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Contemporary research trends on nanoparticles in endodontics: a bibliometric and scientometric analysis of the top 100 most-cited articles
Sıla Nur Usta, Zeliha Uğur-Aydın, Kadriye Demirkaya, Cumhur Aydın
Restor Dent Endod 2023;48(3):e27.   Published online July 26, 2023
DOI: https://doi.org/10.5395/rde.2023.48.e27
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Objectives

Advancements in nanotechnology have led to the widespread usage of nanoparticles in the endodontic field. This bibliometric study aimed to determine and analyze the top 100 most-cited articles about nanoparticles in endodontics from 2000 to 2022.

Materials and Methods

A detailed electronic search was conducted on the “Clarivate Analytics Web of Science, All Databases” to receive the most-cited articles related to the topic. Articles were ranked in descending order based on their citation counts, and the first 100 were selected for bibliometric analysis. Parameters such as citation density, publication year, journal, country, institution, author, study design, study field, evidence level, and keywords were analyzed.

Results

The top 100 most-cited articles received 4,698 citations (16–271) with 970.21 (1.91–181) citation density in total. Among decades, citations were significantly higher in 2011–2022 (p < 0.001). Journal of Endodontics had the largest number of publications. Canada and the University of Toronto made the highest contribution as country and institution, respectively. Anil Kishen was the 1 who participated in the largest number of articles. The majority of the articles were designed in vitro. The main study field was “antibacterial effect.” Among keywords, “nanoparticles” followed by “Enterococcus faecalis” were used more frequently.

Conclusions

Developments in nanotechnology had an impact on the increasing number of studies in recent years. This bibliometric study provides a comprehensive view of nanoparticle advances and trends using citation analysis.

Citations

Citations to this article as recorded by  
  • Research trends and mapping knowledge for maxillary sinus augmentation in oral and maxillofacial surgery
    Özlem Saraç Atagün, Şeyma Çardakcı Bahar, Seval Ceylan Şen, Gülbahar Ustaoğlu
    Journal of Stomatology, Oral and Maxillofacial Surgery.2025; 126(4): 102116.     CrossRef
  • Exploring vital pulp Therapies: A bibliometric analysis of the most cited articles
    Gustavo Henrique Sousa, Rodolfo Lima Gonçalves, Barbara Figueiredo, Vilton Cardozo Moreira Dias, Ana Carolina Soares Mendes, Valéria de Cássia Bueno Melo, Adriana Guimarães Rodrigues, Hebertt Gonzaga dos Santos Chaves
    The Saudi Dental Journal.2024; 36(5): 778.     CrossRef
  • The cutting-edge roles of lasers in endodontics: A bibliometric and scientometric analysis of the 100 most-cited articles
    Sıla Nur Usta, Pablo Betancourt, Alper Ceylan, Cangül Keskin
    Lasers in Medical Science.2024;[Epub]     CrossRef
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  • 9 Download
  • 3 Web of Science
  • 3 Crossref
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Physicochemical properties of a calcium aluminate cement containing nanoparticles of zinc oxide
Amanda Freitas da Rosa, Thuany Schmitz Amaral, Maria Eduarda Paz Dotto, Taynara Santos Goulart, Hebert Luís Rossetto, Eduardo Antunes Bortoluzzi, Cleonice da Silveira Teixeira, Lucas da Fonseca Roberti Garcia
Restor Dent Endod 2023;48(1):e3.   Published online December 8, 2022
DOI: https://doi.org/10.5395/rde.2023.48.e3
AbstractAbstract PDFPubReaderePub
Objectives

This study evaluated the effect of different nanoparticulated zinc oxide (nano-ZnO) and conventional-ZnO ratios on the physicochemical properties of calcium aluminate cement (CAC).

Materials and Methods

The conventional-ZnO and nano-ZnO were added to the cement powder in the following proportions: G1 (20% conventional-ZnO), G2 (15% conventional-ZnO + 5% nano-ZnO), G3 (12% conventional-ZnO + 3% nano-ZnO) and G4 (10% conventional-ZnO + 5% nano-ZnO). The radiopacity (Rad), setting time (Set), dimensional change (Dc), solubility (Sol), compressive strength (Cst), and pH were evaluated. The nano-ZnO and CAC containing conventional-ZnO were also assessed using scanning electron microscopy, transmission electron microscopy, and energy-dispersive X-ray spectroscopy. Radiopacity data were analyzed by the 1-way analysis of variance (ANOVA) and Bonferroni tests (p < 0.05). The data of the other properties were analyzed by the ANOVA, Tukey, and Fisher tests (p < 0.05).

