Citations

Citations to this article as recorded by  

• Efficacy of different adhesive systems in bonding direct resin composite restorations: a systematic review and meta-analysis
  Ravinder S. Saini, Rajesh Vyas, Sunil Kumar Vaddamanu, Syed Altafuddin Quadri, Seyed Ali Mosaddad, Artak Heboyan
  Evidence-Based Dentistry.2025;[Epub]     CrossRef
• Resin tags formation by modified Renewal MI formulations in a carious dentine model
  Nabih Alkhouri, Wendy Xia, Paul Ashley, Anne Young
  Frontiers in Oral Health.2024;[Epub]     CrossRef
• Effect of propolis added to single‐bottle adhesives on water permeation through the hybrid layer
  Lucineide Silva da Rocha, Daniela Ferreira de Oliveira, Cinthya Luna Veloso de Lima, Ticiano Gomes do Nascimento, Johnnatan Duarte de Freitas, Jeniffer Mclaine Duarte de Freitas, Isabel Cristina Celerino de Moraes Porto
  European Journal of Oral Sciences.2024;[Epub]     CrossRef
• Exploration and preliminary clinical investigation of an adhesive approach for primary tooth restoration
  Xiangqin Xu, Jiansheng Zhu, May Lei Mei, Huaying Wu, Kaipeng Xie, Shoulin Wang, Yaming Chen
  The Journal of Biomedical Research.2023; 37(2): 138.     CrossRef
• Adhesion to enamel and dentine: an update
  Rana Alkattan
  Primary Dental Journal.2023; 12(3): 33.     CrossRef
• Effects of carbodiimide combined with ethanol–wet bonding pretreatment on dentin bonding properties: an in vitro study
  Xiaoxiao You, Long Chen, Jie Xu, Sihui Li, Zhenghao Zhang, Ling Guo
  PeerJ.2022; 10: e14238.     CrossRef
• The effects of amalgam contamination and different surface modifications on microleakage of dentin bonded to bulk fill composite when using different adhesive protocols
  Nojoud Alshehri, Abdullah Aljamhan, Mohammed Bin-Shuwaish
  BMC Oral Health.2022;[Epub]     CrossRef
• Development of low-shrinkage dental adhesives via blending with spiroorthocarbonate expanding monomer and unsaturated epoxy resin monomer
  Zonghua Wang, Xiaoran Zhang, Shuo Yao, Jiaxin Zhao, Chuanjian Zhou, Junling Wu
  Journal of the Mechanical Behavior of Biomedical Materials.2022; 133: 105308.     CrossRef
• Influence of silver nanoparticles on the resin-dentin bond strength and antibacterial activity of a self-etch adhesive system
  Jia Wang, Wei Jiang, Jingping Liang, Shujun Ran
  The Journal of Prosthetic Dentistry.2022; 128(6): 1363.e1.     CrossRef

Matrix metalloproteinases (MMPs) are enzymes that can degrade collagen in hybrid layer and reduce the longevity of adhesive restorations. As scientific understanding of the MMPs has advanced, useful strategies focusing on preventing these enzymes' actions by MMP inhibitors have quickly developed in many medical fields. However, in restorative dentistry, it is still not well established. This paper is an overview of the strategies to inhibit MMPs that can achieve a long-lasting material-tooth adhesion. Literature search was performed comprehensively using the electronic databases: PubMed, ScienceDirect and Scopus including articles from May 2007 to December 2019 and the main search terms were “matrix metalloproteinases”, “collagen”, and “dentin” and “hybrid layer”. MMPs typical structure consists of several distinct domains. MMP inhibitors can be divided into 2 main groups: synthetic (synthetic-peptides, non-peptide molecules and compounds, tetracyclines, metallic ions, and others) and natural bioactive inhibitors mainly flavonoids. Selective inhibitors of MMPs promise to be the future for specific targeting of preventing dentin proteolysis. The knowledge about MMPs functionality should be considered to synthesize drugs capable to efficiently and selectively block MMPs chemical routes targeting their inactivation in order to overcome the current limitations of the therapeutic use of MMPs inhibitors, i.e., easy clinical application and long-lasting effect.

