhost until October 2019. Two reviewers were independently involved in the selection of the articles and data extraction process. Risk of bias of the studies was independently appraised using revised Cochrane Risk of Bias tool (RoB 2.0) based on 5 domains.

Results

Thirteen studies fulfilled the selection criteria. The overall risk of bias was moderate. QMix was found to have better smear layer removal ability than mixture of tetracycline isonomer, an acid and a detergent (MTAD), sodium hypochlorite (NaOCl), and phytic acid. The efficacy was less effective than 7% maleic acid and 10% citric acid. No conclusive results could be drawn between QMix and 17% ethylenediaminetetraacetic acid due to conflicting results. QMix was more effective when used for 3 minutes than 1 minute.

Conclusions

QMix has better smear layer removal ability compared to MTAD, NaOCl, Tubulicid Plus, and Phytic acid. In order to remove the smear layer more effectively with QMix, it is recommended to use it for a longer duration.

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Biological and chemical properties of new multi-functional root canal irrigants
Nidambur Vasudev Ballal, Rajkumar Narkedamalli, Padmaja A Shenoy, Shubhankar Das, Saravana Karthikeyan Balasubramanian, Jothi Varghese, Herman Sunil Dsouza, Kevin Epps, Theodroe Ravenel, Franklin R. Tay
Journal of Dentistry.2025; 153: 105551. CrossRef
Chitosan’s Ability to Remove the Smear Layer—A Systematic Review of Ex Vivo Studies
Ana Ferreira-Reguera, Inês Ferreira, Irene Pina-Vaz, Benjamín Martín-Biedma, José Martín-Cruces
Medicina.2025; 61(1): 114. CrossRef
The advancement in irrigation solution within the field of endodontics, A Review
Fatima Fahad , Raghad A Al-Hashimi , Munther J Hussain
Journal of Baghdad College of Dentistry.2024; 36(1): 54. CrossRef
The effect of final irrigation with different solutions on smear layer removal and dentin erosion: A scanning electron microscope study
Mohammed AlBatati, Ammar AbuMostafa, Miriam Fatima Zaccaro Scelza
PLOS ONE.2024; 19(8): e0308606. CrossRef
Effect of QMix as final irrigation protocol on periapical healing after single‐visit root canal treatment: A randomised controlled clinical trial
Cemre Sapmaz Ucan, Aysin Dumani, Ilker Unal, Sehnaz Yilmaz, Oguz Yoldas
Australian Endodontic Journal.2023; 49(S1): 113. CrossRef
Effectiveness of Different Final Irrigation Procedures on Enterococcus faecalis Infected Root Canals: An In Vitro Evaluation
Sanda Ileana Cîmpean, Ioana-Sofia Pop-Ciutrila, Sebastian-Roberto Matei, Ioana Alina Colosi, Carmen Costache, Gheorghe Zsolt Nicula, Iulia Clara Badea, Loredana Colceriu Burtea
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Yasser Alsayed Tolibah, Line Droubi, Saleh Alkurdi, Mohammad Tamer Abbara, Nada Bshara, Thuraya Lazkani, Chaza Kouchaji, Ibrahim Ali Ahmad, Ziad D. Baghdadi
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Influence of chelating solutions on tubular dentin sealer penetration: A systematic review with network meta‐analysis
Felipe de Souza Matos, Camila Maria Peres de Rosatto, Thaís Christina Cunha, Maria Tereza Campos Vidigal, Cauane Blumenberg, Luiz Renato Paranhos, Camilla Christian Gomes Moura
Australian Endodontic Journal.2021; 47(3): 715. CrossRef

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Influence of autoclave sterilization procedures on the cyclic fatigue resistance of heat-treated nickel-titanium instruments: a systematic review: Emmanuel João Nogueira Leal Silva, Mayara Zanon, Fernanda Hecksher, Felipe Gonçalves Belladonna, Rafaela Andrade de Vasconcelos, Tatiana Kelly da Silva Fidalgo; Restor Dent Endod 2020;45(2):e25. Published online March 31, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e25

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Objectives

This systematic review evaluated the influence of autoclave sterilization procedures on the cyclic fatigue resistance of heat-treated nickel-titanium (NiTi) instruments.

Materials and Methods

A systematic search without restrictions was conducted in the following electronic databases: PubMed, Scopus, Web of Science, ScienceDirect, Cochrane, and Open Grey. The hand search was also performed in the main endodontic journals. The eligible studies were submitted to the methodological assessment and data extraction.