Results

The nano-ZnO and CAC containing conventional-ZnO powders presented particles with few impurities and nanometric and micrometric sizes, respectively. G1 had the highest Rad mean value (p < 0.05). When compared to G1, groups containing nano-ZnO had a significant reduction in the Set (p < 0.05) and lower values of Dc at 24 hours (p < 0.05). The Cst was higher for G4, with a significant difference for the other groups (p < 0.05). The Sol did not present significant differences among groups (p > 0.05).

Conclusions

The addition of nano-ZnO to CAC improved its dimensional change, setting time, and compressive strength, which may be promising for the clinical performance of this cement.

Citations

Citations to this article as recorded by  
  • Calcium aluminate cement: a study on the effect of additives for dental applications
    Sara Ghorbani, Rahim Naghizadeh, Ebrahim Ghasemi, Hamidreza Rezaie
    Advances in Cement Research.2025; 37(4): 269.     CrossRef
  • Experimental Study on Cement-Based Materials Modified by Nano-Zinc Oxide and Nano-Zirconia Based on Response Surface Optimization Design
    Hongyin Hu, Fufei Wu, Jiao Chen, Shuangshuang Guan, Peng Qu, Hongqin Zhang, Yuyi Chen, Zirun Xu, Chuanteng Huang, Shuang Pu
    Materials.2025; 18(7): 1515.     CrossRef
  • 289 View
  • 13 Download
  • 1 Web of Science
  • 2 Crossref
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Calcium-doped zinc oxide nanocrystals as an innovative intracanal medicament: a pilot study
Gabriela Leite de Souza, Thamara Eduarda Alves Magalhães, Gabrielle Alves Nunes Freitas, Nelly Xiomara Alvarado Lemus, Gabriella Lopes de Rezende Barbosa, Anielle Christine Almeida Silva, Camilla Christian Gomes Moura
Restor Dent Endod 2022;47(4):e38.   Published online October 4, 2022
DOI: https://doi.org/10.5395/rde.2022.47.e38
AbstractAbstract PDFPubReaderePub
Objectives

This study investigated the cytotoxicity, radiopacity, pH, and dentinal tubule penetration of a paste of 1.0% calcium-doped zinc oxide nanocrystals (ZnO:1.0Ca) combined with propylene glycol (PRG) or polyethylene glycol and propylene glycol (PEG-PRG).

Materials and Methods

The pastes were prepared by mixing calcium hydroxide [Ca(OH)2] or ZnO:1.0Ca with PRG or a PEG-PRG mixture. The pH was evaluated after 24 and 96 hours of storage in deionized water. Digital radiographs were acquired for radiopacity analysis and bubble counting of each material. The materials were labeled with 0.1% fluorescein and applied to root canals, and images of their dentinal tubule penetration were obtained using confocal laser scanning microscopy. RAW264.7 macrophages were placed in different dilutions of culture media previously exposed to the materials for 24 and 96 hours and tested for cell viability using the MTT assay. Analysis of variance and the Tukey test (α = 0.05) were performed.

Results

ZnO:1.0Ca materials showed lower viability at 1:1 and 1:2 dilutions than Ca(OH)2 materials (p < 0.0001). Ca(OH)2 had higher pH values than ZnO:1.0Ca at 24 and 96 hours, regardless of the vehicle (p < 0.05). ZnO:1.0Ca pastes showed higher radiopacity than Ca(OH)2 pastes (p < 0.01). No between-material differences were found in bubble counting (p = 0.0902). The ZnO:1.0Ca pastes had a greater penetration depth than Ca(OH)2 in the apical third (p < 0.0001).

Conclusions

ZnO:1.0Ca medicaments presented higher penetrability, cell viability, and radiopacity than Ca(OH)2. Higher values of cell viability and pH were present in Ca(OH)2 than in ZnO:1.0Ca.

