Restorative Dentistry & Endodontics

Research Articles

Concentrated growth factor scaffold-based pulpotomy of permanent molars with symptomatic irreversible pulpitis: Arthi K. Harith, Vishnupriya Koteeswaran, Dinesh Kowsky, Natanasabapathy Velmurugan, Suresh Nandini; Restor Dent Endod 2025;50(1):e1. Published online January 17, 2025; DOI: https://doi.org/10.5395/rde.2025.50.e1

Abstract PDF PubReader ePub: Objectives
Pulpotomy is a minimally invasive procedure that aims to retain the vitality of the radicular pulp by removing the inflamed coronal pulp tissue. This case series presents the successful management of symptomatic irreversible pulpitis by pulpotomy with concentrated growth factor (CGF) scaffolds.
Methods
Six permanent mandibular molars with a diagnosis of symptomatic irreversible pulpitis were included. Under Local anesthesia and rubber dam isolation, caries were excavated using high-speed bur under coolant. Full coronal pulpotomy was done and hemostasis was achieved. CGF membrane was prepared and placed over the radicular pulp and layered with Biodentine (Septodont). Final restoration of type IX glass ionomer cement and bulk fill composite resin was placed. Patients were assessed for various clinical and radiographic parameters at intervals of 1 week and 3, 6, and 12 months. Five patients fulfilled the success criteria at the end of 1 year.
Results
Pulpotomy is considered an alternative treatment modality for root canal treatment in symptomatic irreversible pulpitis aiming at alleviating symptoms and maintaining vitality. CGF scaffold when used as a capping material acts as a reservoir for growth factors with anti-inflammatory properties and enhances healing.
Conclusions
Scaffold-based pulpotomy can be considered a biological approach to healing inflamed pulp.

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Antimicrobial and cytotoxic properties of calcium-enriched mixture cement, Iranian propolis, and propolis with herbal extracts in primary dental pulp stem cells: Mohammad Esmaeilzadeh, Shirin Moradkhani, Fahimeh Daneshyar, Mohammad Reza Arabestani, Sara Soleimani Asl, Soudeh Tayebi, Maryam Farhadian; Restor Dent Endod 2023;48(1):e2. Published online December 1, 2022; DOI: https://doi.org/10.5395/rde.2023.48.e2

Abstract PDF PubReader ePub

Objectives

In this study, natural substances were introduced as primary dental pulp caps for use in pulp therapy, and the antimicrobial and cytotoxic properties of these substances were investigated.

Materials and Methods

In this in vitro study, the antimicrobial properties of calcium-enriched mixture (CEM) cement, propolis, and propolis individually combined with the extracts of several medicinal plants were investigated against Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Then, the cytotoxicity of each substance or mixture against pulp stem cells extracted from 30 primary healthy teeth was evaluated at 4 concentrations. Data were gathered via observation, and optical density values were obtained using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) test and recorded. SPSS software version 23 was used to analyze the data. Data were evaluated using 2-way analysis of variance and the Tukey test.

Results

Regarding antimicrobial properties, thyme alone and thyme + propolis had the lowest minimum inhibitory concentrations (MICs) against the growth of S. aureus, E. coli, and P. aeruginosa bacteria. For E. faecalis, thyme + propolis had the lowest MIC, followed by thyme alone. At 24 and 72 hours, thyme + propolis, CEM cement, and propolis had the greatest bioviability in the primary dental pulp stem cells, and lavender + propolis had the lowest bioviability.

Conclusions

Of the studied materials, thyme + propolis showed the best results in the measures of practical performance as a dental pulp cap.

Citations

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Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis
Saeed Asgary, Mahtab Aram, Mahta Fazlyab
BioMedical Engineering OnLine.2024;[Epub] CrossRef
Effects of aqueous and ethanolic extracts of Chinese propolis on dental pulp stem cell viability, migration and cytokine expression
Ha Bin Park, Yen Dinh, Pilar Yesares Rubi, Jennifer L. Gibbs, Benoit Michot
PeerJ.2024; 12: e18742. CrossRef

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YouTube as a source of information about pulpotomy and pulp capping: a cross sectional reliability analysis: Konstantinos Kodonas, Anastasia Fardi; Restor Dent Endod 2021;46(3):e40. Published online July 6, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e40

Abstract PDF PubReader ePub

Objectives

The purpose of this study was to critically evaluate the quality, reliability and educational content of the information of vital pulp treatment videos available on YouTube.

