Restorative Dentistry & Endodontics

Research Articles

Assessment of mechanical allodynia in healthy teeth adjacent and contralateral to endodontically diseased teeth: a clinical study: Vaishnavi Ratnakar Patankar, Ashish K Jain, Rahul D Rao, Prajakta R Rao; Restor Dent Endod 2024;49(3):e31. Published online July 29, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e31

Abstract PDF PubReader ePub: Objectives
The present study investigated the prevalence of mechanical allodynia (MA) in healthy teeth adjacent and contralateral to endodontically diseased teeth.
Materials and Methods
This cross-sectional study included 114 patients with symptomatic irreversible pulpitis and apical periodontitis in permanent mandibular first molars who possessed healthy teeth adjacent and contralateral to the endodontically diseased tooth. The mechanical sensitivity of the teeth was determined by percussion testing. The presence or absence of pain on percussion in the teeth adjacent and contralateral to the endodontically diseased tooth and the tooth distal to the contralateral symmetrical tooth was recorded according to coding criteria. The prevalence of MA was computed as a percentage, and binary logistic regression analysis was done. The Fisher exact test and Mann-Whitney U test were used for binary and ordinal data.
Results
Age and sex did not influence the prevalence of MA. An increased prevalence of MA was found in patients with higher levels of spontaneous pain (p < 0.001). The prevalence of allodynia was 57% in teeth adjacent to endodontically diseased teeth and 10.5% in teeth contralateral to endodontically diseased teeth. In addition, on the ipsilateral side, there were more painful sensations distal to the diseased tooth than mesially.
Conclusions
Despite being disease-free, teeth adjacent and contralateral to endodontically diseased teeth exhibited pain on percussion. There was a direct association between the severity of the patient’s pain and the presence of MA.

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The status of clinical trials regarding root canal sealers: Ahmad AL Malak, Yasmina EL Masri, Mira Al Ziab, Nancy Zrara, Tarek Baroud, Pascale Salameh; Restor Dent Endod 2024;49(1):e5. Published online January 15, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e5

Abstract PDF PubReader ePub: Objectives
This study aimed to present the results and analyses of clinical trials, including updates on the different functions of root canal sealers.
Materials and Methods
In June 2023, we performed a comprehensive search of ClinicalTrials.gov to identify interventional clinical trials pertaining to root canal sealers. In total, 23 clinical trials conducted up to June 2023 were included in this study.
Results
Approximately half of the trials (11 out of 23) were completed, while none were terminated or withdrawn. Each included trial had a minimum of 10 participants, with 11 trials having more than 100 participants. None of the assessed trials provided outcomes, and the majority (17 out of 23) lacked associated publications. In terms of geographic distribution, the USA and Canada did not contribute to any root canal sealer trials.
Conclusions
This study highlights the lack of diversity in trial locations, the absence of reported results, and a scarcity of clinical trials examining the physicochemical properties of different sealers. Most published trials primarily focused on assessing the post-operative pain effect of these sealers, but no significant difference was found regarding post-operative pain control.

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Incidence of interappointment emergencies in multiple-visit root canal treatments performed with or without intracanal medicament by undergraduate students: Annemarie Baaij, Corine Mirjam Visscher, Manon Jansen, Ahmet Rifat Özok; Restor Dent Endod 2023;48(3):e31. Published online August 14, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e31

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This retrospective cohort study examined the incidence of interappointment emergencies during multiple-visit molar root canal treatments conducted by undergraduate students. Treatments performed without the use of intracanal medicament were compared to treatments that incorporated calcium hydroxide as an intracanal medicament.
Materials and Methods
Interappointment emergencies, defined as instances of pain or swelling that required the patient to make an unscheduled follow-up visit, were recorded for up to 2 months after the intervention. To avoid the influence of obturation on the observed incidence of emergency visits, only unscheduled visits occurring between the start and end of the root canal treatment were included.
Results
Of the 719 patients included in this study, 77 (10.7%) were recorded as experiencing interappointment emergencies. Of these emergencies, 62% occurred within 2 weeks following the most recent intervention. In the group of patients who did not receive intracanal medicament, the incidence of interappointment emergencies was 11.9% (46 of 385 patients). In comparison, this rate was 9.3% (31 of 334 patients) among those who received calcium hydroxide as an intracanal medicament (odds ratio, 1.33; 95% confidence interval, 0.82–2.15; p = 0.249).
Conclusions
Interappointment emergencies may arise at any point during root canal treatment, but they most commonly occur within the first 2 weeks following intervention. The omission of intracanal medicament in multiple-visit molar root canal treatments, performed by undergraduate students, did not significantly increase the incidence of these emergencies.

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Effect of cryotherapy duration on experimentally induced connective tissue inflammation in vivo: Jorge Vera, Mayra Alejandra Castro-Nuñez, María Fernanda Troncoso-Cibrian, Ana Gabriela Carrillo-Varguez, Edgar Ramiro Méndez Sánchez, Viviana Sarmiento, Lourdes Lanzagorta-Rebollo, Prasanna Neelakantan, Monica Romero, Ana Arias; Restor Dent Endod 2023;48(3):e29. Published online August 2, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e29

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Objectives

This study tested the hypothesis that cryotherapy duration influences lipopolysaccharide (LPS)-induced inflammation in a rat model.

Materials and Methods

Six Wistar rats (Rattus norvegicus albinus) were used. Five sites were selected per animal and divided into 5 groups: a negative control group (NC), 2 positive control groups (PC1 and PC2), and 2 experimental groups (E1 and E2). Cryotherapy was applied for 1 minute (E1) or 5 minutes (E2). An acute inflammatory response was induced in the PC and E groups via subcutaneous administration of 0.5 mL/kg. In the PC2 group, a catheter was inserted without additional treatment. For the E1 and E2 groups, 2.5°C saline solution was administered through the implanted catheters for 1 and 5 minutes, respectively. The rats were sacrificed, and samples were obtained and processed for histological analysis, specifically examining the presence of polymorphonuclear neutrophils and hemorrhage. The χ² test was used to compare the presence of acute inflammation across groups. Dependent variables were compared using the linear-by-linear association test.

Results

Inflammation and hemorrhage varied significantly among the groups (p = 0.001). A significantly higher degree of acute inflammation was detected (p = 0.0002) in the PC and E1 samples than in the E2 group, in which cryotherapy was administered for 5 minutes. The PC and E1 groups also exhibited significantly greater numbers of neutrophils (p = 0.007), which were essentially absent in both the NC and E2 groups.

Conclusions

Cryotherapy administration for 5 minutes reduced the acute inflammation associated with LPS and catheter implantation.

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Determining Efficacy of Intracanal Cryotherapy on Post Endodontic Pain in Irreversible Pulpitis
Anam Fayyaz Bashir, Ussamah Waheed Jatala, Moeen ud din Ahmad, Muhammad Talha Khan, Saima Razzaq Khan, Aisha Arshad Butt
Pakistan Journal of Health Sciences.2024; : 68. CrossRef

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Review Article

Effect of endodontic sealer on postoperative pain: a network meta-analysis: Cynthia Maria Chaves Monteiro, Ana Cristina Rodrigues Martins, Alessandra Reis, Juliana Larocca de Geus; Restor Dent Endod 2023;48(1):e5. Published online December 29, 2022; DOI: https://doi.org/10.5395/rde.2023.48.e5

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This systematic review and network meta-analysis aimed to answer the following focused research question: “Does the type of endodontic sealer affect the postoperative pain in patients who received endodontic treatment?” Different databases and grey literature were surveyed. Only one randomized controlled trial were included. The risk of bias in the studies was evaluated by using the Cochrane Collaboration’s tool. A random-effects meta-analysis was conducted to compare the risk and intensity of postoperative pain. The quality of the body of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Out of 11,601 studies, 15 remained for qualitative analyses and 12 for meta-analysis. Seven studies were classified at high risk of bias, and 8 studies raised some concerns. No significant differences between the endodontic materials were observed in the direct comparisons, both in risk and in intensity of postoperative pain (pairwise comparisons with 2 studies: I² = 0%; p > 0.05 and 8 studies: I² = 23%; p > 0.05, respectively). The certainty of the evidence was graded as low or moderate. There was no difference in the risk and intensity of postoperative pain after filling with different endodontic sealers. Further systematic reviews should be conducted.

