Restorative Dentistry & Endodontics

Review Article

Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review: Dina A. Hammouda, Alaa M Mansour, Mahmoud A. Saeed, Ahmed R. Zaher, Mohammed E. Grawish; Restor Dent Endod 2023;48(2):e20. Published online May 3, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e20

This mini-review was conducted to present an overview of the use of exosomes in regenerating the dentin-pulp complex (DPC). The PubMed and Scopus databases were searched for relevant articles published between January 1, 2013 and January 1, 2023. The findings of basic in vitro studies indicated that exosomes enhance the proliferation and migration of mesenchymal cells, as human dental pulp stem cells, via mitogen-activated protein kinases and Wingless-Int signaling pathways. In addition, they possess proangiogenic potential and contribute to neovascularization and capillary tube formation by promoting endothelial cell proliferation and migration of human umbilical vein endothelial cells. Likewise, they regulate the migration and differentiation of Schwann cells, facilitate the conversion of M1 pro-inflammatory macrophages to M2 anti-inflammatory phenotypes, and mediate immune suppression as they promote regulatory T cell conversion. Basic in vivo studies have indicated that exosomes triggered the regeneration of dentin-pulp–like tissue, and exosomes isolated under odontogenic circumstances are particularly strong inducers of tissue regeneration and stem cell differentiation. Exosomes are a promising regenerative tool for DPC in cases of small pulp exposure or for whole-pulp tissue regeneration.

Citations

Citations to this article as recorded by

Cell Homing Strategies in Regenerative Endodontic Therapy
David Kim, Sahng G. Kim
Cells.2025; 14(3): 201. CrossRef
Exosomes as Promising Therapeutic Tools for Regenerative Endodontic Therapy
Qingyue Kong, Yujie Wang, Nan Jiang, Yifan Wang, Rui Wang, Xiaohan Hu, Jing Mao, Xin Shi
Biomolecules.2024; 14(3): 330. CrossRef
Role and Molecular Mechanism of miR-586 in the Differentiation of Dental Pulp Stem Cells into Odontoblast-like Cells
Gang Pan, Qianwen Zhou, Chenhua Pan, Yingxue Zhang
Cell Biochemistry and Biophysics.2024; 83(1): 507. CrossRef

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Research Articles

Dentinal tubule penetration of sodium hypochlorite in root canals with and without mechanical preparation and different irrigant activation methods: Renata Aqel de Oliveira, Theodoro Weissheimer, Gabriel Barcelos Só, Ricardo Abreu da Rosa, Matheus Albino Souza, Rodrigo Gonçalves Ribeiro, Marcus Vinicius Reis Só; Restor Dent Endod 2023;48(1):e1. Published online December 1, 2022; DOI: https://doi.org/10.5395/rde.2023.48.e1

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Objectives

This study evaluated the dentinal penetration depth of 2.5% sodium hypochlorite (NaOCl) in root canals with and without preparation and different irrigant activation protocols.

Materials and Methods

Sixty-three bovine mandibular incisors were randomly allocated to 6 groups (n = 10): G1, preparation + conventional needle irrigation (CNI); G2, preparation + passive ultrasonic irrigation (PUI); G3, preparation + Odous Clean (OC); G4, no preparation + CNI; G5, no preparation + PUI; G6, no preparation + OC; and CG (negative control; n = 3). Samples were filled with crystal violet for 72 hours. Irrigant activation was performed. Samples were sectioned perpendicularly along the long axis, 3 mm and 7 mm from the apex. Images of the root thirds of each block were captured with a stereomicroscope and analyzed with an image analysis software. One-way analysis of variance, followed by the Tukey post hoc test, and the Student’s t-test were used for data analysis, with a significance level of 5%.

Results

The NaOCl penetration depth was similar when preparation was performed, regardless of the method of irrigation activation (p > 0.05). In the groups without preparation, G6 showed greater NaOCl penetration depth (p < 0.05). The groups without preparation had a greater NaOCl penetration depth than those with preparation (p = 0.0019).

Conclusions

The NaOCl penetration depth was similar in groups with root canal preparation. Without root canal preparation, OC allowed deeper NaOCl penetration. The groups without preparation had greater NaOCl penetration than those undergoing root canal preparation.

Citations

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Impact of different activation procedures on sodium hypochlorite penetration into dentinal tubules after endodontic retreatment via confocal laser scanning microscopy
Betul Gunes, Kübra Yeşildal Yeter, Yasin Altay
BMC Oral Health.2024;[Epub] CrossRef
Debridement ability of the WaveOne Gold and TruNatomy systems in the apical third of root canals: ex vivo assessment
Sara Carvalho Avelar de Oliveira, Carlos Eduardo da Silveira Bueno, Rina Andréa Pelegrine, Carlos Eduardo Fontana, Alexandre Sigrist de Martin, Carolina Pessoa Stringheta
Brazilian Dental Journal.2024;[Epub] CrossRef
Combined effect of electrical energy and graphene oxide on Enterococcus faecalis biofilms
Myung-Jin LEE, Mi-Ah KIM, Kyung-San MIN
Dental Materials Journal.2023; 42(6): 844. CrossRef

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Evaluation of blood clot, platelet-rich plasma, and platelet-rich fibrin–mediated regenerative endodontic procedures in teeth with periapical pathology: a CBCT study: Swati Markandey, Haridas Das Adhikari; Restor Dent Endod 2022;47(4):e41. Published online October 21, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e41

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Objectives

This study compared the clinical and radiological outcomes of regenerative endodontic procedures (REPs) using blood clots (BCs), platelet-rich plasma (PRP), and platelet-rich fibrin (PRF) through intraoral periapical radiography (IOPAR) and cone-beam computed tomography (CBCT).

Materials and Methods

Forty-five single-rooted necrotic teeth with periapical pathology were randomly allocated to receive BC, PRP, or PRF as an individual scaffold. Outcomes were evaluated in 35 teeth in 23 patients with a follow-up period of 12–24 months through qualitative IOPAR scoring and quantitative CBCT measurements. Healing of periapical lesions and in immature teeth, changes in the apical foramen diameter (AFD), root wall thickness (RWT), and root length (RL) were assessed. A p value less than 0.05 was considered to indicate statistical significance.

