Restorative Dentistry & Endodontics

Review Article

Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review: Dina A. Hammouda, Alaa M Mansour, Mahmoud A. Saeed, Ahmed R. Zaher, Mohammed E. Grawish; Restor Dent Endod 2023;48(2):e20. Published online May 3, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e20

This mini-review was conducted to present an overview of the use of exosomes in regenerating the dentin-pulp complex (DPC). The PubMed and Scopus databases were searched for relevant articles published between January 1, 2013 and January 1, 2023. The findings of basic in vitro studies indicated that exosomes enhance the proliferation and migration of mesenchymal cells, as human dental pulp stem cells, via mitogen-activated protein kinases and Wingless-Int signaling pathways. In addition, they possess proangiogenic potential and contribute to neovascularization and capillary tube formation by promoting endothelial cell proliferation and migration of human umbilical vein endothelial cells. Likewise, they regulate the migration and differentiation of Schwann cells, facilitate the conversion of M1 pro-inflammatory macrophages to M2 anti-inflammatory phenotypes, and mediate immune suppression as they promote regulatory T cell conversion. Basic in vivo studies have indicated that exosomes triggered the regeneration of dentin-pulp–like tissue, and exosomes isolated under odontogenic circumstances are particularly strong inducers of tissue regeneration and stem cell differentiation. Exosomes are a promising regenerative tool for DPC in cases of small pulp exposure or for whole-pulp tissue regeneration.

Citations

Citations to this article as recorded by

Cell Homing Strategies in Regenerative Endodontic Therapy
David Kim, Sahng G. Kim
Cells.2025; 14(3): 201. CrossRef
Exosomes as Promising Therapeutic Tools for Regenerative Endodontic Therapy
Qingyue Kong, Yujie Wang, Nan Jiang, Yifan Wang, Rui Wang, Xiaohan Hu, Jing Mao, Xin Shi
Biomolecules.2024; 14(3): 330. CrossRef
Role and Molecular Mechanism of miR-586 in the Differentiation of Dental Pulp Stem Cells into Odontoblast-like Cells
Gang Pan, Qianwen Zhou, Chenhua Pan, Yingxue Zhang
Cell Biochemistry and Biophysics.2024; 83(1): 507. CrossRef

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Research Articles

Antimicrobial and cytotoxic properties of calcium-enriched mixture cement, Iranian propolis, and propolis with herbal extracts in primary dental pulp stem cells: Mohammad Esmaeilzadeh, Shirin Moradkhani, Fahimeh Daneshyar, Mohammad Reza Arabestani, Sara Soleimani Asl, Soudeh Tayebi, Maryam Farhadian; Restor Dent Endod 2023;48(1):e2. Published online December 1, 2022; DOI: https://doi.org/10.5395/rde.2023.48.e2

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Objectives

In this study, natural substances were introduced as primary dental pulp caps for use in pulp therapy, and the antimicrobial and cytotoxic properties of these substances were investigated.

Materials and Methods

In this in vitro study, the antimicrobial properties of calcium-enriched mixture (CEM) cement, propolis, and propolis individually combined with the extracts of several medicinal plants were investigated against Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Then, the cytotoxicity of each substance or mixture against pulp stem cells extracted from 30 primary healthy teeth was evaluated at 4 concentrations. Data were gathered via observation, and optical density values were obtained using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) test and recorded. SPSS software version 23 was used to analyze the data. Data were evaluated using 2-way analysis of variance and the Tukey test.

Results

Regarding antimicrobial properties, thyme alone and thyme + propolis had the lowest minimum inhibitory concentrations (MICs) against the growth of S. aureus, E. coli, and P. aeruginosa bacteria. For E. faecalis, thyme + propolis had the lowest MIC, followed by thyme alone. At 24 and 72 hours, thyme + propolis, CEM cement, and propolis had the greatest bioviability in the primary dental pulp stem cells, and lavender + propolis had the lowest bioviability.

Conclusions

Of the studied materials, thyme + propolis showed the best results in the measures of practical performance as a dental pulp cap.

