Restorative Dentistry & Endodontics

Review Article

Does photobiomodulation on the root surface decrease the occurrence of root resorption in reimplanted teeth? A systematic review of animal studies: Theodoro Weissheimer, Karolina Frick Bischoff, Carolina Horn Troian Michel, Bruna Barcelos Só, Manoela Domingues Martins, Matheus Albino Souza, Ricardo Abreu da Rosa, Marcus Vinícius Reis Só; Restor Dent Endod 2023;48(3):e24. Published online June 12, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e24

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This review aimed to answer the following question “Does photobiomodulation treatment of the root surface decrease the occurrence of root resorption in reimplanted teeth?” Electronic searches were performed in the MEDLINE/PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Grey Literature Report databases. Risk of bias was evaluated using SYRCLE Risk of Bias tool. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) tool was used to assess the certainty of evidence. In total, 6 studies were included. Five studies reported a reduced occurrence of root resorption in teeth that received photobiomodulation treatment of the root surface prior to replantation. Only 1 study reported contradictory results. The photobiomodulation parameters varied widely among studies. GRADE assessment showed a low certainty of evidence. It can be inferred that photobiomodulation treatment of the root surface prior to replantation of teeth can reduce the occurrence of root resorption. Nonetheless, further clinical studies are needed.

Trial Registration

PROSPERO Identifier: CRD42022349891

Citations

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Feasibility and Outcomes of Cell-based Regenerative Endodontic Therapy in Postautogenous Transplantation of a Mature Tooth: A Case Report
Noriaki Yoshihashi
Journal of Endodontics.2025; 51(1): 85. CrossRef
Photobiomodulation Literature Watch September 2023
James D. Carroll
Photobiomodulation, Photomedicine, and Laser Surgery.2024; 42(7): 498. CrossRef

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Research Articles

Effects of different calcium-silicate based materials on fracture resistance of immature permanent teeth with replacement root resorption and osteoclastogenesis: Gabriela Leite de Souza, Gabrielle Alves Nunes Freitas, Maria Tereza Hordones Ribeiro, Nelly Xiomara Alvarado Lemus, Carlos José Soares, Camilla Christian Gomes Moura; Restor Dent Endod 2023;48(2):e21. Published online May 5, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e21

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Objectives

This study evaluated the effects of Biodentine (BD), Bio-C Repair (BCR), and mineral trioxide aggregate (MTA) plug on the fracture resistance of simulated immature teeth with replacement root resorption (RRR) and in vitro-induced osteoclastogenesis.

Materials and Methods

Sixty bovine incisors simulating immature teeth and RRR were divided into 5 groups: BD and BCR groups, with samples completely filled with the respective materials; MTA group, which utilized a 3-mm apical MTA plug; RRR group, which received no root canal filling; and normal periodontal ligament (PL) group, which had no RRR and no root canal filling. All the teeth underwent cycling loading, and compression strength testing was performed using a universal testing machine. RAW 264.7 macrophages were treated with 1:16 extracts of BD, BCR, and MTA containing receptor activator of nuclear factor-kappa B ligand (RANKL) for 5 days. RANKL-induced osteoclast differentiation was assessed by staining with tartrate-resistant acid phosphatase. The fracture load and osteoclast number were analyzed using 1-way ANOVA and Tukey’s test (α = 0.05).

Results

No significant difference in fracture resistance was observed among the groups (p > 0.05). All materials similarly inhibited osteoclastogenesis (p > 0.05), except for BCR, which led to a lower percentage of osteoclasts than did MTA (p < 0.0001).

Conclusions

The treatment options for non-vital immature teeth with RRR did not strengthen the teeth and promoted a similar resistance to fractures in all cases. BD, MTA, and BCR showed inhibitory effects on osteoclast differentiation, with BCR yielding improved results compared to the other materials.

