Citations

Citations to this article as recorded by  

• Eco-conscious synthesis of novel 1,2,4-triazolo[1,5-a]pyrimidine derivatives as potent Anti-microbial agent and comparative study of cell viability and cytotoxicity in HEK-293 cell line utilizing Indian gooseberry (Phyllanthus emblica) fruit extract
  Bhaktiben R. Bhatt, Kamalkishor Pandey, Tarosh Patel, Anupama Modi, Chandani Halpani, Vaibhav D. Bhatt, Bharat C. Dixit
  Bioorganic Chemistry.2024; 153: 107936.     CrossRef
• Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy
  Peng Zhao, Tian Sun, Cheng Lyu, Kaini Liang, Yanan Du
  Cell Regeneration.2023;[Epub]     CrossRef
• Insight into the development of versatile dentin bonding agents to increase the durability of the bonding interface
  Isabel Cristina Celerino de Moraes Porto, Teresa de Lisieux Guedes Ferreira Lôbo, Raphaela Farias Rodrigues, Rodrigo Barros Esteves Lins, Marcos Aurélio Bomfim da Silva
  Frontiers in Dental Medicine.2023;[Epub]     CrossRef

Matrix metalloproteinases (MMPs) are enzymes that can degrade collagen in hybrid layer and reduce the longevity of adhesive restorations. As scientific understanding of the MMPs has advanced, useful strategies focusing on preventing these enzymes' actions by MMP inhibitors have quickly developed in many medical fields. However, in restorative dentistry, it is still not well established. This paper is an overview of the strategies to inhibit MMPs that can achieve a long-lasting material-tooth adhesion. Literature search was performed comprehensively using the electronic databases: PubMed, ScienceDirect and Scopus including articles from May 2007 to December 2019 and the main search terms were “matrix metalloproteinases”, “collagen”, and “dentin” and “hybrid layer”. MMPs typical structure consists of several distinct domains. MMP inhibitors can be divided into 2 main groups: synthetic (synthetic-peptides, non-peptide molecules and compounds, tetracyclines, metallic ions, and others) and natural bioactive inhibitors mainly flavonoids. Selective inhibitors of MMPs promise to be the future for specific targeting of preventing dentin proteolysis. The knowledge about MMPs functionality should be considered to synthesize drugs capable to efficiently and selectively block MMPs chemical routes targeting their inactivation in order to overcome the current limitations of the therapeutic use of MMPs inhibitors, i.e., easy clinical application and long-lasting effect.