Citations

Citations to this article as recorded by

Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis
Saeed Asgary, Mahtab Aram, Mahta Fazlyab
BioMedical Engineering OnLine.2024;[Epub] CrossRef
Effects of aqueous and ethanolic extracts of Chinese propolis on dental pulp stem cell viability, migration and cytokine expression
Ha Bin Park, Yen Dinh, Pilar Yesares Rubi, Jennifer L. Gibbs, Benoit Michot
PeerJ.2024; 12: e18742. CrossRef

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Cryopreservation of mesenchymal stem cells derived from dental pulp: a systematic review: Sabrina Moreira Paes, Yasmine Mendes Pupo, Bruno Cavalini Cavenago, Thiago Fonseca-Silva, Carolina Carvalho de Oliveira Santos; Restor Dent Endod 2021;46(2):e26. Published online April 29, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e26

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Objectives

The aim of the present systematic review was to investigate the cryopreservation process of dental pulp mesenchymal stromal cells and whether cryopreservation is effective in promoting cell viability and recovery.

Materials and Methods

This systematic review was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and the research question was determined using the population, exposure, comparison, and outcomes strategy. Electronic searches were conducted in the PubMed, Cochrane Library, Science Direct, LILACS, and SciELO databases and in the gray literature (dissertations and thesis databases and Google Scholar) for relevant articles published up to March 2019. Clinical trial studies performed with dental pulp of human permanent or primary teeth, containing concrete information regarding the cryopreservation stages, and with cryopreservation performed for a period of at least 1 week were included in this study.

Results

The search strategy resulted in the retrieval of 185 publications. After the application of the eligibility criteria, 21 articles were selected for a qualitative analysis.

Conclusions

The cryopreservation process must be carried out in 6 stages: tooth disinfection, pulp extraction, cell isolation, cell proliferation, cryopreservation, and thawing. In addition, it can be inferred that the use of dimethyl sulfoxide, programmable freezing, and storage in liquid nitrogen are associated with a high rate of cell viability after thawing and a high rate of cell proliferation in both primary and permanent teeth.

Citations

Citations to this article as recorded by

The Antimicrobial Effect of the Incorporation of Inorganic Substances into Heat-Cured Denture Base Resins—A Systematic Review
Mariana Lima, Helena Salgado, André Correia, Patrícia Fonseca
Prosthesis.2024; 6(5): 1189. CrossRef
Sphingosine-1-phosphate Treatment Improves Cryopreservation Efficiency in Human Mesenchymal Stem Cells
Seong-Ju Oh, Chan-Hee Jo, Tae-Seok Kim, Chae-Yeon Hong, Sung-Lim Lee, Young-Hoon Kang, Gyu-Jin Rho
Life.2023; 13(6): 1286. CrossRef
Time- and Concentration-Dependent Effects of the Stem Cells Derived from Human Exfoliated Deciduous Teeth on Osteosarcoma Cells
Razieh Alipour, Batool Hashemibeni, Vajihe Asgari, Hamid Bahramian
Advanced Biomedical Research.2023;[Epub] CrossRef

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Bioactivity of endodontic biomaterials on dental pulp stem cells through dentin: Bahar Javid, Narges Panahandeh, Hassan Torabzadeh, Hamid Nazarian, Ardavan Parhizkar, Saeed Asgary; Restor Dent Endod 2020;45(1):e3. Published online November 4, 2019; DOI: https://doi.org/10.5395/rde.2020.45.e3

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Objectives

This study investigated the indirect effect of calcium-enriched mixture (CEM) cement and mineral trioxide aggregate (MTA), as 2 calcium silicate-based hydraulic cements, on human dental pulp stem cells (hDPSCs) through different dentin thicknesses.

Materials and Methods

Two-chamber setups were designed to simulate indirect pulp capping (IPC). Human molars were sectioned to obtain 0.1-, 0.3-, and 0.5-mm-thick dentin discs, which were placed between the 2 chambers to simulate an IPC procedure. Then, MTA and CEM were applied on one side of the discs, while hDPSCs were cultured on the other side. After 2 weeks of incubation, the cells were removed, and cell proliferation, morphology, and attachment to the discs were evaluated under scanning electron microscopy (SEM). Energy-dispersive X-ray (EDXA) spectroscopy was performed for elemental analysis. Alkaline phosphatase (ALP) activity was assessed quantitatively. The data were analyzed using the Kruskal-Wallis and Mann-Whitney tests.

Results

SEM micrographs revealed elongated cells, collagen fibers, and calcified nucleations in all samples. EDXA verified that the calcified nucleations consisted of calcium phosphate. The largest calcifications were seen in the 0.1-mm-thick dentin subgroups. There was no significant difference in ALP activity across the CEM subgroups; however, ALP activity was significantly lower in the 0.1-mm-thick dentin subgroup than in the other MTA subgroups (p < 0.05).