Materials and Methods

The keywords “pulpotomy” and “pulp capping” were searched on YouTube on 5th July 2020, until 60 English language videos of each search term with a duration shorter than 15 minutes were acquired. Video characteristics were recorded and Video Power Index (VPI) was calculated. Reliability and educational quality of videos were evaluated using the Modified DISCERN score, the Journal of American Medical Association (JAMA) benchmark criteria and Global Quality Scores (GQS). Videos were categorized by uploading source.

Results

Regarding pulpotomy, 31.7% of the videos were uploaded by specialists and 68.3% were directed by non-specialists. In the case of pulp capping, the corresponding percentages were 45% and 55%, respectively. Videos uploaded by specialists had significantly higher modified DISCERN, JAMA and GQS scores compared to those uploaded by non-specialists. Endodontists tended to have the highest reliability and VPI scores.

Conclusions

YouTube videos on vital pulp treatment contain low educational quality or incomplete information. Low popularity of dental pulp capping and pulpotomy videos may be attributed to the specialized nature of these procedures. As YouTube represents an important source for patient information about different health topics, reliable informative videos should be uploaded by specialized dental professionals.

Citations

Citations to this article as recorded by

Assessing the Quality of YouTube® Videos on Nitrous Oxide/Oxygen Inhalation: A Multi-Dimensional Approach for Pediatric Dentists
Sanaa N. Al-Haj Ali, Nehal AlHarbi, Hessah H. Almutairi
Pesquisa Brasileira em Odontopediatria e Clínica Integrada.2025;[Epub] CrossRef
Quality of Patient-Centered eHealth Information on Erosive Tooth Wear: Systematic Search and Evaluation of Websites and YouTube Videos
Lena Holland, Amelie Friederike Kanzow, Annette Wiegand, Philipp Kanzow
Journal of Medical Internet Research.2024; 26: e49514. CrossRef
Is it safe to learn about vital pulp capping from YouTube™ videos? A content and quality analysis
Celalettin Topbaş, Tuğçe Paksoy, Ayşe Gülnihal İslamoğlu, Kemal Çağlar, Abdurrahman Kerim Kul
International Journal of Medical Informatics.2024; 185: 105409. CrossRef
Assessment of the quality of oral biopsy procedure videos shared on YouTube
A. Díaz‐Rodríguez, J. Limeres‐Posse, R. Albuquerque, V. Brailo, R. Cook, J. C. Fricain, G. Lodi, L. Monteiro, L. Silva, B. Carey, M. Diniz‐Freitas
Oral Diseases.2024; 30(5): 3081. CrossRef
İmplant üstü protezler hakkında bilgi veren internet sitelerinin okunabilirliklerinin değerlendirilmesi
Tugba TEMİZCİ
Selcuk Dental Journal.2023; 10(4): 156. CrossRef
Online Audio-Visual Information on the Treatment of OSA with Mandibular Advancement Devices: Analysis of Quality, Reliability and Contents
Serena Incerti-Parenti, Maria Lavinia Bartolucci, Elena Biondi, Andrea Fiordelli, Corrado Paganelli, Giulio Alessandri-Bonetti
Applied Sciences.2023; 13(9): 5727. CrossRef
Evaluating YouTube as a Patient Information Source for the Risks of Root Canal Treatment
Stewart McLean, Neil Cook, Alexander Rovira-Wilde, Shanon Patel, Shalini Kanagasingam
Journal of Endodontics.2023; 49(2): 155. CrossRef
Assessment of reliability and information quality of YouTube videos about root canal treatment after 2016
Myoung-jun Jung, Min-Seock Seo
BMC Oral Health.2022;[Epub] CrossRef
Is the YouTube™ a useful resource of information about orthognathic surgery?: A cross-sectional study
Seyma Bayazıt, Bilal Ege, Mahmut Koparal
Journal of Stomatology, Oral and Maxillofacial Surgery.2022; 123(6): e981. CrossRef
YoutubeTM Content Analysis as a Means of Information in Oral Medicine: A Systematic Review of the Literature
Antonio Romano, Fausto Fiori, Massimo Petruzzi, Fedora Della Vella, Rosario Serpico
International Journal of Environmental Research and Public Health.2022; 19(9): 5451. CrossRef