Trial Registration

PROSPERO Identifier: CRD42020215314

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Comparative evaluation of postoperative pain and periapical healing after root canal treatment using three different endodontic sealers: A randomized controlled clinical trial
Ruchika Pandey, Nitin Kararia, Deepak Kumar Sharma, Vishal Rathod, Anand Vilas Bansod, Dhaval Desai
Journal of Conservative Dentistry and Endodontics.2024; 27(9): 962. CrossRef
Effect of bioceramic-based and resin-based sealers on postoperative discomfort following root canal therapy: a systematic review and meta-analysis
Mansi Supare, Ajinkya M. Pawar, Kashmira Sawant, Dian Agustin Wahjuningrum, Suraj Arora, Firas Elmsmari, Mohmed Isaqali Karobari, Bhagyashree Thakur
PeerJ.2024; 12: e18198. CrossRef
Comparative Evaluation of Incidences of Post Operative Pain in Patient Treated in Single Visit Root Canal Treatment by Using Different Sealers: - An in-Vivo Study
Sadashiv Daokar, Aishwarya Ranjalkar, Kalpana Pawar, Komal Potfode, Dhanashri Padwal, Sana Khan
International Journal of Innovative Science and Research Technology (IJISRT).2024; : 2743. CrossRef

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Research Articles

Effect of intracanal cryotherapy on postoperative pain after endodontic treatment: systematic review with meta-analysis: Fernanda Garcias Hespanhol, Ludmila Silva Guimarães, Lívia Azeredo Alves Antunes, Leonardo Santos Antunes; Restor Dent Endod 2022;47(3):e30. Published online July 4, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e30

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Objectives

This study aimed to evaluate the effectiveness of final irrigation with cold saline solution after endodontic treatment compared with saline solution at room temperature against postoperative pain following endodontic treatment.

Materials and Methods

A broad search was performed in the PubMed, Web of Science, Scopus, Cochrane Library, Virtual Health Library (LILACS), and Grey Literature databases. Two independent reviewers performed data extraction, risk of bias using the Cochrane methodology, and certainty of evidence using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.

Results

Eight studies were included in qualitative synthesis. Intracanal cryotherapy favored the reduction of postoperative pain in the systematic review. Four studies were included in meta-analyses. The meta-analysis showed that intracanal cryotherapy reduced postoperative pain in teeth with symptomatic apical periodontitis (SAP) at 24 hours. There was no association between intracanal cryotherapy and control (room temperature) groups in teeth with normal periapical tissue with respect to postoperative pain at 24 hours and 48 hours.

Conclusions

Intracanal cryotherapy was effective in reducing postoperative pain after endodontic treatment in teeth with SAP.

Citations

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Determining Efficacy of Intracanal Cryotherapy on Post Endodontic Pain in Irreversible Pulpitis
Anam Fayyaz Bashir, Ussamah Waheed Jatala, Moeen ud din Ahmad, Muhammad Talha Khan, Saima Razzaq Khan, Aisha Arshad Butt
Pakistan Journal of Health Sciences.2024; : 68. CrossRef
The effect of intracanal cryotherapy with and without foraminal enlargement on pain prevention after endodontic treatment: a randomized clinical trial
Marcos Felipe Iparraguirre Nuñovero, Marco Antonio Hungaro Duarte, André Vinícius Kaled Segato, Ulisses Xavier da Silva Neto, Vania Portela Ditzel Westphalen, Everdan Carneiro
Scientific Reports.2024;[Epub] CrossRef
Effect of cryotherapy duration on experimentally induced connective tissue inflammationin vivo
Jorge Vera, Mayra Alejandra Castro-Nuñez, María Fernanda Troncoso-Cibrian, Ana Gabriela Carrillo-Varguez, Edgar Ramiro Méndez Sánchez, Viviana Sarmiento, Lourdes Lanzagorta-Rebollo, Prasanna Neelakantan, Monica Romero, Ana Arias
Restorative Dentistry & Endodontics.2023;[Epub] CrossRef
Evaluation of knowledge and awareness of pediatric oral health among school teachers of Hazaribag before and after oral health education.
Vipin Ahuja, Annapurna Ahuja, Nilima Thosar
F1000Research.2023; 12: 1292. CrossRef

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Effects of different topical anesthetics on pain from needle insertion and injection, and the influence of anxiety in patients awaiting endodontic treatment: Fatih Aksoy, Samet Tosun; Restor Dent Endod 2022;47(3):e25. Published online June 7, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e25

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Objectives

This study aimed to evaluate the effects of 5% lidocaine and 2.5% lidocaine/2.5% prilocaine topical anesthetic on pain during needle insertion and infiltration injection in the labial mucosa of anterior maxillary teeth, and to assess the relationship between patients’ anxiety and pain scores.

Materials and Methods

The Modified Dental Anxiety Scale questionnaire was applied and recorded. Patients were randomly divided into 4 groups (n = 30), as follows: G1 group: 5% lidocaine and placebo for 1 minute, G2 group: 2.5% lidocaine/2.5% prilocaine and placebo for 1 minute, G3 group: 5% lidocaine and placebo for 3 minutes, and G4 group: 2.5% lidocaine/2.5% prilocaine and placebo for 3 minutes. Before the application of topical anesthesia, one side was randomly selected as the topical anesthesia and the contralateral side as the placebo. The pain levels were measured with Visual Analog Scale (VAS) immediately after needle insertion and injection and were compared. The correlation between anxiety and pain scores was analyzed.

Results

Administration of 5% lidocaine for 1 minute had significantly higher pain scores for both insertion and infiltration injection than the other groups (p < 0.05). There was a significant moderate positive correlation between dental anxiety and the injection-induced VAS pain score in the placebo side in all groups (p < 0.05).

Conclusions

Topical anesthetics significantly reduced the pain caused by both needle insertion and injection pain in comparison to the placebo side. The pain scores of patients with dental anxiety were lower on the topical anesthesia compared to the placebo side.

Trial Registration

Thai Clinical Trials Registry Identifier: TCTR20201217002

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Phacoemulsification Techniques and Their Effects on Corneal Endothelial Cells and Visual Acuity: A Review of "Direct-Chop" and "Stop-and-Chop" Approaches Under Topical Anesthesia
Devwrath Upasani, Sachin Daigavane
Cureus.2024;[Epub] CrossRef
Local anaesthetics in pediatric dental practice (literature review)
E. V. Ekimov, G. I. Skripkina, A. Zh. Garifullina, N. V. Chumichkin
Pediatric dentistry and dental prophylaxis.2023; 23(3): 211. CrossRef

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Postoperative pain after endodontic treatment of necrotic teeth with large intentional foraminal enlargement: Ricardo Machado, Daniel Comparin, Sérgio Aparecido Ignácio, Ulisses Xavier da Silva Neto; Restor Dent Endod 2021;46(3):e31. Published online May 31, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e31

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Objectives

To evaluate postoperative pain after endodontic treatment of necrotic teeth using large intentional foraminal enlargement (LIFE).

Materials and Methods

The sample included 60 asymptomatic necrotic teeth (with or without chronic apical periodontitis), and a periodontal probing depth of 3 mm, previously accessed and referred to perform endodontic treatment. After previous procedures, the position and approximate size of the apical foramen (AF) were determined by using an apex locator and K flexo-files, respectively. The chemomechanical preparation was performed with Profile 04 files 2 mm beyond the AF to achieve the LIFE, using 2.5 mL of 2.5% NaOCl at each file change. The filling was performed by Tagger's hybrid technique and EndoFill sealer. Phone calls were made to all the patients at 24, 48 and 72 hours after treatment, to classify postoperative pain. Statistical analysis was performed by different tests with a significance level of 5%.

Results

Age, gender, periradicular status and tooth type did not influence postoperative pain (p > 0.05). Only 1 patient (1.66%) reported severe pain after 72 hours. Moderate pain was reported by 7, 4 and 3 patients after 24, 48 and 72 hours, respectively (p = 0.0001). However, paired analyses showed a statistically significant difference only between 24 and 72 hours (p = 0.04). Sealer extrusion did not influence the postoperative pain (p > 0.05).

Conclusions

Acute or moderate postoperative pain was uncommon after endodontic treatment of necrotic teeth with LIFE.