Results

From 203 abstracts, a total of 10 articles matched the eligible criteria. After reading the full articles, 2 were excluded because of the absence of the heat-treated instruments in the experimental design and 3 due to the lack of a control group using heat-treated instruments without autoclave sterilization. From the 5 included studies, 1 presented a low risk of bias, 3 presented moderate and 1 high risk. It was observed heterogeneous findings in the included studies, with autoclave sterilization cycles increasing, decreasing or not affecting the cyclic fatigue life of heat-treated NiTi instruments. However, the retrieved studies evaluating the cyclic fatigue resistance of endodontic instruments presented different protocols and assessing outcomes, this variability makes the findings less comparable within and also between groups and preclude the establishment of an unbiased scientific evidence base.

Conclusions

Considering the little scientific evidence and considerable risk of bias, it is still possible to conclude that autoclave sterilization procedures appear to influence the cyclic fatigue resistance of heat-treated NiTi instruments.

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Effect of simulated clinical use and sterilization on the cyclic fatigue resistance of nickel titanium files
Mohammad Alajemi, Ammar AbuMostafa
PeerJ.2024; 12: e17418. CrossRef
Cyclic Fatigue of Different Ni-Ti Endodontic Rotary File Alloys: A Comprehensive Review
Dina Abdellatif, Alfredo Iandolo, Michela Scorziello, Giuseppe Sangiovanni, Massimo Pisano
Bioengineering.2024; 11(5): 499. CrossRef
Cyclic Fatigue Resistance of Rotary versus Reciprocating Endodontic Files: A Systematic Review and Meta-Analysis
Ana De Pedro-Muñoz, Cristina Rico-Romano, Patricia Sánchez-Llobet, José María Montiel-Company, Jesús Mena-Álvarez
Journal of Clinical Medicine.2024; 13(3): 882. CrossRef
Influence of sodium hypochlorite on cyclic fatigue resistance of nickel–titanium instruments: A systematic review and meta-analysis of in vitro studies
Alexandre Henrique dos Reis-Prado, Lucas Guimarães Abreu, Lara Cancella de Arantes, Kiani dos Santos de Paula, Sabrina de Castro Oliveira, Juliana Goto, Ana Cecília Diniz Viana, Francine Benetti
Clinical Oral Investigations.2023; 27(11): 6291. CrossRef
Cyclic fatigue resistance of EdgeTaper Platinum, Protaper Gold, and TruNatomy Prime rotary files before and after autoclave sterilization
Rahaf A. Almohareb, Reem M. Barakat, Fahda N. Algahtani, Manal F. Alkadi
PeerJ.2023; 11: e14656. CrossRef
Effect of calcium hydroxide on fracture resistance and microhardness of dentin in human teeth
Simar Sethi, Alpa Gupta, Ansy Hanna Kurian, Dax Abraham, Parul Chauhan, Kritika Aneja, Sucheta Jala, Arundeep Singh
Endodontology.2022; 34(4): 223. CrossRef
Effect of body temperature on the cyclic fatigue resistance of the nickel”titanium endodontic instruments: A systematic review and meta-analysis of in vitro studies
Selventhra Savitha, Sidhartha Sharma, Vijay Kumar, Amrita Chawla, Perumal Vanamail, Ajay Logani
Journal of Conservative Dentistry.2022; 25(4): 338. CrossRef
Fracture Resistance of Heat-Treated Nickel-Titanium Rotary Files After Usage and Autoclave Sterilization: An In Vitro Study
Rashid El Abed, Aisha Alshehhi, Yoo Jung Kang, Dana Al Raeesi, Amar H. Khamis, Mohamed Jamal, Hyeon-Cheol Kim
Journal of Endodontics.2022; 48(11): 1428. CrossRef
Effect of Autoclaving Cycles on the Cyclic Fatigue Resistance of Race and Race Evo Nickel-Titanium Endodontic Rotary Files: An In Vitro Study
Rahaf A. Almohareb, Reem Barakat, Aroob Albakri, Manal Altamimi
Metals.2021; 11(12): 1947. CrossRef
Effect of number of uses and sterilization on the instrumented area and resistance of reciprocating instruments
Victor de Ornelas Peraça, Samantha Rodrigues Xavier, Fabio de Almeida Gomes, Luciane Geanini Pena dos Santos, Erick Miranda Souza, Fernanda Geraldo Pappen
Restorative Dentistry & Endodontics.2021;[Epub] CrossRef
Influence of sterilization procedures on the physical and mechanical properties of rotating endodontic instruments: a systematic review and network meta-analysis
Mario Dioguardi, Claudia Arena, Diego Sovereto, Riccardo Aiuto, Luigi Laino, Gaetano Illuzzi, Enrica Laneve, Bruna Raddato, Vito Carlo Alberto Caponio, Antonio Dioguardi, Khrystyna Zhurakivska, Giuseppe Troiano, Lorenzo Lo Muzio
Frontiers in Bioscience-Landmark.2021;[Epub] CrossRef

