Restorative Dentistry & Endodontics

Research Articles

Retention of BioAggregate and MTA as coronal plugs after intracanal medication for regenerative endodontic procedures: an ex vivo study: Suzan Abdul Wanees Amin, Shaimaa Ismail Gawdat; Restor Dent Endod 2018;43(3):e18. Published online April 26, 2018; DOI: https://doi.org/10.5395/rde.2018.43.e18

Objectives

This study compared the retention of BioAggregate (BA; Innovative BioCeramix) and mineral trioxide aggregate (MTA; Angelus) as coronal plugs after applying different intracanal medications (ICMs) used in regenerative endodontics.

Materials and Methods

One-hundred human maxillary central incisors were used. The canals were enlarged to a diameter of 1.7 mm. Specimens were divided into 5 groups (n = 20) according to the ICM used: calcium hydroxide (CH), 2% chlorhexidine (CHX), triple-antibiotic paste (TAP), double-antibiotic paste (DAP), and no ICM (control; CON). After 3 weeks of application, ICMs were removed and BA or MTA were placed as the plug material (n = 10). The push-out bond strength and the mode of failure were assessed. The data were analyzed using 2-way analysis of variance, the Tukey's test, and the χ² test; p values < 0.05 indicated statistical significance.

Results

The type of ICM and the type of plug material significantly affected bond strength (p < 0.01). Regardless of the type of ICM, BA showed a lower bond strength than MTA (p < 0.05). For MTA, CH showed a higher bond strength than CON, TAP and DAP; CHX showed a higher bond strength than DAP (p < 0.01). For BA, CH showed a higher bond strength than DAP (p < 0.05). The mode of failure was predominantly cohesive for BA (p < 0.05).

Conclusions

MTA may show better retention than BA. The mode of bond failure with BA can be predominantly cohesive. BA retention may be less affected by ICM type than MTA retention.

Citations

Citations to this article as recorded by

An in vitro comparative evaluation of the effect of three intracanal medicaments – chlorhexidine gel, triple antibiotic paste, and calcium hydroxide paste on the push-out bond strength of MTA Plus, Biodentine, and calcium-enriched mixture
Gouthami Datta, Ramya Raghu, Ashish Shetty, Gautham P Manjunath, Dishant Patel, Subhashini Rajasekhara
Endodontology.2023; 35(1): 60. CrossRef
Effects of calcium hydroxide intracanal medicament on push‐out bond strength of endodontic sealers: A systematic review and meta‐analysis
Mohammed Nasser Alhajj, Fadhilah Daud, Sadeq Ali Al‐Maweri, Yanti Johari, Zuryati Ab‐Ghani, Mariatti Jaafar, Yoshihito Naito, Widyasri Prananingrum, Zaihan Ariffin
Journal of Esthetic and Restorative Dentistry.2022; 34(8): 1166. CrossRef
A Breakthrough in the Era of Calcium Silicate-Based Cements: A Critical Review
Payal S Chaudhari, Manoj G Chandak, Akshay A Jaiswal, Nikhil P Mankar, Priyanka Paul
Cureus.2022;[Epub] CrossRef
Modern Medicaments for Endodontic Treatment in Children
Н.В. Шаковец, О.С. Романова
Стоматология. Эстетика. Инновации.2021; (4): 408. CrossRef
Do intracanal medications used in regenerative endodontics affect the bond strength of powder-to-liquid and ready-to-use cervical sealing materials?
MarinaCarvalho Prado, Kevillin Martiniano, AndreaCardoso Pereira, KarineL Cortellazzi, MarinaA Marciano, Gabriel Abuna, Adriana de-Jesus-Soares
Journal of Conservative Dentistry.2021; 24(5): 464. CrossRef
In vivo Biocompatibility and Bioactivity of Calcium Silicate-Based Bioceramics in Endodontics
Wencheng Song, Wei Sun, Lili Chen, Zhenglin Yuan
Frontiers in Bioengineering and Biotechnology.2020;[Epub] CrossRef
Effect of Hydrogel-Based Antibiotic Intracanal Medicaments on Push-Out Bond Strength
Rayan B. Yaghmoor, Jeffrey A. Platt, Kenneth J. Spolnik, Tien Min Gabriel Chu, Ghaeth H. Yassen
European Journal of Dentistry.2020; 14(04): 575. CrossRef
Regenerative Endodontic Procedures, Disinfectants and Outcomes: A Systematic Review
Adam S. Kharchi, Nara Tagiyeva-Milne, Shalini Kanagasingam
Primary Dental Journal.2020; 9(4): 65. CrossRef

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Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry: Jia Kim, Young-Sang Song, Kyung-San Min, Sun-Hun Kim, Jeong-Tae Koh, Bin-Na Lee, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Yun-Chan Hwang; Restor Dent Endod 2016;41(1):29-36. Published online January 4, 2016; DOI: https://doi.org/10.5395/rde.2016.41.1.29

Abstract PDF PubReader ePub

Objectives

The purpose of this study was to assess the ability of two new calcium silicate-based pulp-capping materials (Biodentine and BioAggregate) to induce healing in a rat pulp injury model and to compare them with mineral trioxide aggregate (MTA).