Citations

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Comparative Analysis of Gene Expression in Periodontal Ligament Stem Cells Exposed to Biodentine and Bio-C Repair: Implications for Cementogenesis—An In Vitro Study
Mahmoud M. Bakr, Mahmoud Al Ankily, Mohammed Meer, Mohamed Shamel
Oral.2025; 5(1): 19. CrossRef
Evaluation of Different Techniques and Materials for Filling in 3-dimensional Printed Teeth Replicas with Perforating Internal Resorption by Means of Micro–Computed Tomography
Angelo J.S. Torres-Carrillo, Helena C. Assis, Rodrigo E. Salazar-Gamarra, Leonardo Moreira Teodosio, Alice C. Silva-Sousa, Jardel F. Mazzi-Chaves, Priscila B. Ferreira-Soares, Manoel D. Sousa-Neto, Fabiane C. Lopes-Olhê
Journal of Endodontics.2024; 50(2): 205. CrossRef
In vitro comparison of fracture strength of maxillary incisors with the simulated external root resorption cavities repaired with BioMTA or Biodentine
Tufan Ozasir, Birgul Ozasir, Nagihan Aribal, Derin Bugu Yuzer, Baris Kandemir, Kamran Gulsahi
Journal of Dental Sciences.2024;[Epub] CrossRef

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The prevalence and characteristics of external cervical resorption based on cone-beam computed tomographic imaging: a cross-sectional study: Matheus Diniz Ferreira, Matheus Barros-Costa, Felipe Ferreira Costa, Deborah Queiroz Freitas; Restor Dent Endod 2022;47(4):e39. Published online October 11, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e39

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Objectives

This study investigated the prevalence and characteristics of external cervical resorption (ECR) regarding sex, age, tooth, stages of progression, and portal of entry, using cone-beam computed tomography (CBCT) scans.

Materials and Methods

CBCT scans of 1,313 patients from a Brazilian subpopulation comprising 883 female and 430 male patients (mean age, 55.2 years), acquired using a PreXion 3D CBCT unit, were evaluated. All permanent teeth included in the scans were evaluated for the presence of ECR according to the 3-dimensional classification and the portal of entry. The association between the presence of ECR and the factors studied was assessed using the χ² test. Intra-observer agreement was analyzed with the kappa test (α = 0.05).

Results

In total, 6,240 teeth were analyzed, of which 84 (1.35%) were affected by ECR. A significant association was found between the presence of ECR and sex, with a higher prevalence in male patients (p = 0.002). The most frequently affected teeth were the mandibular and maxillary central incisors. The most common height was the mid-third of the root. For the portal of entry, 44% of cases were on the proximal surfaces, 40.5% on the lingual/palatal surface and 15.5% on the buccal surface. Intra-observer agreement was excellent.

Conclusions

The prevalence of ECR was 1.35%, with a higher prevalence in male patients and a wide age distribution. The mandibular and maxillary central incisors were the most commonly affected teeth, and cases of ECR most frequently showed a height into the mid-third of the root and proximal entry.

Citations

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Prevalence and Characterization of External Cervical Resorption Using Cone Beam Computed Tomography
Isadora Carneiro Pereira Machado, Marilia Oliveira Morais, Adriana Lustosa Pereira Bicalho, Patricia Helena Pereira Ferrari, Juliano Martins Bueno, José Luiz Cintra Junqueira, Mariana Quirino Silveira Soares
Journal of Endodontics.2024; 50(2): 164. CrossRef
Influence of tube current and metal artifact reduction on the diagnosis of external cervical resorption in teeth adjacent to a dental implant in CBCT: an ex-vivo study
Thamiles Gonzalez-Passos, Matheus Barros-Costa, Matheus L Oliveira, Deborah Queiroz Freitas
Clinical Oral Investigations.2024;[Epub] CrossRef
Maxillary anterior teeth with extensive root resorption treated with multidisciplinary approach: A case report
Thais Machado de Carvalho Coutinho, Carollyne Souza Campello, Juliana Pires Abdelnur, Vivian Ronquete, Carlos Henrique Sardenberg Pereira, Marilia F Marceliano-Alves
International Journal of Case Reports and Images.2023; 14(1): 8. CrossRef
Clinical and radiographic features of external cervical resorption – An observational study
Shanon Patel, Francesc Abella, Kreena Patel, Paul Lambrechts, Nassr Al‐Nuaimi
International Endodontic Journal.2023; 56(12): 1475. CrossRef

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A micro-computed tomography evaluation of voids using calcium silicate-based materials in teeth with simulated internal root resorption: Vildan Tek, Sevinç Aktemur Türker; Restor Dent Endod 2020;45(1):e5. Published online November 29, 2019; DOI: https://doi.org/10.5395/rde.2020.45.e5

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Objectives

The obturation quality of MTA, Biodentine, Total Fill BC root canal sealer (RCS), and warm gutta-percha (WGP) in teeth with simulated internal root resorption (IRR) was evaluated by using micro-computed tomography.