Citations

Citations to this article as recorded by  

• Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies
  Bruna Tavares Carneiro, Marina Minici Dumont Prado, Iara de Oliveira Nogueira, Allyson Nogueira Moreira, Carolina Bosso André
  Odontology.2025; 113(1): 15.     CrossRef
• Multifunctional Dual Enzyme-Responsive Nanostructured Lipid Carriers for Targeting and Enhancing the Treatment of Bacterial Infections
  Kerisha Chetty, Xylia Q. Peters, Calvin A. Omolo, Eman A. Ismail, Mohammed A. Gafar, Eman Elhassan, Sania Z. F. Kassam, Jasoda Govender, Sbongumusa Dlamini, Thirumala Govender
  ACS Applied Bio Materials.2025; 8(1): 548.     CrossRef
• Impact of silver diamine fluoride on composite resin bond strength: An In vitro study with various adhesive systems
  Farzaneh Shirani, Shirin Ravanbod, Mohammad Soroush Sehat
  Heliyon.2025; 11(2): e41731.     CrossRef
• Riboflavin-Mediated Photodynamic Therapy in Periodontology: A Systematic Review of Applications and Outcomes
  Jakub Fiegler-Rudol, Maciej Łopaciński, Artur Los, Dariusz Skaba, Rafał Wiench
  Pharmaceutics.2025; 17(2): 217.     CrossRef
• Evolution of Dental Resin Adhesives—A Comprehensive Review
  Waad Khalid Alomran, Mohammed Zahedul Islam Nizami, Hockin H. K. Xu, Jirun Sun
  Journal of Functional Biomaterials.2025; 16(3): 104.     CrossRef
• Dentin biomodification with Er, Cr: YSGG laser prior to conditioning with grape seed, green tea and Salvadora persica extracts
  Abdullah Alshehri, Ali A. Elkaffas, Abdullah Ali Alqahtani, Mubashir Baig Mirza, Yasser F. Alfawaz, Laila Taher Kashkosh, Basil Almutairi, Abdulellah F. Almudahi, Rania Bayoumi
  Lasers in Dental Science.2025;[Epub]     CrossRef
• A Novel Approach to Strengthening the Microtensile Bond Between Lithium Disilicate Ceramics Manufactured by CAD/CAM and Dentin Using Coatings of Natural and Synthetic Bio-Modifiers
  Abdulellah Almudahi, Abdullah Alshehri, Ali R. Alqahtani, Basil Almutairi, Ali A. Elkaffas, Refal Saad Albaijan, Mohammed Ali Abuelqomsan
  Ceramics.2025; 8(2): 34.     CrossRef
• Long-term hybrid stability and matrix metalloproteinase inhibition by fucosterol in resin-dentin bonding biomechanics
  Hyeryeong Kim, Yu-Jung Jung, Yeon Kim, Moon-Kyoung Bae, Kyung-Hyeon Yoo, Seog-Young Yoon, Hae Ryoun Park, In-Ryoung Kim, Yong-Il Kim
  Scientific Reports.2024;[Epub]     CrossRef
• Multifunctional Dental Adhesives Formulated with Silane-Coated Magnetic Fe3O4@m-SiO2 Core–Shell Particles to Counteract Adhesive Interfacial Breakdown
  Lamia Sami Mokeem, Isadora Martini Garcia, Abdulrahman A. Balhaddad, Yucheng Lan, Dereje Seifu, Michael D. Weir, Mary Anne Melo
  ACS Applied Materials & Interfaces.2024; 16(2): 2120.     CrossRef
• Improving the Push-Out Bond Strength of Fiber Posts in Diabetic Dentin: The Role of Chlorexidine Irrigation and Resin Cements
  Beyza Arslandaş Dinçtürk, Arzu Şahin Mantı, Cemile Kedici Alp, Ayşenur Altuğ Yıldırım, Arzu Kaya Mumcu
  Journal of Functional Biomaterials.2024; 16(1): 4.     CrossRef
• Serum levels of matrix metalloproteinases 1, 2, and 7, and their tissue inhibitors 1, 2, 3, and 4 in polytraumatized patients: Time trajectories, correlations, and their ability to predict mortality
  Lukas L. Negrin, Greta L. Carlin, Robin Ristl, Stefan Hajdu, Andre van Wijnen
  PLOS ONE.2024; 19(3): e0300258.     CrossRef
• Current approaches to produce durable biomaterials: Trends in polymeric materials for restorative dentistry applications
  Carmem S. Pfeifer, Fernanda S. Lucena, Matthew G. Logan, Devatha Nair, Steven H. Lewis
  Dental Materials.2024; 40(12): 2122.     CrossRef
• Effect of Different MMP Inhibitors on the Bond Strength and Durability of an Etch-and-rinse and a Self-etch Adhesive
  Ahmet Hazar, Mine Betül Üçtaşlı
  ADO Klinik Bilimler Dergisi.2024; 13(3): 453.     CrossRef
• Matrix metalloproteinases in dentin: Assessing their presence, activity, and inhibitors – a review of current trends
  Lavanya Anumula, Sindhu Ramesh, Venkata Suneel Kumar Kolaparthi
  Dental Materials.2024; 40(11): 2051.     CrossRef
• Effect of nonthermal atmospheric plasma application at different time intervals on the dentinal shear bond strength pretreated with 2% chlorhexidine as cavity disinfectant: An in vitro study
  Roopadevi Garlapati, Nagesh Bolla, Gali Praveen Kumar, Mayana Aameena Banu, Bandlapally Sreenivasa Guptha Anila, Shaik Afreen Kamal
  Journal of Conservative Dentistry and Endodontics.2024; 27(7): 769.     CrossRef
• Effect of MMP Inhibitors on Shear Bond Strength of Adhesive to Dentin after Different Drying Techniques: An In-Vitro Study
  Sheethal K. Narayanan, Krishnan Hari, Joy Mathew, Anila Sukumaran, Basil Joy, Joel Mathew
  Journal of Pharmacy and Bioallied Sciences.2024; 16(Suppl 5): S4639.     CrossRef
• Effect of Selective Dentine Pre-Treatment with Butane Tetracarboxylic Acid on Composite-Dentine Bond
  Nikita Sharma, Anand Susila, Aruna Kumari Veronica, R. J. Fiona, Shamini Sai, Sriganesh Anguswamy
