Restorative Dentistry & Endodontics

Review Article

Silver nanoparticles in endodontics: recent developments and applications: Aysenur Oncu, Yan Huang, Gulin Amasya, Fatma Semra Sevimay, Kaan Orhan, Berkan Celikten; Restor Dent Endod 2021;46(3):e38. Published online July 1, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e38

The elimination of endodontic biofilms and the maintenance of a leak-proof canal filling are key aspects of successful root canal treatment. Several materials have been introduced to treat endodontic disease, although treatment success is limited by the features of the biomaterials used. Silver nanoparticles (AgNPs) have been increasingly considered in dental applications, especially endodontics, due to their high antimicrobial activity. For the present study, an electronic search was conducted using MEDLINE (PubMed), the Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and EMBASE. This review provides insights into the unique characteristics of AgNPs, including their chemical, physical, and antimicrobial properties; limitations; and potential uses. Various studies involving different application methods of AgNPs were carefully examined. Based on previous clinical studies, the synthesis, means of obtaining, usage conditions, and potential cytotoxicity of AgNPs were evaluated. The findings indicate that AgNPs are effective antimicrobial agents for the elimination of endodontic biofilms.

Citations

Citations to this article as recorded by

Scoping review on the genotoxicity of silver nanoparticles in endodontics: therapeutic saviors or genetic saboteurs?
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Odontology.2025; 113(2): 457. CrossRef
Bioceramics in Endodontics: Limitations and Future Innovations—A Review
Peramune Arachchilage Amila Saman Prasad Kumara, Paul Roy Cooper, Peter Cathro, Maree Gould, George Dias, Jithendra Ratnayake
Dentistry Journal.2025; 13(4): 157. CrossRef
Antimicrobial Effects of Formulations of Various Nanoparticles and Calcium Hydroxide as Intra-canal Medications Against Enterococcus faecalis: A Systematic Review
Seema H Bukhari, Dax Abraham, Shakila Mahesh
Cureus.2024;[Epub] CrossRef
The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles
Karla Navarrete-Olvera, Nereyda Niño-Martínez, Idania De Alba-Montero, Nuria Patiño-Marín, Facundo Ruiz, Horacio Bach, Gabriel-Alejandro Martínez-Castañón
Molecules.2024; 29(18): 4422. CrossRef
Synergistic bactericidal activity of chlorhexidine loaded on positively charged ionic liquid-protected silver nanoparticles as a root canal disinfectant against Enterococcus faecalis: An ex vivo study
Abbas Abbaszadegan, Elham Tayebikhorami, Ahmad Gholami, Nazanin Bonyanpour, Bahar Asheghi, Sara Nikmanesh
Journal of Ionic Liquids.2024; 4(2): 100117. CrossRef
Improving the Antimicrobial Potency of Berberine for Endodontic Canal Irrigation Using Polymeric Nanoparticles
Célia Marques, Liliana Grenho, Maria Helena Fernandes, Sofia A. Costa Lima
Pharmaceutics.2024; 16(6): 786. CrossRef
A narrative review on application of metal and metal oxide nanoparticles in endodontics
Roohollah Sharifi, Ahmad Vatani, Amir Sabzi, Mohsen Safaei
Heliyon.2024; 10(15): e34673. CrossRef
The Effectiveness of Silver Nanoparticles Mixed with Calcium Hydroxide against Candida albicans: An Ex Vivo Analysis
Maha Alghofaily, Jood Alfraih, Aljohara Alsaud, Norah Almazrua, Terrence S. Sumague, Sayed H. Auda, Fahd Alsalleeh
Microorganisms.2024; 12(2): 289. CrossRef
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KHanisha Reddy, Lekshmi Chandran, TMurali Mohan, K Sudha, DL Malini, Bonney Dominic
Journal of Conservative Dentistry.2023; 26(1): 94. CrossRef
Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review
Farzaneh Afkhami, Parisa Forghan, James L. Gutmann, Anil Kishen
Pharmaceutics.2023; 15(3): 715. CrossRef
Nanopartículas antimicrobianas en endodoncia: Revisión narrativa
Gustavo Adolfo Tovar Rangel , Fanny Mildred González Sáenz , Ingrid Ximena Zamora Córdoba , Lina María García Zapata
Revista Estomatología.2023;[Epub] CrossRef
Functionalized Nanoparticles: A Paradigm Shift in Regenerative Endodontic Procedures
Vinoo Subramaniam Ramachandran, Mensudar Radhakrishnan, Malathi Balaraman Ravindrran, Venkatesh Alagarsamy, Gowri Shankar Palanisamy
Cureus.2022;[Epub] CrossRef