Results

All teeth were asymptomatic except 1 in the PRP group. Periapical lesion healing was seen in all except 2 teeth in the BC group and 3 in the PRP group. Both IOPAR and CBCT revealed no significant differences in bone healing or changes in AFD, RWT, and RL among the 3 groups. A positive pulp sensibility response to the cold test was seen in 2 teeth in the BC group, but none to the electric pulp test. Intracanal calcification (ICC) was evident in more teeth in the BC group than in the PRP and PRF groups, and was also significantly higher in immature teeth.

Conclusions

Our results revealed that BC, PRP, and PRF have similar potential as scaffolds in REPs, and ICC may be a concern for long-term outcomes.

Citations

Citations to this article as recorded by

Regenerative potential of concentrated growth factor compared to platelet-rich fibrin in treatment of necrotic mature teeth: a randomized clinical trial
Taghreed Salah, Wael Hussein, Heba Abdelkafy
BDJ Open.2025;[Epub] CrossRef
Biomimetic pulp scaffolds prepared from extracellular matrix derived from stem cells from human exfoliated deciduous teeth promote pulp–dentine complex regeneration
Ning Yang, Rou Shen, Wenxiao Yang, Shengcai Zhang, Tianxing Gong, Yao Liu
International Endodontic Journal.2024; 57(9): 1279. CrossRef
Arrest and Repair of Inflammatory Root Resorption After an Endodontic Regeneration Procedure – A Hypothesis and Case Report
Arieh Y. Kaufman, Bill Kahler
Journal of Endodontics.2024; 50(12): 1743. CrossRef
Effect of Platelet Rich Plasma in Regenerative Endodontic Treatment: A Review of Clinical Trials
Hojat Rezazadeh, Mehrnaz Okhovatfard
Research Journal of Pharmacy and Technology.2023; : 5562. CrossRef

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Clinical and radiographic outcomes of regenerative endodontic treatment performed by endodontic postgraduate students: a retrospective study: Hadi Rajeh Alfahadi, Saad Al-Nazhan, Fawaz Hamad Alkazman, Nassr Al-Maflehi, Nada Al-Nazhan; Restor Dent Endod 2022;47(2):e24. Published online May 9, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e24

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Objectives

Regenerative endodontic treatment is a clinical procedure aimed at biologically regenerating damaged root canal tissue of immature permanent teeth. This study aimed to report the outcomes of regenerative endodontic treatment performed by endodontic postgraduate students.

Materials and Methods

Clinical and radiographic data of 27 patients, aged 10–22 years, who underwent regenerative treatment of immature permanent teeth from 2015 to 2019 were followed up, wherein clinical and radiographic examinations were performed for each patient. Postoperative success rate and tooth survival were analyzed, and the postoperative radiographic root area changes were quantified.

Results

A total of 23 patients attended the dental appointments, showing that all teeth survived and were asymptomatic. Specifically, 7 periapical pathosis cases were completely healed, 12 were incompletely healed, and 4 cases failed. Moreover, significant differences were found between discolored and non-discolored teeth, and between the presence or absence of periapical radiolucency. Additionally, 3 anterior teeth showed complete closure of the apical foramen, while the apical foramen width was reduced in 17 teeth and failed in 3 teeth. Root length was also found to have been increased in 7 anterior and 4 posterior teeth, and the average length ranged from 4.00–0.63 mm in the anterior teeth, 2.85–1.48 mm of the mesial root, and 2.73–2.16 mm of the molar teeth distal root. Furthermore, calcified tissue deposition was observed in 7 teeth.

Conclusions

A favorable outcome of regenerative endodontic treatment of immature permanent teeth with necrotic pulp was achieved with a high survival rate.

Citations

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Allogeneic Bone Marrow Mesenchymal Stromal Cell Transplantation Induces Dentin Pulp Complex-like Formation in Immature Teeth with Pulp Necrosis and Apical Periodontitis
Jose Francisco Gomez-Sosa, José E. Cardier, Olga Wittig, Dylana Díaz-Solano, Eloisa Lara, Kharelys Duque, Giselle Ramos-González
Journal of Endodontics.2024; 50(4): 483. CrossRef
Radiographic assessment of dental post and core placement at different educational levels in an undergraduate student clinic: a 4-year retrospective study
Turki Alshehri, Nourhan M. Aly, Raand Altayyar, Deena Alghamdi, Shahad Alotaibi, Passent Ellakany
F1000Research.2024; 12: 976. CrossRef
Evaluation of the efficacy of injectable platelet‐rich fibrin versus platelet‐rich plasma in the regeneration of traumatized necrotic immature maxillary anterior teeth: A randomized clinical trial
Maha Mohamed Abo‐Heikal, Jealan M. El‐Shafei, Samia A. Shouman, Nehal N. Roshdy
Dental Traumatology.2024; 40(1): 61. CrossRef
Radiographical assessment of post and core placement errors encountered by Saudi dental students at different educational levels
Turki Alshehri, Nourhan M. Aly, Raand Altayyar, Deena Alghamdi, Shahad Alotaibi, Passent Ellakany
F1000Research.2023; 12: 976. CrossRef

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Comparative analysis of bond strength to root dentin and compression of bioceramic cements used in regenerative endodontic procedures: Maykely Naara Morais Rodrigues, Kely Firmino Bruno, Ana Helena Gonçalves de Alencar, Julyana Dumas Santos Silva, Patrícia Correia de Siqueira, Daniel de Almeida Decurcio, Carlos Estrela; Restor Dent Endod 2021;46(4):e59. Published online November 9, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e59

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Objectives

This study compared the Biodentine, MTA Repair HP, and Bio-C Repair bioceramics in terms of bond strength to dentin, failure mode, and compression.