Conclusions

The employed capping biomaterials exerted biological activity on hDPSCs, as shown by cell proliferation, morphology, and attachment and calcific precipitations, through 0.1- to 0.5-mm-thick layers of dentin. In IPC, the bioactivity of these endodontic biomaterials is probably beneficial.

Citations

Citations to this article as recorded by

Effect of pulp capping materials on odontogenic differentiation of human dental pulp stem cells: An in vitro study
Mahmoud M. Bakr, Mohamed Shamel, Shereen N. Raafat, Robert M. Love, Mahmoud M. Al‐Ankily
Clinical and Experimental Dental Research.2024;[Epub] CrossRef
Effects of Growth Factors on the Differentiation of Dental Stem Cells: A Systematic Review and Meta-analysis (Part I)
Sayna Shamszadeh, Armin Shirvani, Hassan Torabzadeh, Saeed Asgary
Current Stem Cell Research & Therapy.2024; 19(4): 523. CrossRef
The Role of Growth Factor Delivery Systems on Cellular Activities of Dental Stem Cells: A Systematic Review (Part II)
Sayna Shamszadeh, Armin Shirvani, Saeed Asgary
Current Stem Cell Research & Therapy.2024; 19(4): 587. CrossRef
Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis
Saeed Asgary, Mahtab Aram, Mahta Fazlyab
BioMedical Engineering OnLine.2024;[Epub] CrossRef
Evaluation of dental pulp stem cells behavior after odontogenic differentiation induction by three different bioactive materials on two different scaffolds
Basma Ahmed, Mai H. Ragab, Rania A. Galhom, Hayam Y. Hassan
BMC Oral Health.2023;[Epub] CrossRef
Characterization of Dental Pulp Stem Cell Responses to Functional Biomaterials Including Mineralized Trioxide Aggregates
Sejin Bae, Bueonguk Kang, Hyungbin Lee, Harrison Luu, Eric Mullins, Karl Kingsley
Journal of Functional Biomaterials.2021; 12(1): 15. CrossRef
Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an in vitro study
Fábio Rocha Bohns, Vicente Castelo Branco Leitune, Isadora Martini Garcia, Bruna Genari, Nélio Bairros Dornelles, Silvia Stanisçuaski Guterres, Fabrício Aulo Ogliari, Mary Anne Sampaio de Melo, Fabrício Mezzomo Collares
Restorative Dentistry & Endodontics.2020;[Epub] CrossRef

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Development of a mouse model for pulp-dentin complex regeneration research: a preliminary study: Sunil Kim, Sukjoon Lee, Han-Sung Jung, Sun-Young Kim, Euiseong Kim; Restor Dent Endod 2019;44(2):e20. Published online May 7, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e20

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Objectives

To achieve pulp-dentin complex regeneration with tissue engineering, treatment efficacies and safeties should be evaluated using in vivo orthotopic transplantation in a sufficient number of animals. Mice have been a species of choice in which to study stem cell biology in mammals. However, most pulp-dentin complex regeneration studies have used large animals because the mouse tooth is too small. The purpose of this study was to demonstrate the utility of the mouse tooth as a transplantation model for pulp-dentin complex regeneration research.

Materials and Methods

Experiments were performed using 7-week-old male Institute of Cancer Research (ICR) mice; a total of 35 mice had their pulp exposed, and 5 mice each were sacrificed at 1, 2, 4, 7, 9, 12 and 14 days after pulp exposure. After decalcification in 5% ethylenediaminetetraacetic acid, the samples were embedded and cut with a microtome and then stained with hematoxylin and eosin. Slides were observed under a high-magnification light microscope.

Results

Until 1 week postoperatively, the tissue below the pulp chamber orifice appeared normal. The remaining coronal portion of the pulp tissue was inflammatory and necrotic. After 1 week postoperatively, inflammation and necrosis were apparent in the root canals inferior to the orifices. The specimens obtained after experimental day 14 showed necrosis of all tissue in the root canals.

Conclusions

This study could provide opportunities for researchers performing in vivo orthotopic transplantation experiments with mice.