  Indian Journal of Dental Research.2024; 35(4): 443.     CrossRef
• In situ detection of endogenous proteolytic activity and the effect of inhibitors on tooth root surface
  Izumi Sakurai, Gen Mayanagi, Satoru Yamada, Nobuhiro Takahashi
  Journal of Dentistry.2023; 131: 104471.     CrossRef
• Effects of Cathepsin K Inhibitors on Dentin Erosion: An in vitro Study
  Yi-ying Chen, Xiu-jiao Lin, Zhi-cen Lu, Annette Wiegand, Hao Yu
  Caries Research.2023; 57(2): 159.     CrossRef
• The Role of Duration of Chlorhexidine Gluconate 2% Application on the Shear Bond Strength of a Total Etch Bonding Agent: A Comparative Study
  Azmi Fasya, Yolanda Yolanda, Ayu Trisna Hayati
  Clinical, Cosmetic and Investigational Dentistry.2023; Volume 15: 281.     CrossRef
• The effect of kaempferol on the dentin bonding stability through matrix metalloproteinases inhibition and collagen crosslink in dentin biomodification
  Jeonghwa Cho, Hyeryeong Kim, Kyung-Hyeon Yoo, Youna Paik, In-Ryoung Kim, Seog-Young Yoon, Yong-Il Kim
  Journal of Dental Sciences.2023; 18(3): 1023.     CrossRef
• EFFECT OF TiO2 DECORATED CELLULOSIC MATERIALS ADDITION ON MECHANICAL AND BIOLOGICAL PROPERTIES OF DENTAL ADHESIVE COMPOSITES
  HUMAIRA JABEEN, NAWSHAD MUHAMMAD, USAMA SIDDIQUI, MUHAMMAD SABIR, NAVEED AHMAD, SAAD LIAQAT
  Cellulose Chemistry and Technology.2023; 57(5-6): 541.     CrossRef
• Insight into the development of versatile dentin bonding agents to increase the durability of the bonding interface
  Isabel Cristina Celerino de Moraes Porto, Teresa de Lisieux Guedes Ferreira Lôbo, Raphaela Farias Rodrigues, Rodrigo Barros Esteves Lins, Marcos Aurélio Bomfim da Silva
  Frontiers in Dental Medicine.2023;[Epub]     CrossRef
• Current Strategies to Control Recurrent and Residual Caries with Resin Composite Restorations: Operator- and Material-Related Factors
  Moataz Elgezawi, Rasha Haridy, Moamen A. Abdalla, Katrin Heck, Miriam Draenert, Dalia Kaisarly
  Journal of Clinical Medicine.2022; 11(21): 6591.     CrossRef
• Adhesive Strength in Dentin Conditioned with 18% Ethylenediaminetetraacetic Acid versus 35% Phosphoric Acid: In Vitro Study with 1-Year Artificial Aging
  Esther Alcántara-Obispo, Flor Santander-Rengifo, Marysela Ladera-Castañeda, Carlos López-Gurreonero, Antonieta Castro Pérez-Vargas, Alberto Cornejo-Pinto, Luis Cervantes-Ganoza, César Cayo-Rojas
  Polymers.2022; 14(20): 4291.     CrossRef
• Effects of the Combined Application of Trimethylated Chitosan and Carbodiimide on the Biostability and Antibacterial Activity of Dentin Collagen Matrix
  Xiangyao Wang, Qilin Li, Haibo Lu, Zhuo Liu, Yaxin Wu, Jing Mao, Shiqiang Gong
  Polymers.2022; 14(15): 3166.     CrossRef
• Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects
  Moataz Elgezawi, Rasha Haridy, Khalid Almas, Moamen A. Abdalla, Omar Omar, Hatem Abuohashish, Abeer Elembaby, Uta Christine Wölfle, Yasir Siddiqui, Dalia Kaisarly
  International Journal of Molecular Sciences.2022; 23(16): 8929.     CrossRef
• Mussel-inspired monomer – A new selective protease inhibitor against dentine collagen degradation
  Kang Li, Fung Man Ngo, Angela Yat Laam Yau, Winnie Wai Ling Tam, Edmund Chun Ming Tse, James Kit Hon Tsoi, Cynthia Kar Yung Yiu
  Dental Materials.2022; 38(7): 1149.     CrossRef
• Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis
  Louis Hardan, Umer Daood, Rim Bourgi, Carlos Enrique Cuevas-Suárez, Walter Devoto, Maciej Zarow, Natalia Jakubowicz, Juan Eliezer Zamarripa-Calderón, Mateusz Radwanski, Giovana Orsini, Monika Lukomska-Szymanska
  Cells.2022; 11(15): 2417.     CrossRef
• Marginal Integrity of Composite Restoration with and without Surface Pretreatment by Gold and Silver Nanoparticles vs Chlorhexidine: A Randomized Controlled Trial
  Aya AEM Nemt-Allah, Shereen H Ibrahim, Amira F El-Zoghby
  The Journal of Contemporary Dental Practice.2022; 22(10): 1087.     CrossRef
• Use of the adhesive layer as a controlled release platform for doxycycline, as promising advancement for longer durability of dentin adhesion
  Lívia Rodrigues de Menezes, Dayane Carvalho Ramos Salles de Oliveira, Cássia Almeida Brito, Emerson Oliveira da Silva
  International Journal of Adhesion and Adhesives.2021; 108: 102889.     CrossRef
• Understanding collagen interactions and their targeted regulation by novel drugs
  Marialucia Gallorini, Simone Carradori
  Expert Opinion on Drug Discovery.2021; 16(11): 1239.     CrossRef
• Effect of Curcumin Suspension and Vitamin C on Dentin Shear Bond Strength and Durability. A Pilot Study
  Dalia A. Abuelenain, Ensanya A. Abou Neel, Tariq S. Abuhaimed, Amal M. Alamri, Hanan S. Ammar, Sahar M. N. Bukhary
  The Open Dentistry Journal.2021; 15(1): 540.     CrossRef
• Reinforced Universal Adhesive by Ribose Crosslinker: A Novel Strategy in Adhesive Dentistry
  Rim Bourgi, Umer Daood, Mohammed Nadeem Bijle, Amr Fawzy, Maroun Ghaleb, Louis Hardan
  Polymers.2021; 13(5): 704.     CrossRef

