The surface integrity of gutta-percha cones is a crucial factor in the success of endodontic procedures. Disinfecting solutions play a pivotal role in sterilizing gutta-percha cones, but their influence on gutta-percha surface topography remains a subject of concern. This systematic review aimed to present a qualitative synthesis of available laboratory studies assessing the influence of disinfecting solutions on the surface topography of gutta-percha and offers insights into the implications for clinical practice. The present review followed PRISMA 2020 guidelines. An advanced database search was performed in PubMed, Google Scholar, Embase, Scopus, LILAC, non-indexed citations and reference lists of eligible studies in May 2024. Laboratory studies, in English language, were considered for inclusion. The quality (risk of bias) of the included studies was assessed using parameters for in vitro studies. A total of 28 studies were included in the qualitative synthesis. Based on the included in vitro studies, surface deposits and alterations in the physical properties of gutta-percha cones were observed after the disinfection protocol. A comprehensive review of the available literature indicates that the choice of disinfecting solution, its concentration, and immersion time significantly affect the surface topography of gutta-percha cones.

This study aimed to describe the outcomes of the GentleWave system (GW) (Sonendo) on root canal treatment. Published articles were collected from scientific databases (MEDLINE/PubMed platform, Web of Science, Scopus, Science Direct and Embase). A total of 24 studies were collected from August/2014 to July/2021, 20 in vitro and 4 clinical. GW System was not associated with extrusion of the irrigant, promoted faster organic dissolution than conventional syringe irrigation (CSI), passive ultrasonic irrigation (PUI) continuous ultrasonic irrigation (CUI) and EndoVac, reduced more bacterial DNA and biofilm than PUI and CUI, promoted higher penetration of sodium hypochlorite into dentinal tubules than PUI and CUI in vitro, and removed more intracanal medication than CSI and PUI. GW was able to remove pulp tissue and calcifications. Moreover, its ability to remove hard-tissue debris and smear layer was better than that of CSI, and its ability to remove root canal obturation residues was lower or similar to that of PUI, and similar to that of CSI and EndoVac. Regarding root canal obturation of minimally instrumented molar canals, GW was associated with high-quality obturation. Clinically, the success rate of endodontic treatment using GW was 97.3%, and the short-term postoperative pain in the GW group was not different from CSI. Further research, mainly clinical, is needed to establish whether GW has any advantages over other available irrigation methods.

Citations

Citations to this article as recorded by  

• Use of the gentlewave system in endodonticsUse of the gentlewave system in endodontics
  Daiana Jacobi Lazzarotto, Mayara Colpo Prado, Lara Dotto, Rafael Sarkis-Onofre
  Brazilian Journal of Oral Sciences.2025; 24: e254250.     CrossRef
• A Comparison Between Multisonic and Ultrasonic Irrigant Activation Techniques for Multispecies Biofilm Removal During Root Canal Disinfection: A Systematic Review
  Preethi Varadan, Sangavi Ra, Mathan R Rajendran
  Cureus.2025;[Epub]     CrossRef
• The effect of ultrasonic and multisonic irrigation on root canal microbial communities: An ex vivo study
  Ki Hong Park, Ronald Ordinola‐Zapata, W. Craig Noblett, Bruno P. Lima, Christopher Staley
  International Endodontic Journal.2024; 57(7): 895.     CrossRef
• An Experimental Anatomic CBCT Study on the Correlations Between MB1 and MB2 of the Mesio-Vestibular Root of the Upper First Molars
  Luca Fiorillo, Cesare D’Amico, Giusy Rita Maria La Rosa, Francesco Calanna, Alfio Pappalardo, Eugenio Pedullà
  Journal of Craniofacial Surgery.2024; 35(2): 672.     CrossRef
• Bioceramics in Endodontics: Updates and Future Perspectives
  Xu Dong, Xin Xu
  Bioengineering.2023; 10(3): 354.     CrossRef
• Comparative analysis of the effectiveness of modern irrigants activation techniques in the process of mechanical root canal system treatment (Literature review)
  Anatoliy Potapchuk, Vasyl Almashi, Arsenii Horzov, Victor Buleza
  InterConf.2023; (34(159)): 200.     CrossRef
• Evaluation of machine-assisted irrigation on removal of intracanal biofilm and extrusion of sodium hypochlorite using a three-dimensionally printed root canal model
  Ji-Yoon Shin, Mi-Ah Kim, Hee-Jin Kim, Prasanna Neelakantan, Mi-Kyung Yu, Kyung-San Min
  Journal of Oral Science.2023; 65(3): 158.     CrossRef
• Analysis of the efficiency of sound impact on the system of canals of the tooth root: A laboratory study
  Anatolii A. Adamchik, Valerii V. Tairov, Irina O. Kamyshnikova, Ekaterina S. Zaporozhskaya-Abramova, Zhanna V. Solovyeva, Viktoria A. Ivashchenko, Natalia V. Lapina, Armenak V. Arutyunov, Olga N. Risovannaya, Ksenia D. Kirsch, Valeria D. Golubina
  Russian Journal of Dentistry.2023; 27(4): 261.     CrossRef
• Multispecies biofilm removal by a multisonic irrigation system in mandibular molars
  Hernán Coaguila‐Llerena, Ronald Ordinola‐Zapata, Christopher Staley, Matthew Dietz, Ruoqiong Chen, Gisele Faria
  International Endodontic Journal.2022; 55(11): 1252.     CrossRef

