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Disinfectant effectiveness of chlorhexidine gel compared to sodium hypochlorite: a systematic review with meta-analysis
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Theodoro Weissheimer, Karem Paula Pinto, Emmanuel João Nogueira Leal da Silva, Lina Naomi Hashizume, Ricardo Abreu da Rosa, Marcus Vinicius Reis Só
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Restor Dent Endod 2023;48(4):e37. Published online October 26, 2023
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DOI: https://doi.org/10.5395/rde.2023.48.e37
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Abstract
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This study aimed to compare the disinfectant ability of chlorhexidine (CHX) gel and sodium hypochlorite (NaOCl). Systematic searches were conducted from inception until December 8th, 2022 (MEDLINE/PubMed, Cochrane Library, Web of Science, Scopus, Embase, and Grey Literature databases). Only randomized clinical trials were included. The revised Cochrane risk of bias tools for randomized trials were used to assess the quality of studies. Meta-analyses were performed. The overall quality of evidence was assessed through the Grading of Recommendations Assessment, Development, and Evaluation tool. Six studies were included. Five had a low risk of bias and 1 had some concerns. Three studies assessed bacterial reduction. Two were included in the meta-analysis for bacterial reduction (mean difference, 75.03 [confidence interval, CI, −271.15, 421.22], p = 0.67; I2 = 74%); and 3 in the meta-analysis for cultivable bacteria after chemomechanical preparation (odds ratio, 1.03 [CI, 0.20, 5.31], P = 0.98; I2 = 49%). Five studies assessed endotoxin reduction. Three were included in a meta-analysis (mean difference, 20.59 [CI, −36.41, 77.59], p = 0.48; I2 = 74%). There seems to be no difference in the disinfectant ability of CHX gel and NaOCl, but further research is necessary.
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- Preparing porcine lens to mimic human lens capsule
Yajing Pei, Shaofeng Han, Mingfeng Lu, Yang Yang, Ke Ma Journal of Cataract & Refractive Surgery.2024; 50(9): 963. CrossRef - Comparative Evaluation of Disinfection Protocols for Dental Impressions in Prosthodontics
Subhash Sonkesriya, Ghanshyam Gaur, Akanksha Maheshwari, Arun Kumar Ashahiya, Simran Kaur Aulakh, Amit Kumar, Bhumika Kamal Badiyani Cureus.2024;[Epub] CrossRef
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Does photobiomodulation on the root surface decrease the occurrence of root resorption in reimplanted teeth? A systematic review of animal studies
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Theodoro Weissheimer, Karolina Frick Bischoff, Carolina Horn Troian Michel, Bruna Barcelos Só, Manoela Domingues Martins, Matheus Albino Souza, Ricardo Abreu da Rosa, Marcus Vinícius Reis Só
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Restor Dent Endod 2023;48(3):e24. Published online June 12, 2023
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DOI: https://doi.org/10.5395/rde.2023.48.e24
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Abstract
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This review aimed to answer the following question “Does photobiomodulation treatment of the root surface decrease the occurrence of root resorption in reimplanted teeth?” Electronic searches were performed in the MEDLINE/PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Grey Literature Report databases. Risk of bias was evaluated using SYRCLE Risk of Bias tool. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) tool was used to assess the certainty of evidence. In total, 6 studies were included. Five studies reported a reduced occurrence of root resorption in teeth that received photobiomodulation treatment of the root surface prior to replantation. Only 1 study reported contradictory results. The photobiomodulation parameters varied widely among studies. GRADE assessment showed a low certainty of evidence. It can be inferred that photobiomodulation treatment of the root surface prior to replantation of teeth can reduce the occurrence of root resorption. Nonetheless, further clinical studies are needed. Trial RegistrationPROSPERO Identifier: CRD42022349891
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Citations to this article as recorded by 
- Feasibility and Outcomes of Cell-based Regenerative Endodontic Therapy in Postautogenous Transplantation of a Mature Tooth: A Case Report
Noriaki Yoshihashi Journal of Endodontics.2025; 51(1): 85. CrossRef - Photobiomodulation Literature Watch September 2023
James D. Carroll Photobiomodulation, Photomedicine, and Laser Surgery.2024; 42(7): 498. CrossRef
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Dentinal tubule penetration of sodium hypochlorite in root canals with and without mechanical preparation and different irrigant activation methods
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Renata Aqel de Oliveira, Theodoro Weissheimer, Gabriel Barcelos Só, Ricardo Abreu da Rosa, Matheus Albino Souza, Rodrigo Gonçalves Ribeiro, Marcus Vinicius Reis Só
