Restorative Dentistry & Endodontics

Research Article

Evaluation of blood clot, platelet-rich plasma, and platelet-rich fibrin–mediated regenerative endodontic procedures in teeth with periapical pathology: a CBCT study: Swati Markandey, Haridas Das Adhikari; Restor Dent Endod 2022;47(4):e41. Published online October 21, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e41

Abstract PDF Supplementary Material PubReader ePub

Objectives

This study compared the clinical and radiological outcomes of regenerative endodontic procedures (REPs) using blood clots (BCs), platelet-rich plasma (PRP), and platelet-rich fibrin (PRF) through intraoral periapical radiography (IOPAR) and cone-beam computed tomography (CBCT).

Materials and Methods

Forty-five single-rooted necrotic teeth with periapical pathology were randomly allocated to receive BC, PRP, or PRF as an individual scaffold. Outcomes were evaluated in 35 teeth in 23 patients with a follow-up period of 12–24 months through qualitative IOPAR scoring and quantitative CBCT measurements. Healing of periapical lesions and in immature teeth, changes in the apical foramen diameter (AFD), root wall thickness (RWT), and root length (RL) were assessed. A p value less than 0.05 was considered to indicate statistical significance.

Results

All teeth were asymptomatic except 1 in the PRP group. Periapical lesion healing was seen in all except 2 teeth in the BC group and 3 in the PRP group. Both IOPAR and CBCT revealed no significant differences in bone healing or changes in AFD, RWT, and RL among the 3 groups. A positive pulp sensibility response to the cold test was seen in 2 teeth in the BC group, but none to the electric pulp test. Intracanal calcification (ICC) was evident in more teeth in the BC group than in the PRP and PRF groups, and was also significantly higher in immature teeth.

Conclusions

Our results revealed that BC, PRP, and PRF have similar potential as scaffolds in REPs, and ICC may be a concern for long-term outcomes.

Citations

Citations to this article as recorded by

Regenerative potential of concentrated growth factor compared to platelet-rich fibrin in treatment of necrotic mature teeth: a randomized clinical trial
Taghreed Salah, Wael Hussein, Heba Abdelkafy
BDJ Open.2025;[Epub] CrossRef
Clinical and radiographic outcomes of non-surgical retreatment of mature maxillary incisions using two regenerative endodontic techniques in adolescents: a 24-month randomized clinical trial
Ahmad Abdel Hamid Elheeny, Sherif Shafik EL Bahnasy, Yassmin Mohamed ElMakawi, Mohammed Turky, Eman Farouk Ahmed, Norhan Khaled Omar Wahba
BDJ Open.2025;[Epub] CrossRef
Biomimetic pulp scaffolds prepared from extracellular matrix derived from stem cells from human exfoliated deciduous teeth promote pulp–dentine complex regeneration
Ning Yang, Rou Shen, Wenxiao Yang, Shengcai Zhang, Tianxing Gong, Yao Liu
International Endodontic Journal.2024; 57(9): 1279. CrossRef
Arrest and Repair of Inflammatory Root Resorption After an Endodontic Regeneration Procedure – A Hypothesis and Case Report
Arieh Y. Kaufman, Bill Kahler
Journal of Endodontics.2024; 50(12): 1743. CrossRef
Effect of Platelet Rich Plasma in Regenerative Endodontic Treatment: A Review of Clinical Trials
Hojat Rezazadeh, Mehrnaz Okhovatfard
Research Journal of Pharmacy and Technology.2023; : 5562. CrossRef

671 View
25 Download
4 Web of Science
5 Crossref

Case Reports

Management of apicomarginal defect in esthetic region associated with a tooth with anomalies: Vinayak Venkoosa Meharwade, Dipali Yogesh Shah, Pradyna Prabhakar Mali, Vidya Vinayak Meharwade; Restor Dent Endod 2015;40(4):314-321. Published online June 24, 2015; DOI: https://doi.org/10.5395/rde.2015.40.4.314

Abstract PDF PubReader ePub

Tooth related factors such as palatoradicular groove can be one of the causes for localized periodontal destruction. Such pathological process may result in apicomarginal defect along with inflammation of pulp. This creates challenging situation which clinician must be capable of performing advanced periodontal regenerative procedures for the successful management. This case report discusses clinical management of apicomarginal defect associated with extensive periradicular destruction in a maxillary lateral incisor, along with histopathologic aspect of the lesion.