Citations

Citations to this article as recorded by

PRIASE 2021 guidelines for reporting animal studies in Endodontology: explanation and elaboration
V. Nagendrababu, A. Kishen, P. E. Murray, M. H. Nekoofar, J. A. P. de Figueiredo, E. Priya, J. Jayaraman, S. J. Pulikkotil, A. Jakovljevic, P. M. H. Dummer
International Endodontic Journal.2021; 54(6): 858. CrossRef

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In vitro characterization of human dental pulp stem cells isolated by three different methods: Ji-Hyun Jang, Hyeon-Woo Lee, Kyu Min Cho, Hee-Woong Shin, Mo Kwan Kang, Sang Hyuk Park, Euiseong Kim; Restor Dent Endod 2016;41(4):283-295. Published online October 12, 2016; DOI: https://doi.org/10.5395/rde.2016.41.4.283

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Objectives

In this study, we characterized human dental pulp cells (HDPCs) obtained by different culture methods to establish the most suitable methodology for dental tissue engineering and regenerative endodontic applications.

Materials and Methods

HDPCs were isolated by the outgrowth method (HDPCs-OG), the enzymatic digestion method (collagenase/dispase/trypsin, HDPCs-ED), or the combination of both methods (HDPCs-Combined). The expression of mesenchymal stem cell markers (CD105, CD90, and CD73) was investigated. In vitro differentiation capacities of HDPCs into adipogenic, osteogenic, and chondrogenic lineages were compared. Differentiation markers were analyzed by quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blotting.

Results

Our data indicated that whole HDPCs-ED, HPDCs-OG, and HDPCs-Combined could be differentiated into adipogenic, chrondrogenic, and osteogenic cell types. However, we found that the methods for isolating and culturing HDPCs influence the differentiation capacities of cells. HDPCs-OG and HDPCs-ED were preferably differentiated into adipogenic and osteogenic cells, respectively. Differentiation markers shown by RT-PCR and western blotting analysis were mostly upregulated in the treated groups compared with the control groups.

Conclusions

Our findings confirmed that cell populations formed by two different culture methods and the combined culture method exhibited different properties. The results of this study could provide an insight into regenerative endodontic treatment using HDPCs.

Citations

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Effects of simulated microgravity on dental pulp stem cell stemness
Huailong Hou, Zhengjun Qiu, Jingyi Che, Yanping Li, Jingxuan Sun, Weiwei Zhang, Jinjie Ma, Shuang Zhang, Mengdi Li, Yumei Niu, Lina He
Journal of Molecular Histology.2025;[Epub] CrossRef
ISOLATION OF HUMAN ADULT DENTAL PULP STEM CELLS USING ENZYMATIC DIGESTION
Sehrish Khan, Saima Butt, Shumaila Usman, Sana Mirza
JOURNAL OF KHYBER COLLEGE OF DENTISTRY.2024; 14(4): 9. CrossRef
Diş Hekimliğinde Oromaksillofasiyal Bölgeden Alınabilen Mezenkimal Kök Hücreler
Sefer MAHMUTOĞLU, Ayşegül MENDİ, Derviş YILMAZ
ADO Klinik Bilimler Dergisi.2022; 11(2): 184. CrossRef
Sinking Our Teeth in Getting Dental Stem Cells to Clinics for Bone Regeneration
Sarah Hani Shoushrah, Janis Lisa Transfeld, Christian Horst Tonk, Dominik Büchner, Steffen Witzleben, Martin A. Sieber, Margit Schulze, Edda Tobiasch
International Journal of Molecular Sciences.2021; 22(12): 6387. CrossRef
Isolation, Characterization, and Differentiation of Stem Cells From Various Dental Sources: An In Vitro Study
Sandeep S. Katti, Kishore Bhat, Chetana Bogar
Journal of Advanced Oral Research.2021; 12(2): 254. CrossRef
Intra-Individual Variability of Human Dental Pulp Stem Cell Features Isolated from the Same Donor
Nela Pilbauerova, Jan Schmidt, Tomas Soukup, Jan Duska, Jakub Suchanek
International Journal of Molecular Sciences.2021; 22(24): 13515. CrossRef
Comparison of Osteogenic Potentials of Dental Pulp and Bone Marrow Mesenchymal Stem Cells Using the New Cell Transplantation Platform, CellSaic, in a Rat Congenital Cleft-Jaw Model
Jinzhao Lyu, Yoshiya Hashimoto, Yoshitomo Honda, Naoyuki Matsumoto
International Journal of Molecular Sciences.2021; 22(17): 9478. CrossRef
In Vitro Characterization of Dental Pulp Stem Cells Cultured in Two Microsphere-Forming Culture Plates
Nam-Ung Bu, Hyo-Seol Lee, Bin-Na Lee, Yun-Chan Hwang, Sun-Young Kim, Seok Woo Chang, Kyoung-Kyu Choi, Duck-Su Kim, Ji-Hyun Jang
Journal of Clinical Medicine.2020; 9(1): 242. CrossRef
Micro-computed tomographic evaluation of the flow and filling ability of endodontic materials using different test models
Fernanda Ferrari Esteves Torres, Juliane Maria Guerreiro-Tanomaru, Gisselle Moraima Chavez-Andrade, Jader Camilo Pinto, Fábio Luiz Camargo Villela Berbert, Mario Tanomaru-Filho
Restorative Dentistry & Endodontics.2020;[Epub] CrossRef
Enzymatic Isolation, Amplification and Characterization of Dental Pulp Stem Cells
Nela Pilbauerova, T. Soukup, T. Suchánková Kleplová, J. Suchánek
Folia Biologica.2019; 65(3): 124. CrossRef
Metabolism as an early predictor of DPSCs aging
Dannie Macrin, Ammar Alghadeer, Yan Ting Zhao, Jason W. Miklas, Abdiasis M. Hussein, Damien Detraux, Aaron M. Robitaille, Anup Madan, Randall T. Moon, Yuliang Wang, Arikketh Devi, Julie Mathieu, Hannele Ruohola-Baker
Scientific Reports.2019;[Epub] CrossRef
The effect of platelet lysate in culture of PDLSCs: anin vitrocomparative study
Duaa A. Abuarqoub, Nazneen Aslam, Raghda B. Barham, Nidaa A. Ababneh, Diana A. Shahin, Abdallah A. Al-oweidi, Hanan D. Jafar, Mazin A. Al-Salihi, Abdalla S. Awidi
PeerJ.2019; 7: e7465. CrossRef
Progress in the use of dental pulp stem cells in regenerative medicine
Eduardo Anitua, María Troya, Mar Zalduendo
Cytotherapy.2018; 20(4): 479. CrossRef
Identification of a novel heterozygous mutation of ACAN in a Korean family with proportionate short stature
Yoo-Mi Kim, Chong Kun Cheon, Han Hyuk Lim, Han-Wook Yoo
Journal of Genetic Medicine.2018; 15(2): 102. CrossRef
Conditioned medium from relapsing-remitting multiple sclerosis patients reduces the expression and release of inflammatory cytokines induced by LPS-gingivalis in THP-1 and MO3.13 cell lines
Patrizia Ballerini, Francesca Diomede, Nicola Petragnani, Simona Cicchitti, Ilaria Merciaro, Marcos F.X.B. Cavalcanti, Oriana Trubiani
Cytokine.2017; 96: 261. CrossRef