Apical periodontitis is a biofilm-mediated infection. The biofilm protects bacteria from host defenses and increase their resistance to intracanal disinfecting protocols. Understanding the virulence of these endodontic microbiota within biofilm is essential for the development of novel therapeutic procedures for intracanal disinfection. Both the disruption of biofilms and the killing of their bacteria are necessary to effectively treat apical periodontitis. Accordingly, a review of endodontic biofilm types, antimicrobial resistance mechanisms, and current and future therapeutic procedures for endodontic biofilm is provided.

Citations

Citations to this article as recorded by  

• Evaluation of Anti-Biofilm Property of Zirconium Oxide Nanoparticles on Streptococcus mutans and Enterococcus faecalis: An In Vitro Study
  Anu Priya Guruswamy Pandian, Anil Kumar Ramachandran, Priyanka Kodaganallur Pitchumani, Blessy Mathai, Davis C Thomas
  Cureus.2025;[Epub]     CrossRef
• Self-Sacrificial Antibacterial Coating with Photothermal Response for Inhibiting Implant Infection
  Jinglin Zhang, Aijian Cao, Lizhen Chen, Dongliang Huo, Jingxian Zhang, Langhuan Huang, Shaozao Tan
  ACS Applied Nano Materials.2024; 7(23): 26907.     CrossRef
• Biofilm in Endodontic Infection and its Advanced Therapeutic Options – An Updated Review
  Srilekha Jayakumar, Dinesh Sridhar, Bindu M. John, Karthikeyan Arumugam, Prashanth Ponnusamy, Hema Pulidindi
  Journal of Pharmacy and Bioallied Sciences.2024; 16(Suppl 2): S1104.     CrossRef
• Analysis of the chemical interaction of polyhexanide with endodontic irrigants
  Z. S. Zurab, Yu. A. Generalova, A. A. Kulikova, A. Yu. Umarov, F. V. Badalov, A. Wehbe, E. M. Kakabadze
  Endodontics Today.2024; 22(4): 319.     CrossRef
• In vitro evaluation of three engineered multispecies endodontic biofilms on a dentinal disk substrate
  Wajih Hage, Dolla Karam Sarkis, Mireille Kallasy, May Mallah, Carla Zogheib
  Biomaterial Investigations in Dentistry.2023;[Epub]     CrossRef
• In vitro evaluation of enterococcus faecalis growth in different conditions on dentinal substrate
  Wajih Hage, Dolla Karam Sarkis, Mireille Kallassy, May Mallah, Carla Zogheib
  Biomaterial Investigations in Dentistry.2023;[Epub]     CrossRef
• Bacteria associated with apical periodontitis promotes in vitro the differentiation of macrophages to osteoclasts
  A. P. Torres-Monjarás, R. Sánchez-Gutiérrez, B. Hernández-Castro, L. González-Baranda, D. L. Alvarado-Hernández, A. Pozos-Guillén, A. Muñoz-Ruiz, V. Méndez-González, R. González-Amaro, M. Vitales-Noyola
  Clinical Oral Investigations.2023; 27(6): 3139.     CrossRef
• Antimicrobial efficacy of Kerr pulp canal sealer (EWT) in combination with 10% amoxicillin on Enterococcus faecalis: A confocal laser scanning microscopic study
  Madhureema De Sarkar, Kundabala Mala, Suchitra Shenoy Mala, Shama Prasada Kabekkodu, Srikant Natarajan, Neeta Shetty, Priyanka Madhav Kamath, Manuel Thomas
  F1000Research.2023; 12: 725.     CrossRef
• Antimicrobial efficacy of Kerr pulp canal sealer (EWT) in combination with 10% amoxicillin on Enterococcus faecalis: A confocal laser scanning microscopic study
  Madhureema De Sarkar, Kundabala Mala, Suchitra Shenoy Mala, Shama Prasada Kabekkodu, Srikant Natarajan, Neeta Shetty, Priyanka Madhav Kamath, Manuel Thomas
  F1000Research.2023; 12: 725.     CrossRef
• Combined effect of electrical energy and graphene oxide on Enterococcus faecalis biofilms
  Myung-Jin LEE, Mi-Ah KIM, Kyung-San MIN
  Dental Materials Journal.2023; 42(6): 844.     CrossRef
• Innovative Curved-Tip Reactor for Non-Thermal Plasma and Plasma-Treated Water Generation: Synergistic Impact Comparison with Sodium Hypochlorite in Dental Root Canal Disinfection
  Raúl Arguello-Sánchez, Régulo López-Callejas, Benjamín Gonzalo Rodríguez-Méndez, Rogelio Scougall-Vilchis, Ulises Velázquez-Enríquez, Antonio Mercado-Cabrera, Rosendo Peña-Eguiluz, Raúl Valencia-Alvarado, Carlo Eduardo Medina-Solís
  Materials.2023; 16(22): 7204.     CrossRef
• Impact of antimicrobial photodynamic therapy on the bond-strength and penetration of endodontic sealers: A systematic review
  Khalid H Almadi
  Photodiagnosis and Photodynamic Therapy.2023; 41: 103249.     CrossRef
• Apical periodontitis in mesiobuccal roots of maxillary molars: influence of anatomy and quality of root canal treatment, a CBCT study
  Samantha Jannone Carrion, Marcelo Santos Coelho, Adriana de Jesus Soares, Marcos Frozoni
  Restorative Dentistry & Endodontics.2022;[Epub]     CrossRef
• Potential relationship between clinical symptoms and the root canal microbiomes of root filled teeth based on the next‐generation sequencing
  Yajing Hou, Liu Wang, Lan Zhang, Xuelian Tan, Dingming Huang, Dongzhe Song
  International Endodontic Journal.2022; 55(1): 18.     CrossRef
• Efficacy of 6% Sodium Hypochlorite on Infectious Content of Teeth with Symptomatic Irreversible Pulpitis
  Rodrigo Arruda-Vasconcelos, Marlos Barbosa-Ribeiro, Lidiane M. Louzada, Beatriz I.N. Lemos, Adriana de-Jesus-Soares, Caio C.R. Ferraz, José F.A. Almeida, Marina A. Marciano, Brenda P.F. A. Gomes
  Journal of Endodontics.2022; 48(2): 179.     CrossRef
• Specialized pro-resolving lipid mediators in endodontics: a narrative review
  Davy Aubeux, Ove A. Peters, Sepanta Hosseinpour, Solène Tessier, Valérie Geoffroy, Fabienne Pérez, Alexis Gaudin
  BMC Oral Health.2021;[Epub]     CrossRef
• Effects of curcumin-mediated antimicrobial photodynamic therapy associated to different chelators against Enterococcus faecalis biofilms
  Daniela Alejandra Cusicanqui Méndez, Maricel Rosario Cardenas Cuéllar, Victor Feliz Pedrinha, Evelyn Giuliana Velásquez Espedilla, Flaviana Bombarda de Andrade, Patrícia de Almeida Rodrigues, Thiago Cruvinel
  Photodiagnosis and Photodynamic Therapy.2021; 35: 102464.     CrossRef
• Effectiveness of D,L‐2‐hydroxyisocaproic acid (HICA) and alpha‐mangostin against endodontopathogenic microorganisms in a multispecies bacterial–fungal biofilm in anex vivotooth model
  Warat Leelapornpisid, Lilyann Novak‐Frazer, Alison Qualtrough, Riina Rautemaa‐Richardson
  International Endodontic Journal.2021; 54(12): 2243.     CrossRef
• In Vitro Evaluation of a New Combination of Three Antibiotic Paste Against Common Endodontic Pathogens
  Prasanna Dahake, Nilima Thosar
  Journal of Islamic Dental Association of IRAN.2021; 33(3): 58.     CrossRef
• Effect of using diode laser on Enterococcus faecalis and its lipoteichoic acid (LTA) in chronic apical periodontitis
  Zhaohui Zou, Junu Bhandari, Baiyan Xiao, Xiaoyue Liang, Yu Zhang, Guohui Yan
  Lasers in Medical Science.2021; 36(5): 1059.     CrossRef
• Prevalence of Bacteria of Genus Actinomyces in Persistent Extraradicular Lesions—Systematic Review
  Mario Dioguardi, Vito Crincoli, Luigi Laino, Mario Alovisi, Diego Sovereto, Lorenzo Lo Muzio, Giuseppe Troiano
  Journal of Clinical Medicine.2020; 9(2): 457.     CrossRef
• Evaluation of in vitro biofilm elimination of Enterococcus faecalis using a continuous ultrasonic irrigation device
  Jennifer Galván-Pacheco, Marlen Vitales-Noyola, Ana M. González-Amaro, Heriberto Bujanda-Wong, Antonio Aragón-Piña, Verónica Méndez-González, Amaury Pozos-Guillén
  Journal of Oral Science.2020; 62(4): 415.     CrossRef
• Comparison of the use of d-enantiomeric and l-enantiomeric antimicrobial peptides incorporated in a calcium-chelating irrigant against Enterococcus faecalis root canal wall biofilms
  Wei-hu Ye, Lara Yeghiasarian, Christopher W. Cutler, Brian E. Bergeron, Stephanie Sidow, Hockin H.K. Xu, Li-na Niu, Jing-zhi Ma, Franklin R. Tay
  Journal of Dentistry.2019; 91: 103231.     CrossRef