Citations

Citations to this article as recorded by

Surgical treatment of apico-marginal defect associated with maxillary incisor teeth with a large periapical lesion using sticky bone & platelet rich fibrin membrane – A case report
Snigdho Das, Parthasarathi Mondal, Dipanjan Das, Kurchi Mandal, Kallol Kumar Saha
IP Annals of Prosthodontics and Restorative Dentistry.2024; 10(3): 250. CrossRef
Comparative evaluation of sticky bone with guided tissue regeneration and platelet-rich fibrin membranes in healing of apicomarginal defects with periapical pathology: An in-vivo study
D. Das, P. Mondal, K. K. Saha, S. Das, D. Karmakar, A. Bhagawati
Endodontics Today.2024; 22(4): 335. CrossRef

197 View
1 Download
2 Crossref

The use of platelet rich plasma in the treatment of immature tooth with periapical lesion: a case report: Günseli Güven Polat, Ceren Yıldırım, Özlem Martı Akgün, Ceyhan Altun, Didem Dinçer, Cansel Köse Özkan; Restor Dent Endod 2014;39(3):230-234. Published online June 2, 2014; DOI: https://doi.org/10.5395/rde.2014.39.3.230

Abstract PDF PubReader ePub

This study describes the treatment of an immature permanent tooth with periapical lesion which was treated with regenerative approach using platelet rich plasma (PRP). The root canal of immature human permanent tooth with periapical lesion was gently debrided of necrotic tissue and disinfected with 2.5% NaOCl, and then medicated with triple antibiotic paste comprised of ciprofloxacin, metronidazole, and tetracycline. When the tooth was asymptomatic, PRP and mineral trioxide aggregate (MTA) were placed into the root canal. Six months after PRP treatment, radiographical examination revealed resolution of the radiolucency and progressive thickening of the root wall and apical closure. Our findings suggest that PRP can be used for the treatment of immature permanent teeth with periapical lesion, as part of a regenerative endodontic treatment procedure.