Citations

Citations to this article as recorded by  

• Advances in scaffolds used forpulp–dentinecomplex tissue engineering: A narrative review
  Parisa Noohi, Mohammad J. Abdekhodaie, Mohammad H. Nekoofar, Kerstin M. Galler, Paul M. H. Dummer
  International Endodontic Journal.2022; 55(12): 1277.     CrossRef
• In vitro performance of a nanobiocomposite scaffold containing boron-modified bioactive glass nanoparticles for dentin regeneration
  Reza Moonesi Rad, Engin Pazarçeviren, Elif Ece Akgün, Zafer Evis, Dilek Keskin, Sıla Şahin, Ayşen Tezcaner
  Journal of Biomaterials Applications.2019; 33(6): 834.     CrossRef
• Biological effects of silk fibroin 3D scaffolds on stem cells from human exfoliated deciduous teeth (SHEDs)
  M. Collado-González, M. P. Pecci-Lloret, D. García-Bernal, S. Aznar-Cervantes, R. E. Oñate-Sánchez, J. M. Moraleda, J. L. Cenis, F. J. Rodríguez-Lozano
  Odontology.2018; 106(2): 125.     CrossRef
• Pulp Regeneration Concepts for Nonvital Teeth: From Tissue Engineering to Clinical Approaches
  Valérie Orti, Pierre-Yves Collart-Dutilleul, Sofía Piglionico, Orsolya Pall, Frédéric Cuisinier, Ivan Panayotov
  Tissue Engineering Part B: Reviews.2018; 24(6): 419.     CrossRef
• Investigation of Human Dental Pulp Cells on a Potential Injectable Poly(lactic-co-glycolic acid) Microsphere Scaffold
  Huiru Zou, Guanhua Wang, Fang Song, Xudong Shi
  Journal of Endodontics.2017; 43(5): 745.     CrossRef
• Biocompatibility of hydrogel-based scaffolds for tissue engineering applications
  Sheva Naahidi, Mousa Jafari, Megan Logan, Yujie Wang, Yongfang Yuan, Hojae Bae, Brian Dixon, P. Chen
  Biotechnology Advances.2017; 35(5): 530.     CrossRef

Citations

Citations to this article as recorded by  

• Elucidating epigenetic mechanisms governing odontogenic differentiation in dental pulp stem cells: an in-depth exploration
  Lei Huang, Xuan Chen, Xiaoxia Yang, Yinchun Zhang, Yiyun Liang, Xiaoling Qiu
  Frontiers in Cell and Developmental Biology.2024;[Epub]     CrossRef
• Evaluation of the genotoxicity, cytotoxicity, and bioactivity of calcium silicate-based cements
  Merve Esen, Yeliz Guven, Mehmet Fatih Seyhan, Handan Ersev, Elif Bahar Tuna-Ince
  BMC Oral Health.2024;[Epub]     CrossRef
• GelMA‐based hydrogel biomaterial scaffold: A versatile platform for regenerative endodontics
  Lei Huang, Xuan Chen, XiaoXia Yang, Yinchun Zhang, Xiaoling Qiu
  Journal of Biomedical Materials Research Part B: Applied Biomaterials.2024;[Epub]     CrossRef
• Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways
  Md. Niaj Morshed, Reshmi Akter, Imran Mahmud, Ah-Yeong Gwon, Jin Woo Jeang, Yeong-Geun Lee, Dae Won Park, Deok Chun Yang, Yeon Ju Kim, Se-Chan Kang
  Life.2024; 15(1): 41.     CrossRef
• Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2
  Da Eun Lee, Kun Hee Park, Joo-Hyun Hong, Seon Hee Kim, Ki-Moon Park, Ki Hyun Kim
  Archives of Pharmacal Research.2023; 46(9-10): 771.     CrossRef
• In Silico and In Vitro Evaluation of Antiobesogenic and Osteoprotective Effect of Pomegranate Juice Fermented by Tannin Acyl Hydrolase and Lactobacillus vespulae DCY75 via the Wnt/β-Catenin Pathway
  Reshmi Akter, Vinothini Boopathi, Muhammad Awais, Juha Park, Byoung Man Kong, Se-Woung Oh, Ji-Hyung Oh, Jong Chan Ahn, Deok Chun Yang
  ACS Food Science & Technology.2023; 3(11): 1975.     CrossRef
• Early induction of Hes1 by bone morphogenetic protein 9 plays a regulatory role in osteoblastic differentiation of a mesenchymal stem cell line
  Chang‐Hwan Seong, Norika Chiba, Mardiyantoro Fredy, Joji Kusuyama, Kiyohide Ishihata, Toshiro Kibe, Muhammad Subhan Amir, Ryohei Tada, Tomokazu Ohnishi, Norifumi Nakamura, Tetsuya Matsuguchi
  Journal of Cellular Biochemistry.2023; 124(9): 1366.     CrossRef
• Effects of Fucoidan Powder Combined with Mineral Trioxide Aggregate as a Direct Pulp-Capping Material
  Mijoo Kim, Marc Hayashi, Bo Yu, Thomas K. Lee, Reuben H. Kim, Deuk-Won Jo
  Polymers.2022; 14(12): 2315.     CrossRef
• Nerve growth factor promotes osteogenic differentiation of MC3T3-E1 cells via BMP-2/Smads pathway
  Xuming Yang, Donggang Mou, Qunying Yu, Jimei Zhang, Ying Xiong, Zhimin Zhang, Shan Xing
  Annals of Anatomy - Anatomischer Anzeiger.2022; 239: 151819.     CrossRef
• Anti-Osteoporosis Effects of the Fruit of Sea Buckthorn (Hippophae rhamnoides) through Promotion of Osteogenic Differentiation in Ovariectomized Mice
  Kun Hee Park, Joo-Hyun Hong, Seon-Hee Kim, Jin-Chul Kim, Ki Hyun Kim, Ki-Moon Park
  Nutrients.2022; 14(17): 3604.     CrossRef
• Oroactive dental biomaterials and their use in endodontic therapy
  Ebrahim Patel, Priyamvada Pradeep, Pradeep Kumar, Yahya E. Choonara, Viness Pillay
  Journal of Biomedical Materials Research Part B: Applied Biomaterials.2020; 108(1): 201.     CrossRef
• BMP-2 and type I collagen preservation in human deciduous teeth after demineralization
  Nina Bono, Paolo Tarsini, Gabriele Candiani
  Journal of Applied Biomaterials & Functional Materials.2019;[Epub]     CrossRef
• An assessment of the overexpression of BMP‐2 in transfected human osteoblast cells stimulated by mineral trioxide aggregate and Biodentine
  E. M. Rodrigues, A. L. Gomes‐Cornélio, A. Soares‐Costa, L. P. Salles, M. Velayutham, C. Rossa‐Junior, J. M. Guerreiro‐Tanomaru, M. Tanomaru‐Filho
  International Endodontic Journal.2017;[Epub]     CrossRef
• Sandblasting and fibronectin-derived peptide immobilization on titanium surface increase adhesion and differentiation of osteoblast-like cells (MC3T3-E1)
  Samdharu Pramono, Kamolparn Pugdee, Jintamai Suwanprateep, Sittichai Koontongkaew
  Journal of Dental Sciences.2016; 11(4): 427.     CrossRef
• Combined Effects of Growth Hormone and Mineral Trioxide Aggregate on Growth, Differentiation, and Angiogenesis in Human Dental Pulp Cells
  Hyung-Mun Yun, Seok-Woo Chang, Kyung-Ran Park, Lan Herr, Eun-Cheol Kim
  Journal of Endodontics.2016; 42(2): 269.     CrossRef
• Combined effects of mineral trioxide aggregate and human placental extract on rat pulp tissue and growth, differentiation and angiogenesis in human dental pulp cells
  Seok-Woo Chang, Ji-Youn Kim, Mi-Joo Kim, Ga-Hyun Kim, Jin-Kyu Yi, Deok-Won Lee, Kee-Yeon Kum, Eun-Cheol Kim
  Acta Odontologica Scandinavica.2016; 74(4): 298.     CrossRef
• Mineral trioxide aggregate induces osteoblastogenesis via Atf6
  Toyonobu Maeda, Atsuko Suzuki, Satoshi Yuzawa, Yuh Baba, Yuichi Kimura, Yasumasa Kato
  Bone Reports.2015; 2: 36.     CrossRef
• Locally controlled delivery of TNFα antibody from a novel glucose-sensitive scaffold enhances alveolar bone healing in diabetic conditions
  Qi Wang, Hao Li, Yu Xiao, Shuan Li, Bo Li, Xiaowen Zhao, Lin Ye, Bin Guo, Xinmin Chen, Yi Ding, Chongyun Bao
  Journal of Controlled Release.2015; 206: 232.     CrossRef