Citations

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• Effect of various disinfectant solutions on the tensile strength of gutta-percha using the rapid sterilization technique
  Sandeep Rudranaik, Yoganatha Hanasoge Nagashetty, Sahadev Chikmagarvalli Krishna Gowda, Bharath Makonahalli Jaganath, K. B. Nirmala, M. C. Bharath Gowda
  Journal of Conservative Dentistry and Endodontics.2024; 27(2): 154.     CrossRef
• Evaluation of antimicrobial efficacy of herbal extracts and their effect on the surface characteristics of gutta-percha cones: An in vitro study
  Anshuman Shetty, Shivprasad Rai, Shetty Suhani Sudhakar
  Endodontology.2023; 35(2): 142.     CrossRef
• Comparative evaluation of various herbal agents for the disinfection of guttapercha cones – An in vitro study
  Gunnam Anjany Chowdary
  IP Indian Journal of Conservative and Endodontics.2023; 8(2): 86.     CrossRef
• Dynamics of herbal medicine processing and production in Benue State Nigeria
  P. Adigwe Obi, F. Builders Philip, Alfa John, Oladosu Peter
  African Journal of Pharmacy and Pharmacology.2022; 16(7): 110.     CrossRef
• Antimicrobial Efficacy of Acacia Nilotica (Babul) Extract and its Effectiveness in Disinfecting Gutta Percha Cones - An In Vitro Study
  Dolly R. Jagyasi, Neelam D. Chandwani, Mohit K. Gunwal, Aastha S. Ranka
  Indian Journal of Dental Research.2021; 32(2): 221.     CrossRef
• The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka
  Mayuri Napagoda, Jana Gerstmeier, Hannah Butschek, Sudhara De Soyza, Simona Pace, Sybille Lorenz, Mallique Qader, Sanjeeva Witharana, Ajith Nagahawatte, Gaya Wijayaratne, Aleš Svatoš, Lalith Jayasinghe, Andreas Koeberle, Oliver Werz
  Molecules.2020; 25(8): 1894.     CrossRef
• Comparación de desinfección de diferentes marcas de punta de gutapercha con hipoclorito de sodio
  Jorge Morales García, Mónica Badillo Barba, María Guadalupe  Chávez García, Vanessa  García Ruíz, Adolfo Gutiérrez García
  Revista de la Asociación Dental Mexicana.2020; 77(4): 185.     CrossRef
• Current herbal medicine as an alternative treatment in dentistry: In vitro, in vivo and clinical studies
  Ehsan Tafazoli Moghadam, Mohsen Yazdanian, Elahe Tahmasebi, Hamid Tebyanian, Reza Ranjbar, Alireza Yazdanian, Alexander Seifalian, Ali Tafazoli
  European Journal of Pharmacology.2020; 889: 173665.     CrossRef
• Gutta-percha in endodontics - A comprehensive review of material science
  Vijetha Vishwanath, HMurali Rao
  Journal of Conservative Dentistry.2019; 22(3): 216.     CrossRef

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Citations to this article as recorded by  