Materials and Methods

Eighteen rats were anesthetized, cavities were prepared and the pulp was capped with either of ProRoot MTA, Biodentine, or BioAggregate. The specimens were scanned using a high-resolution micro-computed tomography (micro-CT) system and were prepared and evaluated histologically and immunohistochemically using dentin sialoprotein (DSP).

Results

On micro-CT analysis, the ProRoot MTA and Biodentine groups showed significantly thicker hard tissue formation (p < 0.05). On H&E staining, ProRoot MTA showed complete dentin bridge formation with normal pulpal histology. In the Biodentine and BioAggregate groups, a thick, homogeneous hard tissue barrier was observed. The ProRoot MTA specimens showed strong immunopositive reaction for DSP.

Conclusions

Our results suggest that calcium silicate-based pulp-capping materials induce favorable effects on reparative processes during vital pulp therapy and that both Biodentine and BioAggregate could be considered as alternatives to ProRoot MTA.

Citations

Citations to this article as recorded by

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Evaluation of pH and Calcium Ion Diffusion from Intracanal MTA and Bioaggregate to Simulated External Resorption Cavities Through Dentinal Tubules
Umut AKSOY, Kaan POLATOĞLU, Feridun ŞAKLAR
European Annals of Dental Sciences.2022; 49(3): 108. CrossRef
Pulpa Kuafajı ve Kuafaj Materyallerine Güncel Bir Bakış: Derleme
Dilek AKIN, Çiğdem ATALAYIN ÖZKAYA
Selcuk Dental Journal.2022; 9(2): 617. CrossRef
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Mirona Paula Palczewska-Komsa, Bartosz Gapiński, Alicja Nowicka
Journal of Clinical Medicine.2022; 11(11): 3091. CrossRef
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Hemalatha Hiremath, Aishwarya Singh Solanki, Shivangi Trivedi, Devansh Verma
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Multiple growth factors accommodated degradable submicron calcium sulfate hemihydrate/porous hydroxyapatite for dentin-pulp regeneration
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Cytotoxicity and physical properties of tricalcium silicate-based endodontic materials: Young-Eun Jang, Bin-Na Lee, Jeong-Tae Koh, Yeong-Joon Park, Nam-Eok Joo, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Yun-Chan Hwang; Restor Dent Endod 2014;39(2):89-94. Published online March 21, 2014; DOI: https://doi.org/10.5395/rde.2014.39.2.89

Abstract PDF PubReader ePub

Objectives

The aim of this study was to evaluate the cytotoxicity, setting time and compressive strength of MTA and two novel tricalcium silicate-based endodontic materials, Bioaggregate (BA) and Biodentine (BD).

Materials and Methods

Cytotoxicity was evaluated by using a 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazolium hydroxide (XTT) assay. Measurements of 9 heavy metals (arsenic, cadmium, chromium, copper, iron, lead, manganese, nickel, and zinc) were performed by inductively coupled plasma-mass spectrometry (ICP-MS) of leachates obtained by soaking the materials in distilled water. Setting time and compressive strength tests were performed following ISO requirements.

Results

BA had comparable cell viability to MTA, whereas the cell viability of BD was significantly lower than that of MTA. The ICP-MS analysis revealed that BD released significantly higher amount of 5 heavy metals (arsenic, copper, iron, manganese, and zinc) than MTA and BA. The setting time of BD was significantly shorter than that of MTA and BA, and the compressive strength of BA was significantly lower than that of MTA and BD.

Conclusions

BA and BD were biocompatible, and they did not show any cytotoxic effects on human periodontal ligament fibroblasts. BA showed comparable cytotoxicity to MTA but inferior physical properties. BD had somewhat higher cytotoxicity but superior physical properties than MTA.

Citations

Citations to this article as recorded by

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Root perforations: a review of diagnosis, prognosis and materials
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V Ballal, JN Marques, CN Campos, CO Lima, RA Simão, M Prado
Australian Dental Journal.2018; 63(2): 170. CrossRef
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Dental Materials.2018; 34(12): 1797. CrossRef
Retention of BioAggregate and MTA as coronal plugs after intracanal medication for regenerative endodontic procedures: an ex vivo study
Suzan Abdul Wanees Amin, Shaimaa Ismail Gawdat
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Basic Research

Biocompatibility of bioaggregate cement on human pulp and periodontal ligament (PDL) derived cells: Choo-Ryung Chung, Euiseong Kim, Su-Jung Shin; J Korean Acad Conserv Dent 2010;35(6):473-478. Published online November 30, 2010; DOI: https://doi.org/10.5395/JKACD.2010.35.6.473

Abstract PDF PubReader ePub

Objectives

This study was performed to investigate the biocompatibility of newly introduced Bioaggregate on human pulp and PDL cells.

Materials and Methods

Cells were collected from human pulp and PDL tissue of extracted premolars. Cell culture plate was coated either with Bioaggregate or white MTA, then the same number of cells were poured to cell culture dishes. Cell attachment and growth was examined under a phase microscope after 1,3 and 7 days of seeding. Cell viability was measured and the data was analyzed using Student t-test and one way ANOVA.

Results

Both types of cells used in this study were well attached and grew healthy on Bioaggregate and MTA coated culture dishes. No cell inhibition zone was observed in Bioaggregate group. There was no statistical difference of viable cells between bioaggreagte and MTA groups.

Conclusions

Bioaggregate appeared to be biocompatible compared with white MTA on human pulp and PDL cells.

Citations

Citations to this article as recorded by

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