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Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth: Bharti Kusum, Kumar Rakesh, Khanna Richa; Restor Dent Endod 2015;40(4):276-285. Published online September 9, 2015; DOI: https://doi.org/10.5395/rde.2015.40.4.276

Abstract PDF PubReader ePub

Objectives

The purpose of this study was to evaluate the efficacy of mineral trioxide aggregate (MTA), Biodentine and Propolis as pulpotomy medicaments in primary dentition, both clinically and radiographically.

Materials and Methods

A total of 75 healthy 3 to 10 yr old children each having at least one carious primary molar tooth were selected. Random assignment of the pulpotomy medicaments was done as follows: Group I, MTA; Group II, Biodentine; Group III, Propolis. All the pulpotomized teeth were evaluated at 3, 6, and 9 mon clinically and radiographically, based on the scoring criteria system.

Results

The clinical success rates were found to be similar among the three groups at 3 and 6 mon where as a significant decrease in success rate was observed in Group III (84%) compared to both Group I (100%) and Group II (100%) at 9 mon. Radiographic success rates over a period of 9 mon in Groups I, II, and III were 92, 80, and 72%, respectively.

Conclusions

Teeth treated with MTA and Biodentine showed more favorable clinical and radiographic success as compared to Propolis at 9 mon follow-up.