• Influence of photobiomodulation therapy on regenerative potential of non-vital mature permanent teeth in healthy canine dogs
  S. F. Khattab, Y. F. Gomaa, E. A. E. Abdelaziz, N. M. A. Khattab
  European Archives of Paediatric Dentistry.2025;[Epub]     CrossRef
• A 12-month randomized controlled trial to assess the efficacy of revitalization of retreated mature incisors with periapical radiolucency in adolescents
  Ahmad Abdel Hamid Elheeny, Osama Seif-Elnasr Hussien, Mahmoud Ahmed Abdelmotelb, Yassmin Mohamed ElMakawi, Norhan Khaled Omar Wahba
  Scientific Reports.2024;[Epub]     CrossRef
• Failed Regenerative Endodontic Case Treated by Modified Aspiration-irrigation Technique and Apexification
  Loai Alsofi, Sara Almarzouki
  The Journal of Contemporary Dental Practice.2024; 25(1): 92.     CrossRef
• Effectiveness of EndoActivator, PATS Vario system, and XP-endo Finisher files on smear layer removal under scanning electron microscope: A comparative study
  Rishabh Patel, Gaurav Shinde, Prashant Bondarde, Aruna Vishwakarma, Madhuri Bhandare, Vaibhavi Pharne
  Journal of Indian Society of Pedodontics and Preventive Dentistry.2024; 42(3): 195.     CrossRef
• Influence of root canal moisture on the penetration of TotalFill bioceramic sealer into the dentinal tubules: A confocal laser scanning microscopy study
  Archika M Singh, Tarek M Elsewify, Walid S El-Sayed, Husam H Nuawafleh, Ranya F Elemam, Bassem M Eid
  Saudi Endodontic Journal.2024; 14(2): 187.     CrossRef
• Fungi and bacteria occupy distinct spatial niches within carious dentin
  Rosalyn M. Sulyanto, Clifford J. Beall, Kasey Ha, Joseph Montesano, Jason Juang, John R. Dickson, Shahr B. Hashmi, Seth Bradbury, Eugene J. Leys, Mira Edgerton, Sunita P. Ho, Ann L. Griffen, Alex Andrianopoulos
  PLOS Pathogens.2024; 20(5): e1011865.     CrossRef
• The advancement in irrigation solution within the field of endodontics, A Review
  Fatima Fahad , Raghad A Al-Hashimi , Munther J Hussain
  Journal of Baghdad College of Dentistry.2024; 36(1): 54.     CrossRef
• Supplementary methods for filling material removal: A systematic review and meta-analysis of micro-CT imaging studies
  Bruna Venzke Fischer, Taynara Santos Goulart, Filipe Colombo Vitali, Diego Leonardo de Souza, Cleonice da Silveira Teixeira, Lucas da Fonseca Roberti Garcia
  Journal of Dentistry.2024; 151: 105445.     CrossRef
• Impact of calcium hydroxide and 2-hydroxyisocaproic acid on the microhardness of root dentine: an in vitro study
  Nandini T. Niranjan, Protim Ghosh Dastidar, Raghavendra Penukonda, Galvin Sim Siang Lin, Roopa Babannavar, Arun Jaysheel, Harshada Pattar
  Odontology.2024; 112(3): 711.     CrossRef
• Fabrication of Rapidly Soluble Zn2+-Releasing Phosphate-Based Glass and Its Incorporation into Dental Resin
  Fan Deng, Haruaki Kitagawa, Tomoki Kohno, Tingyi Wu, Naoya Funayama, Pasiree Thongthai, Hefei Li, Gabriela L. Abe, Ranna Kitagawa, Jun-Ichi Sasaki, Satoshi Imazato
  Molecules.2024; 29(21): 5098.     CrossRef
• Combined effect of electrical energy and graphene oxide on Enterococcus faecalis biofilms
  Myung-Jin LEE, Mi-Ah KIM, Kyung-San MIN
  Dental Materials Journal.2023; 42(6): 844.     CrossRef
• Effect of Different Irrigant Activation Techniques on the Penetration of Calcium Hydroxide, an Intracanal Medicament: An In Vitro Study
  Radha Kalyani Narla, Ravi kumar J, Tejosmita Chowdary Pavuluri, Krishna Chaitanya P, Ramesh Penumaka, Ratna Kamal Nagelli
  Cureus.2023;[Epub]     CrossRef
• Comparative assessment of antibacterial effect of two types of laser and their effect on morphology and mineral content of dentin
  Soha Adel Abdou, Haythem S Moharrum, Elsayed Abdallah Eltayeb
  Journal of The Arab Society for Medical Research.2023; 18(2): 117.     CrossRef
• Efficacy of Endodontic Disinfection Protocols in an E. faecalis Biofilm Model—Using DAPI Staining and SEM
  Maria Dede, Sabine Basche, Jörg Neunzehn, Martin Dannemann, Christian Hannig, Marie-Theres Kühne
  Journal of Functional Biomaterials.2023; 14(4): 176.     CrossRef
• Antibacterial Effect of Matricaria chamomilla L. Extract Against Enterococcus faecalis
  Ariana Kameri, Arben Haziri, Zeqir Hashani, Agime Dragidella, Kemajl Kurteshi, Arsim Kurti
  Clinical, Cosmetic and Investigational Dentistry.2023; Volume 15: 13.     CrossRef