Materials and Methods

Fifty-four slices obtained from the cervical third of 18 single-rooted human mandibular premolars were randomly distributed (n = 18). After insertion of the bioceramic materials, the push-out test was performed. The failure mode was analyzed using stereomicroscopy. Another set of cylindrically-shaped bioceramic samples (n = 10) was prepared for compressive strength testing. The normality of data distribution was analyzed using the Shapiro-Wilk test. The Kruskal-Wallis and Friedman tests were used for the push-out test data, while compressive strength was analyzed with analysis of variance and the Tukey test, considering a significance level of 0.05.

Results

Biodentine presented a higher median bond strength value (14.79 MPa) than MTA Repair HP (8.84 MPa) and Bio-C Repair (3.48 MPa), with a significant difference only between Biodentine and Bio-C Repair. In the Biodentine group, the most frequent failure mode was mixed (61%), while in the MTA Repair HP and Bio-C Repair groups, it was adhesive (94% and 72%, respectively). Biodentine showed greater resistance to compression (29.59 ± 8.47 MPa) than MTA Repair HP (18.68 ± 7.40 MPa) and Bio-C Repair (19.96 ± 3.96 MPa) (p < 0.05).

Conclusions

Biodentine showed greater compressive strength than MTA Repair HP and Bio-C Repair, and greater bond strength than Bio-C Repair. The most frequent failure mode of Biodentine was mixed, while that of MTA Repair HP and Bio-C Repair was adhesive.

Citations

Citations to this article as recorded by

Comparación de la resistencia compresiva entre el Agregado Trióxido Mineral y BiodentineTM en perforaciones de furca de molares inferiores permanentes
Jheymy Gerardo Huatuco-Granda, John Paul Torres-Navarro, Rosa Josefina Roncal-Espinoza
Revista Facultad de Odontología.2024;[Epub] CrossRef
Effects of different calcium-silicate based materials on fracture resistance of immature permanent teeth with replacement root resorption and osteoclastogenesis
Gabriela Leite de Souza, Gabrielle Alves Nunes Freitas, Maria Tereza Hordones Ribeiro, Nelly Xiomara Alvarado Lemus, Carlos José Soares, Camilla Christian Gomes Moura
Restorative Dentistry & Endodontics.2023;[Epub] CrossRef
Evaluation the Marginal Adaptation for the Bio C Repair and Other Root end Filling Material by Using Scanning Electron Microscope (A Comparative In Vitro Study)
Fatimah HAMADHİ, Zainab M.
Cumhuriyet Dental Journal.2023; 26(3): 261. CrossRef
Dentin Bond Strength of Calcium Silicate-Based Materials: A Systematic Review of In Vitro Studies
Natalia Radulica, José Luis Sanz, Adrián Lozano
Applied Sciences.2023; 14(1): 104. CrossRef
Evaluation Of The Push-out Bond Strength Of The Bio-C Repair And Compare It With The Mineral Trioxide Aggregate And Amalgam When Used As Root-end Filling Material
Fatimah R. Hammadi, Zainab M Abdul-Ameer
Dental Hypotheses.2023; 14(2): 62. CrossRef
Effect of different root canal irrigants on push-out bond strength of two novel root-end filling materials
Nada Omar, Rasha M. Abdelraouf, Tamer M. Hamdy
BMC Oral Health.2023;[Epub] CrossRef
Effect of irrigation systems on the bond strength of calcium-silicate-based cement used as pulp barrier in regenerative endodontic treatment
Cihan Hascizmeci, Burak Buldur
Journal of Adhesion Science and Technology.2023; 37(23): 3393. CrossRef

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Effect of hydrogel-based antibiotic intracanal medicaments on crown discoloration: Rayan B. Yaghmoor, Jeffrey A. Platt, Kenneth J. Spolnik, Tien Min Gabriel Chu, Ghaeth H. Yassen; Restor Dent Endod 2021;46(4):e52. Published online October 5, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e52

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Objectives

This study evaluated the effects of low and moderate concentrations of triple antibiotic paste (TAP) and double antibiotic paste (DAP) loaded into a hydrogel system on crown discoloration and explored whether application of an adhesive bonding agent prevented crown discoloration.

Materials and Methods

Intact human molars (n = 160) were horizontally sectioned 1 mm apical to the cementoenamel junction. The crowns were randomized into 8 experimental groups (calcium hydroxide, Ca[OH]₂; 1, 10, and 1,000 mg/mL TAP and DAP; and no medicament. The pulp chambers in half of the samples were coated with an adhesive bonding agent before receiving the intracanal medicament. Color changes (ΔE) were detected by spectrophotometry after 1 day, 1 week, and 4 weeks, and after 5,000 thermal cycles, with ΔE = 3.7 as a perceptible threshold. The 1-sample t-test was used to determine the significance of color changes relative to 3.7. Analysis of variance was used to evaluate the effects of treatment, adhesive, and time on color change, and the level of significance was p < 0.05.

Results

Ca(OH)₂ and 1 and 10 mg/mL DAP did not cause clinically perceivable tooth discoloration. Adhesive agent use significantly decreased tooth discoloration in the 1,000 mg/mL TAP group up to 4 weeks. However, adhesive use did not significantly improve coronal discoloration after thermocycling when 1,000 mg/mL TAP was used.

Conclusions

Ca(OH)₂ and 1 and 10 mg/mL DAP showed no clinical discoloration. Using an adhesive significantly improved coronal discoloration up to 4 weeks with 1,000 mg/mL TAP.