Citations

Citations to this article as recorded by

The Clinical Effectiveness of Propolis on the Endodontic Treatment of Permanent Teeth: A Systematic Review of Randomized Clinical Trials and Updates
Amirah Y Aldosari, Amira M Aljared, Hanin S Alqurshy, Abdullah M Alfarran, Mohanad G Alnahdi, Sarah S Alharbi, Wed S Alharbi, Faisal T Alghamdi
Cureus.2025;[Epub] CrossRef
Calcium Silicate-Based Cements in Restorative Dentistry: Vital Pulp Therapy Clinical, Radiographic, and Histological Outcomes on Deciduous and Permanent Dentition—A Systematic Review and Meta-Analysis
Maria Teresa Xavier, Ana Luísa Costa, João Carlos Ramos, João Caramês, Duarte Marques, Jorge N. R. Martins
Materials.2024; 17(17): 4264. CrossRef
Outcome assessment methods of bioactive and biodegradable materials as pulpotomy agents in primary and permanent teeth: a scoping review
Yasmine Elhamouly, May M. Adham, Karin M L Dowidar, Rania M. El Backly
BMC Oral Health.2024;[Epub] CrossRef
Comparative Evaluation of the Efficacy of Theracal Lc, Mineral Trioxide Aggregate, and Biodentine As Direct Pulp Capping Materials in Patients With Pulpal Exposure in Posterior Teeth: A Triple Blinded Randomized Parallel Group Clinical Trial
Joyeeta Mahapatra, Pradnya P Nikhade, Aditya Patel, Nikhil Mankar, Prachi Taori
Cureus.2024;[Epub] CrossRef
Efficacy of different endodontic irrigants in the lesion sterilization and tissue repair technique in primary molars: A randomized controlled clinical trial
Anukriti Dimri, Nikhil Srivastava, Vivek Rana, Noopur Kaushik
Journal of Indian Society of Pedodontics and Preventive Dentistry.2024; 42(4): 294. CrossRef
Clinical and Radiographic Success Rates of Pulpotomies in Primary Molars Treated with Formocresol, BiodentineTM, and Endo Repair: A Randomized Clinical Trial
Elham Farokh Gisour, Farzaneh Jalali, Fatemeh Jahanimoghadam, Tania Dehesh
Pesquisa Brasileira em Odontopediatria e Clínica Integrada.2023;[Epub] CrossRef
Evaluation and comparison of mineral trioxide aggregate and cold ceramic in primary tooth pulpotomy: Clinical and radiographic study
Bita Rasteh, Leila Basir, Shirin Taravati, Masoumeh Khataminia
Journal of Family Medicine and Primary Care.2023; 12(12): 3068. CrossRef
Comparison between the Radiographic and Clinical Rates of Success for TheraCal and MTA in Primary Tooth Pulpotomy within a 12‐Month Follow‐Up: A Split‐Mouth Clinical Trial
Sedigheh Hassanpour, Naser Asl Aminabadi, Mahdi Rahbar, Leila Erfanparast, Iole Vozza
BioMed Research International.2023;[Epub] CrossRef
Biodentine™ Pulpotomy in Stage I Primary Molars: A 12-month Follow-up
Balsam Noueiri, Hitaf Nasrallah
International Journal of Clinical Pediatric Dentistry.2023; 15(6): 660. CrossRef
Omega 3 based formulations as new possible pulpotomy agents for primary teeth
Nancy M. Metwally, Amina M. El Hosary, Gamal M. El Maghraby, Maha A. El Demellawy, Mohamed Nabil, Elsayed M. Deraz
Tanta Dental Journal.2022; 19(4): 287. CrossRef
Clinical efficacy of Er:YAG laser application in pulpotomy of primary molars: a 2-year follow-up study
Junhui Wang, Yujiang Chen, Baize Zhang, Xin Ge, Xiaojing Wang
Lasers in Medical Science.2022; 37(9): 3705. CrossRef
Comparative efficacy of medicaments or techniques for pulpotomy of primary molars: a network meta-analysis
Jiehua Guo, Na Zhang, Yuzhao Cheng
Clinical Oral Investigations.2022; 27(1): 91. CrossRef
Comparative evaluation of zinc oxide-eugenol and zinc oxide with Neem oil in root canal treatment of primary teeth
Dhvani Gordhanbhai Patel, Shoba Fernandes, Yash Bafna, Krunal Choksi, Shaila Chaudhary, Priya Mishra
AYU (An International Quarterly Journal of Research in Ayurveda).2022; 43(1): 8. CrossRef
Treatment Outcomes of Pulpotomy with Propolis in Comparison with MTA in Human Primary Molars: A 24-month Follow-up Randomized Controlled Trial
Rayala Chandrasekhar, C Vinay, KS Uloopi, Kakarla Sri RojaRamya
International Journal of Clinical Pediatric Dentistry.2022; 15(S1): S3. CrossRef
Comparison of Clinical and Radiographic Success between MTA and Biodentine in Pulpotomy of Primary Mandibular Second Molars with Irreversible Pulpitis: A Randomized Double-Blind Clinical Trial
Alireza Eshghi, Maryam Hajiahmadi, Mohammad Hossein Nikbakht, Mona Esmaeili, Murilo Baena Lopes
International Journal of Dentistry.2022; 2022: 1. CrossRef
Does the use of natural products for endodontic therapy in primary teeth have sufficient evidence for clinical practice? A scoping review
Filipe Colombo Vitali, Ana Cristina Andrada, Helhen Cristina da Luz Cardoso, Gesner Francisco Xavier-Junior, Cleonice da Silveira Teixeira, Loise Pedrosa Salles, Erica Negrini Lia, Carla Massignan
Clinical Oral Investigations.2022; 26(10): 6043. CrossRef
Prevalence of pain following single-visit pulpectomy with stainless steel crown done by postgraduate students in a university sitting
Ashwin Shravan Kumar, Mahesh Ramakrishnan
Journal of Advanced Pharmaceutical Technology & Research.2022; 13(Suppl 1): S177. CrossRef
Clinical and histological response of human pulp tissue to direct pulp capping with mineral trioxide aggregate, Biodentine and propolis
Zahra Nasri, MaryamZare Jahromi, Atousa Aminzadeh
Dental Research Journal.2022; 19(1): 40. CrossRef
Long-term evaluation of primary teeth molar pulpotomies with Biodentine and MTA: a CONSORT randomized clinical trial
S. Vilella-Pastor, S. Sáez, A. Veloso, F. Guinot-Jimeno, M. Mercadé
European Archives of Paediatric Dentistry.2021; 22(4): 685. CrossRef
Tailored 70S30C Bioactive glass induces severe inflammation as pulpotomy agent in primary teeth: an interim analysis of a randomised controlled trial