Materials and Methods

Standardized IRR cavities were created using 40 extracted maxillary central incisor teeth and randomly assigned into 4 groups (n = 10). IRR cavities were filled with MTA, Biodentine, Total Fill BC RCS (bulk-fill form) and WGP + Total Fill BC RCS. Percentage of voids between resorptive cavity walls and obturation material (external void), and inside the filling materials (internal voids) were measured.

Results

Total Fill BC sealer in the bulk-fill form presented significantly highest values of external and internal void percentages (p < 0.05). Biodentine showed a significantly lowest external void percentage (p < 0.05). WGP + Total Fill BC RCS presented significantly lower values of internal void percentages than all groups (p < 0.05), except Biodentine (p > 0.05).

Conclusion

None of the filling materials were created void-free obturation in resorption cavities. Biodentine may favor its application in teeth with IRR over Angelus MTA and bulk-fill form of Total Fill BC.

Citations

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Evaluation of Different Techniques and Materials for Filling in 3-dimensional Printed Teeth Replicas with Perforating Internal Resorption by Means of Micro–Computed Tomography
Angelo J.S. Torres-Carrillo, Helena C. Assis, Rodrigo E. Salazar-Gamarra, Leonardo Moreira Teodosio, Alice C. Silva-Sousa, Jardel F. Mazzi-Chaves, Priscila B. Ferreira-Soares, Manoel D. Sousa-Neto, Fabiane C. Lopes-Olhê
Journal of Endodontics.2024; 50(2): 205. CrossRef
Three-Dimensional Measurement of Obturation Quality of Bioceramic Materials in Filling Artificial Internal Root Resorption Cavities Using Different Obturation Techniques: An In Vitro Comparative Study
Ammar M. Sharki, Ahmed H. Ali
Journal of Endodontics.2024; 50(7): 997. CrossRef
Evaluation of calcium hydroxide root canal filling materials by cone beam computed tomography and three-dimensional modeling
Asel Usdat Ozturk, Ekin Dogan, Venus Seyedoskuyi, Berk Senguler, Asli Topaloglu-Ak
Folia Medica.2024; 66(2): 250. CrossRef
Clinical applications of calcium silicate‐based materials: a narrative review
S Küçükkaya Eren
Australian Dental Journal.2023;[Epub] CrossRef
A critical analysis of research methods and experimental models to study root canal fillings
Gustavo De‐Deus, Erick Miranda Souza, Emmanuel João Nogueira Leal Silva, Felipe Gonçalves Belladonna, Marco Simões‐Carvalho, Daniele Moreira Cavalcante, Marco Aurélio Versiani
International Endodontic Journal.2022; 55(S2): 384. CrossRef
An Updated Review on Properties and Indications of Calcium Silicate-Based Cements in Endodontic Therapy
Fateme Eskandari, Alireza Razavian, Rozhina Hamidi, Khadije Yousefi, Susan Borzou, Zohaib Khurshid
International Journal of Dentistry.2022; 2022: 1. CrossRef
Efficacy Of Calcium Silicate-Based Sealers In Root Canal Treatment: A Systematic Review
Hattan Mohammed Omar Baismail, Mohammed Ghazi Moiser Albalawi, Alaa Mofareh Thoilek Alanazi, Muhannad Atallah Saleem Alatawi, Badr Soliman Alhussain
Annals of Dental Specialty.2021; 9(1): 87. CrossRef