Citations

Citations to this article as recorded by

Root Canal Dentin Microhardness after Contact with Antibiotic Medications: An In Vitro Study
Amanda Palmeira Arruda Nogueira, Renata Grazziotin-Soares, Adriana Marques Mesquita Leal, Sérgio Alves Guida Freitas Júnior, Bruna Laís Lins Gonçalves, José Bauer, Meire Coelho Ferreira, Ceci Nunes Carvalho
Dentistry Journal.2024; 12(7): 201. CrossRef
Potential Crown Discoloration Induced by the Combination of Various Intracanal Medicaments and Scaffolds Applied in Regenerative Endodontic Therapy
NB Altun, A Turkyilmaz
Nigerian Journal of Clinical Practice.2024; 27(7): 897. CrossRef

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A novel antimicrobial-containing nanocellulose scaffold for regenerative endodontics: Victoria Kichler, Lucas Soares Teixeira, Maick Meneguzzo Prado, Guilherme Colla, Daniela Peressoni Vieira Schuldt, Beatriz Serrato Coelho, Luismar Marques Porto, Josiane de Almeida; Restor Dent Endod 2021;46(2):e20. Published online March 16, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e20

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Objectives

The aim of this study was to evaluate bacterial nanocellulose (BNC) membranes incorporated with antimicrobial agents regarding cytotoxicity in fibroblasts of the periodontal ligament (PDLF), antimicrobial activity, and inhibition of multispecies biofilm formation.

Materials and Methods

The tested BNC membranes were BNC + 1% clindamycin (BNC/CLI); BNC + 0.12% chlorhexidine (BNC/CHX); BNC + nitric oxide (BNC/NO); and conventional BNC (BNC; control). After PDLF culture, the BNC membranes were positioned in the wells and maintained for 24 hours. Cell viability was then evaluated using the MTS calorimetric test. Antimicrobial activity against Enterococcus faecalis, Actinomyces naeslundii, and Streptococcus sanguinis (S. sanguinis) was evaluated using the agar diffusion test. To assess the antibiofilm activity, BNC membranes were exposed for 24 hours to the mixed culture. After sonicating the BNC membranes to remove the remaining biofilm and plating the suspension on agar, the number of colony-forming units (CFU)/mL was determined. Data were analyzed by 1-way analysis of variance and the Tukey, Kruskal-Wallis, and Dunn tests (α = 5%).

Results

PDLF metabolic activity after contact with BNC/CHX, BNC/CLI, and BNC/NO was 35%, 61% and 97%, respectively, compared to BNC. BNC/NO showed biocompatibility similar to that of BNC (p = 0.78). BNC/CLI showed the largest inhibition halos, and was superior to the other BNC membranes against S. sanguinis (p < 0.05). The experimental BNC membranes inhibited biofilm formation, with about a 3-fold log CFU reduction compared to BNC (p < 0.05).

Conclusions

BNC/NO showed excellent biocompatibility and inhibited multispecies biofilm formation, similarly to BNC/CLI and BNC/CHX.

Citations

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Topic: Perspectives on Success and Failure of Endodontic Treatments
Ilma Robo, Manola Kelmendi, Eva Habazaj, Kleves Elezi, Rialda Xhizdari, Nevila Alliu
SN Comprehensive Clinical Medicine.2025;[Epub] CrossRef
Prospective and applications of bacterial nanocellulose in dentistry
Yasmin Alimardani, Esmaeel Mirzakhani, Fereshteh Ansari, Hadi Pourjafar, Nadia Sadeghi
Cellulose.2024; 31(13): 7819. CrossRef
Bacterial nanocelluloses as sustainable biomaterials for advanced wound healing and dressings
Atefeh Zarepour, Bahar Gok, Yasemin Budama-Kilinc, Arezoo Khosravi, Siavash Iravani, Ali Zarrabi
Journal of Materials Chemistry B.2024; 12(48): 12489. CrossRef
Sulfated endospermic nanocellulose crystals prevent the transmission of SARS-CoV-2 and HIV-1
Enrique Javier Carvajal-Barriga, Wendy Fitzgerald, Emilios K. Dimitriadis, Leonid Margolis, R. Douglas Fields
Scientific Reports.2023;[Epub] CrossRef
A Novel Approach for the Fabrication of 3D-Printed Dental Membrane Scaffolds including Antimicrobial Pomegranate Extract
Hatice Karabulut, Songul Ulag, Basak Dalbayrak, Elif Arisan, Turgut Taskin, Mehmet Guncu, Burak Aksu, Alireza Valanezhad, Oguzhan Gunduz
Pharmaceutics.2023; 15(3): 737. CrossRef
Current advances of nanocellulose application in biomedical field
M.Y. Leong, Y.L. Kong, M.Y. Harun, C.Y. Looi, W.F. Wong
Carbohydrate Research.2023; 532: 108899. CrossRef
Bacterial cellulose as a potential biopolymer in biomedical applications: a state-of-the-art review
Prachi Shrivastav, Sheersha Pramanik, Gayatri Vaidya, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Ajeet Singh, Bassam M. Abualsoud, Larissa Souza Amaral, Mohammed A. S. Abourehab
Journal of Materials Chemistry B.2022; 10(17): 3199. CrossRef
Nanocelluloses as new generation materials: natural resources, structure-related properties, engineering nanostructures, and technical challenges
Ahmed Barhoum, Vibhore K. Rastogi, Bhupender K. Mahur, Amit Rastogi, Fatehy M. Abdel-Haleem, Pieter Samyn
Materials Today Chemistry.2022; 26: 101247. CrossRef
The current natural/chemical materials and innovative technologies in periodontal diseases therapy and regeneration: A narrative review
Peyman Esmaeili Fard Barzegar, Reza Ranjbar, Mohsen Yazdanian, Elahe Tahmasebi, Mostafa Alam, Kamyar Abbasi, Hamid Tebyaniyan, Keyvan Esmaeili Fard Barzegar
Materials Today Communications.2022; 32: 104099. CrossRef

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Case Reports

Pulp revascularization with and without platelet-rich plasma in two anterior teeth with horizontal radicular fractures: a case report: Edison Arango-Gómez, Javier Laureano Nino-Barrera, Gustavo Nino, Freddy Jordan, Henry Sossa-Rojas; Restor Dent Endod 2019;44(4):e35. Published online August 20, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e35

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Pulp revascularization is an alternative treatment in immature traumatized teeth with necrotic pulp. However, this procedure has not been reported in horizontal root fractures. This is a case report of a 9-year-old patient with multiple horizontal root fractures in 2 upper central incisors that were successfully treated with pulp revascularization. The patient presented for treatment 2 years after the initial trauma, and revascularization was attempted after the initial treatment with calcium hydroxide had failed. Prior to pulp revascularization, cone-beam computed tomography and autoradiograms demonstrated multiple horizontal fractures in the middle and apical thirds of the roots of the 2 affected teeth. Revascularization was performed in both teeth; platelet-rich plasma (PRP) was used in one tooth (#11) and the conventional method (blood clot) was used in the other tooth (#21). Clinical and radiographic follow-up over 4 years demonstrated pulp calcification in the PRP-treated tooth. Neither of the 2 teeth were lost, and the root canal calcification of tooth #11 was greater than that of tooth #21. This case suggests that PRP-based pulp revascularization may be an alternative for horizontal root fractures.