Yasmine Elhamouly, Rania M. El Backly, Dalia M. Talaat, Samia S. Omar, Maha El Tantawi, Karin M. L. Dowidar
Clinical Oral Investigations.2021; 25(6): 3775. CrossRef
Efficacy of laser photobiomodulation pulpotomy in human primary teeth
Chandrashekar Murugesh Yavagal, Akshaya Lal, Viplavi Vijaysinh Chavan Patil, Puja C. Yavagal, Kiran Kumar Neelakantappa, Madhu Hariharan
Journal of Indian Society of Pedodontics and Preventive Dentistry.2021; 39(4): 436. CrossRef
SÜT DİŞİ AMPUTASYON TEDAVİSİNDE GÜNCEL YAKLAŞIMLAR
Necibe Damla ŞAHİN, Volkan ARIKAN
Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi.2021; : 1. CrossRef
The use of propolis in dentistry, oral health, and medicine: A review
Felix Zulhendri, Rafael Felitti, James Fearnley, Munir Ravalia
Journal of Oral Biosciences.2021; 63(1): 23. CrossRef
Clinical and Radiographic Evaluation of Pulpotomy using MTA, Biodentine and Er,Cr
Pandiyan Ramanandvignesh, Kumar Gyanendra, Dhillon Jatinder Kaur Goswami Mridula
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Comparative Evaluation of Success of Biodentine and Mineral Trioxide Aggregate with Formocresol as Pulpotomy Medicaments in Primary Molars: An In Vivo Study
Ritika Malhotra, Shilpa Ahuja, Dipanshu Kumar, Kapil Gandhi, Rishabh Kapoor, Kumari Surabhi
International Journal of Clinical Pediatric Dentistry.2020; 13(2): 167. CrossRef
Comparison of Partial Pulpotomy in Permanent Molars Using Different Pulp Capping Agents and Restoration Materials
Jimi Lee, Nanyoung Lee, Sangho Lee, Myeongkwan Jih
THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY.2020; 47(2): 148. CrossRef
A Comparative Evaluation between Propolis and Mineral Trioxide Aggregate as Pulpotomy Medicaments in Primary Molars
Kavita Madan, Sudhindra Baliga, Pranjali Deulkar, Nilima Thosar, Nilesh Rathi, Meghana Deshpande, Sphurti Bane
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Efficacy of Biodentine and Mineral Trioxide Aggregate in Primary Molar Pulpotomies—A Systematic Review and Meta-Analysis With Trial Sequential Analysis of Randomized Clinical Trials
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Efficacy of Alternative Medicaments for Pulp Treatment in Primary Teeth in the Short Term: A Meta-analysis
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The evaluation of MTA and Biodentine as a pulpotomy materials for carious exposures in primary teeth
Burcu Nihan Çelik, Merve Safa Mutluay, Volkan Arıkan, Şaziye Sarı
Clinical Oral Investigations.2019; 23(2): 661. CrossRef
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Bingqing Shi, Yuming Zhao, Xiaojing Yuan
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Comparison of the success rate of a bioactive dentin substitute with those of other root restoration materials in pulpotomy of primary teeth
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BiodentineTM versus formocresol pulpotomy technique in primary molars: a 12–month randomized controlled clinical trial
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Randomized Controlled Trial of Pulpotomy in Primary Molars using MTA and Formocresol Compared to 3Mixtatin: A Novel Biomaterial
Zahra Jamali, Vajiheh Alavi, Ebrahim Najafpour, Naser Asl Aminabadi, Sajjad Shirazi
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Recent Trends in Tricalcium Silicates for Vital Pulp Therapy
Imad About
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Clinical and Radiographic Evaluations of Biodentine™ Pulpotomies in Mature Primary Molars (Stage 2)
Fouad Ayoub, Hitaf Nasrallah, Balsam El Noueiri, Charles Pilipili
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Clinical and radiographic evaluation of biodentine versus calcium hydroxide in primary teeth pulpotomies: a retrospective study
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How does the pulpal response to Biodentine and ProRoot mineral trioxide aggregate compare in the laboratory and clinic?
R. Careddu, H. F. Duncan
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Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part I: vital pulp therapy
M. Parirokh, M. Torabinejad, P. M. H. Dummer
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Pulp treatment for extensive decay in primary teeth
Violaine Smaïl-Faugeron, Anne-Marie Glenny, Frédéric Courson, Pierre Durieux, Michele Muller-Bolla, Helene Fron Chabouis
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S. Rajasekharan, L. C. Martens, R. G. E. C. Cauwels, R. P. Anthonappa
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Microleakage and Shear Bond Strength of Biodentine at Different Setting Time
Yong Ho Song, Nanyoung Lee, Sangho Lee, Myeongkwan Jih
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Evaluation of Biodentine Pulpotomies in Deciduous Molars with Physiological Root Resorption (Stage 3)
Fouad Ayoub, Hitaf Nasrallah, Balsam El Noueiri, Charles Pilipili
International Journal of Clinical Pediatric Dentistry.2018; 11(5): 393. CrossRef
Clinical and radiographic comparison of biodentine, mineral trioxide aggregate and formocresol as pulpotomy agents in primary molars
P. Juneja, S. Kulkarni
European Archives of Paediatric Dentistry.2017; 18(4): 271. CrossRef
Success Rates of Pulpotomies in Primary Molars Using Calcium Silicate-Based Materials: A Randomized Control Trial
Yeliz Guven, Sermin Dicle Aksakal, Nilufer Avcu, Gulcan Unsal, Elif Bahar Tuna, Oya Aktoren
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Imad About
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Case Report