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Review Article

Effect of calcium hydroxide on inflammatory root resorption and ankylosis in replanted teeth compared with other intracanal materials: a review: Maryam Zare Jahromi, Mahmood Reza Kalantar Motamedi; Restor Dent Endod 2019;44(3):e32. Published online August 1, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e32

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Calcium hydroxide (CH) is the gold-standard intracanal dressing for teeth subjected to traumatic avulsion. A common complication after the replantation of avulsed teeth is root resorption (RR). The current review was conducted to compare the effect of CH with that of other intracanal medications and filling materials on inflammatory RR and replacement RR (ankylosis) in replanted teeth. The PubMed and Scopus databases were searched through June 2018 using specific keywords related to the title of the present article. The materials that were compared to CH were in 2 categories: 1) mineral trioxide aggregate (MTA) and endodontic sealers as permanent filling materials for single-visit treatment, and 2) Ledermix, bisphosphonates, acetazolamide, indomethacin, gallium nitrate, and enamel matrix-derived protein (Emdogain) as intracanal medicaments for multiple-visit management of avulsed teeth prior to the final obturation. MTA can be used as a single-visit root filling material; however, there are limited data on its efficacy due to a lack of clinical trials. Ledermix and acetazolamide were comparable to CH in reducing RR. Emdogain seems to be an interesting material, but the data supporting its use as an intracanal medication remain very limited. The conclusions drawn in this study were limited by the insufficiency of clinical trials.

Citations

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Efficacy of Simvastatin in Inhibiting Bone Resorption and Promoting Healing in Delayed Tooth Avulsion: A Case Series
Rajesh Kumar, Supraja N Atluri, Alekhya Achanta, Chittaranjan Bogishetty, Tejaswini R Chunduri, Tejaswini PSS, Ramakrishna Ravi
Cureus.2025;[Epub] CrossRef
Bioactive potential of Bio-C Temp demonstrated by systemic mineralization markers and immunoexpression of bone proteins in the rat connective tissue
Camila Soares Lopes, Mateus Machado Delfino, Mário Tanomaru-Filho, Estela Sasso-Cerri, Juliane Maria Guerreiro-Tanomaru, Paulo Sérgio Cerri
Journal of Materials Science: Materials in Medicine.2024;[Epub] CrossRef
The use of mineral trioxide aggregate for treatment of children with complications of dental trauma
L.Yu. Kharkova, M.V. Korolenkova
Stomatology.2024; 103(4): 59. CrossRef
Instant Re-Implantation of Avulsed Teeth
Smita Paul, Sambarta Das, Nirmal Debbarma, Barun Dasgupta, Bidyut Seal, Ayesha Satapathy
Journal of Pharmacy and Bioallied Sciences.2024; 16(Suppl 4): S3461. CrossRef
Interpretation by literature review of the use of calcium hydroxide as an intra-ductal medication
María Belén Muñoz Padilla, Verónica Alicia Vega Martínez, Camila Alejandra Villafuerte Moya
Salud, Ciencia y Tecnología.2024; 4: 924. CrossRef
Evaluation of the physicochemical properties of intracanal medications used in traumatized teeth
Patricia Almeida da Silva de Macedo, Walbert de Andrade Vieira, Paulo Henrique Gabriel, Karla de Faria Vasconcelos, Francisco Haiter Neto, Ana Carolina Correia Laurindo de Cerqueira Neto, Brenda Paula Figueiredo de Almeida Gomes, Marcos Roberto dos Santo
Brazilian Journal of Oral Sciences.2024; 23: e242997. CrossRef
Treatment of Teeth with Root Resorptions: A Case Report and Systematic Review
Damla Erkal, Abdullah Başoğlu, Damla Kırıcı, Nezahat Arzu Kayar, Simay Koç, Kürşat Er
Galician Medical Journal.2023;[Epub] CrossRef
Successful outcome of permanent maxillary incisor reimplanted after 30 hours of extra‐oral time—a case report with 5‐year follow‐up
Ibadat Preet Kaur, Ashok Kumar, Mukul Kumar, Kanistika Jha
Clinical Case Reports.2023;[Epub] CrossRef
Replantation of an Avulsed Tooth: A Case Report
Nishad Kadulkar, Rubi Kataki, Adrija Deka, Salouno Thonai
Cureus.2023;[Epub] CrossRef
Avulsion of Permanent Mandibular Incisors: A Report of Two Cases with Pertinent Literature
Ibadat Preet Kaur, Jitendra Sharan, Pallawi Sinha, Ashok Kumar, Anand Marya, Leandro Napier de Souza
Case Reports in Dentistry.2023; 2023: 1. CrossRef
The Impact of Autologous Platelet Concentrates on the Periapical Tissues and Root Development of Replanted Teeth: A Systematic Review
Zohaib Khurshid, Faris Yahya I. Asiri, Shariq Najeeb, Jithendra Ratnayake
Materials.2022; 15(8): 2776. CrossRef