Trial Registration

The Brazilian Clinical Trials Registry Identifier: RBR-3r967t

Citations

Citations to this article as recorded by

Assessment of apical extrusion in regenerative endodontics: a comparative study of different irrigation methods using three-dimensional immature tooth models
Vahide Hazal Abat, Gökçen Deniz Bayrak, Mustafa Gündoğar
Odontology.2025; 113(1): 213. CrossRef
Postoperative pain after single-visit root canal treatments in necrotic teeth comparing instruments’ kinematics and apical instrumentation limits – a prospective randomized multicenter clinical trial
Ricardo Machado, Guilherme Moreira, Daniel Comparin, Arthur Pimentel Barroso, Jaqueline Nascimento, Caio Cézar Randi Ferraz, Sérgio Aparecido Ignácio, Lucas da Fonseca Roberti Garcia, Rodrigo Rodrigues Amaral, David Shadid, Ulisses Xavier da Silva Neto
BMC Oral Health.2024;[Epub] CrossRef
Assessment of mechanical allodynia in healthy teeth adjacent and contralateral to endodontically diseased teeth: a clinical study
Vaishnavi Ratnakar Patankar, Ashish K Jain, Rahul D Rao, Prajakta R Rao
Restorative Dentistry & Endodontics.2024;[Epub] CrossRef
A systematic review and meta-analysis on the effects of phototherapy on postoperative pain in conventional endodontic reintervention
Larissa Pereira Nunes, Gabriel Pereira Nunes, Túlio Morandin Ferrisse, Henrico Badaoui Strazzi-Sahyon, Eloi Dezan-Júnior, Luciano Tavares Angelo Cintra, Gustavo Sivieri-Araujo
Clinical Oral Investigations.2024;[Epub] CrossRef
The effect of intracanal cryotherapy with and without foraminal enlargement on pain prevention after endodontic treatment: a randomized clinical trial
Marcos Felipe Iparraguirre Nuñovero, Marco Antonio Hungaro Duarte, André Vinícius Kaled Segato, Ulisses Xavier da Silva Neto, Vania Portela Ditzel Westphalen, Everdan Carneiro
Scientific Reports.2024;[Epub] CrossRef
Clinical determination of anatomical diameter in different dental groups correlating them with gender, age, tooth/canal and pulpoperiradicular diagnosis: an observational clinical study
Ricardo Machado, Gabriel Filipe Pamplona, Claudemir de Souza Júnior, Jaqueline Nascimento, Eduardo Donato Eing Elgelke Back, Daniel Comparin, Sérgio Aparecido Ignácio, Stella Maria Glaci Reinke, Ana Cristina Kovalik, Ulisses Xavier da Silva Neto
Scientific Reports.2023;[Epub] CrossRef
How much to enlarge? A letter to the editor
Krishnamachari Janani, Kavalipurapu Venkata Teja, Kumar Chandan Srivatsava
Saudi Endodontic Journal.2023; 13(3): 288. CrossRef
Efficiency of diode laser in control of post-endodontic pain: a randomized controlled trial
Hend H. Ismail, Maram Obeid, Ehab Hassanien
Clinical Oral Investigations.2023; 27(6): 2797. CrossRef
Periapical Healing following Root Canal Treatment Using Different Endodontic Sealers: A Systematic Review
Akshay Khandelwal, Krishnamachari Janani, KavalipurapuVenkata Teja, Jerry Jose, Gopi Battineni, Francesco Riccitiello, Alessandra Valletta, Ajitha Palanivelu, Gianrico Spagnuolo, Vincenzo Grassia
BioMed Research International.2022;[Epub] CrossRef

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Review Article

Clinical efficacy of activated irrigation in endodontics: a focused review: Amelia Wan Tin Cheung, Angeline Hui Cheng Lee, Gary Shun Pan Cheung; Restor Dent Endod 2021;46(1):e10. Published online January 26, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e10

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Root canal debridement, which includes the removal of infected tissues and microbial biofilms, is considered the corner stone of root canal treatment. Chemical adjuncts play a multitude of functions in this regard, as tissue solvents, antimicrobial agents and for removing the smear layer. These adjuncts (irrigants) are usually delivered using a syringe and needle. With increasing knowledge of the complexity of root canal anatomy and tenacity of microbial biofilms, the need for strategies that potentiate the action of these irrigants within the root canal system cannot be overemphasized. Several such activated irrigation strategies exist. The aim of this review is to comprehensively discuss the different irrigant activation methods from the context of clinical studies.

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REVOLUCIONANDO LA ENDODONCIA: LA IMPORTANCIA DE IRRIGANTES MÚLTIPLES PARA UNA DESINFECCIÓN EFECTIVA DEL SISTEMA DE CONDUCTOS RADICULARES UNA REVISIÓN NARRATIVA
Irving Pablo Fernandez Calle, Edwin Macias Limachi , Abigail Marisol Vargas Ticona , Jenny Paula Aguilar Avalos , Marivel Irene Condori Escobar, Alcides Ramber Maldonado Huaycho , Jenny Claudia Apaza Cayo , Miguel Angel Espinoza Vega , Jesús Alejan
RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218.2024; 5(11): e5115929. CrossRef
Cleaning and disinfection of the root canal system provided by four active supplementary irrigation methods
Alessandra Timponi Goes Cruz, Adriane Antoniw Klemz, Edvaldo Antônio Ribeiro Rosa, Fabiana Soares Grecca, Bianca Mattos, Lucila Piasecki, Ricardo Machado, Sérgio Aparecido Ignácio, Ulisses Xavier da Silva Neto
Scientific Reports.2024;[Epub] CrossRef
Postendodontic Pain Using Single File System with Different Irrigation Protocols in Single-visit Root Canal Treatment: A Randomized Control Trial
Kiran Patel, Kailash Attur, Nishtha Patel, Kamal M Bagda, Karthik P Venkataraghavan, Mohammed B Mustafa, Shylaja K Attur
The Journal of Contemporary Dental Practice.2024; 25(2): 180. CrossRef
Bacteria debridement efficacy of two sonic root canal irrigant activation systems
Chang Zeng, Pei Hu, Colin P. Egan, Brian E. Bergeron, Franklin Tay, Jingzhi Ma
Journal of Dentistry.2024; 140: 104770. CrossRef
Evaluation of different activated irrigation protocols on debridement quality in various access cavity designs
Urvashi M. Ujariya, Mitul Lallubhai Gangani, Rajendra P. Bharatiya, Anjali K. Kothari
Endodontology.2024; 36(4): 400. CrossRef
Synergistic antimicrobial potential of EGCG and fosfomycin against biofilms associated with endodontic infections
Cristiane DUQUE, Amanda Caselato Andolfatto SOUZA, Kelly Limi AIDA, Jesse Augusto PEREIRA, Karina Sampaio CAIAFFA, Vanessa Rodrigues dos SANTOS, Leopoldo COSME-SILVA, Anuradha PRAKKI
Journal of Applied Oral Science.2023;[Epub] CrossRef
Insights of fluid dynamics in an optimally shaped root canal system
Kavalipurapu Venkata Teja, Sindhu Ramesh, Krishnamachari Janani
Saudi Endodontic Journal.2023; 13(2): 216. CrossRef
Diamond–coated ultrasonic tip decreases debris and uninstrumented surface after preparation of curved canals with isthmus
Maria Luiza GIOSTER–RAMOS, Mariana Mena Barreto PIVOTO–JOÃO, Jáder Camilo PINTO, Juliane Maria GUERREIRO–TANOMARU, Mário TANOMARU–FILHO
Brazilian Oral Research.2023;[Epub] CrossRef
Effectiveness of Passive Ultrasonic Irrigation Protocols in Simulated Complex Root Canal Cavities
Flávia A. Plazza, Renan Dal-Fabbro, Leopoldo Cosme-Silva, Paulo C. T. Duarte, Caroline Loureiro, Vitória Z. Custódio, Luciano T. A. Cintra, Marco A. H. Duarte, João Eduardo Gomes-Filho
Oral.2022; 3(1): 1. CrossRef
Comparison of sealer penetration of sonic activation versus conventional needle irrigation: a systematic review and meta-analysis of randomized controlled trials
Li Tan, Qiong Liu, Yun Chen, Ya-Qiong Zhao, Jie Zhao, Marie Aimee Dusenge, Yao Feng, Qin Ye, Jing Hu, Ze-Yue Ou-Yang, Ying-Hui Zhou, Yue Guo, Yun-Zhi Feng
BMC Oral Health.2022;[Epub] CrossRef
Efficacy of Photoinduced Photoacoustic Streaming and Diode Laser Irrigation Techniques on Smear Layer Removal, Sealer Penetration and Push-out Bond Strength
Latifa Mohamed Abdelgawad, Nancy Attia Ahmed ElShafei, Somaia Abdlatif Eissa, Dalia Yahia Ibrahim
Journal of Lasers in Medical Sciences.2022; 13(1): e12. CrossRef
Microbiological Aspects of Root Canal Infections and Disinfection Strategies: An Update Review on the Current Knowledge and Challenges
Jasmine Wong, Daniel Manoil, Peggy Näsman, Georgios N. Belibasakis, Prasanna Neelakantan
Frontiers in Oral Health.2021;[Epub] CrossRef
In vitro evaluation of efficacy of two endodontic sonic-powered irrigant agitation systems in killing single-species intracanal biofilms
Chang Zeng, Joseph Everett, Stephanie Sidow, Brian E. Bergeron, Fucong Tian, Jingzhi Ma, Franklin R. Tay
Journal of Dentistry.2021; 115: 103859. CrossRef
A novel three‐dimensionally printed model to assess biofilm removal by ultrasonically activated irrigation
Min‐Ji Choi, Mi‐Ah Kim, Yoorina Choi, Prasanna Neelakantan, Mi‐Kyung Yu, Kyung‐San Min
International Endodontic Journal.2021; 54(10): 1871. CrossRef