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Restor Dent Endod 2023;48(1):e1. Published online December 1, 2022
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DOI: https://doi.org/10.5395/rde.2023.48.e1
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Abstract
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This study evaluated the dentinal penetration depth of 2.5% sodium hypochlorite (NaOCl) in root canals with and without preparation and different irrigant activation protocols. Materials and MethodsSixty-three bovine mandibular incisors were randomly allocated to 6 groups (n = 10): G1, preparation + conventional needle irrigation (CNI); G2, preparation + passive ultrasonic irrigation (PUI); G3, preparation + Odous Clean (OC); G4, no preparation + CNI; G5, no preparation + PUI; G6, no preparation + OC; and CG (negative control; n = 3). Samples were filled with crystal violet for 72 hours. Irrigant activation was performed. Samples were sectioned perpendicularly along the long axis, 3 mm and 7 mm from the apex. Images of the root thirds of each block were captured with a stereomicroscope and analyzed with an image analysis software. One-way analysis of variance, followed by the Tukey post hoc test, and the Student’s t-test were used for data analysis, with a significance level of 5%. ResultsThe NaOCl penetration depth was similar when preparation was performed, regardless of the method of irrigation activation (p > 0.05). In the groups without preparation, G6 showed greater NaOCl penetration depth (p < 0.05). The groups without preparation had a greater NaOCl penetration depth than those with preparation (p = 0.0019). ConclusionsThe NaOCl penetration depth was similar in groups with root canal preparation. Without root canal preparation, OC allowed deeper NaOCl penetration. The groups without preparation had greater NaOCl penetration than those undergoing root canal preparation.
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- Impact of different activation procedures on sodium hypochlorite penetration into dentinal tubules after endodontic retreatment via confocal laser scanning microscopy
Betul Gunes, Kübra Yeşildal Yeter, Yasin Altay BMC Oral Health.2024;[Epub] CrossRef - Debridement ability of the WaveOne Gold and TruNatomy systems in the apical third of root canals: ex vivo assessment
Sara Carvalho Avelar de Oliveira, Carlos Eduardo da Silveira Bueno, Rina Andréa Pelegrine, Carlos Eduardo Fontana, Alexandre Sigrist de Martin, Carolina Pessoa Stringheta Brazilian Dental Journal.2024;[Epub] CrossRef - Combined effect of electrical energy and graphene oxide on Enterococcus faecalis biofilms
Myung-Jin LEE, Mi-Ah KIM, Kyung-San MIN Dental Materials Journal.2023; 42(6): 844. CrossRef
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Influence of the root canal filling technique on the success rate of primary endodontic treatments: a systematic review
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Daniel Feijolo Marconi, Giovana Siocheta da Silva, Theodoro Weissheimer, Isadora Ames Silva, Gabriel Barcelos Só, Leonardo Thomasi Jahnke, Jovito Adiel Skupien, Marcus Vinicius Reis Só, Ricardo Abreu da Rosa
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Restor Dent Endod 2022;47(4):e40. Published online October 11, 2022
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DOI: https://doi.org/10.5395/rde.2022.47.e40
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Abstract
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- Objectives
This study aimed to investigate the influence of different obturation techniques compared to cold lateral compaction on the success rate of primary non-surgical endodontic treatments. Materials and MethodsSystematic searches were performed for studies published up to May 17th, 2022 in MEDLINE/PubMed, Cochrane Library, Web of Science, Scopus, EMBASE, and Grey Literature Reports. Randomized clinical trials and nonrandomized (nonrandomized clinical trials, prospective or retrospective) studies that evaluated the success rate of primary non-surgical endodontic treatments obturated with the cold lateral compaction (control) and other obturation techniques were included. The revised Cochrane risk of bias tools for randomized trials (RoB 2) and nonrandomized studies of interventions (ROBINS-I) were used to evaluate the risk of bias. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool was used to evaluate the certainty of evidence. ResultsEleven studies (4 randomized clinical trials (RCTs), 4 prospective, and 3 retrospectives) were included. Two RCTs were classified as having some concerns risk of bias and 2 as a low risk of bias. Two nonrandomized studies were classified as having a critical risk of bias and 5 as having a moderate risk of bias. The GRADE analysis demonstrated a very low to moderate certainty of evidence. ConclusionsThis systematic review generally evidenced no differences in the success rate of primary non-surgical endodontic treatments when the cold lateral compaction technique and other obturation techniques are performed. Further well-designed studies are still necessary.