Citations

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Dental pulp mesenchymal stem cells-response to fibrin hydrogel reveals ITGA2 and MMPs expression
David Tong, Stéphanie Gobert, Alicia Reuzeau, Jean-Christophe Farges, Marianne Leveque, Marie Bolon, Arthur Costantini, Marielle Pasdeloup, Jérôme Lafont, Maxime Ducret, Mourad Bekhouche
Heliyon.2024; 10(13): e32891. CrossRef
Pulp regeneration treatment using different bioactive materials in permanent teeth of pediatric subjects
Dina Abdellatif, Alfredo Iandolo, Giuseppina De Benedetto, Francesco Giordano, Davide Mancino, Edouard Euvrard, Massimo Pisano
Journal of Conservative Dentistry and Endodontics.2024; 27(5): 458. CrossRef
Retreatment of a Failed Regenerative Endodontic Treatment in an Immature Tooth with a Horizontal Root Fracture: A Case Report
Zaher Marjy, Iris Slutzky-Goldberg
International Journal of Clinical Pediatric Dentistry.2024; 17(10): 1168. CrossRef
The Impact of the Preferred Reporting Items for Case Reports in Endodontics (PRICE) 2020 Guidelines on the Reporting of Endodontic Case Reports
Sofian Youssef, Phillip Tomson, Amir Reza Akbari, Natalie Archer, Fayjel Shah, Jasmeet Heran, Sunmeet Kandhari, Sandeep Pai, Shivakar Mehrotra, Joanna M Batt
Cureus.2023;[Epub] CrossRef
Evaluation of postoperative pain and healing following regenerative endodontics using platelet‐rich plasma versus conventional endodontic treatment in necrotic mature mandibular molars with chronic periapical periodontitis. A randomized clinical trial
Yassmin Elsayed Ahmed, Geraldine Mohamed Ahmed, Angie Galal Ghoneim
International Endodontic Journal.2023; 56(4): 404. CrossRef
Regenerative endodontic procedures for two traumatized mature anterior teeth with transverse root fractures
Jing Lu, Bill Kahler
BMC Oral Health.2022;[Epub] CrossRef
Are platelet concentrate scaffolds superior to traditional blood clot scaffolds in regeneration therapy of necrotic immature permanent teeth? A systematic review and meta-analysis
Qianwei Tang, Hua Jin, Song Lin, Long Ma, Tingyu Tian, Xiurong Qin
BMC Oral Health.2022;[Epub] CrossRef
Platelet-Rich Fibrin Used as a Scaffold in Pulp Regeneration: Case Series
Ceren ÇİMEN, Selin ŞEN, Elif ŞENAY, Tuğba BEZGİN
Cumhuriyet Dental Journal.2021; 24(1): 113. CrossRef
Plasma rico en plaquetas en Odontología: Revisión de la literatura
Hugo Anthony Rosas Rozas, Hugo Leoncio Rosas Cisneros
Yachay - Revista Científico Cultural.2021; 10(1): 536. CrossRef

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Retreatment of failed regenerative endodontic of orthodontically treated immature permanent maxillary central incisor: a case report: Musaed Fahad Al-Tammami, Saad A. Al-Nazhan; Restor Dent Endod 2017;42(1):65-71. Published online October 28, 2016; DOI: https://doi.org/10.5395/rde.2017.42.1.65

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A revascularization procedure was shown to be the best alternative therapy for immature teeth with necrotic pulp and apical infection. A 12 year old female with a history of trauma to her upper central incisor and a sinus tract was referred for endodontic treatment. She was an active orthodontic patient and had undergone regenerative endodontic treatment for the past 2 years. Clinical examination revealed no response to sensibility, percussion, and palpation tests. The preoperative radiograph showed an open apex and apical rarefaction. The case was diagnosed as previously treated tooth with asymptomatic apical periodontitis. Regenerative endodontic retreatment was performed, and the case was followed for 3 years. Clinical, radiographic, and cone-beam computed tomography follow-up examination revealed an asymptomatic tooth, with evidence of periapical healing and root maturation.