Citations

Citations to this article as recorded by  
  • Nano calcium zincate-assisted synthesis of benzo[ d ]thiazol-2-yl phenylisoxazoles: quantum computational, in silico molecular docking simulations and DNA interaction
    A. K. Smitha, V. Srinivasa Murthy, B. Vinay Kumar, M. Sennappan, A. H. Shridhar, Lohit Naik, K. Yogendra, N. Madhusudhana
    Nucleosides, Nucleotides & Nucleic Acids.2025; : 1.     CrossRef
  • 302 View
  • 7 Download
  • 1 Web of Science
  • 1 Crossref
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The effect of using nanoparticles in bioactive glass on its antimicrobial properties
Maram Farouk Obeid, Kareim Moustafa El-Batouty, Mohammed Aslam
Restor Dent Endod 2021;46(4):e58.   Published online October 29, 2021
DOI: https://doi.org/10.5395/rde.2021.46.e58
AbstractAbstract PDFPubReaderePub
Objectives

This study addresses the effect of using nanoparticles (np) on the antimicrobial properties of bioactive glass (BAG) when used in intracanal medicaments against Enterococcus faecalis (E. faecalis) biofilms.

Materials and Methods

E. faecalis biofilms, grown inside 90 root canals for 21 days, were randomly divided into 4 groups according to the antimicrobial regimen followed (n = 20; BAG-np, BAG, calcium hydroxide [CaOH], and saline). After 1 week, residual live bacteria were quantified in terms of colony-forming units (CFU), while dead bacteria were assessed with a confocal laser scanning microscope.

Results

Although there was a statistically significant decrease in the mean CFU value among all groups, the nano-group performed the best. The highest percentage of dead bacteria was detected in the BAG-np group, with a significant difference from the BAG group.

Conclusions

The reduction of particle size and use of a nano-form of BAG improved the antimicrobial properties of the intracanal treatment of E. faecalis biofilms

Citations

Citations to this article as recorded by  
  • Size matters: radiation shielding superiority of borate glasses with nano vs. micro ZnO
    Aljawhara H. Almuqrin, M.I. Sayyed, M. Elsafi
    Nuclear Engineering and Technology.2025; : 103614.     CrossRef
  • Application of Nanomaterials in Endodontics
    Farzaneh Afkhami, Yuan Chen, Laurence J. Walsh, Ove A. Peters, Chun Xu
    BME Frontiers.2024;[Epub]     CrossRef
  • Antimicrobial efficacy of newly prepared nano-tricalcium silicate-58s bioactive glass-based endodontic sealer
    Nawal Atiya Al-Sabawi, Sawsan Hameed Al-Jubori
    Endodontology.2024;[Epub]     CrossRef
  • Antimicrobial Effects of Formulations of Various Nanoparticles and Calcium Hydroxide as Intra-canal Medications Against Enterococcus faecalis: A Systematic Review
    Seema H Bukhari, Dax Abraham, Shakila Mahesh
    Cureus.2024;[Epub]     CrossRef
  • Effect of nanoparticles on antibacterial efficacy of intracanal medicament: A scoping review
    Alpa Gupta, Arundeep Singh, Vivek Aggarwal
    Endodontology.2023; 35(4): 283.     CrossRef
  • Physical properties, marginal adaptation and bioactivity of an experimental mineral trioxide aggregate-like cement modified with bioactive materials
    Abigailt Flores-Ledesma, Adriana Tejeda-Cruz, María A. Moyaho-Bernal, Ana Wintergerst, Yoshamin A. Moreno-Vargas, Jacqueline A. Rodríguez-Chávez, Carlos E. Cuevas-Suárez, Kenya Gutiérrez-Estrada, Jesús A. Arenas-Alatorre
    Journal of Oral Science.2023; 65(2): 141.     CrossRef
  • Nanopartículas antimicrobianas en endodoncia: Revisión narrativa
    Gustavo Adolfo Tovar Rangel , Fanny Mildred González Sáenz , Ingrid Ximena Zamora Córdoba , Lina María García Zapata
    Revista Estomatología.2023;[Epub]     CrossRef
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  • 2 Web of Science
  • 7 Crossref
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Review Article
Silver nanoparticles in endodontics: recent developments and applications
Aysenur Oncu, Yan Huang, Gulin Amasya, Fatma Semra Sevimay, Kaan Orhan, Berkan Celikten
Restor Dent Endod 2021;46(3):e38.   Published online July 1, 2021
DOI: https://doi.org/10.5395/rde.2021.46.e38
AbstractAbstract PDFPubReaderePub