Use of an apical plug in management of cases with open apices has gained popularity in recent years. Biodentine, a new calcium silicate-based material has recently been introduced as a dentine substitute, whenever original dentine is damaged. This case report describes single visit apexification in a maxillary central incisor with necrotic pulp and open apex using Biodentine as an apical barrier, and a synthetic collagen material as an internal matrix. Following canal cleaning and shaping, calcium hydroxide was placed as an intracanal medicament for 1 mon. This was followed by placement of small piece of absorbable collagen membrane beyond the root apex to serve as matrix. An apical plug of Biodentine of 5 mm thickness was placed against the matrix using pre-fitted hand pluggers. The remainder of canal was back-filled with thermoplasticized gutta-percha and access cavity was restored with composite resin followed by all-ceramic crown. One year follow-up revealed restored aesthetics and function, absence of clinical signs and symptoms, resolution of periapical rarefaction, and a thin layer of calcific tissue formed apical to the Biodentine barrier. The positive clinical outcome in this case is encouraging for the use of Biodentine as an apical plug in single visit apexification procedures.

Citations

Citations to this article as recorded by  

• Comparative evaluation of sealing potential of mineral trioxide aggregate, biodentine, and bio-C repair in furcation perforations: A glucose penetration study
  Ashwija Shetty, Hajira Anjum Sultana, A. Srirekha, C. Champa, Suditi Pal, V. Sahithi
  Journal of Conservative Dentistry and Endodontics.2025; 28(2): 144.     CrossRef
• Treating apical fenestration in a previously endodontically treated tooth
  K. S Rajesh, Riza Farooq, F Abdul Rajak, Pradeep Kumar
  Journal of Conservative Dentistry and Endodontics.2024; 27(11): 1193.     CrossRef
• Influence of Bioceramic Cements on the Quality of Obturation of the Immature Tooth: An In Vitro Microscopic and Tomographic Study
  Raya Al-Rayesse, Ossama Al-Jabban, Ammar Eid, Alaa Kabtoleh, Frédéric Addiego, Davide Mancino, Youssef Haikel, Naji Kharouf
  Bioengineering.2024; 11(3): 213.     CrossRef
• Fracture Susceptibility in Non-Vital Apex Teeth Following Various Modified Apexification Procedure – An In Vitro Study
  NJ Nagaraj, Peyush Pratap Singh Sikarwar, Debkant Jena, Rini Gangwal, Ipsita Mohanty, Adnan Haider Rizvi
  Journal of Pharmacy and Bioallied Sciences.2024; 16(Suppl 4): S3966.     CrossRef
• A Prospective Randomised Clinical Trial Evaluating Pulpotomy in Primary Molars With Three Bioceramic Calcium Silicate Cements: 24 Month Follow‐Up
  Abhinav L. Talekar, Prasad K. Musale, Gayatri S. Chaudhari, Tayaba M. H. Silotry, William F. Waggoner
  International Journal of Paediatric Dentistry.2024;[Epub]     CrossRef
• Bioceramics in Endodontics: Updates and Future Perspectives
  Xu Dong, Xin Xu
  Bioengineering.2023; 10(3): 354.     CrossRef
• Effects of Apical Barriers and Root Filling Materials on Stress Distribution in Immature Teeth: Finite Element Analysis Study
  Minna Chun, Tory Silvestrin, Roberto Savignano, Gina Delia Roque-Torres
  Journal of Endodontics.2023; 49(5): 575.     CrossRef
• Current Bio-based Cements and Radioactive Opacifiers in Endodontic Approaches: A Review of the Materials Used in Clinical Practice
  A.Najah Saud, Erkan Koç , Olcay Özdemir
  European Journal of Therapeutics.2023; 29(4): 930.     CrossRef
• Comparative Evaluation of Mineral Trioxide Aggregate and Biodentine Apical Plug Thickness on Fracture Resistance of Immature Teeth
  Pramod Mohite, Ankita Dadarao Ramteke, Ruchika Gupta, Suvarna Patil, Divya Gupta
  Annals of African Medicine.2022; 21(3): 198.     CrossRef
• Comparison of sealing ability of mineral trioxide aggregate, biodentine with and without bioactive glass as furcation repair materials
  Shaik Afreen Kamal, Roopadevi Garlapati, Nagesh Bolla, Sayesh Vemuri, Bandaru Pydiahnaidu, Yandra Lakshmi Suvarna
  Endodontology.2022; 34(1): 45.     CrossRef
• “BIODENTINE” THE DENTINE IN A CAPSULE AS AN APICAL BARRIER IN TRAUMATIZED MAXILLARY CENTRAL INCISOR WITH TWO YEARS FOLLOW UP.
  Savita Thakur, Udai Bhanu, Gurkirat Singh Grewal
  INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2022; : 64.     CrossRef