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Research Articles

Influence of pain-relieving therapies on inflammation and the expression of proinflammatory neuropeptides after dental bleaching treatment: Livia Maria Alves Valentim da Silva, Luciano Tavares Angelo Cintra, Marjorie de Oliveira Gallinari, Francine Benetti, Vanessa Rahal, Edilson Ervolino, Sibele de Alcântara, André Luiz Fraga Briso; Restor Dent Endod 2020;45(2):e20. Published online February 28, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e20

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Objectives

To minimize the tooth sensitivity caused by in-office bleaching, many dentists use non-steroidal anti-inflammatory drugs and topical desensitizing gels containing potassium nitrate and sodium fluoride. This study aimed to evaluate the influence of these substances on inflammation and the expression of substance P and calcitonin gene-related peptide in pulp nerve fibers.

Materials and Methods

Seventy-two rats were divided into 6 groups as follows: GI, control; GII, only dental bleaching; GIII, only ibuprofen; GIV, ibuprofen administered 30 minutes before and after the bleaching treatment and every 12 hours until the analysis; GV, only topical application of a desensitizing agent; and GVI, topical application of a desensitizing agent before dental bleaching. Placebo gel was applied to the upper left jaw and the bleaching agent was applied to the upper right jaw in all groups. Subsequently, the groups were divided into 3 subgroups based on the time of analysis: 0, 24, and 48 hours after bleaching (n = 8). The rats were euthanized and the maxillae were processed and evaluated by histopathological and immunohistochemical analyses. The data were analyzed using the Kruskal-Wallis test, followed by the Dunn test (p < 0.05).

Results

In the bleaching groups, the inflammatory process and expression of neuropeptides decreased over time. The animals in which a desensitizing agent was applied showed better results within 24 hours.

Conclusions

The use of a desensitizing agent had positive effects on inflammation and pain-related neuropeptide expression, minimizing the painful effects of dental bleaching treatment.

Citations

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Effectiveness of Analgesics in Dental Whitening Pain Management: A Systematic Review and Meta-Analysis
Gabriella Alves Julião Costa, Caio Ferreira Freire Caetano, Ravy Jucá Farias, Diana Araújo Cunha, Dayrine Silveira de Paula, Edson Luiz Cetira Filho, Paulo Goberlânio de Barros Silva
Expert Opinion on Pharmacotherapy.2025; 26(5): 639. CrossRef
Influence of dental bleaching on the pulp tissue: A systematic review of in vivo studies
Mariana Viana Donato, Alexandre Henrique dos Reis‐Prado, Lucas Guimarães Abreu, Lara Cancella de Arantes, Juliana Goto, Hebertt Gonzaga dos Santos Chaves, Luciano Tavares Angelo Cintra, André Luiz Fraga Briso, Isabella Faria da Cunha Peixoto, Francine Ben
International Endodontic Journal.2024; 57(6): 630. CrossRef
Role of induced nitric oxide synthases in orofacial nociception/discomfort after dental tooth bleaching with hydrogen peroxide
Marcílio Rodrigues Pinto, Kirlya Isabel da Silva Medeiros, Letícia Menezes Maia, Antonio Alexandre Coelho, Ana Paula Negreiros Nunes Alves, Caio Ferreira Freire Caetano, Karine Cestaro Mesquita, Paulo Goberlânio de Barros Silva, Fabricio Bitu Sousa
Archives of Oral Biology.2024; 161: 105937. CrossRef
Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research
Letícia Aparecida Silva Batista, Alexandre Henrique dos Reis-Prado, Hebertt Gonzaga dos Santos Chaves, Lara Cancella de Arantes, Luís Fernando Santos Alves Morgan, Carolina Bosso André, Thaís Yumi Suzuki, Francine Benetti
Restorative Dentistry & Endodontics.2023;[Epub] CrossRef
The Effects of Different Drugs with Anti-Inflamatory Potential in Prevention of Pulp Damage During the Teeth Bleaching
Miona Glisic, Andjela Milojevic, Milica Milinkovic, Marina Rankovic
Experimental and Applied Biomedical Research (EABR).2023;[Epub] CrossRef
Bleaching gel volume influences hydrogen peroxide diffusion, inflammation, and the presence of nitric oxide in the pulp tissue: in vitro and in vivo model
Sibele de ALCÂNTARA, Francine BENETTI, Lívia Maria Alves Valentim da SILVA, Nathália Evelyn da Silva MACHADO, Isabela Joane Prado SILVA, Lara Maria Bueno ESTEVES, Edilson ERVOLINO, Luciano Tavares Angelo CINTRA, André Luiz Fraga BRISO
Journal of Applied Oral Science.2023;[Epub] CrossRef
Design of a thermosensitive ibuprofen-loaded nanogel as smart material applied as anti-inflammatory in tooth bleaching: An in vivo study
Samara K.S.C.F. Moura, Milena L.V. dos Santos, Lucas A. do Nascimento, Mariana F.A. da Silva, Glória M. de França, Lucas M. da Costa, Aldo C. Medeiros, Raimundo F. Araújo-Júnior, Aurigena A. de Araújo, Cláudia N. Oliveira, André L. Dorini, Rejane A. de Ca
Journal of Drug Delivery Science and Technology.2022; 68: 103123. CrossRef
Topical application of Otosporin® before in-office bleaching: a split mouth, triple-blind, multicenter randomized clinical trial
Michael Willian Favoreto, Laína Vochikovski, Renata Maria Oleniki Terra, Veridiana Silva Campos, Mariana Evangelista Santos, Sônia Saeger Meireles, Alessandra Reis, Alessandro D. Loguercio
Clinical Oral Investigations.2022; 26(3): 2555. CrossRef
A novel tooth bleaching gel based on peroxymonosulfate/polyphosphates advanced oxidation process: Effective whitening avoiding pulp damage and sensitivity
Su Yang, Baiyan Sui, Xin Liu, Jiao Sun, Jun Wang
Chemical Engineering Journal.2022; 429: 132525. CrossRef
Effectiveness of Violet LED alone or in association with bleaching gel during dental photobleaching: A Systematic Review
Bianca Rossi, Susana Morimoto, Tamara Kerber Tedesco, Sandra Ribeiro Cunha, Anna Carolina Ratto Tempestini Horliana, Karen Müller Ramalho
Photodiagnosis and Photodynamic Therapy.2022; 38: 102813. CrossRef

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Effect of vibratory stimulation on pain during local anesthesia injections: a clinical trial: Sajedeh Ghorbanzadeh, Hoda Alimadadi, Nazanin Zargar, Omid Dianat; Restor Dent Endod 2019;44(4):e40. Published online October 24, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e40

Abstract PDF PubReader ePub

Objectives

This study aimed to assess the effect of DentalVibe on the level of pain experienced during anesthetic injections using 2 different techniques.

Materials and Methods

This randomized crossover clinical trial evaluated 60 patients who required 2-session endodontic treatment. Labial infiltration (LI) anesthesia was administered in the anterior maxilla of 30 patients, while inferior alveolar nerve block (IANB) was performed in the remaining 30 patients. 1.8 mL of 2% lidocaine was injected at a rate of 1 mL/min using a 27-gauge needle. DentalVibe was randomly assigned to either the first or second injection session. A visual analog scale was used to determine participants' pain level during needle insertion and the anesthetic injection. The paired t-test was applied to assess the efficacy of DentalVibe for pain reduction.

Results

In LI anesthesia, the pain level was 12.0 ± 15.5 and 38.1 ± 21.0 during needle insertion and 19.1 ± 16.1 and 48.9 ± 24.6 during the anesthetic injection using DentalVibe and the conventional method, respectively. In IANB, the pain level was 14.1 ± 15.9 and 35.1 ± 20.8 during needle insertion and 17.3 ± 14.2 and 39.5 ± 20.8 during the anesthetic injection using DentalVibe and the conventional method, respectively. DentalVibe significantly decreased the level of pain experienced during needle insertion and the anesthetic injection in anterior LI and mandibular IANB anesthesia.