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Citations
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- Comparative Analysis Of Obturation Techniques In Endodontics: Lateral Vs. Thermoplasticized. Thermoplasticized
Juan Esteban Díaz Pacheco , Rómulo Guillermo López Torres , Verónica Alejandra Salame Ortíz Salud, Ciencia y Tecnología.2025; 5: 1626. CrossRef - Clinical and Radiographic Failure of Nonsurgical Endodontic Treatment and Retreatment Using Single-cone Technique With Calcium Silicate-based Sealers: A Systematic Review and Meta-analysis
Mohammad A. Sabeti, Negah Karimpourtalebi, Arash Shahravan, Omid Dianat Journal of Endodontics.2024; 50(6): 735. CrossRef - Method of microbial decontamination of endodontic absorbent paper points: a randomised experimental study
O. A. Pavlovskaya, O. A. Kachanova, V. V. Volobuev, M. N. Mitropanova, A. R. Gazarova, V. Y. Zobenko, A. G. Uvarova Pediatric dentistry and dental prophylaxis.2024; 24(2): 157. CrossRef - The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles
Karla Navarrete-Olvera, Nereyda Niño-Martínez, Idania De Alba-Montero, Nuria Patiño-Marín, Facundo Ruiz, Horacio Bach, Gabriel-Alejandro Martínez-Castañón Molecules.2024; 29(18): 4422. CrossRef - Clinical outcome of non-surgical root canal treatment using different sealers and techniques of obturation in 237 patients: A retrospective study
Mateusz Radwanski, Krystyna Pietrzycka, Tan Fırat Eyüboğlu, Mutlu Özcan, Monika Lukomska-Szymanska Clinical Oral Investigations.2024;[Epub] CrossRef
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Efficacy of reciprocating instruments and final irrigant activation protocols on retreatment of mesiobuccal roots of maxillary molars: a micro-CT analysis
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Lilian Tietz, Renan Diego Furlan, Ricardo Abreu da Rosa, Marco Antonio Hungaro Duarte, Murilo Priori Alcalde, Rodrigo Ricci Vivan, Theodoro Weissheimer, Marcus Vinicius Reis Só
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Restor Dent Endod 2022;47(1):e13. Published online February 15, 2022
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DOI: https://doi.org/10.5395/rde.2022.47.e13
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Abstract
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This study evaluated the efficacy of 3 reciprocating systems and the effects of 2 instruments for irrigant activation on filling material removal. Materials and MethodsForty mesiobuccal roots of maxillary molars were prepared up to size 25.06 and obturated. Micro-computed tomography (micro-CT) examination #1 was performed. Teeth were then divided into 4 groups (n = 10), according to the retreatment protocol: (1) manual, (2) Reciproc Blue, (3) WaveOne Gold, and (4) X1 Blue. Micro-CT examinations #2 and #3 were performed after filling removal and repreparation, respectively. Next, all teeth were divided into 2 new groups (n = 20) according to the irrigant activation protocol: XP Clean (XP Clean size 25.02) and Flatsonic (Flatsonic ultrasonic tip). Micro-CT examination #4 was performed after irrigant activation. Statistical analysis was performed with a significance level set at 5%. ResultsWaveOne Gold removed a significantly greater amount of filling material than the manual group (p < 0.05). The time to reach the WL was similar for all reciprocating systems (p > 0.05). X1 Blue was faster than the manual group (p < 0.05). Only manual group improved the filling material removal after the repreparation stage (p < 0.05). Both activation protocols significantly improved the filling material removal (p < 0.05), without differences between them (p > 0.05). ConclusionsNone of the tested instruments completely removed the filling material. X1 Blue size 25.06 reached the working length in the shortest time. XP Clean and Flatsonic improved the filling material removal.
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- Supplementary methods for filling material removal: A systematic review and meta-analysis of micro-CT imaging studies
Bruna Venzke Fischer, Taynara Santos Goulart, Filipe Colombo Vitali, Diego Leonardo de Souza, Cleonice da Silveira Teixeira, Lucas da Fonseca Roberti Garcia Journal of Dentistry.2024; 151: 105445. CrossRef - Evaluation of the Ability of 3 Reciprocating Instruments to Remove Obturation Material: A Micro–Computed Tomography Study
Fábio Luiz Cecagno, Alexandre Sigrist De Martin, Carlos Eduardo Fontana, Bruno Cavalini Cavenago, Wayne Martins Nascimento, Ana Grasiela da Silva Limoeiro, Carlos Eduardo da Silveira Bueno Journal of Endodontics.2024; 50(3): 376. CrossRef - Comparative evaluation of cleaning efficiency of single file NiTi rotary system during root canal treatment procedure - A scanning electron microscope study
Ruchi Vashisht, Umesh Kumar, Swaty Jhamb, Ruchi Singla Journal of Conservative Dentistry.2023; 26(3): 316. CrossRef - Influence of rotary and reciprocating kinematics on the accuracy of an integrated apex locator
Verônica de Almeida Gardelin, Júlia Itzel Acosta Moreno Vinholes, Renata Grazziotin‐Soares, Fernanda Geraldo Pappen, Fernando Branco Barletta Australian Endodontic Journal.2023; 49(S1): 202. CrossRef
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