The elimination of endodontic biofilms and the maintenance of a leak-proof canal filling are key aspects of successful root canal treatment. Several materials have been introduced to treat endodontic disease, although treatment success is limited by the features of the biomaterials used. Silver nanoparticles (AgNPs) have been increasingly considered in dental applications, especially endodontics, due to their high antimicrobial activity. For the present study, an electronic search was conducted using MEDLINE (PubMed), the Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and EMBASE. This review provides insights into the unique characteristics of AgNPs, including their chemical, physical, and antimicrobial properties; limitations; and potential uses. Various studies involving different application methods of AgNPs were carefully examined. Based on previous clinical studies, the synthesis, means of obtaining, usage conditions, and potential cytotoxicity of AgNPs were evaluated. The findings indicate that AgNPs are effective antimicrobial agents for the elimination of endodontic biofilms.

Citations

Citations to this article as recorded by  
  • Scoping review on the genotoxicity of silver nanoparticles in endodontics: therapeutic saviors or genetic saboteurs?
    Galvin Sim Siang Lin, Widya Lestari, Mohd Haikal Muhamad Halil, Mohd Syafiq Abd Aziz
    Odontology.2025; 113(2): 457.     CrossRef
  • Bioceramics in Endodontics: Limitations and Future Innovations—A Review
    Peramune Arachchilage Amila Saman Prasad Kumara, Paul Roy Cooper, Peter Cathro, Maree Gould, George Dias, Jithendra Ratnayake
    Dentistry Journal.2025; 13(4): 157.     CrossRef
  • Antimicrobial Effects of Formulations of Various Nanoparticles and Calcium Hydroxide as Intra-canal Medications Against Enterococcus faecalis: A Systematic Review
    Seema H Bukhari, Dax Abraham, Shakila Mahesh
    Cureus.2024;[Epub]     CrossRef
  • The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles
    Karla Navarrete-Olvera, Nereyda Niño-Martínez, Idania De Alba-Montero, Nuria Patiño-Marín, Facundo Ruiz, Horacio Bach, Gabriel-Alejandro Martínez-Castañón
    Molecules.2024; 29(18): 4422.     CrossRef
  • Synergistic bactericidal activity of chlorhexidine loaded on positively charged ionic liquid-protected silver nanoparticles as a root canal disinfectant against Enterococcus faecalis: An ex vivo study
    Abbas Abbaszadegan, Elham Tayebikhorami, Ahmad Gholami, Nazanin Bonyanpour, Bahar Asheghi, Sara Nikmanesh
    Journal of Ionic Liquids.2024; 4(2): 100117.     CrossRef
  • Improving the Antimicrobial Potency of Berberine for Endodontic Canal Irrigation Using Polymeric Nanoparticles
    Célia Marques, Liliana Grenho, Maria Helena Fernandes, Sofia A. Costa Lima
    Pharmaceutics.2024; 16(6): 786.     CrossRef
  • A narrative review on application of metal and metal oxide nanoparticles in endodontics
    Roohollah Sharifi, Ahmad Vatani, Amir Sabzi, Mohsen Safaei
    Heliyon.2024; 10(15): e34673.     CrossRef
  • The Effectiveness of Silver Nanoparticles Mixed with Calcium Hydroxide against Candida albicans: An Ex Vivo Analysis
    Maha Alghofaily, Jood Alfraih, Aljohara Alsaud, Norah Almazrua, Terrence S. Sumague, Sayed H. Auda, Fahd Alsalleeh
    Microorganisms.2024; 12(2): 289.     CrossRef
  • Evaluation of the efficacy of a novel disinfecting material on the surface topography of gutta-percha: An in vitro study
    KHanisha Reddy, Lekshmi Chandran, TMurali Mohan, K Sudha, DL Malini, Bonney Dominic
    Journal of Conservative Dentistry.2023; 26(1): 94.     CrossRef
  • Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review
    Farzaneh Afkhami, Parisa Forghan, James L. Gutmann, Anil Kishen
    Pharmaceutics.2023; 15(3): 715.     CrossRef
  • Nanopartículas antimicrobianas en endodoncia: Revisión narrativa
    Gustavo Adolfo Tovar Rangel , Fanny Mildred González Sáenz , Ingrid Ximena Zamora Córdoba , Lina María García Zapata
    Revista Estomatología.2023;[Epub]     CrossRef
  • Functionalized Nanoparticles: A Paradigm Shift in Regenerative Endodontic Procedures
    Vinoo Subramaniam Ramachandran, Mensudar Radhakrishnan, Malathi Balaraman Ravindrran, Venkatesh Alagarsamy, Gowri Shankar Palanisamy
    Cureus.2022;[Epub]     CrossRef
  • 575 View
  • 17 Download
  • 8 Web of Science
  • 12 Crossref
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Research Articles
Can silver diamine fluoride or silver nanoparticle-based anticaries agents to affect enamel bond strength?
Jaqueline Costa Favaro, Yana Cosendey Toledo de Mello Peixoto, Omar Geha, Flaviana Alves Dias, Ricardo Danil Guiraldo, Murilo Baena Lopes, Sandrine Bittencourt Berger
Restor Dent Endod 2021;46(1):e7.   Published online January 12, 2021
DOI: https://doi.org/10.5395/rde.2021.46.e7
AbstractAbstract PDFPubReaderePub
Objectives