Citations

Citations to this article as recorded by  

• Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies
  Bruna Tavares Carneiro, Marina Minici Dumont Prado, Iara de Oliveira Nogueira, Allyson Nogueira Moreira, Carolina Bosso André
  Odontology.2025; 113(1): 15.     CrossRef
• Multifunctional Dual Enzyme-Responsive Nanostructured Lipid Carriers for Targeting and Enhancing the Treatment of Bacterial Infections
  Kerisha Chetty, Xylia Q. Peters, Calvin A. Omolo, Eman A. Ismail, Mohammed A. Gafar, Eman Elhassan, Sania Z. F. Kassam, Jasoda Govender, Sbongumusa Dlamini, Thirumala Govender
  ACS Applied Bio Materials.2025; 8(1): 548.     CrossRef
• Impact of silver diamine fluoride on composite resin bond strength: An In vitro study with various adhesive systems
  Farzaneh Shirani, Shirin Ravanbod, Mohammad Soroush Sehat
  Heliyon.2025; 11(2): e41731.     CrossRef
• Riboflavin-Mediated Photodynamic Therapy in Periodontology: A Systematic Review of Applications and Outcomes
  Jakub Fiegler-Rudol, Maciej Łopaciński, Artur Los, Dariusz Skaba, Rafał Wiench
  Pharmaceutics.2025; 17(2): 217.     CrossRef
• Evolution of Dental Resin Adhesives—A Comprehensive Review
  Waad Khalid Alomran, Mohammed Zahedul Islam Nizami, Hockin H. K. Xu, Jirun Sun
  Journal of Functional Biomaterials.2025; 16(3): 104.     CrossRef
• Dentin biomodification with Er, Cr: YSGG laser prior to conditioning with grape seed, green tea and Salvadora persica extracts
  Abdullah Alshehri, Ali A. Elkaffas, Abdullah Ali Alqahtani, Mubashir Baig Mirza, Yasser F. Alfawaz, Laila Taher Kashkosh, Basil Almutairi, Abdulellah F. Almudahi, Rania Bayoumi
  Lasers in Dental Science.2025;[Epub]     CrossRef
• A Novel Approach to Strengthening the Microtensile Bond Between Lithium Disilicate Ceramics Manufactured by CAD/CAM and Dentin Using Coatings of Natural and Synthetic Bio-Modifiers
  Abdulellah Almudahi, Abdullah Alshehri, Ali R. Alqahtani, Basil Almutairi, Ali A. Elkaffas, Refal Saad Albaijan, Mohammed Ali Abuelqomsan
  Ceramics.2025; 8(2): 34.     CrossRef
• Long-term hybrid stability and matrix metalloproteinase inhibition by fucosterol in resin-dentin bonding biomechanics
  Hyeryeong Kim, Yu-Jung Jung, Yeon Kim, Moon-Kyoung Bae, Kyung-Hyeon Yoo, Seog-Young Yoon, Hae Ryoun Park, In-Ryoung Kim, Yong-Il Kim
  Scientific Reports.2024;[Epub]     CrossRef
• Multifunctional Dental Adhesives Formulated with Silane-Coated Magnetic Fe3O4@m-SiO2 Core–Shell Particles to Counteract Adhesive Interfacial Breakdown
  Lamia Sami Mokeem, Isadora Martini Garcia, Abdulrahman A. Balhaddad, Yucheng Lan, Dereje Seifu, Michael D. Weir, Mary Anne Melo
  ACS Applied Materials & Interfaces.2024; 16(2): 2120.     CrossRef
• Improving the Push-Out Bond Strength of Fiber Posts in Diabetic Dentin: The Role of Chlorexidine Irrigation and Resin Cements
  Beyza Arslandaş Dinçtürk, Arzu Şahin Mantı, Cemile Kedici Alp, Ayşenur Altuğ Yıldırım, Arzu Kaya Mumcu
  Journal of Functional Biomaterials.2024; 16(1): 4.     CrossRef
• Serum levels of matrix metalloproteinases 1, 2, and 7, and their tissue inhibitors 1, 2, 3, and 4 in polytraumatized patients: Time trajectories, correlations, and their ability to predict mortality
  Lukas L. Negrin, Greta L. Carlin, Robin Ristl, Stefan Hajdu, Andre van Wijnen
  PLOS ONE.2024; 19(3): e0300258.     CrossRef