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Antimicrobial efficacy of QMix on Enterococcus faecalis infected root canals: a systematic review of in vitro studies: Benjamin Syek Hur Lim, Abhishek Parolia, Margaret Soo Yee Chia, Jayakumar Jayaraman, Venkateshbabu Nagendrababu; Restor Dent Endod 2020;45(2):e23. Published online March 11, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e23

Abstract PDF PubReader ePub

Objectives

This study aimed to summarize the outcome of in vitro studies comparing the antibacterial effectiveness of QMix with other irrigants against Enterococcus faecalis.

Materials and Methods

The research question was developed by using population, intervention, comparison, outcome, and study design framework. The literature search was performed using 3 electronic databases: PubMed, Scopus, and EBSCOhost until October 2019. The additional hand search was performed from the reference list of the eligible studies. The risk of bias of the studies was independently appraised using the revised Cochrane Risk of Bias tool (RoB 2.0).

Results

Fourteen studies were included in this systematic review. The overall risk of bias for the selected studies was moderate. QMix was found to have a higher antimicrobial activity compared to 2% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA), 2% chlorhexidine (CHX), mixture of tetracycline isonomer, an acid and a detergent (MTAD), 0.2% Cetrimide, SilverSol/H2O2, HYBENX, and grape seed extract (GSE). QMix had higher antibacterial efficacy compared to NaOCl, only when used for a longer time (10 minutes) and with higher volume (above 3 mL).

Conclusions

QMix has higher antibacterial activity than 17% EDTA, 2% CHX, MTAD, 0.2% Cetrimide, SilverSol/H2O2, HYBENX, GSE and NaOCl with lower concentration. To improve the effectiveness, QMix is to use for a longer time and at a higher volume.

Trial Registration

PROSPERO International prospective register of systematic reviews Identifier: CRD42018096763

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Karthikeyan Anbalagan, Amit Jena, Saumyakanta Mohanty, Rashmirekha Mallick, Govind Shashirekha, Priyanka Sarangi
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Mi-Ah KIM, Vinicius ROSA, Kyung-San MIN
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Jakub Kowalski, Joanna Rygas, Karolina Homa, Wojciech Dobrzyński, Rafal J. Wiglusz, Jacek Matys, Maciej Dobrzyński
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Dania Alkhourbotly, Mohamed K Altinawi, Rouaida Abou-Samra, Hasan M Alzoubi, Abedulrahman K Ebrahim
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Jasmine Wong, Daniel Manoil, Peggy Näsman, Georgios N. Belibasakis, Prasanna Neelakantan
Frontiers in Oral Health.2021;[Epub] CrossRef

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The effect of preheating resin composites on surface hardness: a systematic review and meta-analysis: Ali A. Elkaffas, Radwa I. Eltoukhy, Salwa A. Elnegoly, Salah H. Mahmoud; Restor Dent Endod 2019;44(4):e41. Published online October 29, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e41

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Objectives

This paper presents a systematic review and meta-analysis of the effect of preheating on the hardness of nanofilled, nanoceramic, nanohybrid, and microhybrid resin composites.

Materials and Methods

An electronic search of papers on MEDLINE/PubMed, ScienceDirect, and EBSCOhost was performed. Only in vitro studies were included. Non-English studies, case reports, clinical trials, and review articles were excluded. A meta-analysis of the reviewed studies was conducted to quantify differences in the microhardness of the Z250 microhybrid resin composite using the Comprehensive Meta-Analysis software.

Results

Only 13 studies met the inclusion criteria for this systematic review. The meta-analysis showed that there were significant differences between the non-preheated and preheated modes for both the top and bottom surfaces of the specimens (p < 0.05). The microhardness of the Z250 resin composite on the top surface in the preheated mode (78.1 ± 2.9) was higher than in the non-preheated mode (67.4 ± 4.0; p < 0.001). Moreover, the microhardness of the Z250 resin composite on the bottom surface in the preheated mode (71.8 ± 3.8) was higher than in the non-preheated mode (57.5 ± 5.7, p < 0.001).

Conclusions

Although the results reported in the reviewed studies showed great variability, sufficient scientific evidence was found to support the hypothesis that preheating can improve the hardness of resin composites.