• Comparative Efficacy of Bioceramics Apexification in Periradicular Healing and Root-end Calcific Tissue Repair in Immature Traumatized Permanent Anterior Teeth
  Shalini Garg, Sumit Singla, Satyavan Gangaram Damle, Abhishek Dhindsa, Ashish Loomba, Pragati Poddar
  World Journal of Dentistry.2022; 13(S2): S194.     CrossRef
• Amnion Membrane Matrix And Bio Dentine In The Management Of An External Apical Root Resorption
  Gyanendra Pratap Singh, Shruthi H Attavar, Sivaji Kavuri
  Annals of Dental Specialty.2022; 10(2): 11.     CrossRef
• Morphological and Chemical Analysis of Different Types of Calcium Silicate-Based Cements
  Okba Mahmoud, Nashwan Abdullah Al-Afifi, Mohideen Salihu Farook, Maysara Adnan Ibrahim, Saaid Al Shehadat, Mohammed Amjed Alsaegh, Sandrine Bittencourt Berger
  International Journal of Dentistry.2022; 2022: 1.     CrossRef
• Evaluation of a Novel Tool for Apical Plug Formation during Apexification of Immature Teeth
  Yasser Alsayed Tolibah, Line Droubi, Saleh Alkurdi, Mohammad Tamer Abbara, Nada Bshara, Thuraya Lazkani, Chaza Kouchaji, Ibrahim Ali Ahmad, Ziad D. Baghdadi
  International Journal of Environmental Research and Public Health.2022; 19(9): 5304.     CrossRef
• Fracture resistance of simulated immature roots using Biodentine and fiber post compared with different canal-filling materials under aging conditions
  Amr Elnaghy, Shaymaa Elsaka
  Clinical Oral Investigations.2020; 24(3): 1333.     CrossRef
• Modified Apexification Procedure for Immature Permanent Teeth with a Necrotic Pulp/Apical Periodontitis: A Case Series
  Kamolthip Songtrakul, Talayeh Azarpajouh, Matthew Malek, Asgeir Sigurdsson, Bill Kahler, Louis M. Lin
  Journal of Endodontics.2020; 46(1): 116.     CrossRef
• Efficacy of cavity liners with/without atmospheric cold helium plasma jet for dentin remineralization
  Hamid Kermanshah, Reza Saeedi, Elham Ahmadi, Ladan Ranjbar Omrani
  Biomaterial Investigations in Dentistry.2020; 7(1): 120.     CrossRef
• APICAL MICROLEAKAGE OF VARIOUS BIOMATERIALS IN SIMULATED IMMATURE APICES
  Fatih TULUMBACI, Volkan ARIKAN, Aylin AKBAY OBA, İşıl SÖNMEZ ŞAROĞLU
  Selcuk Dental Journal.2019; 6(3): 247.     CrossRef
• Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part II: other clinical applications and complications
  M. Torabinejad, M. Parirokh, P. M. H. Dummer
  International Endodontic Journal.2018; 51(3): 284.     CrossRef
• Recent Trends in Tricalcium Silicates for Vital Pulp Therapy
  Imad About
  Current Oral Health Reports.2018; 5(3): 178.     CrossRef
• Biodentine™ material characteristics and clinical applications: a 3 year literature review and update
  S. Rajasekharan, L. C. Martens, R. G. E. C. Cauwels, R. P. Anthonappa
  European Archives of Paediatric Dentistry.2018; 19(1): 1.     CrossRef
• Will Bioceramics be the Future Root Canal Filling Materials?
  Josette Camilleri
  Current Oral Health Reports.2017; 4(3): 228.     CrossRef
• Clinical and Molecular Perspectives of Reparative Dentin Formation
  Minju Song, Bo Yu, Sol Kim, Marc Hayashi, Colby Smith, Suhjin Sohn, Euiseong Kim, James Lim, Richard G. Stevenson, Reuben H. Kim
  Dental Clinics of North America.2017; 61(1): 93.     CrossRef
• Management of Dens Invaginatus Type II Associated with Immature Apex and Large Periradicular Lesion Using Platelet-rich Fibrin and Biodentine
  Shruti Goel, Ruchika Roongta Nawal, Sangeeta Talwar
  Journal of Endodontics.2017; 43(10): 1750.     CrossRef
• Biodentine: from biochemical and bioactive properties to clinical applications
  Imad About
  Giornale Italiano di Endodonzia.2016; 30(2): 81.     CrossRef
• Apical Closure in Apexification: A Review and Case Report of Apexification Treatment of an Immature Permanent Tooth with Biodentine
  Karla Vidal, Gabriela Martin, Oscar Lozano, Marco Salas, Jaime Trigueros, Gabriel Aguilar
  Journal of Endodontics.2016; 42(5): 730.     CrossRef
• Influence of Biodentine® - A Dentine Substitute - On Collagen Type I Synthesis in Pulp Fibroblasts In Vitro
  Frangis Nikfarjam, Kim Beyer, Anke König, Matthias Hofmann, Manuel Butting, Eva Valesky, Stefan Kippenberger, Roland Kaufmann, Detlef Heidemann, August Bernd, Nadja Nicole Zöller, Dimitrios Karamichos
  PLOS ONE.2016; 11(12): e0167633.     CrossRef