Citations

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Revascularization of Non-Vital, Immature, Permanent Teeth with Two Bioceramic Cements: A Randomized Controlled Trial
Alaa Shaker, Mohamed Salem Rekab, Mohammad Alharissy, Naji Kharouf
Ceramics.2024; 7(1): 86. CrossRef
Orthodontically induced external apical root resorption considerations of root-filled teeth vs vital pulp teeth: a systematic review and meta-analysis
Danning Zhao, Kun Xue, Jiayuan Meng, Meijing Hu, Fei Bi, Xuelian Tan
BMC Oral Health.2023;[Epub] CrossRef
Regenerative Endodontic Therapy for Management of an Immature Permanent Tooth with Recurrent Post-treatment Apical Periodontitis
Renato Lenzi, Sandra R Hernández, Flávio R F Alves, Isabela N Ro[Combining Circumflex Accent]c[COMBINING CEDILLA]as, Jose[Combining Acute Accent] F Siqueira
Journal of International Society of Preventive and Community Dentistry.2022; 12(4): 468. CrossRef
Rejeneratif Endodontik Tedavi: Bir Literatür Derlemesi
Enes Mustafa AŞAR, Murat Selim BOTSALI
Selcuk Dental Journal.2022; 9(1): 335. CrossRef
Clinical and radiographic outcomes of regenerative endodontic treatment performed by endodontic postgraduate students: a retrospective study
Hadi Rajeh Alfahadi, Saad Al-Nazhan, Fawaz Hamad Alkazman, Nassr Al-Maflehi, Nada Al-Nazhan
Restorative Dentistry & Endodontics.2022;[Epub] CrossRef
Endodontic Regenerative Procedures in Necrotic Adult Teeth
Sara Garrido-Parada, Pablo Castelo-Baz, Nancy Feijoo-Pato, José Gaviño-Orduña, Benjamín Martín-Biedma
Applied Sciences.2022; 12(9): 4212. CrossRef
Different Approaches to the Regeneration of Dental Tissues in Regenerative Endodontics
Anna M. Krupińska, Katarzyna Skośkiewicz-Malinowska, Tomasz Staniowski
Applied Sciences.2021; 11(4): 1699. CrossRef
Histologic, Radiographic, and Micro-Computed Tomography Evaluation of Experimentally Enlarged Root Apices in Dog Teeth with Apical Periodontitis after Regenerative Treatment
Mohammed S. Alenazy, Saad Al-Nazhan, Hezekiah A Mosadomi
Current Therapeutic Research.2021; 94: 100620. CrossRef
Revitalizing previously treated teeth with open apices: A case report and a literature review
Ali Nosrat, Behnam Bolhari, Shima Saber Tahan, Omid Dianat, Paul Michael Howell Dummer
International Endodontic Journal.2021; 54(10): 1782. CrossRef
PRICE 2020 guidelines for reporting case reports in Endodontics: explanation and elaboration
V. Nagendrababu, B. S. Chong, P. McCabe, P. K. Shah, E. Priya, J. Jayaraman, S. J. Pulikkotil, P. M. H. Dummer
International Endodontic Journal.2020; 53(7): 922. CrossRef
Regenerative Endodontics: A Systematic Analysis of the Failed Cases
Waleed Almutairi, Ghaeth H. Yassen, Anita Aminoshariae, Kristin A. Williams, Andre Mickel
Journal of Endodontics.2019; 45(5): 567. CrossRef
Alternative to Avoid Tooth Discoloration after Regenerative Endodontic Procedure: A Systematic Review
Luciane Geanini Pena dos Santos, Luiz Alexandre Chisini, Camila Guerner Springmann, Beatriz Dulcineia Mendes de Souza, Fernanda Geraldo Pappen, Flávio Fernando Demarco, Mara Cristina Santos Felippe, Wilson Tadeu Felippe
Brazilian Dental Journal.2018; 29(5): 409. CrossRef

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Research Articles

Biocompatibility of two experimental scaffolds for regenerative endodontics: Dephne Jack Xin Leong, Frank C. Setzer, Martin Trope, Bekir Karabucak; Restor Dent Endod 2016;41(2):98-105. Published online March 28, 2016; DOI: https://doi.org/10.5395/rde.2016.41.2.98

Abstract PDF PubReader ePub

Objectives

The biocompatibility of two experimental scaffolds for potential use in revascularization or pulp regeneration was evaluated.

Materials and Methods

One resilient lyophilized collagen scaffold (COLL), releasing metronidazole and clindamycin, was compared to an experimental injectable poly(lactic-co-glycolic) acid scaffold (PLGA), releasing clindamycin. Human dental pulp stem cells (hDPSCs) were seeded at densities of 1.0 × 10⁴, 2.5 × 10⁴, and 5.0 × 10⁴. The cells were investigated by light microscopy (cell morphology), MTT assay (cell proliferation) and a cytokine (IL-8) ELISA test (biocompatibility).

Results

Under microscope, the morphology of cells coincubated for 7 days with the scaffolds appeared healthy with COLL. Cells in contact with PLGA showed signs of degeneration and apoptosis. MTT assay showed that at 5.0 × 10⁴ hDPSCs, COLL demonstrated significantly higher cell proliferation rates than cells in media only (control, p < 0.01) or cells co-incubated with PLGA (p < 0.01). In ELISA test, no significant differences were observed between cells with media only and COLL at 1, 3, and 6 days. Cells incubated with PLGA expressed significantly higher IL-8 than the control at all time points (p < 0.01) and compared to COLL after 1 and 3 days (p < 0.01).

Conclusions

The COLL showed superior biocompatibility and thus may be suitable for endodontic regeneration purposes.

Citations

Citations to this article as recorded by

Advances in scaffolds used forpulp–dentinecomplex tissue engineering: A narrative review
Parisa Noohi, Mohammad J. Abdekhodaie, Mohammad H. Nekoofar, Kerstin M. Galler, Paul M. H. Dummer
International Endodontic Journal.2022; 55(12): 1277. CrossRef
In vitro performance of a nanobiocomposite scaffold containing boron-modified bioactive glass nanoparticles for dentin regeneration
Reza Moonesi Rad, Engin Pazarçeviren, Elif Ece Akgün, Zafer Evis, Dilek Keskin, Sıla Şahin, Ayşen Tezcaner
Journal of Biomaterials Applications.2019; 33(6): 834. CrossRef
Biological effects of silk fibroin 3D scaffolds on stem cells from human exfoliated deciduous teeth (SHEDs)
M. Collado-González, M. P. Pecci-Lloret, D. García-Bernal, S. Aznar-Cervantes, R. E. Oñate-Sánchez, J. M. Moraleda, J. L. Cenis, F. J. Rodríguez-Lozano
Odontology.2018; 106(2): 125. CrossRef
Pulp Regeneration Concepts for Nonvital Teeth: From Tissue Engineering to Clinical Approaches
Valérie Orti, Pierre-Yves Collart-Dutilleul, Sofía Piglionico, Orsolya Pall, Frédéric Cuisinier, Ivan Panayotov
Tissue Engineering Part B: Reviews.2018; 24(6): 419. CrossRef
Investigation of Human Dental Pulp Cells on a Potential Injectable Poly(lactic-co-glycolic acid) Microsphere Scaffold
Huiru Zou, Guanhua Wang, Fang Song, Xudong Shi
Journal of Endodontics.2017; 43(5): 745. CrossRef
Biocompatibility of hydrogel-based scaffolds for tissue engineering applications
Sheva Naahidi, Mousa Jafari, Megan Logan, Yujie Wang, Yongfang Yuan, Hojae Bae, Brian Dixon, P. Chen
Biotechnology Advances.2017; 35(5): 530. CrossRef