Citations

Citations to this article as recorded by

Influence of preheating and water storage on the color, whiteness, and translucency of modern resin‐based composites
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Journal of Esthetic and Restorative Dentistry.2025; 37(2): 533. CrossRef
Effects of pre-heating on physical–mechanical–chemical properties of contemporary resin composites
Thamires Bueno, Nivien Masoud, Anna Akkus, Italo Silva, Karen McPherson, Adilson Yoshio Furuse, Fabio Rizzante
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Clinical performance of different bulk‐fill composite resin systems in classIIcavities: A 2‐year randomized clinical trial
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Journal of Esthetic and Restorative Dentistry.2024; 36(8): 1122. CrossRef
Comparative evaluation of microleakage in Class II cavities restored with snowplow technique using flowable or preheated packable bulk-fill composite resin as gingival increment by dye extraction method: An in vitro study
M. A. Ranjini, V. Geetha, B. Vedavathi, H. K. Ashok, Akshata J. Airsang, S. Swathi
Journal of Conservative Dentistry and Endodontics.2024; 27(11): 1158. CrossRef
Influence of Light‐Curing Time and Increment Thickness on the Properties of Bulk Fill Composite Resins With Distinct Application Systems
Carlos Rocha Gomes Torres, Taiana Paola Prado, Daniele Mara da Silva Ávila, Cesar Rogério Pucci, Alessandra Bühler Borges, Heng Bo Jiang
International Journal of Dentistry.2024;[Epub] CrossRef
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M. Delgado
Endodontics Today.2024; 21(4): 305. CrossRef
The clinical performance of dental resin composite repeatedly preheated: A randomized controlled clinical trial
Mahmoud Elkady, Safaa Abdelhakim, Mona Riad
Journal of Dentistry.2024; 144: 104940. CrossRef
Preheating effect on microhardness and depth of cure of three bulk-fill composite resins: An in vitro study
Aashna Sunil Sahetia, Divya Rupesh Jain, Padmaja Panditrao Sirsat, Meenal N. Gulve, Swapnil J. Kolhe, Surbhi P. Patel
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Dentistry Journal.2024; 12(12): 410. CrossRef
Effect of preheating on the physicochemical properties and bond strength of composite resins utilized as dental cements: An in vitro study
Carolina Carramilo Raposo, Luanna Marinho Sereno Nery, Edilausson Moreno Carvalho, Paulo Vitor Campos Ferreira, Diego Machado Ardenghi, José Bauer, Darlon Martins Lima
The Journal of Prosthetic Dentistry.2023; 129(1): 229.e1. CrossRef
Examining the Impact of Preheating on the Fracture Toughness and Microhardness of Composite Resin: A Systematic Review
Jay Bhopatkar, Anuja Ikhar, Manoj Chandak, Aditya Patel, Paridhi Agrawal
Cureus.2023;[Epub] CrossRef
In Vitro Effect of Mouthrinses on the Microhardness of Three Different Nanohybrid Composite Resins
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Wear and Color Stability of Preheated Bulk-fill and Conventional Resin Composites
AA Abdulmajeed, AA Suliman, BJ Selivany, A Altitinchi, TA Sulaiman
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Do universal adhesives promote bonding to dentin? A systematic review and meta-analysis: Ali A. Elkaffas, Hamdi H. H. Hamama, Salah H. Mahmoud; Restor Dent Endod 2018;43(3):e29. Published online June 18, 2018; DOI: https://doi.org/10.5395/rde.2018.43.e29

Abstract PDF PubReader ePub

Objectives

The aims of this study were to conduct a systematic review of the microtensile bond strength (µTBS) of multi-mode adhesives to dentin and to perform a meta-analysis to assess the significance of differences in the µTBS of one of the most commonly used universal adhesives (Scotchbond Universal, 3M ESPE) depending on whether the etch-and-rinse or self-etch mode was used.

Materials and Methods

An electronic search was performed of MEDLINE/PubMed, ScienceDirect, and EBSCOhost. Laboratory studies that evaluated the µTBS of multi-mode adhesives to dentin using either the etch-and-rinse or self-etch mode were selected. A meta-analysis was conducted of the reviewed studies to quantify the differences in the µTBS of Scotchbond Universal adhesive.

Results

Only 10 studies fulfilled the inclusion criteria for the systematic review. Extensive variation was found in the restorative materials, testing methodologies, and failure mode in the reviewed articles. Furthermore, variation was also observed in the dimensions of the microtensile testing beams. The meta-analysis showed no statistically significant difference between the etch-and-rinse and self-etch modes for Scotchbond Universal adhesive (p > 0.05).

Conclusions

Multi-mode ‘universal’ adhesives can achieve substantial bonding to dentin, regardless of the used modes (either etch-and-rinse or self-etch).

Citations

Citations to this article as recorded by

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