Conservative approach of a symptomatic carious immature permanent tooth using a tricalcium silicate cement (Biodentine): a case report: Cyril Villat, Brigitte Grosgogeat, Dominique Seux, Pierre Farge; Restor Dent Endod 2013;38(4):258-262. Published online November 12, 2013; DOI: https://doi.org/10.5395/rde.2013.38.4.258

Abstract PDF PubReader ePub

The restorative management of deep carious lesions and the preservation of pulp vitality of immature teeth present real challenges for dental practitioners. New tricalcium silicate cements are of interest in the treatment of such cases. This case describes the immediate management and the follow-up of an extensive carious lesion on an immature second right mandibular premolar. Following anesthesia and rubber dam isolation, the carious lesion was removed and a partial pulpotomy was performed. After obtaining hemostasis, the exposed pulp was covered with a tricalcium silicate cement (Biodentine, Septodont) and a glass ionomer cement (Fuji IX extra, GC Corp.) restoration was placed over the tricalcium silicate cement. A review appointment was arranged after seven days, where the tooth was asymptomatic with the patient reporting no pain during the intervening period. At both 3 and 6 mon follow up, it was noted that the tooth was vital, with normal responses to thermal tests. Radiographic examination of the tooth indicated dentin-bridge formation in the pulp chamber and the continuous root formation. This case report demonstrates a fast tissue response both at the pulpal and root dentin level. The use of tricalcium silicate cement should be considered as a conservative intervention in the treatment of symptomatic immature teeth.

Citations

Citations to this article as recorded by

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Dental Materials Journal.2020; 39(4): 587. CrossRef
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Yan Sun, Jun Liu, Tao Luo, Ya Shen, Ling Zou
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Large Periapical or Cystic Lesions in Association with Roots Having Open Apices Managed Nonsurgically Using 1-step Apexification Based on Platelet-rich Fibrin Matrix and Biodentine Apical Barrier: A Case Series
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Research Article

A preliminary report on histological outcome of pulpotomy with endodontic biomaterials vs calcium hydroxide: Ali Nosrat, Ali Peimani, Saeed Asgary; Restor Dent Endod 2013;38(4):227-233. Published online November 12, 2013; DOI: https://doi.org/10.5395/rde.2013.38.4.227

Abstract PDF PubReader ePub

Objectives

The purpose of the study was to evaluate human dental pulp response to pulpotomy with calcium hydroxide (CH), mineral trioxide aggregate (MTA), and calcium enriched mixture (CEM) cement.

Materials and Methods

A total of nine erupted third molars were randomly assigned to each pulpotomy group. The same clinician performed full pulpotomies and coronal restorations. The patients were followed clinically for six months; the teeth were then extracted and prepared for histological assessments. The samples were blindly assessed by an independent observer for pulp vitality, pulp inflammation, and calcified bridge formation.