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Research Article

Effects of the cathepsin K inhibitor with mineral trioxide aggregate cements on osteoclastic activity: Hee-Sun Kim, Soojung Kim, Hyunjung Ko, Minju Song, Miri Kim; Restor Dent Endod 2019;44(2):e17. Published online April 23, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e17

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Objectives

Root resorption is an unexpected complication after replantation procedures. Combining anti-osteoclastic medicaments with retrograde root filling materials may avert this resorptive activity. The purpose of this study was to assess effects of a cathepsin K inhibitor with calcium silicate-based cements on osteoclastic activity.

Methods

MC3T3-E1 cells were cultured for biocompatibility analyses. RAW 264.7 cells were cultured in the presence of the receptor activator of nuclear factor-kappa B and lipopolysaccharide, followed by treatment with Biodentine (BIOD) or ProRoot MTA with or without medicaments (Odanacatib [ODN], a cathepsin inhibitor and alendronate, a bisphosphonate). After drug treatment, the cell counting kit-8 assay and Alizarin red staining were performed to evaluate biocompatibility in MC3T3-E1 cells. Reverse-transcription polymerase chain reaction, tartrate-resistant acid phosphatase (TRAP) staining and enzyme-linked immunosorbent assays were performed in RAW 264.7 cells to determine the expression levels of inflammatory cytokines, interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2). Data were analyzed by one-way analysis of variance and Tukey's post hoc test (p < 0.05).

Results

Biocompatibility results showed that there were no significant differences among any of the groups. RAW 264.7 cells treated with BIOD and ODN showed the lowest levels of TNF-α and PGE2. Treatments with BIOD + ODN were more potent suppressors of inflammatory cytokine expression (p < 0.05).

Conclusion

The cathepsin K inhibitor with calcium silicate-based cement inhibits osteoclastic activity. This may have clinical application in preventing inflammatory root resorption in replanted teeth.

Citations

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Root-filling materials for endodontic surgery: biological and clinical aspects
Andreas Koutroulis, Vasileios Kapralos, Dag Ørstavik, Pia Titterud Sunde
Biomaterial Investigations in Dentistry.2024; 11: 115. CrossRef
Effect of intra‐alveolar delivery of Frondoside A on inflammatory response of delayed tooth replantation
Lar Herr, Ju Ri Ye, Sang Wook Kang, Sang Tae Ro, Yong Kwon Chae, Ko Eun Lee, Mi Sun Kim, Myeong Kwan Jih, Chunui Lee, Sung Chul Choi, Ok Hyung Nam
Dental Traumatology.2024; 40(2): 178. CrossRef
Bone-targeting PLGA derived lipid drug delivery system ameliorates bone loss in osteoporotic ovariectomized rats
Youyun Zeng, Yiding Shen, Shuyi Wu, Lei Cai, Zhen Wang, Kexin Cai, Jiating Shen, Kendrick Hii Ru Yie, Hualin Zhang, Lihua Xu, Jinsong Liu
Materials & Design.2022; 221: 110967. CrossRef

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Case Report

Surgical management of a failed internal root resorption treatment: a histological and clinical report: Saeed Asgary, Mohammad Jafar Eghbal, Leili Mehrdad, Sanam Kheirieh, Ali Nosrat; Restor Dent Endod 2014;39(2):137-142. Published online March 21, 2014; DOI: https://doi.org/10.5395/rde.2014.39.2.137