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Research Article

Influence of silver nanoparticles on resin-dentin bond strength durability in a self-etch and an etch-and-rinse adhesive system: Zahra Jowkar, Fereshteh Shafiei, Elham Asadmanesh, Fatemeh Koohpeima; Restor Dent Endod 2019;44(2):e13. Published online March 29, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e13

Abstract PDF PubReader ePub

Objectives

This study evaluated the effect of dentin pretreatment with silver nanoparticles (SNPs) and chlorhexidine (CHX) on the microshear bond strength (µSBS) durability of different adhesives to dentin.

Materials and Methods

Occlusal surfaces of 120 human molars were ground to expose flat dentin surfaces. The specimens were randomly assigned to six groups (n = 20). Three groups (A, B, and C) were bonded with Adper Single Bond 2 (SB) and the other groups (D, E, and F) were bonded with Clearfil SE Bond (SEB). Dentin was pretreated with CHX in groups B and E, and with SNPs in groups C and F. The specimens were restored with Z250 composite. Half of the bonded surfaces in each group underwent µSBS testing after 24 hours and the other half was tested after 6 months of water storage.

Results

SNP application was associated with a higher µSBS than was observed in the CHX and control groups for SEB after 24 hours (p < 0.05). A significantly lower µSBS was observed when no dentin pretreatment was applied compared to dentin pretreatment with CHX and SNPs for SB after 24 hours (p < 0.05). The µSBS values of the 6-month specimens were significantly lower than those obtained from the 24-hour specimens for all groups (p < 0.05). This decrease was much more pronounced when both adhesives were used without any dentin pretreatment (p < 0.05).

Conclusions

SNPs and CHX reduced the degradation of resin-dentin bonds over a 6-month period for both adhesive systems.

Citations

Citations to this article as recorded by

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Applied Sciences.2024; 14(24): 11639. CrossRef
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Journal of Dentistry.2024; 143: 104897. CrossRef
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Shuya Zhao, Yunyang Zhang, Yun Chen, Xianghui Xing, Yu Wang, Guofeng Wu
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Influence of silver nanoparticles on the resin-dentin bond strength and antibacterial activity of a self-etch adhesive system
Jia Wang, Wei Jiang, Jingping Liang, Shujun Ran
The Journal of Prosthetic Dentistry.2022; 128(6): 1363.e1. CrossRef
Marginal Integrity of Composite Restoration with and without Surface Pretreatment by Gold and Silver Nanoparticles vs Chlorhexidine: A Randomized Controlled Trial
Aya AEM Nemt-Allah, Shereen H Ibrahim, Amira F El-Zoghby
The Journal of Contemporary Dental Practice.2022; 22(10): 1087. CrossRef
Effect of Cavity Disinfectants on Dentin Bond Strength and Clinical Success of Composite Restorations—A Systematic Review of In Vitro, In Situ and Clinical Studies
Ana Coelho, Inês Amaro, Beatriz Rascão, Inês Marcelino, Anabela Paula, José Saraiva, Gianrico Spagnuolo, Manuel Marques Ferreira, Carlos Miguel Marto, Eunice Carrilho
International Journal of Molecular Sciences.2020; 22(1): 353. CrossRef

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