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Effect of dentin treatment on proliferation and differentiation of human dental pulp stem cells: Minjeong Park, Nan-Sim Pang, Il-Young Jung; Restor Dent Endod 2015;40(4):290-298. Published online September 23, 2015; DOI: https://doi.org/10.5395/rde.2015.40.4.290

Abstract PDF PubReader ePub

Objectives

Sodium hypochlorite (NaOCl) is an excellent bactericidal agent, but it is detrimental to stem cell survival, whereas intracanal medicaments such as calcium hydroxide (Ca[OH]₂) promote the survival and proliferation of stem cells. This study evaluated the effect of sequential NaOCl and Ca[OH]₂ application on the attachment and differentiation of dental pulp stem cells (DPSCs).

Materials and Methods

DPSCs were obtained from human third molars. All dentin specimens were treated with 5.25% NaOCl for 30 min. DPSCs were seeded on the dentin specimens and processed with additional 1 mg/mL Ca[OH]₂, 17% ethylenediaminetetraacetic acid (EDTA) treatment, file instrumentation, or a combination of these methods. After 7 day of culture, we examined DPSC morphology using scanning electron microscopy and determined the cell survival rate with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. We measured cell adhesion gene expression levels after 4 day of culture and odontogenic differentiation gene expression levels after 4 wk using quantitative real-time polymerase chain reaction.

Results

DPSCs did not attach to the dentin in the NaOCl-treated group. The gene expression levels of fibronectin-1 and secreted phosphoprotein-1 gene in both the Ca[OH]₂- and the EDTA-treated groups were significantly higher than those in the other groups. All Ca[OH]₂-treated groups showed higher expression levels of dentin matrix protein-1 than that of the control. The dentin sialophosphoprotein level was significantly higher in the groups treated with both Ca[OH]₂ and EDTA.

Conclusions

The application of Ca[OH]₂ and additional treatment such as EDTA or instrumentation promoted the attachment and differentiation of DPSCs after NaOCl treatment.

Citations

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Effect of erbium yttrium aluminium garnet laser dentin conditioning on dental pulp stem cells viability
Aryan Jafari, Mehdi Vatanpour, Nooshin Barikrow, Pouyan Razavi, Sohrab Tour Savadkouhi
Heliyon.2024; 10(5): e26954. CrossRef
Comparison of the effect of NaOCL, curcumin, and EDTA on differentiation, proliferation, and adhesion of dental pulp stem cells
Vahid Zand, Amin Salem Milani, Carolyn Primus, Marzie Aghazade, Hadi Mokhtari, Sabete Bagheri Sabzevar, Pardis Tehranchi
Journal of Oral Biology and Craniofacial Research.2023; 13(2): 347. CrossRef
Differential Effects of Extracellular Matrix Glycoproteins Fibronectin and Laminin-5 on Dental Pulp Stem Cell Phenotypes and Responsiveness
Hyungbin Lee, Allen Bae, John Kim, Karl Kingsley
Journal of Functional Biomaterials.2023; 14(2): 91. CrossRef
Assessment of the Influence of Various Concentrations of Sodium Hypochlorite on Stem Cell Derived From Human Exfoliated Deciduous Teeth (SHED) Proliferation and Differentiation
Viral Maru, Ashwini KB, Manisha Madkaikar, R K Sarada Devi, Ashita Gada, Salil Bapat
Cureus.2022;[Epub] CrossRef
Effects of sodium hypochlorite and ethylenediaminetetraacetic acid on proliferation, osteogenic/odontogenic differentiation, and mechanosensitive gene expression of human dental pulp stem cells
Yuejun Li, Changlong Jin, Shouliang Zhao, Han Xie
Tissue and Cell.2022; 79: 101955. CrossRef
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Alexandre H. dos Reis‐Prado, Lucas G. Abreu, Rogéria R. Fagundes, Sabrina de C. Oliveira, Marco C. Bottino, Antônio P. Ribeiro‐Sobrinho, Francine Benetti
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Jeen Nee Lui, Wen Yi Lim, Domenico Ricucci
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Odontoblast-like differentiation and mineral formation of pulpsphere derived cells on human root canal dentin in vitro
Jörg Neunzehn, Sandra Pötschke, Christian Hannig, Hans-Peter Wiesmann, Marie-Theres Weber
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Journal of Endodontics.2017; 43(2): 289. CrossRef

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Review Articles

A review of the regenerative endodontic treatment procedure: Bin-Na Lee, Jong-Wook Moon, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Yun-Chan Hwang; Restor Dent Endod 2015;40(3):179-187. Published online March 16, 2015; DOI: https://doi.org/10.5395/rde.2015.40.3.179

Abstract PDF PubReader ePub

Traditionally, apexification has been used to treat immature permanent teeth that have lost pulp vitality. This technique promotes the formation of an apical barrier to close the open apex so that the filling materials can be confined to the root canal. Because tissue regeneration cannot be achieved with apexification, a new technique called regenerative endodontic treatment was presented recently to treat immature permanent teeth. Regenerative endodontic treatment is a treatment procedure designed to replace damaged pulp tissue with viable tissue which restores the normal function of the pulp-dentin structure. After regenerative endodontic treatment, continued root development and hard tissue deposition on the dentinal wall can occur under ideal circumstances. However, it is difficult to predict the result of regenerative endodontic treatment. Therefore, the purpose of this study was to summarize multiple factors effects on the result of regenerative endodontic treatment in order to achieve more predictable results. In this study, we investigated the features of regenerative endodontic treatment in comparison with those of other pulp treatment procedures and analyzed the factors that have an effect on regenerative endodontic treatment.