Results

All patients were free of clinical signs/symptoms of pulpal/periradicular diseases during the follow up period. In CH group, one tooth had necrotic radicular pulp; other two teeth in this group had vital uninflamed pulps with complete dentinal bridge formation. In CEM cement and MTA groups all teeth had vital uninflamed radicular pulps. A complete dentinal bridge was formed beneath CEM cement and MTA in all roots. Odontoblast-like cells were present beneath CEM cement and MTA in all samples.

Conclusions

This study revealed that CEM cement and MTA were reliable endodontic biomaterials in full pulpotomy treatment. In contrast, the human dental pulp response to CH might be unpredictable.

Citations

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International Endodontic Journal.2025;[Epub] CrossRef
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Amjad Alagha, Abdulwahab Nourallah, Sahar Alhariri
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Case Report

Apexogenesis and revascularization treatment procedures for two traumatized immature permanent maxillary incisors: a case report: Maryam Forghani, Iman Parisay, Amir Maghsoudlou; Restor Dent Endod 2013;38(3):178-181. Published online August 23, 2013; DOI: https://doi.org/10.5395/rde.2013.38.3.178

Abstract PDF PubReader ePub

Traumatic injuries to an immature permanent tooth may result in cessation of dentin deposition and root maturation. Endodontic treatment is often complicated in premature tooth with an uncertain prognosis. This article describes successful treatment of two traumatized maxillary central incisors with complicated crown fracture three months after trauma. The radiographic examination showed immature roots in maxillary central incisors of a 9-year-old boy with a radiolucent lesion adjacent to the right central incisor. Apexogenesis was performed for the left central incisor and revascularization treatment was considered for the right one. In 18-month clinical and radiographic follow-up both teeth were asymptomatic, roots continued to develop, and periapical radiolucency of the right central incisor healed. Considering the root development of these contralateral teeth it can be concluded that revascularization is an appropriate treatment method in immature necrotic teeth.