Conclusions

The results suggest that DentalVibe can be used to reduce the level of pain experienced by adult patients during needle insertion and anesthetic injection.

Citations

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Effect of Vibration on Acute and Chronic Back Pain After Spinal Anesthesia: A Randomized Clinical Trial
Shervin Shahinpour, Fatemeh Refahi, Nader Ali Nazemian
Anesthesiology and Pain Medicine.2024;[Epub] CrossRef
Vibrating toothbrush, ice, or topical anesthetic agent to reduce pain of local anesthetic injection in 5- to 12-year-old children undergoing dental procedures — a randomized controlled trial
Meenu Mittal, Ashok Kumar, Radhika Chopra, Gurvinder Kaur, Sarang Sharma
Ain-Shams Journal of Anesthesiology.2023;[Epub] CrossRef
A Clinical Comparison of Pain Perception and Behavior in Children Using Conventional and Vibraject Injection Techniques
KS Mukunda, Calvin Hilary, C Preeja, G Midhun Mohan
World Journal of Dentistry.2022; 13(6): 623. CrossRef
Topical Anesthesia in Pediatric Dentistry: An Update

International Journal of Clinical Pediatric Dentistry.2022; 15(2): 240. CrossRef
Effect of Photobiomodulation Therapy with 915 nm Diode Laser on Pain Perception during Local Anesthesia of Maxillary Incisors: A Randomized Controlled Trial
Hamid Kermanshah, Nasim Chiniforush, Mahsa Kolahdouz Mohammadi, Fariba Motevasselian
Photochemistry and Photobiology.2022; 98(6): 1471. CrossRef
Comparative evaluation of pain perception during conventional greater palatine injections versus the use of a novel barovibrotactile device - In vivo study
Aishwarya Avinash Gangawane, Sonal Bhavesh Shah, Tanvi Eknath Malankar, Anmol Mathur, Shriya Shrirang Ginde, Manne Lakshmi Priyanka
Journal of Oral Biology and Craniofacial Research.2022; 12(5): 542. CrossRef
Efficacy of Higher Gauged Needles or Topical Pre-Cooling for Pain Reduction during Local Anesthesia Injection: A Split-Mouth Randomized Trial
Srikanth Gadicherla, Mihika Mahandwan, Shane Quek Yi Xuan, Kalyana-Chakravarthy Pentapati
Pesquisa Brasileira em Odontopediatria e Clínica Integrada.2021;[Epub] CrossRef
Auto-controlled Syringe vs Insulin Syringe for Palatal Injections in Children: A Randomized Crossover Trial
Sunny P Tirupathi, Srinitya Rajasekhar, Pushpalatha Tummakomma, Aishwarya Arya Gangili, Abdul Rehman Ahmed Khan, Mohammed Khurramuddin, Usha Purumandla
The Journal of Contemporary Dental Practice.2020; 21(6): 604. CrossRef

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Comparison of postoperative pain intensity after using reciprocating and continuous rotary glide path systems: a randomized clinical trial: Mehmet Adıgüzel, Koray Yılmaz, Pelin Tüfenkçi; Restor Dent Endod 2019;44(1):e9. Published online February 12, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e9

Abstract PDF PubReader ePub

Objectives

The aim of this study was to compare postoperative pain intensity after root canal treatment with One G (OG) vs. R-Pilot (RP) files used for glide path preparation.

Materials and Methods

Ninety-three single-canaled mandibular premolar teeth with asymptomatic non-vital pulp were randomly assigned into 3 groups (n = 31): OG, RP, or without glide path (WGP). After creating the glide path, the root canals were prepared using sequential Mtwo rotary files to size 30/0.05. One endodontic specialist carried out single-visit endodontic treatment. The patients were asked to rate the severity of postoperative pain on a visual analogue scale at 24, 48, and 72 hours after the visit. They were also asked to record their intake of prescribed analgesics taken. The data were analyzed using the χ², Friedman, Kruskal-Wallis, and Mann-Whitney U tests.

Results

In all 3 groups, postoperative pain decreased significantly at each time interval (p < 0.05). At 24 hours, the OG group had less postoperative pain than the WGP group (p < 0.05). However, no significant difference was found between the RP group and the others. No statistically significant difference was found among the WGP, OG, and RP groups in postoperative pain intensity at 48 or 72 hours or in analgesic tablet intake at the 3 assessed time intervals.

Conclusions

The OG group had less postoperative pain than the WGP group in the first 24 hours. The OG and RP systems were similar regarding postoperative pain intensity and analgesic intake.

Citations

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Postoperative pain in patients following endodontic treatment by XP-endo Shaper files: A systematic review and meta-analysis
Henal Nilesh Dedhia, Vibha R. Hegde, Maitri B. Bhayani, Sanitra R. Hegde
Journal of Conservative Dentistry and Endodontics.2024; 27(11): 1168. CrossRef
Postoperative Pain Following Single Visit Root Canal Treatment With Reciproc Blue And Hyflex EDM Instrumentation; A Prospective Randomized Clinical Trial
Nimet Gençoğlu, Anıl Özgün Karatekin, Mustafa Gündoğar
Meandros Medical And Dental Journal.2024; 25(1): 78. CrossRef
Glide Path in Endodontics: A Literature Review of Current Knowledge
Vlad Mircea Lup, Giulia Malvicini, Carlo Gaeta, Simone Grandini, Gabriela Ciavoi
Dentistry Journal.2024; 12(8): 257. CrossRef
Post-Operative Pain in Reciprocating Versus Rotary Kinematics Post-Endodontic Treatment: A Systematic Review
Youssef Algarni
Archives of Pharmacy Practice.2024; 15(2): 53. CrossRef
Evaluation of Pain Following the Use of Different Single-file Glide Path Systems: A Randomized Clinical Trial
Zeliha Danaci, Kübra Yeşildal Yeter
Journal of Endodontics.2024; 50(2): 120. CrossRef
Incidence of postoperative pain after using single continuous, single reciprocating, and full sequence continuous rotary file system: a prospective randomized clinical trial
Umesh Kumar, Pragnesh Parmar, Ruchi Vashisht, Namita Tandon, Charan Kamal Kaur
Journal of Dental Anesthesia and Pain Medicine.2023; 23(2): 91. CrossRef
Impact of kinematics on the efficiency and safety of an engine-driven file for glide path preparation in MB2 canals of maxillary molars
Larissa B. B. Araújo, Pedro H. S. Calefi, Murilo P. Alcalde, Giulio Gavini, Rodrigo R. Vivan, Marco Antonio Hungaro Duarte
Clinical Oral Investigations.2022; 27(3): 1153. CrossRef
Evaluation of Postoperative Pain after Pulpectomy using Different File Systems in Primary Teeth
Lakshimi Lakshmanan, Sujatha Somasundaram, Ganesh Jeevanandan, EMG Subramanian
Contemporary Clinical Dentistry.2021; 12(1): 3. CrossRef
Evaluation of type of kinematics on glide path procedures and torsional fatigue resistance after preparation of moderately curved canals
Murilo Priori Alcalde, Marco Antonio Hungaro Duarte, Pedro Henrique Souza Calefi, Victor de Moraes Cruz, Bruno Carvalho de Vasconcelos, Marcus Vinícius Reis Só, Rodrigo Ricci Vivan
Brazilian Oral Research.2021;[Epub] CrossRef
Influence of glide path kinematics during endodontic treatment on the occurrence and intensity of intraoperative and postoperative pain: a systematic review of randomized clinical trials
Thaís Christina Cunha, Felipe de Souza Matos, Luiz Renato Paranhos, Ítalo de Macedo Bernardino, Camilla Christian Gomes Moura
BMC Oral Health.2020;[Epub] CrossRef

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Intraoperative discomfort associated with the use of a rotary or reciprocating system: a prospective randomized clinical trial: Aline Cristine Gomes, Adriana Jesus Soares, Erick M Souza, Alexandre Augusto Zaia, Emmanuel João Nogueira Leal Silva; Restor Dent Endod 2017;42(2):140-145. Published online April 20, 2017; DOI: https://doi.org/10.5395/rde.2017.42.2.140

Abstract PDF PubReader ePub

Objectives

The aim of this randomized, controlled, prospective clinical study was to evaluate patients' intraoperative discomfort during root canal preparations in which either multi-file rotary (Mtwo) or single-file reciprocating (Reciproc) systems were used.