• Efficacy of Smear Layer Removal at the Apical One-Third of the Root Using Different Protocols of Erbium-Doped Yttrium Aluminium Garnet (Er:YAG) Laser
  Amel Yousif Habshi, Nausheen Aga, Khadija Yousif Habshi, Muna Eisa Mohamed Hassan, Ziaullah Choudhry, Muhammad Adeel Ahmed, Azeem Ul Yaqin Syed, Rizwan Jouhar
  Medicina.2023; 59(3): 433.     CrossRef
• Minimally invasive management of vital teeth requiring root canal therapy
  E. Karatas, M. Hadis, W. M. Palin, M. R. Milward, S. A. Kuehne, J. Camilleri
  Scientific Reports.2023;[Epub]     CrossRef
• Functionalized surface of PLGA nanoparticles in thermosensitive gel to enhance the efficacy of antibiotics against antibiotic resistant infections in endodontics: A randomized clinical trial
  Mona G. Arafa, Hadeel A. Mousa, Mohamed Medhat Kataia, Shehabeldin M., Nagia N. Afifi
  International Journal of Pharmaceutics: X.2023; 6: 100219.     CrossRef
• Critical analysis of research methods and experimental models to study removal of root filling materials
  Mahdi A. Ajina, Pratik K. Shah, Bun San Chong
  International Endodontic Journal.2022; 55(S1): 119.     CrossRef
• TREATMENT OF PERIODONTITIS WITH INCLUSIVE ANTIFUNGAL DRUGS
  Lyudmila Tatintsyan, Janna Khachatryan, Sona Ambartsumyan, Arsen Mikaelyan, Valery Tatintsyan, Minas Pogosyan, Anna Hakobyan, Arsen Kupelyan, Armen Shahinyan
  BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY.2022; : 15.     CrossRef
• Antimicrobial action of photodynamic therapy on Enterococcus faecalis biofilm using curing light, curcumin and riboflavin
  Mahsa Moradi, Mahta Fazlyab, Maryam Pourhajibagher, Nasim Chiniforush
  Australian Endodontic Journal.2022; 48(2): 274.     CrossRef
• Candida albicans and Enterococcus faecalis biofilm frenemies: When the relationship sours
  Om Alkhir Alshanta, Khawlah Albashaireh, Emily McKloud, Christopher Delaney, Ryan Kean, William McLean, Gordon Ramage
  Biofilm.2022; 4: 100072.     CrossRef
• Calcium hydroxide/iodoform nanoparticles as an intracanal filling medication: synthesis, characterization, and in vitro study using a bovine primary tooth model
  Arturo Garrocho-Rangel, Diana María Escobar-García, Mariana Gutiérrez-Sánchez, Denisse Herrera-Badillo, Fernanda Carranco-Rodríguez, Juan Carlos Flores-Arriaga, Amaury Pozos-Guillén
  Odontology.2021; 109(3): 687.     CrossRef
• Dentin Disinfection Efficacy Using Four Different Irrigation Protocols
  David Jaramillo, Jose L Ibarrola, Ana Arias, Phillipe Sleiman, Ali Naji, David E Jaramillo
  Dental Research and Management.2021; : 33.     CrossRef
• Histologic, Radiographic, and Micro-Computed Tomography Evaluation of Experimentally Enlarged Root Apices in Dog Teeth with Apical Periodontitis after Regenerative Treatment
  Mohammed S. Alenazy, Saad Al-Nazhan, Hezekiah A Mosadomi
  Current Therapeutic Research.2021; 94: 100620.     CrossRef
• Comparative evaluation of dentin volume removal and centralization of the root canal after shaping with the ProTaper Universal, ProTaper Gold, and One-Curve instruments using micro-CT
  Hatice Yalniz, Mehrdad Koohnavard, Aysenur Oncu, Berkan Celikten, Ayse Isil Orhan, Kaan Orhan
  Journal of Dental Research, Dental Clinics, Dental Prospects.2021; 15(1): 47.     CrossRef
• The influence of centrifugation and inoculation time on the number, distribution, and viability of intratubular bacteria and surface biofilm in deciduous and permanent bovine dentin
  Viktoria A. Dezhurko-Korol, Nina E. Novozhilova, Irina M. Makeeva, Anastasia Yu. Arkhipova, Mihail M. Moisenovich, Ludmila V. Akhmadishina, Alexander N. Lukashev, Alexander M. Semenov, Maria R. Leontieva, Svetlana F. Byakova
  Archives of Oral Biology.2020; 114: 104716.     CrossRef
• Antimicrobial efficacy of synthetic and natural-derived novel endodontic irrigating solution – An In vitro study
  Thangi Sowjanya, Sudhakar Naidu, MahendraVarma Nadimpalli, GowtamDev Dondapati, TB V G Raju, ParvathaneniKrishna Prasad
  Journal of the International Clinical Dental Research Organization.2020; 12(1): 21.     CrossRef
• Comparative Evaluation of Antimicrobial Efficacy of Three Different Intracanal Medicaments against Candida albicans: An In Vitro Study
  Ravi Vaiyapuri, Jambai S Sivakumar, Chittrarasu Mathimaraiselvan, Andamuthu Sivakumar, Anjaneya Shiva Prasad, Sasmitha Chandrasekaran