The aim of the current study is to investigate the effect of different anticaries agents, such as experimental agents based on silver nanoparticles (SNPs) and silver diamine fluoride (SDF), on the micro-shear bond strength (μ-SBS) of composite resin applied to intact enamel (IE) or demineralized enamel (DE).

Materials and Methods

Sixty dental enamel fragments were collected from human third molars and categorized into 6 groups (n = 10): positive control (IE), negative control (DE), IE + SDF, DE + SDF, IE + SNP and DE + SNP. Samples from DE, DE + SDF and DE + SNP groups were subjected to pH cycling; superficial microhardness test was performed to confirm demineralization. Resin composite build-ups were applied to the samples (0.75-mm diameter and 1-mm height) after the treatments (except for IE and DE groups); μ-SBS was also evaluated. Samples were analyzed under a stereomicroscope at 40× magnification to identify failure patterns. Data were subjected to one-way analysis of variance, followed by Tukey's and Dunnett's tests (p < 0.05).

Results

There was no significant difference among the IE, IE + SNP, DE + SDF, and DE + SNP groups. The IE + SDF and DE groups recorded the highest and the lowest μ-SBS values, respectively. Adhesive-type failures were the most frequent for all treatments.

Conclusions

Anticaries agents did not have a negative effect on the μ-SBS of composite resin when it was used on IE or DE.

Citations

Citations to this article as recorded by  
  • Impact of Incorporating Nanoparticles to Adhesive Resin on the Demineralization of Enamel: A Systematic Review
    Naif Almosa
    Dentistry Journal.2025; 13(3): 89.     CrossRef
  • The use of silver diamine fluoride to prevent/treat enamel carious lesions: a narrative review
    Rasha N. AlSheikh
    PeerJ.2024; 12: e17897.     CrossRef
  • Phosphoric Acid Etch Partially Restores the Initial Bond Strength of Composite to Silver Diamine Fluoride–Treated Enamel Using Universal Adhesives
    Zaher Jabbour, Mijoo Kim, Marc Hayashi, Reuben Kim
    Dentistry Journal.2023; 11(7): 161.     CrossRef
  • Efficacy of Nano Silver Fluoride and/or Diode Laser In Enhancing Enamel Anticariogenicity around orthodontic brackets
    Aya Anwar Alsherif, Mohamed Ali Farag, Mai Badreldin Helal
    BDJ Open.2023;[Epub]     CrossRef
  • Amelioration Strategies for Silver Diamine Fluoride: Moving from Black to White
    Amjad Almuqrin, Inder Preet Kaur, Laurence J. Walsh, Chaminda Jayampath Seneviratne, Sobia Zafar
    Antibiotics.2023; 12(2): 298.     CrossRef
  • The Effect of Loading Time on Color Stability of Various Restorative Materials Bonded to Silver Diamine Fluoride-Treated Demineralized Dentin
    Mohammed M Aldosari, Fares S Al-Sehaibany
    Clinical, Cosmetic and Investigational Dentistry.2022; Volume 14: 123.     CrossRef
  • In vitro study of the effect of nanosilver fluoride on shear bond strength of orthodontic brackets and demineralization of enamel
    Mariam H. El-Toukhy, Eman M. El-Shourbagy, Neveen M. Fakhry
    Tanta Dental Journal.2022; 19(4): 281.     CrossRef
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  • 6 Web of Science
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Effects of zinc oxide and calcium–doped zinc oxide nanocrystals on cytotoxicity and reactive oxygen species production in different cell culture models
Gabriela Leite de Souza, Camilla Christian Gomes Moura, Anielle Christine Almeida Silva, Juliane Zacour Marinho, Thaynara Rodrigues Silva, Noelio Oliveira Dantas, Jéssica Fernanda Sena Bonvicini, Ana Paula Turrioni
Restor Dent Endod 2020;45(4):e54.   Published online October 19, 2020
DOI: https://doi.org/10.5395/rde.2020.45.e54
AbstractAbstract PDFPubReaderePub
Objectives