Materials and Methods

Fifty-five adult patients, aged between 25 and 69 years old, with irreversible pulpitis or pulp necrosis participated in this study. Either the mesiobuccal or the distobuccal canals for maxillary molars and either the mesiobuccal or the mesiolingual canals for mandibular molars were randomly chosen to be instrumented with Mtwo multi-file rotary or Reciproc single-file reciprocating systems. Immediately after each canal instrumentation under anesthesia, patient discomfort was assessed using a 1 - 10 visual analog scale (VAS), ranging from ‘least possible discomfort’ (1) to ‘greatest possible discomfort’ (10). The Wilcoxon signed-rank test was used to determine significant differences at p< 0.05.

Results

Little intraoperative discomfort was found in all cases. No statistically significant differences in intraoperative discomfort between the 2 systems were found (p = 0.660).

Conclusions

Root canal preparation with multi-file rotary or single-file reciprocating systems had similar and minimal effects on patients' intraoperative discomfort.

Citations

Citations to this article as recorded by

Post-Operative Pain in Reciprocating Versus Rotary Kinematics Post-Endodontic Treatment: A Systematic Review
Youssef Algarni
Archives of Pharmacy Practice.2024; 15(2): 53. CrossRef
Postoperative pain perception and associated risk factors in children after continuous rotation versus reciprocating kinematics: A randomised prospective clinical trial
Ahmad Abdel Hamid Elheeny, Dania Ibrahem Sermani, Mahmoud Ahmed Abdelmotelb
Australian Endodontic Journal.2023; 49(S1): 345. CrossRef
Patient discomfort levels during instrumentation procedure using nickel‐titanium files with different kinetic movements
So‐Ra Park, Se‐Hee Park, Kyung‐Mo Cho, Jin‐Woo Kim, Hyeon‐Cheol Kim
Australian Endodontic Journal.2022; 48(3): 372. CrossRef
Effect of XP‐endo Shaper versus conventional rotary files on postoperative pain and bacterial reduction in oval canals with necrotic pulps: a randomized clinical study
R. S. Emara, S. I. Gawdat, H. M. M. El‐Far
International Endodontic Journal.2021; 54(7): 1026. CrossRef
Effectiveness of a reciprocating single file, single cone endodontic treatment approach: a randomized controlled pragmatic clinical trial
Fabricio Eneas Diniz de Figueiredo, Laila F. Lima, Ludmila S. Oliveira, Maria A. Ribeiro, Marcos B. Correa, Manoel Brito-Junior, André L. Faria-e-Silva
Clinical Oral Investigations.2020; 24(7): 2247. CrossRef
Influence of glide path kinematics during endodontic treatment on the occurrence and intensity of intraoperative and postoperative pain: a systematic review of randomized clinical trials
Thaís Christina Cunha, Felipe de Souza Matos, Luiz Renato Paranhos, Ítalo de Macedo Bernardino, Camilla Christian Gomes Moura
BMC Oral Health.2020;[Epub] CrossRef
Comparison of postoperative pain intensity following the use of three different instrumentation techniques: A randomized clinical trial
Mehmet Adiguzel, Pelin Tufenkci, ismail Ilker Pamukcu
Journal of Dental Research, Dental Clinics, Dental Prospects.2019; 13(2): 133. CrossRef
Reciprocating kinematics leads to lower incidences of postoperative pain than rotary kinematics after endodontic treatment: A systematic review and meta-analysis of randomized controlled trial
ChristineMen Martins, VictorEduardo De Souza Batista, AmandaCaselato Andolfatto Souza, AnaCristina Andrada, GrazielaGarrido Mori, JoaoEduardo Gomes Filho
Journal of Conservative Dentistry.2019; 22(4): 320. CrossRef
Intraoperative Pain During Glide Path Creation with the Use of a Rotary or Reciprocating System
Pelin TUFENKCİ, Mehmet ADIGUZEL, Koray YILMAZ
Cumhuriyet Dental Journal.2019; 22(1): 66. CrossRef

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Prevalence of referral reasons and clinical symptoms for endodontic referrals: Seonah Kim; Restor Dent Endod 2014;39(3):210-214. Published online June 23, 2014; DOI: https://doi.org/10.5395/rde.2014.39.3.210

Abstract PDF PubReader ePub

Objectives

To investigate the prevalence of different primary reasons for endodontic referrals and the clinical symptoms of the referred cases.

Materials and Methods

Clinical data of total endodontic treatment cases (1,014 teeth) including endodontic referral cases (224 teeth) between January 1, 2010 and December 31, 2012, at Kangdong Sacred Heart Hospital, were investigated retrospectively. The one major reason for referral, the clinical symptoms, and the resulting treatment procedures of referral cases were recorded. The percentages of clinical symptoms of the endodontic referral cases and the total endodontic treatment cases were compared by χ² test for each symptom.

Results

Persistent pain was the most frequent reason for endodontic referral (29.5%), followed by presence of gingival swelling and sinus tract (24.1%), and apical radiolucency (12.9%). Referrals in cases involving endodontic difficulties such as canal calcification, broken instruments, post, perforation, and resorption were less than 5.0%, respectively. The percentages of four major clinical symptoms of pain, apical radiolucency, previous endodontic treatment, and gingival swelling and sinus tract were significantly higher in the endodontic referral cases than those in the total endodontic cases (p = 0.001). Among the included referral cases, 72.8% were treated with nonsurgical endodontic treatment only. Teeth other than the referred teeth were diagnosed as the origin of the problem in 5.8% of the referrals.

Conclusions

The high prevalence of pain, apical radiolucency, previous treatment, and gingival swelling and sinus tract in endodontic referral cases suggest that these symptoms may be what general practitioners consider to be difficult and refer to endodontists.

Citations

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VARIABLES AFFECTING PATIENT REFERRALS FROM GENERAL DENTAL PRACTITIONERS TO ENDODONTISTS
R. Peršić Bukmir, E Paljević, J. Vidas Hrstić, E Božac, I. Vidović Zdrilić, I. Brekalo Pršo
Česká stomatologie a praktické zubní lékařství.2024; 124(4): 89. CrossRef
The necessity and reasons for referrals to endodontists among general dentists in Mashhad: A cross-sectional study
Maryam Gharechahi, Armita Rouhani, Amin Khazai Ahmadi, Mina Davaji
Saudi Endodontic Journal.2024; 14(1): 75. CrossRef
A comparison of endodontic referrals and treatment in the public and private sectors in Western Australia
Charn Thanissorn, Johnson Ye, Daniel Girgis, Nathan van Dort, Paul V. Abbott
Australian Endodontic Journal.2023; 49(S1): 390. CrossRef
Case complexity of root canal treatments accepted for training in a secondary care setting assessed by three complexity grading systems: A service evaluation
Ruby Long, Arindam Dutta, Matthew B. M. Thomas, Morgana Eli Vianna
International Endodontic Journal.2022; 55(11): 1190. CrossRef
Comparing the pulp/tooth area ratio and dentin thickness of mandibular first molars in different age groups: A cone-beam computed tomography study
Mathukan Chaleefong, Sangsom Prapayasatok, Sakarat Nalampang, Phumisak Louwakul
Journal of Conservative Dentistry.2021; 24(2): 166. CrossRef
Survival of molar teeth in need of complex endodontic treatment: Influence of the endodontic treatment and quality of the restoration
Maurits C.F.M. de Kuijper, Eric W. Meisberger, Amarins G. Rijpkema, Cathleen T. Fong, Jantien H.W. De Beus, Mutlu Özcan, Marco S. Cune, Marco M.M. Gresnigt
Journal of Dentistry.2021; 108: 103611. CrossRef
Novel tier 2 service model for complex NHS endodontics
Gareth M. Thomas, Richard Newton, Warren J. Tolley, Karl Bishop
British Dental Journal.2021;[Epub] CrossRef
Assessment of Dentists’ Referral Patterns to Endodontist in Turkey
Öznur SARIYILMAZ, Elif KALYONCUOĞLU
Middle Black Sea Journal of Health Science.2020; 6(2): 220. CrossRef
Characteristics of teeth referred to a dental university hospital for endodontic reason
Su-Jin Jeon, Soo-Jeong Hwang, Min-Seock Seo
Journal of Dental Rehabilitation and Applied Science.2019; 35(3): 143. CrossRef
Characteristics of teeth referred to a public dental specialist clinic in endodontics
D. Sebring, H. Dimenäs, S. Engstrand, T. Kvist
International Endodontic Journal.2017; 50(7): 629. CrossRef

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Chlorhexidine gel associated with papain in pulp tissue dissolution: Gabriel Couto De Oliveira, Caio Souza Ferraz, Carlos Vieira Andrade Júnior, Matheus Melo Pithon; Restor Dent Endod 2013;38(4):210-214. Published online November 12, 2013; DOI: https://doi.org/10.5395/rde.2013.38.4.210

Abstract PDF PubReader ePub

Objectives

This study aimed to evaluate the capacity of 2% chlorhexidine gel associated with 8% papain gel in comparison with 5.25% sodium hypochlorite in bovine pulp tissue dissolution.