Citations

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Gihan Mohamed Abuelniel, Monty Singh Duggal, Nihal Kabel
Dental Traumatology.2020; 36(4): 400. CrossRef
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review
Luiz Alexandre Chisini, Marcus Cristian Muniz Conde, Guillermo Grazioli, Alissa Schmidt San Martin, Rodrigo Varella de Carvalho, Letícia Regina Morello Sartori, Flávio Fernando Demarco
Brazilian Dental Journal.2019; 30(2): 77. CrossRef
Regenerative in endodontics: how, when and where
AL Ahmar Rima, Bassam Sanaa, Salloum Sarah, El Husseini Hassan, AL Ahmar Rima
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Yanjun Fang, Xinhuan Wang, Jingjing Zhu, Chaonan Su, Ying Yang, Liuyan Meng
Journal of Endodontics.2018; 44(3): 414. CrossRef
Alternative to Avoid Tooth Discoloration after Regenerative Endodontic Procedure: A Systematic Review
Luciane Geanini Pena dos Santos, Luiz Alexandre Chisini, Camila Guerner Springmann, Beatriz Dulcineia Mendes de Souza, Fernanda Geraldo Pappen, Flávio Fernando Demarco, Mara Cristina Santos Felippe, Wilson Tadeu Felippe
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Musaed Fahad Al-Tammami, Saad A. Al-Nazhan
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Pollyana Rodrigues de Souza Araújo, Luciano Barreto Silva, Alexandrino Pereira dos Santos Neto, José Alcides Almeida de Arruda, Pâmella Recco Álvares, Ana Paula Veras Sobral, Severino Alves Júnior, Jair Carneiro Leão, Rodivan Braz da Silva, Gerhilde Callo
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Elif Sungurtekin Ekçi
Cumhuriyet Dental Journal.2017; 19(3): 238. CrossRef
Regenerative Endodontics
Kristina Feigin, Bonnie Shope
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M. C. M. Conde, L. A. Chisini, R. Sarkis‐Onofre, H. S. Schuch, J. E. Nör, F. F. Demarco
International Endodontic Journal.2017; 50(9): 860. CrossRef
Histologic Findings of a Human Immature Revascularized/Regenerated Tooth with Symptomatic Irreversible Pulpitis
Chufang Peng, Yuming Zhao, Wenjun Wang, Yuan Yang, Man Qin, Lihong Ge
Journal of Endodontics.2017; 43(6): 905. CrossRef
Regenerative Endodontic Treatment or Mineral Trioxide Aggregate Apical Plug in Teeth with Necrotic Pulps and Open Apices: A Systematic Review and Meta-analysis
Mahmoud Torabinejad, Ali Nosrat, Prashant Verma, Oyoyo Udochukwu
Journal of Endodontics.2017; 43(11): 1806. CrossRef
A Review of Tooth Discoloration after Regenerative Endodontic Therapy
Bill Kahler, Giampiero Rossi-Fedele
Journal of Endodontics.2016; 42(4): 563. CrossRef
Regenerative Endodontic Therapy: A Data Analysis of Clinical Protocols
Evangelos G. Kontakiotis, Christos G. Filippatos, Giorgos N. Tzanetakis, Anastasia Agrafioti
Journal of Endodontics.2015; 41(2): 146. CrossRef
Is revascularization of immature permanent teeth an effective and reproducible technique?
Yu‐Po Chen, Maria del Mar Jovani‐Sancho, Chirag C. Sheth
Dental Traumatology.2015; 31(6): 429. CrossRef
A review of the regenerative endodontic treatment procedure
Bin-Na Lee, Jong-Wook Moon, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Yun-Chan Hwang
Restorative Dentistry & Endodontics.2015; 40(3): 179. CrossRef
Mineral trioxide aggregate upregulates odonto/osteogenic capacity of bone marrow stromal cells from craniofacial bones via JNK and ERK MAPK signalling pathways
Y. Wang, J. Li, W. Song, J. Yu
Cell Proliferation.2014; 47(3): 241. CrossRef
The use of platelet rich plasma in the treatment of immature tooth with periapical lesion: a case report
Günseli Güven Polat, Ceren Yıldırım, Özlem Martı Akgün, Ceyhan Altun, Didem Dinçer, Cansel Köse Özkan
Restorative Dentistry & Endodontics.2014; 39(3): 230. CrossRef
Levels of Evidence for the Outcome of Regenerative Endodontic Therapy
Evangelos G. Kontakiotis, Christos G. Filippatos, Anastasia Agrafioti
Journal of Endodontics.2014; 40(8): 1045. CrossRef
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Adult stem cell-based apexogenesis
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World Journal of Methodology.2014; 4(2): 99. CrossRef

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Original Article

Tissue response of Pro-Root® MTA with rhBMP-2 in pulpotomized rat teeth: Kyungtae Park, Wonkyung Yang, Hyunjung Ko, Miri Kim; J Korean Acad Conserv Dent 2007;32(5):403-410. Published online September 30, 2007; DOI: https://doi.org/10.5395/JKACD.2007.32.5.403

Abstract PDF PubReader ePub

The purpose of this study was to investigate whether rhBMP-2 (BMP2) could induce synergistic effect with Pro-Root® MTA (MTA) in pulpotomized teeth in the rats. Healthy upper first molars from thirty-two, 10 weeks old, Sprague-Dawley rats were used for this investigation. The molars were exposed with round bur, and light pressure was applied with sterilized cotton to control hemorrhage. 1.2 grams of MTA cement was placed in right first molars as a control group. In left first molars, 1 µg of BMP2 was additionally placed on exposed pulps with MTA. All cavities were back-filled with light-cured glass-ionomer cements. The rats were sacrificed after 2 weeks and 7 weeks, respectively. Then histologic sections were made and assessed by light microscopy. Data were statistically analyzed via student t-test with SPSSWIN 12.0 program (p < 0.05).

Inflammation observed in 2 weeks groups were severe compared to the 7 weeks groups. But the differences were not statistically significant. BMP2-addition groups had less inflammation than MTA groups in both periods, though these differences were also not statistically significant. In conclusion, the combination of BMP2 and MTA showed no differences with MTA only for pulpotomy of rat teeth.

Citations

Citations to this article as recorded by

A bioactivity study of Portland cement mixed with β-glycerophosphosphate on human pulp cell
Young-Hwan Oh, Young-Joo Jang, Yong-Bum Cho
Journal of Korean Academy of Conservative Dentistry.2009; 34(5): 415. CrossRef

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