  Journal of Operative Dentistry & Endodontics.2020; 5(2): 79.     CrossRef
• Assessment of Nitrofurantoin as an Experimental Intracanal Medicament in Endodontics
  Mewan Salahalddin A. Alrahman, Bestoon Muhammed Faraj, Kawa F. Dizaye, Abdelwahab Omri
  BioMed Research International.2020;[Epub]     CrossRef
• Conjugate of chitosan nanoparticles with chloroaluminium phthalocyanine: Synthesis, characterization and photoinactivation of Streptococcus mutans biofilm
  Leonardo Lobo Ribeiro Cavalcante, Antonio Claudio Tedesco, Luandra Aparecida Unten Takahashi, Fabiana Almeida Curylofo-Zotti, Aline Evangelista Souza-Gabriel, Silmara Aparecida Milori Corona
  Photodiagnosis and Photodynamic Therapy.2020; 30: 101709.     CrossRef
• Effect of triple antibiotic loaded apatitic nanocarriers on Enterococcus faecalis biofilm – An In vitro study
  S. Nagarathinam, V. Sujatha, K. Madhumathi, S. Mahalaxmi, P.Pranav Vanajassun, T.S.Sampath Kumar
  Journal of Drug Delivery Science and Technology.2019; 51: 499.     CrossRef
• Wear profile of canal wall surfaces and bond strength of endodontic sealers after in situ acid challenge
  R. D. Silva‐Neto, M. D. Sousa‐Neto, J. D. Pécora, R. G. Palma‐Dibb, A. E. Souza‐Gabriel
  International Endodontic Journal.2018; 51(3): 364.     CrossRef
• Bacterial invasion of dentinal tubules from the external root surface with and without an intact cemental layer- a confocal laser scanning microscopic study
  Jovita D’souza, Sneha Gokhale, Vikram Padbidri, Lovely M
  Advances in Tissue Engineering & Regenerative Medicine: Open Access.2018;[Epub]     CrossRef
• AgCa-PLGA submicron particles inhibit the growth and colonization of E. Faecalis and P. Gingivalis on dentin through infiltration into dentinal tubules
  Wei Fan, Danfeng Liu, Yanyun Li, Qing Sun, Bing Fan
  International Journal of Pharmaceutics.2018; 552(1-2): 206.     CrossRef
• Antimicrobial Photodynamic Therapy Associated with Conventional Endodontic Treatment: A Clinical and Molecular Microbiological Study
  Caroline C. da Silva, Sérgio P. Chaves Júnior, Gabriela L. D. Pereira, Karla B. F. da C. Fontes, Lívia A. A. Antunes, Helvécio C. C. Póvoa, Leonardo S. Antunes, Natalia L. P. P. Iorio
  Photochemistry and Photobiology.2018; 94(2): 351.     CrossRef
• Human teeth biobank: Microbiological analysis of the teeth storage solution
  Fabiana Almeida Curylofo‐Zotti, Francine Lorencetti‐Silva, Jéssica de Almeida Coelho, Rachel Maciel Monteiro, Evandro Watanabe, Silmara Aparecida Milori Corona
  Microscopy Research and Technique.2018; 81(3): 332.     CrossRef
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  Ling He, Juan Zhong, Qimei Gong, Bin Cheng, Sahng G. Kim, Junqi Ling, Jeremy J. Mao
  Dental Clinics of North America.2017; 61(1): 143.     CrossRef
• Regenerative Endodontics for Adult Patients
  Ling He, Sahng G. Kim, Qimei Gong, Juan Zhong, Sainan Wang, Xuedong Zhou, Ling Ye, Junqi Ling, Jeremy J. Mao
  Journal of Endodontics.2017; 43(9): S57.     CrossRef
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  BioMed Research International.2017; 2017: 1.     CrossRef
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  Lasers in Dental Science.2017; 1(2-4): 91.     CrossRef
• Study of invasion and colonization of E. faecalis in microtubes by a novel device
  Xiaoqiang Sun, Shujing Wang, Yue Yang, Chunxiong Luo, Benxiang Hou
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  Skin Appendage Disorders.2016; 2(3-4): 137.     CrossRef
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  Leron Khalifa, Mor Shlezinger, Shaul Beyth, Yael Houri-Haddad, Shunit Coppenhagen-Glazer, Nurit Beyth, Ronen Hazan
  Journal of Oral Microbiology.2016; 8(1): 32157.     CrossRef
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  Journal of lasers in medical sciences.2015; 6(4): 139.     CrossRef
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• Clinical and Radiographic Evaluation between Conventional Mineral Trioxide Aggregate and Gel-based Mineral Trioxide Aggregate in Indirect Pulp Therapy: A Randomized Clinical Trial
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  BDJ Open.2020;[Epub]     CrossRef
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  British Dental Journal.2016; 221(8): 453.     CrossRef