Citations

Citations to this article as recorded by  

• Intentional Replantation of Failed Root Canal Treated Tooth
  Pritesh Kisanlal Agrawal, Narayan G. Jibhkate, Saurabh A. Redij
  Journal of Interdisciplinary Dentistry.2024; 14(2): 128.     CrossRef
• Enamel matrix derivative in the treatment of tooth replantation: from a biological basis to clinical application
  Yao Lin, Liangping Chen, Yuling Xu, Mingwei Xu, Qinghua Liu, Junbing He
  Annals of Medicine.2024;[Epub]     CrossRef
• Fibrillin protein, a candidate for creating a suitable scaffold in PDL regeneration while avoiding ankylosis
  Kyoko Oka
  genesis.2022;[Epub]     CrossRef
• Can delayed grafting of frozen teeth achieve periodontal ligament healing?
  Yue Chen, Liang Chen, Min Zhou, Shouyin Yi, Juan Ran, Yuansi Long, Jing Luo, Kun Tian
  Medical Hypotheses.2022; 167: 110945.     CrossRef
• Permanent tooth avulsion in children and adults: Therapeutic options for longer survival
  Simona Stojanović, Miloš Tijanić, Kristina Burić, Nina Burić, Milan Spasić, Kosta Todorović, Branislava Stojković, Marija Jovanović, Milica Petrović, Dušan Mitić
  Acta stomatologica Naissi.2021; 37(83): 2213.     CrossRef
• Evidence mapping and quality assessment of systematic reviews in dental traumatology
  Nitesh Tewari, Vijay Prakash Mathur, Amandeep Kaur, Divesh Sardana, Morankar Rahul, Rigzen Tamchos, Priyanshi Ritwik, Shubhi Goel, Julie Schiavo
  Dental Traumatology.2021; 37(1): 17.     CrossRef
• Application of Enamel Matrix Derivative (Emdogain) in Endodontic Therapy: A Comprehensive Literature Review
  Howard H. Wang, Nima D. Sarmast, Elham Shadmehr, Nikola Angelov, Shahrokh Shabahang, Mahmoud Torabinejad
  Journal of Endodontics.2018; 44(7): 1066.     CrossRef
• Periodontal wound healing following reciprocal autologous root transplantation in class III furcation defects
  Naoshi Takeuchi, Yoshinori Shirakata, Yukiya Shinohara, Kotaro Sena, Kazuyuki Noguchi
  Journal of Periodontal & Implant Science.2017; 47(6): 352.     CrossRef
• Effects of Fibrillin Application on Periodontal Ligament Regeneration in Mouse Model of Tooth Replantation
  Shougo Tamura, Kyoko Oka, Satoshi Itaya, Michiko Kira-Tatsuoka, Masako Toda, Arisa Higa, Masao Ozaki
  Journal of Hard Tissue Biology.2016; 25(3): 295.     CrossRef
• Autotransplantation: a viable treatment option for adolescent patients with significantly compromised teeth
  D Ong, Y Itskovich, G Dance
  Australian Dental Journal.2016; 61(4): 396.     CrossRef
• Influence of enamel matrix derivative on healing of root surfaces after bonding treatment and intentional replantation of vertically fractured roots
  Tsutomu Sugaya, Mahito Tomita, Youji Motoki, Hirofumi Miyaji, Masamitsu Kawamami
  Dental Traumatology.2016; 32(5): 397.     CrossRef
• The effect of cathepsin K inhibitor on osteoclastic activity compared to alendronate and enamel matrix protein
  Wonkyung Yang, Hyunjung Ko, Heesun Kim, Miri Kim
  Dental Traumatology.2015; 31(3): 202.     CrossRef
• The effects of bone morphogenetic protein-2 and enamel matrix derivative on the bioactivity of mineral trioxide aggregate in MC3T3-E1cells
  Youngdan Jeong, Wonkyung Yang, Hyunjung Ko, Miri Kim
  Restorative Dentistry & Endodontics.2014; 39(3): 187.     CrossRef
• What is the Best Root Surface Treatment for Avulsed Teeth?
  Elif B Tuna , Duygu Yaman , Seiko Yamamato
  The Open Dentistry Journal.2014; 8(1): 175.     CrossRef