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Effect of dentin treatment on proliferation and differentiation of human dental pulp stem cells: Minjeong Park, Nan-Sim Pang, Il-Young Jung; Restor Dent Endod 2015;40(4):290-298. Published online September 23, 2015; DOI: https://doi.org/10.5395/rde.2015.40.4.290

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Objectives

Sodium hypochlorite (NaOCl) is an excellent bactericidal agent, but it is detrimental to stem cell survival, whereas intracanal medicaments such as calcium hydroxide (Ca[OH]₂) promote the survival and proliferation of stem cells. This study evaluated the effect of sequential NaOCl and Ca[OH]₂ application on the attachment and differentiation of dental pulp stem cells (DPSCs).

Materials and Methods

DPSCs were obtained from human third molars. All dentin specimens were treated with 5.25% NaOCl for 30 min. DPSCs were seeded on the dentin specimens and processed with additional 1 mg/mL Ca[OH]₂, 17% ethylenediaminetetraacetic acid (EDTA) treatment, file instrumentation, or a combination of these methods. After 7 day of culture, we examined DPSC morphology using scanning electron microscopy and determined the cell survival rate with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. We measured cell adhesion gene expression levels after 4 day of culture and odontogenic differentiation gene expression levels after 4 wk using quantitative real-time polymerase chain reaction.

Results

DPSCs did not attach to the dentin in the NaOCl-treated group. The gene expression levels of fibronectin-1 and secreted phosphoprotein-1 gene in both the Ca[OH]₂- and the EDTA-treated groups were significantly higher than those in the other groups. All Ca[OH]₂-treated groups showed higher expression levels of dentin matrix protein-1 than that of the control. The dentin sialophosphoprotein level was significantly higher in the groups treated with both Ca[OH]₂ and EDTA.

Conclusions

The application of Ca[OH]₂ and additional treatment such as EDTA or instrumentation promoted the attachment and differentiation of DPSCs after NaOCl treatment.