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Effects of a Bioactive Scaffold Containing a Sustained Transforming Growth Factor-β1–releasing Nanoparticle System on the Migration and Differentiation of Stem Cells from the Apical Papilla
Craig Bellamy, Suja Shrestha, Calvin Torneck, Anil Kishen
Journal of Endodontics.2016; 42(9): 1385. CrossRef
Effects of Novel 3-dimensional Antibiotic-containing Electrospun Scaffolds on Dentin Discoloration
Margaret Louise A. Porter, Eliseu A. Münchow, Maria T.P. Albuquerque, Kenneth J. Spolnik, Anderson T. Hara, Marco C. Bottino
Journal of Endodontics.2016; 42(1): 106. CrossRef

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Platelet rich fibrin - a novel acumen into regenerative endodontic therapy: Kavita Hotwani, Krishna Sharma; Restor Dent Endod 2014;39(1):1-6. Published online January 20, 2014; DOI: https://doi.org/10.5395/rde.2014.39.1.1

Abstract PDF PubReader ePub

Research into regenerative dentistry has added impetus onto the field of molecular biology. It can be documented as a prototype shift in the therapeutic armamentarium for dental disease. Regenerative endodontic procedures are widely being added to the current armamentarium of pulp therapy procedures. The regenerative potential of platelets has been deliberated. A new family of platelet concentrates called the platelet rich fibrin (PRF) has been recently used by several investigators and has shown application in diverse disciplines of dentistry. This paper is intended to add light on the various prospects of PRF and clinical insights to regenerative endodontic therapy.

Citations

Citations to this article as recorded by

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Advanced Platelet-rich Fibrin-mediated Regeneration of Necrotic Immature Permanent Teeth: A Clinico-radiographic Observational Study
Ashi Chug, Sagrika Shukla, Tulika Wakhloo, Mridul Dhar
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Satyendra K. Singh, Sri Rupa
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Saumya Johri, Promila Verma, Aseem Prakash Tikku, Rhythm Bains, Neera Kohli
Journal of Tissue Engineering and Regenerative Medicine.2022; 16(12): 1208. CrossRef
Effect of biodentine coated with emdogain on proliferation and differentiation of human stem cells from the apical papilla
Hamed Karkehabadi, Erfan Ahmadyani, Rezvan Najafi, Elham Khoshbin
Molecular Biology Reports.2022; 49(5): 3685. CrossRef
SINGLE VISIT- APEXIFICATION USING MTA AND AUTOLOGOUS PRF AS AN INTERNAL MATRIX. A CASE SERIES.
Deepika Deepika, Abhishek Sharma, Ajay Kumar Nagpal, Muhammad Mutiur Rahman
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2022; : 61. CrossRef
COMPARATIVE CLINICAL, RADIOGRAPHICAL AND HISTOLOGICAL EVALUATION OF CORONAL PULPOTOMY TECHNIQUE WITH PRF AND A NOVEL CROSSLINKED PRF AS AN ALTERNATIVE TO PULPECTOMY FOR PRESERVING THE TOOTH VITALITY IN CONTEXT OF TISSUE ENGINEERING.
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Case Report

Prevention of tooth discoloration associated with triple antibiotics: Bona Kim, Min-Ju Song, Su-Jung Shin, Jeong-Won Park; Restor Dent Endod 2012;37(2):119-122. Published online May 18, 2012; DOI: https://doi.org/10.5395/rde.2012.37.2.119

Abstract PDF PubReader ePub

Regenerative endodontics has a potential to heal a partially necrotic pulp, which can be beneficial for the continued root development and strengthening of immature teeth. For this purpose, triple antibiotic mixture of ciprofloxacin, metronidazole, and minocycline was recommended as intracanal medicament in an attempt to disinfect the root canal system for revascularization of a tooth with a necrotic pulp. However, discoloration of the tooth was reported after applying this. This case shows the idea for preventing the tooth discoloration using a delivery syringe (SW-O-01, Shinwoo dental) to avoid the contact between the clinical crown and the antibiotics.

Citations

Citations to this article as recorded by

Non-surgical Management of a Large Periapical Lesion: A Case Study of the Successful Application of a Modified Triple Antibacterial Paste
Srushti Awghad, Joyeeta Mahapatra, Amit Reche, Ankita Burse, Aradhana Kibe
Cureus.2024;[Epub] CrossRef
Evaluation of the antimicrobial efficacy of two combinations of drugs on bacteria taken from infected primary teeth (in vitro)
R. Rafatjou, R. Yousefimashouf, M. Farhadian, S. Afzalsoltani
European Archives of Paediatric Dentistry.2019; 20(6): 609. CrossRef
Triple antibiotic paste: momentous roles and applications in endodontics: a review
Ardavan Parhizkar, Hanieh Nojehdehian, Saeed Asgary
Restorative Dentistry & Endodontics.2018;[Epub] CrossRef
Clinical Effectiveness of Different Polishing Systems and Self-Etch Adhesives in Class V Composite Resin Restorations: Two-Year Randomized Controlled Clinical Trial
J-H Jang, H-Y Kim, S-M Shin, C-O Lee, DS Kim, K-K Choi, S-Y Kim
Operative Dentistry.2017; 42(1): 19. CrossRef
Revascularization of Necrotic Immature Permanent Teeth: An Update
N Velmurugan
Journal of Operative Dentistry & Endodontics.2016; 1(1): 18. CrossRef
Treatment of non-vital immature teeth with amoxicillin-containing triple antibiotic paste resulting in apexification
Hyon-Beom Park, Bin-Na Lee, Yun-Chan Hwang, In-Nam Hwang, Won-Mann Oh, Hoon-Sang Chang
Restorative Dentistry & Endodontics.2015; 40(4): 322. CrossRef

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