Materials and Methods

Ninety bovine pulps of standardized sizes were used and fragmented into 5-mm sizes. The fragments were removed from the root middle third region. They were divided into 6 experimental groups (n = 15), 1) 8% papain; 2) 2% chlorhexidine; 3) 2% chlorhexidine associated with 8% papain; 4) 0.9% saline solution; 5) 2.5% sodium hypochlorite; and 6) 5.25% sodium hypochlorite. The pulp fragments were weighed and put into immobile test tubes for dissolution for time intervals of 30, 60, 90, and 120 min.

Results

The 5.25% sodium hypochlorite had greater dissolution potential than the pure papain, and when associated with chlorhexidine, both promoted greater dissolution than did the saline solution and 2% chlorhexidine groups (p < 0.05). The 2.5% sodium hypochlorite promoted dissolution to a lesser extent than the groups with papain within a period of 30 min (p < 0.05), but, was comparable to the saline solution and chlorhexidine. After 120 min, the 2.5% and 5.25% sodium hypochlorite promoted dissolution of 100% of the pulp fragments, and papain, 61%, while chlorhexidine associated with papain and chlorhexidine alone dissolved only 55% and 3%, respectively.

Conclusions

The 8% papain in gel, both alone and in association with chlorhexidine, was able to dissolve bovine pulp tissue, but to a lesser extent than did 5.25% sodium hypochlorite.

Citations

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Effects of traditional and novel proteolytic agents on tissue dissolution and dentine microhardness
Shwetha Elizabeth Jacob, Niharika Prasad, Sreya Dutta, Vasavi Kumblekar, Srikant Natarajan, Kukkila Jayaprakash, Manuel Sebastian Thomas
Australian Endodontic Journal.2023; 49(2): 287. CrossRef
A Comparative Evaluation of Pulp Tissue Dissolving Ability of Three Different Pulp Dissolving Agents With 5.25% Sodium Hypochlorite: An In-Vitro Study
Ganesh Kalandar, Manoj Ramugade, Kishor Sapkale, Abrar Sayed, Sapna Sonkurla
International Journal of Orofacial Research.2023; 7(2): 42. CrossRef
Effect of bromelain and papain gel on enamel deproteinisation before orthodontic bracket bonding
Matheus Melo Pithon, Matheus Souza Campos, Raildo da Silva Coqueiro
Australasian Orthodontic Journal.2016; 32(1): 23. CrossRef

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The relationship between the level of salivary alpha amylase activity and pain severity in patients with symptomatic irreversible pulpitis: Fatemeh Ahmadi-Motamayel, Shahriar Shahriari, Mohammad Taghi Goodarzi, Abbas Moghimbeigi, Mina Jazaeri, Parisa Babaei; Restor Dent Endod 2013;38(3):141-145. Published online August 23, 2013; DOI: https://doi.org/10.5395/rde.2013.38.3.141

Abstract PDF PubReader ePub

Objectives

Assessment of dental pain severity is very challenging in dentistry. Previous studies have suggested that elevated salivary alpha amylase may contribute to increased physical stresses. There is a close association between salivary alpha amylase and plasma norepinephrine under stressful physical conditions. The aim of this study was to evaluate the relationship between pain severity and salivary alpha amylase levels in patients with symptomatic irreversible pulpitis.

Materials and Methods

Thirty-six patients (20 females and 16 males) with severe tooth pain due to symptomatic irreversible pulpitis were selected. The visual analogue scale (VAS) score was used to assess the pain severity in each patient. Unstimulated whole saliva was collected, and the level of alpha amylase activity was assessed by the spectrophotometric method. Statistical analysis was performed using SPSS 13.

Results

The level of alpha amylase was significantly increased in the saliva in association with pain severity assessed by VAS. The salivary alpha amylase was also elevated with increased age and in males.

Conclusions

There was a significant correlation between the VAS pain scale and salivary alpha amylase level, which indicates this biomarker may be a good index for the objective assessment of pain intensity.

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Diagnosis of Pain Deception Using Minnesota Multiphasic Personality Inventory-2 Based on XGBoost Machine Learning Algorithm: A Single-Blinded Randomized Controlled Trial
Hyewon Chung, Kihwan Nam, Subin Lee, Ami Woo, Joongbaek Kim, Eunhye Park, Hosik Moon
Medicina.2024; 60(12): 1989. CrossRef
Utilizing Saliva Biomarkers for Diagnostic Purposes
Fatemeh Ahmadi -Motamayel, Ali Mahdavinezhad, Seyedeh Sareh Hendi
Avicenna Journal of Dental Research.2024; 16(1): 46. CrossRef
Clinical correlation of salivary alpha-amylase levels with pain intensity in patients undergoing emergency endodontic treatment
Kavalipurapu Venkata Teja, Sindhu Ramesh, Krishnamachari Janani, Kumar Chandan Srivastava, Deepti Shrivastava, Valentino Natoli, Marco Di Blasio, Marco Cicciù, Giuseppe Minervini
BMC Oral Health.2023;[Epub] CrossRef
Statherin and alpha-amylase levels in saliva from patients with gingivitis and periodontitis
Hanife Merva Parlak, Esra Buber, Ali Tugrul Gur, Erdem Karabulut, Ferda Alev Akalin
Archives of Oral Biology.2023; 145: 105574. CrossRef
Topical review – salivary biomarkers in chronic muscle pain
Hajer Jasim
Scandinavian Journal of Pain.2023; 23(1): 3. CrossRef
Relationship between salivary alpha-amylase activity and pain relief scale score after low level laser therapy: a prospective interventional pilot study
Ryoji Iida, Junpei Konishi, Takahiro Suzuki
Lasers in Medical Science.2022; 37(1): 681. CrossRef
Assessment of salivary stress and pain biomarkers and their relation to self-reported pain intensity during orthodontic tooth movement: a longitudinal and prospective study
Nehir Canigur Bavbek, Erdal Bozkaya, Sila Cagri Isler, Sehri Elbeg, Ahu Uraz, Sema Yuksel
Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie.2022; 83(5): 339. CrossRef
Pain intensity and salivary α‐amylase activity in patients following mandibular third molar surgery
Wanvipa Surin, Piyanart Chatiketu, Nuntouchaporn Hutachok, Somdet Srichairatanakool, Vuttinun Chatupos
Clinical and Experimental Dental Research.2022; 8(5): 1082. CrossRef
Application of Salivary Biomarkers in the Diagnosis of Fibromyalgia
Rebeca Illescas-Montes, Víctor J. Costela-Ruiz, Lucía Melguizo-Rodríguez, Elvira De Luna-Bertos, Concepción Ruiz, Javier Ramos-Torrecillas
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The Correlation between Pain, Stress, and Oral Function in Oral and Maxillofacial Infection and Trauma Patients
Medyannisa Shafira, Tantry Maulina, Nurnayly Putri Lyana, Endang Sjamsudin, Andri Hardianto
The Open Dentistry Journal.2021; 15(1): 266. CrossRef
Comparison of the Zurich Observation Pain Assessment with the Behavioural Pain Scale and the Critical Care Pain Observation Tool in nonverbal patients in the intensive care unit: A prospective observational study
Martin R. Fröhlich, Gabriele Meyer, Rebecca Spirig, Lucas M. Bachmann
Intensive and Critical Care Nursing.2020; 60: 102874. CrossRef
Salivary Alpha-Amylase in Experimentally-Induced Muscle Pain
Nikolaos Christidis, Pegah Baghernejad, Aylin Deyhim, Hajer Jasim
Diagnostics.2020; 10(9): 722. CrossRef
Protein Signature in Saliva of Temporomandibular Disorders Myalgia
Hajer Jasim, Malin Ernberg, Anders Carlsson, Björn Gerdle, Bijar Ghafouri
International Journal of Molecular Sciences.2020; 21(7): 2569. CrossRef
The Relationship Between Salivary Alpha Amylase Activity and Score of McGill Pain Questionnaire in Patients With Tension Type Headache
Mohammad Vahedi, Mehrdokht Mazdeh, Mehrdad Hajilooi, Maryam Farhadian, Yasamin Barakian, Parastoo Sadr
Basic and Clinical Neuroscience Journal.2018; 9(1): 59. CrossRef
Salivary Stress-Related Responses in Tinnitus: A Preliminary Study in Young Male Subjects with Tinnitus
Ola A. Alsalman, Denise Tucker, Sven Vanneste
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Pain during embryo transfer is independently associated with clinical pregnancy in fresh/frozen assisted reproductive technology cycles
Sotirios H. Saravelos, Alice WY. Wong, Grace WS. Kong, Jin Huang, Robert Klitzman, Tin‐Chiu Li
Journal of Obstetrics and Gynaecology Research.2016; 42(6): 684. CrossRef