This study aimed to synthesize nanocrystals (NCs) of zinc oxide (ZnO) and calcium ion (Ca2+)-doped ZnO with different percentages of calcium oxide (CaO), to evaluate cytotoxicity and to assess the effects of the most promising NCs on cytotoxicity depending on lipopolysaccharide (LPS) stimulation.

Materials and Methods

Nanomaterials were synthesized (ZnO and ZnO:xCa, x = 0.7; 1.0; 5.0; 9.0) and characterized using X-ray diffractometry, scanning electron microscopy, and methylene blue degradation. SAOS-2 and RAW 264.7 were treated with NCs, and evaluated for viability using the MTT assay. NCs with lower cytotoxicity were maintained in contact with LPS-stimulated (+LPS) and nonstimulated (−LPS) human dental pulp cells (hDPCs). Cell viability, nitric oxide (NO), and reactive oxygen species (ROS) production were evaluated. Cells kept in culture medium or LPS served as negative and positive controls, respectively. One-way analysis of variance and the Dunnett test (α = 0.05) were used for statistical testing.

Results

ZnO:0.7Ca and ZnO:1.0Ca at 10 µg/mL were not cytotoxic to SAOS-2 and RAW 264.7. +LPS and −LPS hDPCs treated with ZnO, ZnO:0.7Ca, and ZnO:1.0Ca presented similar NO production to negative control (p > 0.05) and lower production compared to positive control (p < 0.05). All NCs showed reduced ROS production compared with the positive control group both in +LPS and −LPS cells (p < 0.05).

Conclusions

NCs were successfully synthesized. ZnO, ZnO:0.7Ca and ZnO:1.0Ca presented the highest percentages of cell viability, decreased ROS and NO production in +LPS cells, and maintenance of NO production at basal levels.

