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HOME > Restor Dent Endod > Volume 30(5); 2005 > Article
Original Article The Effect of Estrogen Deficiency on Rat Pulpodentinal Complex
Miri Kim1, Won-Kyung Yang1, Jin Baek2, Jong-Jin Kim2, Won-Kyung Kim3, Young-Kyoo Lee3,*
J Korean Acad Conserv Dent 2005;30(5):-408.
DOI: https://doi.org/10.5395/JKACD.2005.30.5.402
Published online: January 14, 2005

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*Corresponding author: Young-Kyoo Lee, Department of Dentistry, Asan Medical Center, 388-1 Poongnap-Dong, Songpa-Gu, Seoul, Korea 138-736, Tel: 82-2-3010-3824 Fax: 82-2-3010-6967, E-mail: kmr333@unitel.co.kr
• Received: March 23, 2005   • Revised: June 22, 2005   • Accepted: August 24, 2005

Copyright © 2005 The Korean Academy of Conservative Dentistry

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • The purpose of this study was to investigate the effects of estrogen deficiency on pulpodentinal complex of tooth in ovariectomized rats. Thirty female Sprague-Dawley rats, 10 weeks old, were used. Rats were grouped into two groups. One group (n = 15) was subjected to sham surgery (SHAM) and the other group (n = 15) was ovariectomized bilaterally (OVX). Animals were sacrificed 12 weeks later, and their mandibular molars and associated periodontal supporting tissues were dissected out, and fixed in 10% buffered formalin. For comparison of groups, immunostained for osteonectin. Histomorphometrical measurement of change of teeth was performed using an image analysis system and paired t-test was used and the level of significance for overall differences was set at p < 0.05.
    In immunostaining of osteonectin, they were significantly different from each other. The predentin thickness in OVX rats was wider than in SHAM rats. And in SHAM rats, osteonectin was more specifically stained in predentin areas than in OVX rats. These results indicate that estrogen deficiency increased the unmineralized predentin areas and decreased osteonectin content in pulpal tissues in rats. If our result is applicable to human studies, odotoblast is affected by estrogen deficiency.
  • Keywords: Ovariectomy; Estrogen deficiency; Osteonectin; Predentin; Pulp
Figure 1.
Radiographic view of mandibular sections of SHAM Rat.
jkacd-30-402f1.jpg
Figure 2.
Radiographic view of mandibular sections of OVX Rat.
jkacd-30-402f2.jpg
Figure 3.
Immunohistochemical staining of SHAM Rat (original magnification × 400). Osteonectin (Arrow-brown) in the cytoplasm of active, matrix-producing odontoblasts in predentin areas.
jkacd-30-402f3.jpg
Figure 4.
Immunohistochemical staining of SHAM Rat (original magnification × 400). Adjoining immunoreactive polarized odontoblasts (Arrow) were stained heavily with osteonectin antibodies.
jkacd-30-402f4.jpg
Figure 5.
Immunohistochemical staining of OVX Rat (original magnification × 400). Absence of staining of quiescent odotoblasts in the predentin areas.
jkacd-30-402f5.jpg
Figure 6.
Immunohistochemical staining of OVX Rat (original magnification × 400). Weakly osteonectin labeling (Arrow) is present in polarized odontoblasts, but absent from the cells of the central pulp and dentin.
jkacd-30-402f6.jpg
Table 1.
The mean and standard deviation for predentin thickness of the OVX rats and SHAM rats are shown (p < 0.05)
SHAM OVX
Rat 1 0.8 1.2
Rat 2 1.0 2.0
Rat 3 0.7 1.5
Rat 4 0.6 1.6
Rat 5 0.8 1.5
Rat 6 0.7 1.4
Rat 7 0.6 1.8
Rat 8 0.9 1.7
Rat 9 1.0 2.0
Rat 10 0.7 1.2
Rat 11 0.6 1.1
Rat 12 0.9 1.5
Rat 13 0.8 1.2
Rat 14 0.9 1.2
Rat 15
 1.1
 1.2
Mean (S.D.) 0.81 (0.16) 1.47 (0.30)
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      The Effect of Estrogen Deficiency on Rat Pulpodentinal Complex
      J Korean Acad Conserv Dent. 2005;30(5):402-408.   Published online January 14, 2005
      DOI: https://doi.org/10.5395/JKACD.2005.30.5.402
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    The Effect of Estrogen Deficiency on Rat Pulpodentinal Complex
    Image Image Image Image Image Image
    Figure 1. Radiographic view of mandibular sections of SHAM Rat.
    Figure 2. Radiographic view of mandibular sections of OVX Rat.
    Figure 3. Immunohistochemical staining of SHAM Rat (original magnification × 400). Osteonectin (Arrow-brown) in the cytoplasm of active, matrix-producing odontoblasts in predentin areas.
    Figure 4. Immunohistochemical staining of SHAM Rat (original magnification × 400). Adjoining immunoreactive polarized odontoblasts (Arrow) were stained heavily with osteonectin antibodies.
    Figure 5. Immunohistochemical staining of OVX Rat (original magnification × 400). Absence of staining of quiescent odotoblasts in the predentin areas.
    Figure 6. Immunohistochemical staining of OVX Rat (original magnification × 400). Weakly osteonectin labeling (Arrow) is present in polarized odontoblasts, but absent from the cells of the central pulp and dentin.

    Figure 1.

    Figure 2.

    Figure 3.

    Figure 4.

    Figure 5.

    Figure 6.

    The Effect of Estrogen Deficiency on Rat Pulpodentinal Complex
    SHAM OVX
    Rat 1 0.8 1.2
    Rat 2 1.0 2.0
    Rat 3 0.7 1.5
    Rat 4 0.6 1.6
    Rat 5 0.8 1.5
    Rat 6 0.7 1.4
    Rat 7 0.6 1.8
    Rat 8 0.9 1.7
    Rat 9 1.0 2.0
    Rat 10 0.7 1.2
    Rat 11 0.6 1.1
    Rat 12 0.9 1.5
    Rat 13 0.8 1.2
    Rat 14 0.9 1.2
    Rat 15
    		 1.1
    		 1.2
    Mean (S.D.) 0.81 (0.16) 1.47 (0.30)
    Table 1. The mean and standard deviation for predentin thickness of the OVX rats and SHAM rats are shown (p < 0.05)

    Table 1.

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