Citations

Citations to this article as recorded by

Evaluation of postoperative pain and healing following regenerative endodontics using platelet‐rich plasma versus conventional endodontic treatment in necrotic mature mandibular molars with chronic periapical periodontitis. A randomized clinical trial
Yassmin Elsayed Ahmed, Geraldine Mohamed Ahmed, Angie Galal Ghoneim
International Endodontic Journal.2023; 56(4): 404. CrossRef
Different Approaches to the Regeneration of Dental Tissues in Regenerative Endodontics
Anna M. Krupińska, Katarzyna Skośkiewicz-Malinowska, Tomasz Staniowski
Applied Sciences.2021; 11(4): 1699. CrossRef
Coronal tooth discoloration induced by regenerative endodontic treatment using different scaffolds and intracanal coronal barriers: a 6-month ex vivo study
Noushin Shokouhinejad, Hassan Razmi, Maryam Farbod, Marzieh Alikhasi, Josette Camilleri
Restorative Dentistry & Endodontics.2019;[Epub] CrossRef
Efficacy of Autologous Platelet Concentrates in Regenerative Endodontic Treatment: A Systematic Review of Human Studies
Joanna Metlerska, Irini Fagogeni, Alicja Nowicka
Journal of Endodontics.2019; 45(1): 20. CrossRef
Bone, Periodontal and Dental Pulp Regeneration in Dentistry: A Systematic Scoping Review
Luiz Alexandre Chisini, Marcus Cristian Muniz Conde, Guillermo Grazioli, Alissa Schmidt San Martin, Rodrigo Varella de Carvalho, Letícia Regina Morello Sartori, Flávio Fernando Demarco
Brazilian Dental Journal.2019; 30(2): 77. CrossRef
Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part II: other clinical applications and complications
M. Torabinejad, M. Parirokh, P. M. H. Dummer
International Endodontic Journal.2018; 51(3): 284. CrossRef
Alternative to Avoid Tooth Discoloration after Regenerative Endodontic Procedure: A Systematic Review
Luciane Geanini Pena dos Santos, Luiz Alexandre Chisini, Camila Guerner Springmann, Beatriz Dulcineia Mendes de Souza, Fernanda Geraldo Pappen, Flávio Fernando Demarco, Mara Cristina Santos Felippe, Wilson Tadeu Felippe
Brazilian Dental Journal.2018; 29(5): 409. CrossRef
Influence of Apical Diameter on the Outcome of Regenerative Endodontic Treatment in Teeth with Pulp Necrosis: A Review
Yanjun Fang, Xinhuan Wang, Jingjing Zhu, Chaonan Su, Ying Yang, Liuyan Meng
Journal of Endodontics.2018; 44(3): 414. CrossRef
A scoping review of root canal revascularization: relevant aspects for clinical success and tissue formation
M. C. M. Conde, L. A. Chisini, R. Sarkis‐Onofre, H. S. Schuch, J. E. Nör, F. F. Demarco
International Endodontic Journal.2017; 50(9): 860. CrossRef
Effects of Epigallocatechin Gallate, an Antibacterial Cross-linking Agent, on Proliferation and Differentiation of Human Dental Pulp Cells Cultured in Collagen Scaffolds
Young-Sun Kwon, Hee-Jin Kim, Yun-Chan Hwang, Vinicius Rosa, Mi-Kyung Yu, Kyung-San Min
Journal of Endodontics.2017; 43(2): 289. CrossRef
Regenerative Endodontics
Kristina Feigin, Bonnie Shope
Journal of Veterinary Dentistry.2017; 34(3): 161. CrossRef
Regenerative Endodontic Treatment or Mineral Trioxide Aggregate Apical Plug in Teeth with Necrotic Pulps and Open Apices: A Systematic Review and Meta-analysis
Mahmoud Torabinejad, Ali Nosrat, Prashant Verma, Oyoyo Udochukwu
Journal of Endodontics.2017; 43(11): 1806. CrossRef
Platelet concentrates for revitalization of immature necrotic teeth: a systematic review of the clinical studies
Alessandra Lolato, Cristina Bucchi, Silvio Taschieri, Ahmed El Kabbaney, Massimo Del Fabbro
Platelets.2016; 27(5): 383. CrossRef
Regenerative endodontics—Creating new horizons
Harnoor Dhillon, Mamta Kaushik, Roshni Sharma
Journal of Biomedical Materials Research Part B: Applied Biomaterials.2016; 104(4): 676. CrossRef
The impact of autologous platelet concentrates on endodontic healing: a systematic review
Nastaran Meschi, Ana B. Castro, Katleen Vandamme, Marc Quirynen, Paul Lambrechts
Platelets.2016; 27(7): 613. CrossRef
Pulp and Periodontal Regeneration of an Avulsed Permanent Mature Incisor Using Platelet-rich Plasma after Delayed Replantation: A 12-month Clinical Case Study
Harini Priya M, Pavan B. Tambakad, Jaya Naidu
Journal of Endodontics.2016; 42(1): 66. CrossRef
Platelet preparations in dentistry: How? Why? Where? When?
Luigi Fabrizio Rodella
World Journal of Stomatology.2015; 4(2): 39. CrossRef

234 View
2 Download
17 Crossref

First
Prev
Page of 1
Next
Last

Search