The limited durability of resin-dentin bonds severely compromises the longevity of composite resin restorations. Resin-dentin bond degradation might occur via degradation of water-rich and resin sparse collagen matrices by host-derived matrix metalloproteinases (MMPs). This review article provides overview of current knowledge of the role of MMPs in dentin matrix degradation and four experimental strategies for extending the longevity of resin-dentin bonds. They include: (1) the use of broad-spectrum inhibitors of MMPs, (2) the use of cross-linking agents for silencing the activities of MMPs, (3) ethanol wet-bonding with hydrophobic resin, (4) biomimetic remineralization of water-filled collagen matrix. A combination of these strategies will be able to overcome the limitations in resin-dentin adhesion.

Citations

Citations to this article as recorded by  

• Remineralization Effects of Silver Fluoride, Silver Diamine Fluoride, and Sodium Fluoride Varnish
  Jihyeon Lee, Hwalim Lee, Jongsoo Kim, Joonhaeng Lee, Jongbin Kim, Jisun Shin, Miran Han
  International Journal of Clinical Preventive Dentistry.2024; 20(1): 19.     CrossRef

Citations

Citations to this article as recorded by  

• Anti‐Inflammatory Effects of Melatonin and 5‐Methoxytryptophol on Lipopolysaccharide‐Induced Acute Pulpitis in Rats
  Fatma Kermeoğlu, Umut Aksoy, Abdullah Sebai, Gökçe Savtekin, Hanife Özkayalar, Serkan Sayıner, Ahmet Özer Şehirli, Shuai CHEN
  BioMed Research International.2021;[Epub]     CrossRef
• Cross-Talk between Ciliary Epithelium and Trabecular Meshwork Cells In-Vitro: A New Insight into Glaucoma
  Natalie Lerner, Elie Beit-Yannai, Wayne Iwan Lee Davies
  PLoS ONE.2014; 9(11): e112259.     CrossRef

The purpose of this study was to regenerate human dental pulp tissues similar to native pulp tissues. Using the mixture of type I collagen solution, primary cells collected from the different tissues (pulp, gingiva, and skin) and NIH 3T3 (1 × 10⁵ cells/ml/well) were cultured at 12-well plate at 37℃ for 14 days. Standardized photographs were taken with digital camera during 14 days and the diameter of the contracted collagen gel matrix was measured and statistically analyzed with student t-test. As one of the pulp tissue engineering, normal human dental pulp tissue and collagen gel matrix cultured with dental pulp cells for 14 days were fixed and stained with Hematoxyline & Eosin.

According to this study, the results were as follows:

1. The contraction of collagen gel matrix cultured with pulp cells for 14 days was significantly higher than other fibroblasts (gingiva, skin) (p < 0.05).

2. The diameter of collagen gel matrix cultured with pulp cells was reduced to 70.4% after 7 days, and 57.1% after 14 days.

3. The collagen gel without any cells did not contract, whereas the collagen gel cultured with gingiva and skin showed mild contraction after 14 days (88.1% and 87.6% respectively).

4. The contraction of the collagen gel cultured with NIH 3T3 cells after 14 days was higher than those cultured with gingival and skin fibroblasts, but it was not statistically significant (72.1%, p > 0.05).

5. The collagen gel matrix cultured with pulp cells for 14 days showed similar shape with native pulp tissue without blood vessels.

This approach may provide a means of engineering a variety of other oral tissue as well and these cell behaviors may provide information needed to establish pulp tissue engineering protocols.

Citations

Citations to this article as recorded by  

• Human amniotic membrane extracellular matrix scaffold for dental pulp regeneration in vitro and in vivo
  Hengameh Bakhtiar, Azin Ashoori, Sarah Rajabi, Mohamad Pezeshki‐Modaress, Alireza Ayati, Mohammad Reza Mousavi, Mohammad Reza Ellini, Amir Kamali, Amir Azarpazhooh, Anil Kishen
  International Endodontic Journal.2022; 55(4): 374.     CrossRef