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This article presents the successful surgical management of a failed mineral trioxide aggregate (MTA) orthograde obturation of a tooth with a history of impact trauma and perforated internal root resorption. A symptomatic maxillary lateral incisor with a history of perforation due to internal root resorption and nonsurgical repair using MTA was referred. Unintentional overfill of the defect with MTA had occurred 4 yr before the initial visit. The excess MTA had since disappeared, and a radiolucent lesion adjacent to the perforation site was evident radiographically. Surgical endodontic retreatment was performed using calcium enriched mixture (CEM) cement as a repair material. Histological examination of the lesion revealed granulation tissue with chronic inflammation, and small fragments of MTA encapsulated within fibroconnective tissue. At the one and two year follow up exams, all signs and symptoms of disease had resolved and the tooth was functional. Complete radiographic healing of the lesion was observed two years after the initial visit. This case report illustrates how the selection of an appropriate approach to treatment of a perforation can affect the long term prognosis of a tooth. In addition, extrusion of MTA into a periradicular lesion should be avoided.

Citations

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Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis
Saeed Asgary, Mahtab Aram, Mahta Fazlyab
BioMedical Engineering OnLine.2024;[Epub] CrossRef
The various forms of tooth resorption
Jordan Samuel Blum
Australian Endodontic Journal.2024; 50(2): 191. CrossRef
Bioceramics in Endodontics: Updates and Future Perspectives
Xu Dong, Xin Xu
Bioengineering.2023; 10(3): 354. CrossRef
Imaging techniques and various treatment modalities used in the management of internal root resorption: A systematic review
R. S Digholkar, S D Aggarwal, P S Kurtarkar, P. B Dhatavkar, V L Neil, D N Agarwal
Endodontology.2023; 35(2): 85. CrossRef
Treatment of Teeth with Root Resorptions: A Case Report and Systematic Review
Damla Erkal, Abdullah Başoğlu, Damla Kırıcı, Nezahat Arzu Kayar, Simay Koç, Kürşat Er
Galician Medical Journal.2023;[Epub] CrossRef
Effects of calcium silicate cements on neuronal conductivity
Derya Deniz-Sungur, Mehmet Ali Onur, Esin Akbay, Gamze Tan, Fügen Daglı-Comert, Taner Cem Sayın
Restorative Dentistry & Endodontics.2022;[Epub] CrossRef
Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part II: other clinical applications and complications
M. Torabinejad, M. Parirokh, P. M. H. Dummer
International Endodontic Journal.2018; 51(3): 284. CrossRef
Periodontal healing following non-surgical repair of an old perforation with pocket formation and oral communication
Saeed Asgary, Prashant Verma, Ali Nosrat
Restorative Dentistry & Endodontics.2018;[Epub] CrossRef
Conservative Management of Class 4 Invasive Cervical Root Resorption Using Calcium-enriched Mixture Cement
Saeed Asgary, Ali Nosrat
Journal of Endodontics.2016; 42(8): 1291. CrossRef
Importance of CBCT in the management plan of upper canine with internal resorption
Roberto Fornara, Dario Re Cecconi
Giornale Italiano di Endodonzia.2015; 29(2): 70. CrossRef

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Research Article

Enamel matrix derivative for replanted teeth in animal models: a systematic review and meta-analysis: Sahng G. Kim, Steven I. Ryu; Restor Dent Endod 2013;38(4):194-203. Published online November 12, 2013; DOI: https://doi.org/10.5395/rde.2013.38.4.194

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Objectives

To investigate the effect of enamel matrix derivative (EMD) on periodontal healing of replanted teeth in animal models.

Materials and Methods

The authors searched MEDLINE, PubMed, EMBASE, Cochrane Library, Web of Knowledge and Scopus for articles published up to Oct 2012. Animal studies in which EMD was applied in transplanted or replanted teeth with adequate controls and histological data were considered. Normal periodontal healing or root resorption determined by histology after EMD was applied in replanted teeth with adequate controls was used as outcome measures. The following search strategy was used: ('Emdogain' OR 'enamel matrix proteins' OR 'enamel matrix derivative') AND ('avulsion' OR 'transplantion' OR 'autotransplantation' OR 'replantation').