• Current approaches to produce durable biomaterials: Trends in polymeric materials for restorative dentistry applications
  Carmem S. Pfeifer, Fernanda S. Lucena, Matthew G. Logan, Devatha Nair, Steven H. Lewis
  Dental Materials.2024; 40(12): 2122.     CrossRef
• Effect of Different MMP Inhibitors on the Bond Strength and Durability of an Etch-and-rinse and a Self-etch Adhesive
  Ahmet Hazar, Mine Betül Üçtaşlı
  ADO Klinik Bilimler Dergisi.2024; 13(3): 453.     CrossRef
• Matrix metalloproteinases in dentin: Assessing their presence, activity, and inhibitors – a review of current trends
  Lavanya Anumula, Sindhu Ramesh, Venkata Suneel Kumar Kolaparthi
  Dental Materials.2024; 40(11): 2051.     CrossRef
• Effect of nonthermal atmospheric plasma application at different time intervals on the dentinal shear bond strength pretreated with 2% chlorhexidine as cavity disinfectant: An in vitro study
  Roopadevi Garlapati, Nagesh Bolla, Gali Praveen Kumar, Mayana Aameena Banu, Bandlapally Sreenivasa Guptha Anila, Shaik Afreen Kamal
  Journal of Conservative Dentistry and Endodontics.2024; 27(7): 769.     CrossRef
• Effect of MMP Inhibitors on Shear Bond Strength of Adhesive to Dentin after Different Drying Techniques: An In-Vitro Study
  Sheethal K. Narayanan, Krishnan Hari, Joy Mathew, Anila Sukumaran, Basil Joy, Joel Mathew
  Journal of Pharmacy and Bioallied Sciences.2024; 16(Suppl 5): S4639.     CrossRef
• Effect of Selective Dentine Pre-Treatment with Butane Tetracarboxylic Acid on Composite-Dentine Bond
  Nikita Sharma, Anand Susila, Aruna Kumari Veronica, R. J. Fiona, Shamini Sai, Sriganesh Anguswamy
  Indian Journal of Dental Research.2024; 35(4): 443.     CrossRef
• In situ detection of endogenous proteolytic activity and the effect of inhibitors on tooth root surface
  Izumi Sakurai, Gen Mayanagi, Satoru Yamada, Nobuhiro Takahashi
  Journal of Dentistry.2023; 131: 104471.     CrossRef
• Effects of Cathepsin K Inhibitors on Dentin Erosion: An in vitro Study
  Yi-ying Chen, Xiu-jiao Lin, Zhi-cen Lu, Annette Wiegand, Hao Yu
  Caries Research.2023; 57(2): 159.     CrossRef
• The Role of Duration of Chlorhexidine Gluconate 2% Application on the Shear Bond Strength of a Total Etch Bonding Agent: A Comparative Study
  Azmi Fasya, Yolanda Yolanda, Ayu Trisna Hayati
  Clinical, Cosmetic and Investigational Dentistry.2023; Volume 15: 281.     CrossRef
• The effect of kaempferol on the dentin bonding stability through matrix metalloproteinases inhibition and collagen crosslink in dentin biomodification
  Jeonghwa Cho, Hyeryeong Kim, Kyung-Hyeon Yoo, Youna Paik, In-Ryoung Kim, Seog-Young Yoon, Yong-Il Kim
  Journal of Dental Sciences.2023; 18(3): 1023.     CrossRef
• EFFECT OF TiO2 DECORATED CELLULOSIC MATERIALS ADDITION ON MECHANICAL AND BIOLOGICAL PROPERTIES OF DENTAL ADHESIVE COMPOSITES
  HUMAIRA JABEEN, NAWSHAD MUHAMMAD, USAMA SIDDIQUI, MUHAMMAD SABIR, NAVEED AHMAD, SAAD LIAQAT
  Cellulose Chemistry and Technology.2023; 57(5-6): 541.     CrossRef
• Insight into the development of versatile dentin bonding agents to increase the durability of the bonding interface
  Isabel Cristina Celerino de Moraes Porto, Teresa de Lisieux Guedes Ferreira Lôbo, Raphaela Farias Rodrigues, Rodrigo Barros Esteves Lins, Marcos Aurélio Bomfim da Silva
  Frontiers in Dental Medicine.2023;[Epub]     CrossRef