Whenever endodontic therapy is performed on mandibular posterior teeth, damage to the inferior alveolar nerve or any of its branches is possible. Acute periapical infection in mandibular posterior teeth may also sometimes disturb the normal functioning of the inferior alveolar nerve. The most common clinical manifestation of these insults is the paresthesia of the inferior alveolar nerve or mental nerve paresthesia. Paresthesia usually manifests as burning, prickling, tingling, numbness, itching or any deviation from normal sensation. Altered sensation and pain in the involved areas may interfere with speaking, eating, drinking, shaving, tooth brushing and other events of social interaction which will have a disturbing impact on the patient. Paresthesia can be short term, long term or even permanent. The duration of the paresthesia depends upon the extent of the nerve damage or persistence of the etiology. Permanent paresthesia is the result of nerve trunk laceration or actual total nerve damage. Paresthesia must be treated as soon as diagnosed to have better treatment outcomes. The present paper describes a case of mental nerve paresthesia arising after the start of the endodontic therapy in left mandibular first molar which was managed successfully by conservative treatment.

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  Selcuk Dental Journal.2023; 10(4): 350.     CrossRef
• Mental Nerve Paraesthesia: A Report of Two Cases Associated with Endodontic Etiology
  Neeta Patel, Akshayraj Langaliya, Shikha Kanodia, Aravind Kumbhar, Aastha Buch, Aarshvi Shah, Himani Bhatt, Drashti Panchal, Sharan Shah, Jinali Shah, Darko Macan
  Case Reports in Dentistry.2021; 2021: 1.     CrossRef
• Anatomic Danger Zones of the Head and Neck
  Guy Talmor, Andy Trang, Omeed Ahadiat, Boris Paskhover, Ashley Wysong
  Dermatologic Surgery.2020; 46(12): 1549.     CrossRef
• The anatomical relationship between the roots of erupted permanent teeth and the mandibular canal: a systematic review
  Michał Puciło, Mariusz Lipski, Magdalena Sroczyk-Jaszczyńska, Aleksandra Puciło, Alicja Nowicka
  Surgical and Radiologic Anatomy.2020; 42(5): 529.     CrossRef
• Endodontic-related inferior alveolar nerve injuries: A review and a therapeutic flow chart
  R. Castro, M. Guivarc'h, J.M. Foletti, J.H. Catherine, C. Chossegros, L. Guyot
  Journal of Stomatology, Oral and Maxillofacial Surgery.2018; 119(5): 412.     CrossRef
• Neuropathy of Trigeminal Nerve Branches After Oral and Maxillofacial Treatment
  Jimoh Olubanwo Agbaje, Elke Van de Casteele, Marjolein Hiel, Ciska Verbaanderd, Ivo Lambrichts, Constantinus Politis
  Journal of Maxillofacial and Oral Surgery.2016; 15(3): 321.     CrossRef
• Facial nerve paralysis following endodontic treatment of lower first molar
  Umut Demetoglu, Gokhan Ozkan, Hasan Onur Simsek
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2016; 28(3): 267.     CrossRef

