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HOME > Restor Dent Endod > Volume 30(6); 2005 > Article
Original Article REGULATION OF PULPAL MICROCIRCULATION BY CALCITONIN GENE-RELATED PEPTIDE
Sung-Kyo Kim,1, Young-Kyung Kim, Myoung-Uk Jin
J Korean Acad Conserv Dent 2005;30(6):-476.
DOI: https://doi.org/10.5395/JKACD.2005.30.6.470
Published online: January 14, 2005

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*Corresponding Author: Sung-Kyo Kim, Department of Conservative Dentistry and Laboratory of Pulp Biology, School of Dentistry, Kyungpook National University, 188-1, Samdeok-Dong 2-Ga, Jung-Gu, Daegu. Korea, 700-412 Tel : 82-53-420-5935 Fax : 82-53-426-8958, Email : skykim@knu.ac.kr
• Received: July 9, 2005   • Revised: August 24, 2005   • Accepted: August 26, 2005

Copyright © 2005 The Korean Academy of Conservative Dentistry

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • The purpose of this study was to investigate the function of calcitonin gene-related peptide (CGRP) in regulatory mechanism of pulpal microcirculation with the aim of elucidating neurogenic inflammation.
    Experiments were performed on twelve cats under general anesthesia. CGRP was administered through the femoral vein to see the systemic influence and through the external carotid artery to see the local effect. Sympathetic nerve to the dental pulp was stimulated electrically and pulpal blood flow (PBF) was measured with a laser Doppler flowmeter on the canine teeth to the drug administration. The paired variables of control and experimental data were compared by paired t-test and differences with p < 0.05 were considered statistically significant.
    Systemic administration of CGRP (0.3 μg/kg) exerted decreases in systemic blood pressure and caused changes in PBF with an initial increase followed by decrease and a more marked second increase and decrease.
    Close intra-arterial (i.a.) injection of CGRP (0.03 μ/kg) resulted in slight PBF increase. The effect of CGRP resulted in no significant increase in PBF in the presence of CGRP8-37.
    The electrical stimulation of the sympathetic nerve alone resulted in PBF decreases. The i.a. administration of CGRP following the electrical stimulation of the sympathetic nerve compensated the decreased PBF. Therefore, CGRP effectively blocked the sympathetic nerve stimulation-induced PBF decrease.
    Results of the present study have provided evidences that even though the local vasodilatory function of CGRP are weak, CGRP is effectively involved in blocking the vasoconstriction caused by sympathetic nerve stimulation in the feline dental pulp.
Figure 1.
Systemic influence of CGRP on pulpal blood flow (PBF, mean ± SEM). Injection of CGRP (0.3 μg/kg) through the femoral vein exerted decreases in systemic blood pressure and caused significant changes in PBF with 4 phases (p < 0.05).
jkacd-30-470f1.jpg
Figure 2.
(A) Polygraph recording showing the reduction of pulpal blood flow (PBF) during electrical stimulation of the sympathetic nerve (SNS). Systemic blood pressure did not change. (B) Polygraph recording showing the blocking effect of intra-arterial (i.a.) injection of CGRP (0.03 μg/kg) on SNS-induced PBF decrease.
jkacd-30-470f2.jpg
Figure 3.
Effect of CGRP alone and during the sympathetic nerve stimulation (SNS)-induced pulpal blood flow (PBF) reduction (mean ± SEM). Intra-arterial injection of CGRP (0.03 μg/kg) effectively recovered the reduced PBF caused by SNS (p < 0.05).
jkacd-30-470f3.jpg
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        REGULATION OF PULPAL MICROCIRCULATION BY CALCITONIN GENE-RELATED PEPTIDE
        J Korean Acad Conserv Dent. 2005;30(6):470-476.   Published online January 14, 2005
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      REGULATION OF PULPAL MICROCIRCULATION BY CALCITONIN GENE-RELATED PEPTIDE
      Image Image Image
      Figure 1. Systemic influence of CGRP on pulpal blood flow (PBF, mean ± SEM). Injection of CGRP (0.3 μg/kg) through the femoral vein exerted decreases in systemic blood pressure and caused significant changes in PBF with 4 phases (p < 0.05).
      Figure 2. (A) Polygraph recording showing the reduction of pulpal blood flow (PBF) during electrical stimulation of the sympathetic nerve (SNS). Systemic blood pressure did not change. (B) Polygraph recording showing the blocking effect of intra-arterial (i.a.) injection of CGRP (0.03 μg/kg) on SNS-induced PBF decrease.
      Figure 3. Effect of CGRP alone and during the sympathetic nerve stimulation (SNS)-induced pulpal blood flow (PBF) reduction (mean ± SEM). Intra-arterial injection of CGRP (0.03 μg/kg) effectively recovered the reduced PBF caused by SNS (p < 0.05).
      REGULATION OF PULPAL MICROCIRCULATION BY CALCITONIN GENE-RELATED PEPTIDE

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