• Current Strategies to Control Recurrent and Residual Caries with Resin Composite Restorations: Operator- and Material-Related Factors
  Moataz Elgezawi, Rasha Haridy, Moamen A. Abdalla, Katrin Heck, Miriam Draenert, Dalia Kaisarly
  Journal of Clinical Medicine.2022; 11(21): 6591.     CrossRef
• Adhesive Strength in Dentin Conditioned with 18% Ethylenediaminetetraacetic Acid versus 35% Phosphoric Acid: In Vitro Study with 1-Year Artificial Aging
  Esther Alcántara-Obispo, Flor Santander-Rengifo, Marysela Ladera-Castañeda, Carlos López-Gurreonero, Antonieta Castro Pérez-Vargas, Alberto Cornejo-Pinto, Luis Cervantes-Ganoza, César Cayo-Rojas
  Polymers.2022; 14(20): 4291.     CrossRef
• Effects of the Combined Application of Trimethylated Chitosan and Carbodiimide on the Biostability and Antibacterial Activity of Dentin Collagen Matrix
  Xiangyao Wang, Qilin Li, Haibo Lu, Zhuo Liu, Yaxin Wu, Jing Mao, Shiqiang Gong
  Polymers.2022; 14(15): 3166.     CrossRef
• Matrix Metalloproteinases in Dental and Periodontal Tissues and Their Current Inhibitors: Developmental, Degradational and Pathological Aspects
  Moataz Elgezawi, Rasha Haridy, Khalid Almas, Moamen A. Abdalla, Omar Omar, Hatem Abuohashish, Abeer Elembaby, Uta Christine Wölfle, Yasir Siddiqui, Dalia Kaisarly
  International Journal of Molecular Sciences.2022; 23(16): 8929.     CrossRef
• Mussel-inspired monomer – A new selective protease inhibitor against dentine collagen degradation
  Kang Li, Fung Man Ngo, Angela Yat Laam Yau, Winnie Wai Ling Tam, Edmund Chun Ming Tse, James Kit Hon Tsoi, Cynthia Kar Yung Yiu
  Dental Materials.2022; 38(7): 1149.     CrossRef
• Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis
  Louis Hardan, Umer Daood, Rim Bourgi, Carlos Enrique Cuevas-Suárez, Walter Devoto, Maciej Zarow, Natalia Jakubowicz, Juan Eliezer Zamarripa-Calderón, Mateusz Radwanski, Giovana Orsini, Monika Lukomska-Szymanska
  Cells.2022; 11(15): 2417.     CrossRef
• Marginal Integrity of Composite Restoration with and without Surface Pretreatment by Gold and Silver Nanoparticles vs Chlorhexidine: A Randomized Controlled Trial
  Aya AEM Nemt-Allah, Shereen H Ibrahim, Amira F El-Zoghby
  The Journal of Contemporary Dental Practice.2022; 22(10): 1087.     CrossRef
• Use of the adhesive layer as a controlled release platform for doxycycline, as promising advancement for longer durability of dentin adhesion
  Lívia Rodrigues de Menezes, Dayane Carvalho Ramos Salles de Oliveira, Cássia Almeida Brito, Emerson Oliveira da Silva
  International Journal of Adhesion and Adhesives.2021; 108: 102889.     CrossRef
• Understanding collagen interactions and their targeted regulation by novel drugs
  Marialucia Gallorini, Simone Carradori
  Expert Opinion on Drug Discovery.2021; 16(11): 1239.     CrossRef
• Effect of Curcumin Suspension and Vitamin C on Dentin Shear Bond Strength and Durability. A Pilot Study
  Dalia A. Abuelenain, Ensanya A. Abou Neel, Tariq S. Abuhaimed, Amal M. Alamri, Hanan S. Ammar, Sahar M. N. Bukhary
  The Open Dentistry Journal.2021; 15(1): 540.     CrossRef
• Reinforced Universal Adhesive by Ribose Crosslinker: A Novel Strategy in Adhesive Dentistry
  Rim Bourgi, Umer Daood, Mohammed Nadeem Bijle, Amr Fawzy, Maroun Ghaleb, Louis Hardan
  Polymers.2021; 13(5): 704.     CrossRef