Results

Six animal studies were included in the final review. There was great heterogeneity in study design among included studies. Two studies with similar study designs were identified and analyzed by a meta-analysis. The pooled estimates showed a significantly higher normal healing and surface resorption and significantly less inflammatory and replacement resorption in EMD-treated groups compared with non-EMD-treated groups.

Conclusions

With the limitations of this systematic review, the use of EMD led to greater normal periodontal healing and surface root resorption and less inflammatory and replacement root resorption in the presence of periodontal ligaments. However, no definite conclusion could be drawn with regard to the effect of EMD on periodontal healing and root resorption when no periodontal ligaments exist.

Citations

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Pritesh Kisanlal Agrawal, Narayan G. Jibhkate, Saurabh A. Redij
Journal of Interdisciplinary Dentistry.2024; 14(2): 128. CrossRef
Enamel matrix derivative in the treatment of tooth replantation: from a biological basis to clinical application
Yao Lin, Liangping Chen, Yuling Xu, Mingwei Xu, Qinghua Liu, Junbing He
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Fibrillin protein, a candidate for creating a suitable scaffold in PDL regeneration while avoiding ankylosis
Kyoko Oka
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Can delayed grafting of frozen teeth achieve periodontal ligament healing?
Yue Chen, Liang Chen, Min Zhou, Shouyin Yi, Juan Ran, Yuansi Long, Jing Luo, Kun Tian
Medical Hypotheses.2022; 167: 110945. CrossRef
Permanent tooth avulsion in children and adults: Therapeutic options for longer survival
Simona Stojanović, Miloš Tijanić, Kristina Burić, Nina Burić, Milan Spasić, Kosta Todorović, Branislava Stojković, Marija Jovanović, Milica Petrović, Dušan Mitić
Acta stomatologica Naissi.2021; 37(83): 2213. CrossRef
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Nitesh Tewari, Vijay Prakash Mathur, Amandeep Kaur, Divesh Sardana, Morankar Rahul, Rigzen Tamchos, Priyanshi Ritwik, Shubhi Goel, Julie Schiavo
Dental Traumatology.2021; 37(1): 17. CrossRef
Application of Enamel Matrix Derivative (Emdogain) in Endodontic Therapy: A Comprehensive Literature Review
Howard H. Wang, Nima D. Sarmast, Elham Shadmehr, Nikola Angelov, Shahrokh Shabahang, Mahmoud Torabinejad
Journal of Endodontics.2018; 44(7): 1066. CrossRef
Periodontal wound healing following reciprocal autologous root transplantation in class III furcation defects
Naoshi Takeuchi, Yoshinori Shirakata, Yukiya Shinohara, Kotaro Sena, Kazuyuki Noguchi
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Effects of Fibrillin Application on Periodontal Ligament Regeneration in Mouse Model of Tooth Replantation
Shougo Tamura, Kyoko Oka, Satoshi Itaya, Michiko Kira-Tatsuoka, Masako Toda, Arisa Higa, Masao Ozaki
Journal of Hard Tissue Biology.2016; 25(3): 295. CrossRef
Autotransplantation: a viable treatment option for adolescent patients with significantly compromised teeth
D Ong, Y Itskovich, G Dance
Australian Dental Journal.2016; 61(4): 396. CrossRef
Influence of enamel matrix derivative on healing of root surfaces after bonding treatment and intentional replantation of vertically fractured roots
Tsutomu Sugaya, Mahito Tomita, Youji Motoki, Hirofumi Miyaji, Masamitsu Kawamami
Dental Traumatology.2016; 32(5): 397. CrossRef
The effect of cathepsin K inhibitor on osteoclastic activity compared to alendronate and enamel matrix protein
Wonkyung Yang, Hyunjung Ko, Heesun Kim, Miri Kim
Dental Traumatology.2015; 31(3): 202. CrossRef
The effects of bone morphogenetic protein-2 and enamel matrix derivative on the bioactivity of mineral trioxide aggregate in MC3T3-E1cells
Youngdan Jeong, Wonkyung Yang, Hyunjung Ko, Miri Kim
Restorative Dentistry & Endodontics.2014; 39(3): 187. CrossRef
What is the Best Root Surface Treatment for Avulsed Teeth?
Elif B Tuna , Duygu Yaman , Seiko Yamamato
The Open Dentistry Journal.2014; 8(1): 175. CrossRef