Citations

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Effect of erbium yttrium aluminium garnet laser dentin conditioning on dental pulp stem cells viability
Aryan Jafari, Mehdi Vatanpour, Nooshin Barikrow, Pouyan Razavi, Sohrab Tour Savadkouhi
Heliyon.2024; 10(5): e26954. CrossRef
Comparison of the effect of NaOCL, curcumin, and EDTA on differentiation, proliferation, and adhesion of dental pulp stem cells
Vahid Zand, Amin Salem Milani, Carolyn Primus, Marzie Aghazade, Hadi Mokhtari, Sabete Bagheri Sabzevar, Pardis Tehranchi
Journal of Oral Biology and Craniofacial Research.2023; 13(2): 347. CrossRef
Differential Effects of Extracellular Matrix Glycoproteins Fibronectin and Laminin-5 on Dental Pulp Stem Cell Phenotypes and Responsiveness
Hyungbin Lee, Allen Bae, John Kim, Karl Kingsley
Journal of Functional Biomaterials.2023; 14(2): 91. CrossRef
Assessment of the Influence of Various Concentrations of Sodium Hypochlorite on Stem Cell Derived From Human Exfoliated Deciduous Teeth (SHED) Proliferation and Differentiation
Viral Maru, Ashwini KB, Manisha Madkaikar, R K Sarada Devi, Ashita Gada, Salil Bapat
Cureus.2022;[Epub] CrossRef
Effects of sodium hypochlorite and ethylenediaminetetraacetic acid on proliferation, osteogenic/odontogenic differentiation, and mechanosensitive gene expression of human dental pulp stem cells
Yuejun Li, Changlong Jin, Shouliang Zhao, Han Xie
Tissue and Cell.2022; 79: 101955. CrossRef
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Alexandre H. dos Reis‐Prado, Lucas G. Abreu, Rogéria R. Fagundes, Sabrina de C. Oliveira, Marco C. Bottino, Antônio P. Ribeiro‐Sobrinho, Francine Benetti
International Endodontic Journal.2022; 55(6): 579. CrossRef
An in-vitro Comparative Evaluation of Quantitative Release of Transforming Growth Factor β-1 from Dentin upon the Action of Endodontic Irrigants, Medicaments, Ultrasonic Activation, and Low-Level Laser Irradiation
Anilkumar Akhila, V. P. Prabath Singh, Kerala R. Varma, Senthil V. Vasudevan, V. Sukhithasri, Salu Sasikumar
Amrita Journal of Medicine.2021; 17(2): 34. CrossRef
Non-Thermal Atmospheric Pressure Plasma-Conditioned Root Dentin Promotes Attraction and Attachment of Primary Human Dental Pulp Stem Cells in Real-Time Ex Vivo
Yeon-Jee Yoo, Min-Ji Kang, Hiran Perinpanayagam, Joo-Cheol Park, Seung-Ho Baek, Kee-Yeon Kum
Applied Sciences.2021; 11(15): 6836. CrossRef
The Effects of Intracanal Irrigants and Medicaments on Dental-Derived Stem Cells Fate in Regenerative Endodontics: An update
Sara Ayoub, Ali Cheayto, Sanaa Bassam, Mehdi Najar, Antoine Berbéri, Mohammad Fayyad-Kazan
Stem Cell Reviews and Reports.2020; 16(4): 650. CrossRef
An Immunofluorescence Study to Analyze Wound Healing Outcomes of Regenerative Endodontics in an Immature Premolar with Chronic Apical Abscess
Jeen Nee Lui, Wen Yi Lim, Domenico Ricucci
Journal of Endodontics.2020; 46(5): 627. CrossRef
Dynamic Irrigation Promotes Apical Papilla Cell Attachment in an Ex Vivo Immature Root Canal Model
Sanupong Prompreecha, Thanapat Sastraruji, Phumisak Louwakul, Tanida Srisuwan
Journal of Endodontics.2018; 44(5): 744. CrossRef
Odontoblast-like differentiation and mineral formation of pulpsphere derived cells on human root canal dentin in vitro
Jörg Neunzehn, Sandra Pötschke, Christian Hannig, Hans-Peter Wiesmann, Marie-Theres Weber
Head & Face Medicine.2017;[Epub] CrossRef
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Young-Sun Kwon, Hee-Jin Kim, Yun-Chan Hwang, Vinicius Rosa, Mi-Kyung Yu, Kyung-San Min
Journal of Endodontics.2017; 43(2): 289. CrossRef

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