The purpose of this study was to determine the effects on the elastic moduli of the adhesive and the hybrid layer from thermocycling. Twenty one human molars were used to create flat dentin surfaces. Each specimen was bonded with a light-cured composite using one of three commercial adhesives (OptiBond FL [OP], Clearfil SE Bond [CL], and Xeno III [XE]). These were sectioned into two halves and subsequently cut to yield 2-mm thickness specimens; one specimen for immediate bonding test without thermocycling and the other subjected to 10,000 times of thermocycling. Nanoindentation test was performed to measure the modulus of elasticity of the adhesive and the hybrid layer, respectively, using an atomic force microscope. After thermocycling, XE showed a significant decrease of the modulus in the adhesive layer (p < 0.05). Adhesives containing hydrophilic monomers are prone to hydrolytic degradation. It may result in the reduced modulus of elasticity, which leads to the mechanically weakened bonding interface.

The purpose of this study was to evaluate the correlation between hybrid layer thickness and bond strength using confocal laser scanning microscope and microtensile bond strength test of two adhesive systems.

The dentin surface of human molars, sectioned to remove the enamel from the occlusal surface. Either Scotchbond Multi-Purpose(3M Dental Product, St. Paul, MN, U.S.A) or Clearfil SE Bond(Kuraray, Osaka, Japan) was bonded to the surface, and covered with resin-composite. The resin-bonded teeth were serially sliced perpendicular to the adhesive interface to measure the hybrid layer thickness by confocal laser scanning microscope. The specimen were trimmed to give a bonded cross-sectional surface area of 1mm², then the micro-tensile bone test was performed at a crosshead speed of 1.0 mm/min. All fractured surfaces were also observed by stereomicroscope.

There was no significant differences in bond strengths the materials(p>0.05). However, the hybrid layers of three-step dentin adhesive system, SM, had significantly thicker than self-etching adhesive system, CS(p<0.05). Pearson's correlation coefficient showed no correlation between hybrid layer thickness and bond strengths(p>0.05). Bond strengths of dentin adhesive systems were not dependent on the thickness of hybrid layer.

Citations

Citations to this article as recorded by  

• Techniques for the restorative management of localized and generalized tooth wear
  Alex Milosevic
  Dental Update.2023; 50(10): 842.     CrossRef

The purpose of this study was to compare in vitro interfacial relationship of restorations bonded with three self-etching primer adhesives and one self-etching adhesive.

Class I cavity preparations were prepared on twenty extracted human molars. Prepared teeth were divided into four groups and restored with four adhesives and composites: Clearfil SE Bond/Clearfil™ AP-X (SE), UniFil Bond/UniFil® F (UF), FL Bond/Filtek™ Z 250 (FL) and Prompt L-Pop/Filtek™ Z 250 (LP)

After storing in distilled water of room temperature for 24 hours, the specimens were vertically sectioned and decalcified. Morphological patterns between the enamel/dentin and adhesives were observed under SEM.

The results of this study were as follows;

1. They showed close adaptation between enamel and SE, UF and FL except for LP.

2. The hybrid layer in dentin was 2 µm thick in SE, 1.5 µm thick in UF, and 0.4 µm in both FL and LP. So, the hybrid layers of SE and UF were slightly thicker than that of FL and LP.

3. The lengths and diameters of resin tags in UF and FL were similar, but those of LP were slightly shorter and slenderer than those of SE.

4. The resin tags were long rod shape in SE, and funnel shape in other groups.

Within the limitations of this study, it was concluded that self-etching primer adhesives showed close adaptation on enamel. In addition, the thickness of hybrid layer ranged from 0.4-1.5 µm between adhesives and dentin. The resin tags were long rod or funnel shape, and dimension of them was similar or different among adhesives.

Citations

Citations to this article as recorded by  

• Influence of appication time of self-etching primers on dentinal microtensile bond strength
  Young-Gon Cho, Young-Gon Lee, Jong-Uk Kim, Byung-Cheul Park, Jong-Jin Kim, Hee-Young Choi, Cheul-Hee Jin, Sang-Hoon Yoo
  Journal of Korean Academy of Conservative Dentistry.2004; 29(5): 430.     CrossRef