Citations

Citations to this article as recorded by  
  • Waste-derived Ca and Zn-based bimetallic (Ca/Zn) nanorods encapsulated chitosan-based haemostatic dressing bandage: A step towards waste to bandages
    Pooja Thakur, Rishabh Anand Omar, Neetu Talreja, Divya Chauhan, Mohammad Ashfaq
    Journal of Industrial and Engineering Chemistry.2025; 143: 327.     CrossRef
  • Europium and calcium-co-doped TiO2 nanocrystals: tuning the biocompatibility and luminescence traceability of Drosophila melanogaster
    Jerusa Maria de Oliveira, Larissa Iolanda M. de Almeida, Francisco Rubens Alves dos Santos, João Paulo S. de Carvalho, Amanda I. dos S. Barbosa, Marcus Andrei R. F. da Costa, Vanessa Tomaz Maciel, Gabriela L. de Souza, Alysson N. Magalhães, Marcos V. Verm
    Environmental Science: Nano.2025; 12(1): 835.     CrossRef
  • Development and evaluation of capsules loaded with red propolis extract and metallic nanoparticles using the ionic gelation method
    Ilza Fernanda Barboza Duarte Rodrigues, Jéssica Maria Pereira, Lívia Maria Santos de Lima, Kathleen Gomes Lins Silva, Melissa Rosa Silva, Valdemir da Costa Silva, Salvana Priscylla Manso Costa, Ticiano Gomes do Nascimento, Adeildo Junior de Oliveira, John
    Journal of Apicultural Research.2025; : 1.     CrossRef
  • Development of antibacterial dual-cure dental resin composites via tetrapod-shaped zinc oxide incorporation
    Hwalim Lee, Yu-Jin Kim, Ye-Jin Yang, Jung-Hwan Lee, Hae-Hyoung Lee
    Dental Materials.2024; 40(11): 1762.     CrossRef
  • Investigation on the non-linear behaviour of silicon nanowires and assessment of the biosensing potential
    M M A Hakim
    Engineering Research Express.2023; 5(2): 025017.     CrossRef
  • Evaluation of Cytotoxicity, Cell Attachment, and Elemental Characterization of Three Calcium Silicate-Based Sealers
    Anahi de Paula Melo, Camila Maria Peres de Rosatto, Danilo Cassiano Ferraz, Gabriela Leite de Souza, Camilla Christian Gomes Moura
    Materials.2023; 16(20): 6705.     CrossRef
  • Metallic Nanoparticles: A New Frontier in the Fight Against Leishmaniasis
    Rhanoica Oliveira Guerra, José Rodrigues do Carmo Neto, Tarcísio de Albuquerque Martins, Thaís Soares Farnesi de-Assunção, Virmondes Rodrigues Junior, Carlo José Freire de Oliveira, Anielle Christine Almeida Silva, Marcos Vinicius da Silva
    Current Medicinal Chemistry.2022; 29(26): 4547.     CrossRef
  • In situ synthesis of zinc oxide/selenium composite for UV blocker application
    Chaoqun Xia, Shi Liu, Baining Cui, Mingjun Li, Hongshui Wang, Chunyong Liang, Phong A. Tran, Yan Wang, Huan Zhou, Lei Yang
    International Journal of Applied Ceramic Technology.2022;[Epub]     CrossRef
  • Biocompatibility and Connectivity of Semiconductor Nanostructures for Cardiac Tissue Engineering Applications
    Roberto Gaetani, Yuriy Derevyanchuk, Andrea Notargiacomo, Marialilia Pea, Massimiliano Renzi, Elisa Messina, Fabrizio Palma
    Bioengineering.2022; 9(11): 621.     CrossRef
  • Calcium-doped zinc oxide nanocrystals as an innovative intracanal medicament: a pilot study
    Gabriela Leite de Souza, Thamara Eduarda Alves Magalhães, Gabrielle Alves Nunes Freitas, Nelly Xiomara Alvarado Lemus, Gabriella Lopes de Rezende Barbosa, Anielle Christine Almeida Silva, Camilla Christian Gomes Moura
    Restorative Dentistry & Endodontics.2022;[Epub]     CrossRef
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Influence of silver nanoparticles on resin-dentin bond strength durability in a self-etch and an etch-and-rinse adhesive system
Zahra Jowkar, Fereshteh Shafiei, Elham Asadmanesh, Fatemeh Koohpeima
Restor Dent Endod 2019;44(2):e13.   Published online March 29, 2019
DOI: https://doi.org/10.5395/rde.2019.44.e13
AbstractAbstract PDFPubReaderePub
Objectives

This study evaluated the effect of dentin pretreatment with silver nanoparticles (SNPs) and chlorhexidine (CHX) on the microshear bond strength (µSBS) durability of different adhesives to dentin.

Materials and Methods

Occlusal surfaces of 120 human molars were ground to expose flat dentin surfaces. The specimens were randomly assigned to six groups (n = 20). Three groups (A, B, and C) were bonded with Adper Single Bond 2 (SB) and the other groups (D, E, and F) were bonded with Clearfil SE Bond (SEB). Dentin was pretreated with CHX in groups B and E, and with SNPs in groups C and F. The specimens were restored with Z250 composite. Half of the bonded surfaces in each group underwent µSBS testing after 24 hours and the other half was tested after 6 months of water storage.

Results

SNP application was associated with a higher µSBS than was observed in the CHX and control groups for SEB after 24 hours (p < 0.05). A significantly lower µSBS was observed when no dentin pretreatment was applied compared to dentin pretreatment with CHX and SNPs for SB after 24 hours (p < 0.05). The µSBS values of the 6-month specimens were significantly lower than those obtained from the 24-hour specimens for all groups (p < 0.05). This decrease was much more pronounced when both adhesives were used without any dentin pretreatment (p < 0.05).

Conclusions

SNPs and CHX reduced the degradation of resin-dentin bonds over a 6-month period for both adhesive systems.