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Basic Research

Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth: Su-Jung Shin, Woocheol Lee, Jae-Il Lee, Seung-Ho Baek, Kee-Yeon Kum, Won-Jun Shon, Kwang-Shik Bae; J Korean Acad Conserv Dent 2011;36(3):196-202. Published online May 31, 2011; DOI: https://doi.org/10.5395/JKACD.2011.36.3.196

Abstract PDF PubReader ePub: Objectives
The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in root canal exudates during root canal treatment (RCT) of nonvital, painful teeth.
Materials and Methods
Patients scheduled for nonsurgical RCT were prospectively selected; the study was performed after obtaining informed consent from the patients and was approved by the Institutional Review Board for Clinical Research of Gangnam Severance Hospital, Yonsei University (3-2008-0118). Canal exudates samples were collected using sterilized paper points from teeth scheduled for RCT across three different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis (p < 0.05).
Results
MMP-8 and SP levels in GCF were decreased during RCT (p < 0.0001), and they showed a weak positive correlation to each other (p < 0.05). Patients'subjective pain levels and the response from percussion test were significantly related to SP level.
Conclusions
This study demonstrated that periradicular inflammation endodontic origin can elevate SP and MMP-8 levels in root canal exudates. Interestingly, SP level of canal exudates showed a possibility of being used as an indicator of pain due to periapical pathosis.

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Original Articles

Clinical diagnosis of herpes zoster presenting as odontogenic pain: Seong-Hak Yang, Dong-Ho Jung, Hae-Doo Lee, Yoon Lee, Hoon-Sang Chang, Kyung-San Min; J Korean Acad Conserv Dent 2008;33(5):452-456. Published online September 30, 2008; DOI: https://doi.org/10.5395/JKACD.2008.33.5.452

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Herpes zoster, an acute viral infection produced by the varicella zoster virus, may affect any of the trigeminal branches. This case report presents a patient with symptoms mimicking odontogenic pain. No obvious cause of the symptoms could be found based on clinical and radiographic examinations. After a dermatologist made a diagnosis of herpes zoster involving the third trigeminal branch, the patient was given antiviral therapy. Two months later, the facial lesions and pain had almost disappeared, and residual pigmented scars were present. During the diagnostic process, clinicians should keep in mind the possibility that orofacial pain might be related to herpes zoster.

Citations

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Herpes Zoster Accompanying Odontogenic Inflammation: A Case Report with Literature Review
Soyeon Lee, Minsik Kim, Jong-Ki Huh, Jae-Young Kim
Journal of Oral Medicine and Pain.2021; 46(1): 9. CrossRef
Recurrent Herpetic Stomatitis Mimicking Post-Root Resection Complication
Sung-Ok Hong, Jae-Kwan Lee, Hoon-Sang Chang
Journal of Dental Rehabilitation and Applied Science.2013; 29(4): 418. CrossRef
Diagnostic challenges of nonodontogenic toothache
Hyung-Ok Park, Jung-Hong Ha, Myoung-Uk Jin, Young-Kyung Kim, Sung-Kyo Kim
Restorative Dentistry & Endodontics.2012; 37(3): 170. CrossRef

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Expression of P2X₃ and its colocalization with trpv1 in the human dental pulp: Young Kyung Kim, Sung Kyo Kim; J Korean Acad Conserv Dent 2007;32(6):514-521. Published online November 30, 2007; DOI: https://doi.org/10.5395/JKACD.2007.32.6.514

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The purinoreceptor, P2X₃ is a ligand-gated cation channel activated by extracellular ATP. It has been reported that ATP can be released during inflammation and tissue damage, which in turn may activate P2X₃ receptors to initiate nociceptive signals. However, little is known about the contribution of P2X₃ to the dental pain during pulpal inflammation. Therefore, the purpose of this study was to investigate the expression of P2X₃ and its colocalization with TRPV1 to understand the mechanism of pain transmission through P2X₃ in the human dental pulp with double labeling immunofluorescence method.

In the human dental pulp, intense P2X₃ immunoreactivity was observed throughout the coronal and radicular pulp. Of all P2X₃-positive fibers examined, 79.4% coexpressed TRPV1.

This result suggests that P2X₃ along with TRPV1 may be involved in the transmission of pain and potentiation of noxious stimuli during pulpal inflammation.

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The effect of calcium hydroxide on post-treatment pain: Wook Nam, Sang-Hyuk Park, Gi-Woon Choi; J Korean Acad Conserv Dent 2006;31(2):86-95. Published online March 31, 2006; DOI: https://doi.org/10.5395/JKACD.2006.31.2.086

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The purpose of this clinical study is to assess whether calcium hydroxide as an intracanal medication affects post-treatment pain in teeth especially odontogenic pain which comes from inflammation of the pulp and periradicular tissues when compared with no intracanal medication.

From 213 patients who has been treated 237 root canals due to significant pain (moderate-to-severe), we recorded their age, sex, treated tooth, degree of pain, pre-operative states of the tooth. We classified patients into 2 test group; Group 1 (not gain intracanal Ca(OH)₂), Group 2 (gain intracanal Ca(OH)₂). Through the survey from the patients, we let them write down the occurrence and degree of post-treatment pain in 4hours, 2days, 7days after treatment as none, mild, moderate or severe. The followings were evaluated; the overall incidence of flare-ups, the overall incidence of post-treatment pain in each group at each time period, the incidence of post-treatment pain in each group at each time period as related to pre-operative states of the teeth. These were compared statistically with Chi-square analysis (p < 0.05).

Under the condition of this investigation, no difference was observed in the incidence of post-treatment pain between the two groups. Therefore, Ca(OH)₂ as intracanal medication had no effect on preventing or decreasing the post-treatment pain.

Citations

Citations to this article as recorded by

Calcium hydroxide intracanal medication effects on pain and flare-up: a systematic review and meta-analysis
Ahmed Mohamed Ibrahim, Siza Yacoub Zakhary, Suzan Abdul Wanees Amin
Restorative Dentistry & Endodontics.2020;[Epub] CrossRef
Intra-canal medication containing silver nanoparticle versus calcium hydroxide in reducing postoperative pain: A randomized clinical trial
Fatma El Zahraa El Abbasy, Salsabyl Ibrahim, Olfat Shaker, Geraldine Ahmed
F1000Research.2018; 7: 1949. CrossRef
A Comparison of the irrigation systems in calcium hydroxide removal
Jae-Seung Eun, Se-Hee Park, Kyung-Mo Cho, Jin-Woo Kim
Journal of Korean Academy of Conservative Dentistry.2009; 34(6): 508. CrossRef

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Measurement of the excessive stimulus time after the sensory threshold level during electric pulp testing: Ki-Chang Nam, Seon-Hui Ahn, Soo-Chan Kim, Deok-Won Kim, Seung-Jong Lee; J Korean Acad Conserv Dent 2004;29(3):226-232. Published online May 31, 2004; DOI: https://doi.org/10.5395/JKACD.2004.29.3.226

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Use of electric pulp testing elicits painful response in vital teeth. In this study, we examined the excessive time from pain feeling to stimulation disconnection in clinical situation. D626D (Parkell Inc., USA.) scan type electric pulp tester was used in total of 23 young healthy individuals. Each of the right central incisors and first premolars were used as testing teeth. Stimulation disconnection was achieved by EMG in anterior belly of digastric muscle, finger span, and voice and the excessive stimulation time over the sensory threshold was recorded. As a result, we found that the short responses before the stimulation disconnection appeared following order; EMG, finger span, and voice. The EMG disconnection is suggested to be used to reduce the excessive stimulus time in electric pulp testing.

Citations

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Evaluation of the change of lower lip sensation after inferior alveolar nerve block by using the electric pulp tester
Myong-Suk Ku, Jin Wook Kim, Young Hoon Jeon, Tae Geon Kwon, Sang Han Lee
Journal of the Korean Association of Oral and Maxillofacial Surgeons.2011; 37(6): 464. CrossRef

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