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Case Report

Invasive cervical resorption: treatment challenges: Yookyung Kim, Chan-Young Lee, Euiseong Kim, Byoung-Duck Roh; Restor Dent Endod 2012;37(4):228-231. Published online November 21, 2012; DOI: https://doi.org/10.5395/rde.2012.37.4.228

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Invasive cervical resorption is a relatively uncommon form of external root resorption. It is characterized by invasion of cervical region of the root by fibrovascular tissue derived from the periodontal ligament. This case presents an invasive cervical resorption occurring in maxillary lateral incisor, following damage in cervical cementum from avulsion and intracoronal bleaching procedure. Flap reflection, debridement and restoration with glass ionomer cement were performed in an attempt to repair the defect. But after 2 mon, more resorption extended apically. Considering root stability and recurrence potential, we decided to extract the tooth. Invasive cervical resorption in advanced stages may present great challenges for clinicians. Therefore, prevention and early detection must be stressed when dealing with patients presenting history of potential predisposing factors.

Citations

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The Outcome of Decoronation in Severe Cases of External Cervical Root Resorption in Young Patients
Dina Moss, Eyal Nuni, Hagay Slutzky, Daniel Moreinos, Iris Slutzky-Goldberg
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Original Article

The verification of the MTT assay on the viability of periodontal ligamental cells in rat molars through the histologic examination: Hyun-Ki Kim, Eui-Seoung Kim, In-Bok Choi, Jin Kim, Seung-Jong Lee; J Korean Acad Conserv Dent 2003;28(5):385-391. Published online September 30, 2003; DOI: https://doi.org/10.5395/JKACD.2003.28.5.385

Abstract PDF PubReader ePub

The purpose of this study is to examine the viability of PDL cells in rat molars by using MTT assay and to verify the MTT assay through the histologic observation. Thirty of Sprague-Dawley white female rats of 4-weeks old with a body weight of about 100 grams were used. Groupings are as follows:

Immediate Group : Positive control group(n=10)-after extraction immediately.

Dried Group : Negative control group(n=10)-after drying for an hour under warm dry.

ViaSpan® Group : 1hour ViaSpan® group(n=10)-after storing in ViaSpan® at 4℃ for 1hour.

Ten teeth of each group were treated as same as above and replanted to the original socket of experimental animals. After two weeks of replantation, all the experimental animals were sacrificed. And after fixation, extracted maxillary jaw was dimineralized. After it was embedded in paraffin, serial section by 5µm was carried out and for construction of specimen, hematoxylin-eosin dye was used.

The mean MTT measurement of immediate group(positive control) is 2.81 and the mean measurement of dried group(negative control) is 0.98 which is significant differnt(P<0.05). The mean measurement of ViaSpan® group is 2.65 and there is significant difference between dried group and ViaSpan® group(P<0.05). However, there is no difference between immediate group and ViaSpan® group. The average resorption points of immediate group is 3.03 points. In the dried group, average 6.44 points resorption and 2.68 points showed resorption in the ViaSpan® group. Unlike with MTT assay, there was no significant difference between the immediate group and ViaSpan® group.

The usage of MTT assay as a viable cell marker may give us a better indication of the maintenance of periodontal ligament cell vitality.

Citations

Citations to this article as recorded by

Effects of Trichosanthis Radix Extract on Collagen Production
Mi-Young Yun, Hye-Won Kim
Journal of the Korean Society of Cosmetology.2024; 30(2): 408. CrossRef
Evaluation of periodontal ligament cell viability in rat teeth according to various extra-oral dry storage times using MTT assay
In-Soo Jeon, Eui-Seong Kim, Jin Kim, Seung-Jong Lee
Journal of Korean Academy of Conservative Dentistry.2006; 31(5): 398. CrossRef

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