Citations

Citations to this article as recorded by  
  • The Effect of Silver Nanoparticles on Bond Strength of Calcium Silicate-Based Sealer: An In Vitro Study
    Sundus Bukhary, Sarah Alkahtany, Dalal AlDabeeb
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Chelating and antibacterial properties of chitosan nanoparticles on dentin
Aldo del Carpio-Perochena, Clovis Monteiro Bramante, Marco Antonio Hungaro Duarte, Marcia Regina de Moura, Fauze Ahmad Aouada, Anil Kishen
Restor Dent Endod 2015;40(3):195-201.   Published online March 30, 2015
DOI: https://doi.org/10.5395/rde.2015.40.3.195
AbstractAbstract PDFPubReaderePub
Objectives

The use of chitosan nanoparticles (CNPs) in endodontics is of interest due to their antibiofilm properties. This study was to investigate the ability of bioactive CNPs to remove the smear layer and inhibit bacterial recolonization on dentin.

Materials and Methods

One hundred bovine dentin sections were divided into five groups (n = 20 per group) according to the treatment. The irrigating solutions used were 2.5% sodium hypochlorite (NaOCl) for 20 min, 17% ethylenediaminetetraacetic acid (EDTA) for 3 min and 1.29 mg/mL CNPs for 3 min. The samples were irrigated with either distilled water (control), NaOCl, NaOCl-EDTA, NaOCl-EDTA-CNPs or NaOCl-CNPs. After the treatment, half of the samples (n = 50) were used to assess the chelating effect of the solutions using portable scanning electronic microscopy, while the other half (n = 50) were infected intra-orally to examine the post-treatment bacterial biofilm forming capacity. The biovolume and cellular viability of the biofilms were analysed under confocal laser scanning microscopy. The Kappa test was performed for examiner calibration, and the non-parametric Kruskal-Wallis and Dunn tests (p < 0.05) were used for comparisons among the groups.

Results

The smear layer was significantly reduced in all of the groups except the control and NaOCl groups (p < 0.05). The CNPs-treated samples were able to resist biofilm formation significantly better than other treatment groups (p < 0.05).

Conclusions

CNPs could be used as a final irrigant during root canal treatment with the dual benefit of removing the smear layer and inhibiting bacterial recolonization on root dentin.

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Antibacterial properties of composite resins incorporating silver and zinc oxide nanoparticles on Streptococcus mutans and Lactobacillus
Shahin Kasraei, Lida Sami, Sareh Hendi, Mohammad-Yousef AliKhani, Loghman Rezaei-Soufi, Zahra Khamverdi
Restor Dent Endod 2014;39(2):109-114.   Published online March 21, 2014
DOI: https://doi.org/10.5395/rde.2014.39.2.109
AbstractAbstract PDFPubReaderePub
Objectives

Recurrent caries was partly ascribed to lack of antibacterial properties in composite resin. Silver and zinc nanoparticles are considered to be broad-spectrum antibacterial agents. The aim of the present study was to evaluate the antibacterial properties of composite resins containing 1% silver and zinc-oxide nanoparticles on Streptococcus mutans and Lactobacillus.

Materials and Methods

Ninety discoid tablets containing 0%, 1% nano-silver and 1% nano zinc-oxide particles were prepared from flowable composite resin (n = 30). The antibacterial properties of composite resin discs were evaluated by direct contact test. Diluted solutions of Streptococcus mutans (PTCC 1683) and Lactobacillus (PTCC 1643) were prepared. 0.01 mL of each bacterial species was separately placed on the discs. The discs were transferred to liquid culture media and were incubated at 37℃ for 8 hr. 0.01 mL of each solution was cultured on blood agar and the colonies were counted. Data was analyzed with Kruskall-Wallis and Mann-Whitney U tests.

Results

Composites containing nano zinc-oxide particles or silver nanoparticles exhibited higher antibacterial activity against Streptococcus mutans and Lactobacillus compared to the control group (p < 0.05). The effect of zinc-oxide on Streptococcus mutans was significantly higher than that of silver (p < 0.05). There were no significant differences in the antibacterial activity against Lactobacillus between composites containing silver nanoparticles and those containing zinc-oxide nanoparticles.

Conclusions

Composite resins containing silver or zinc-oxide nanoparticles exhibited antibacterial activity against Streptococcus mutans and Lactobacillus.

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