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  THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY.2013; 40(4): 268.     CrossRef
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  Restorative Dentistry & Endodontics.2012; 37(3): 130.     CrossRef
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  In-Nam Hwang, Sung-Ok Hong, Bin-Na Lee, Yun-Chan Hwang, Won-Mann Oh, Hoon-Sang Chang
  Journal of Applied Oral Science.2012; 20(5): 576.     CrossRef

It has been documented that periodontopathic bacteria are also implicated in endodontic infections. 16S rDNA gene-directed PCR was to examine the prevalence of periodontopathic bacteria including Actinobacillus actinomycetemcomitans (Aa), Prevotella intermedia (Pi), Prevotella nigrescens (Pn), Porphyromonas gingivalis (Pg), Porphyromonas endodontalis (Pe), and Treponema denticola (Td) in the root canals of 36 endodontically infected teeth having apical lesions with or without clinical symptoms like pain, swelling, and fistula.

In 36 infected root canals, most frequently detected bacterial species was Pg (61.1%), followed by Td (52.8%) and Pe (38.9%).

High prevalence of BPB in the symptomatic teeth but low in the asymptomatic teeth suggests that BPB may play an important role in the pathogenesis of periapical lesions.

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• Isolation of Propionibacterium acnes among the microbiota of primary endodontic infections with and without intraoral communication
  Sadia Ambreen Niazi, Hana Suleiman Al Kharusi, Shanon Patel, Kenneth Bruce, David Beighton, Federico Foschi, Francesco Mannocci
  Clinical Oral Investigations.2016; 20(8): 2149.     CrossRef
• Antimicrobial Activity of Isothiocyanates （ITCs） Extracted from Horseradish （Armoracia rusticana） Root against Oral Microorganisms
  HO-WON PARK, KYU-DUCK CHOI, IL-SHIK SHIN
  Biocontrol Science.2013; 18(3): 163.     CrossRef
• Microbial profile of asymptomatic and symptomatic teeth with primary endodontic infections by pyrosequencing
  Sang-Min Lim, Tae-Kwon Lee, Eun-Jeong Kim, Jun-Hong Park, Yoon Lee, Kwang-Shik Bae, Kee-Yeon Kum
  Journal of Korean Academy of Conservative Dentistry.2011; 36(6): 498.     CrossRef

The purpose of this study was to investigate the frequency of 7 putative pathogens in endodontic infections. The specimens were collected from infected pulpal tissue of patients who were referred for root canal treatment to the department of conservative dentistry, Chosun University. Samples were collected aseptically using a barbed broach and a paper point. The cut barbed broaches and paper points were transferred to an eppendorf tube containing 500 ml of 1 X PBS. DNAs were extracted from the samples by direct DNA extraction method using lysis buffer (0.5% EDTA, 1% Triton X-100). Identification of 7 putative pathogens was performed by PCR based on 16S rDNA. The target species were as follows: Porphyromonas endodontalis, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Bacteroides forsythus, Actinobacillus actinomycetemcomitans, and Treponema denticola. Our data revealed that the prevalence of P. endodontalis was found in 88.6% (39/54), P. gingivalis 52.3% (23/44), P. nigrescens 18.2% (8/44), P. intermedia 15.9% (7/44), B. forsythus 18.2% (8/44), A. actinomycetemcomitans 2.3% (1/44), T. denticola 25% (11/44) of the samples. The high prevalence of P. endodontalis and P. gingivalis suggests that they may play an important role in the etiology of endodontic infections.