Restorative Dentistry & Endodontics

Research Articles

Alkasite restorative material for endodontically treated teeth: a randomized controlled pilot study: Davi Ariel Nobuo Bepu, Renata Siqueira Scatolin, Natalia Saud Junqueira Franco, Luiza Pejon Sanchez, Aline Evangelista Souza-Gabriel, Silmara Aparecida Milori Corona; Restor Dent Endod 2024;49(3):e24. Published online June 11, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e24

Abstract PDF PubReader ePub: Objectives
This study aimed to evaluate the clinical performance of an alkasite restorative material in molars that had undergone root canal treatment.
Materials and Methods
The research was registered in Brazilian Registry of Clinical Trials. The randomized clinical trial involved 33 patients, each with at least 1 mandibular molar requiring restoration after receiving endodontic treatment. Patients were randomly assigned to receive either bulk-fill resin composite (Tetric N Ceram Bulk Fill, Ivoclar Vivadent) or the alkasite restorative material (Cention N, Ivoclar Vivadent). Upon completion of the restorations, 3 calibrated professionals utilized the United States Public Health Service criteria to assess various factors, including retention, secondary caries, marginal adaptation, restoration color, marginal pigmentation, and anatomical form. Evaluations were conducted at intervals of 7 days, 6 months, and 17 months. Additionally, the assessment encompassed the presence of radiolucent lines adjacent to the restoration, material deficiencies or excess, contact points, and caries recurrence. The data underwent analysis using the Friedman and Mann-Whitney tests (α = 0.05).
Results
After 17 months, the results revealed that the alkasite restorative material exhibited greater wear of anatomical shape compared to the bulk-fill resin composite (p = 0.0189). Furthermore, the alkasite restorative material significantly differed from the natural tooth color in most cases (p = 0.0000). However, no other criteria displayed significant differences between the materials or over time (p > 0.05).
Conclusions
The alkasite restorative material (Cention N) emerges as a viable option for restoring endodontically treated teeth, displaying clinically acceptable alterations after a 17-month evaluation period.
Trial Registration
Brazilian Registry of Clinical Trials (ReBEC) Identifier: RBR-97kx5jv

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The effect of using nanoparticles in bioactive glass on its antimicrobial properties: Maram Farouk Obeid, Kareim Moustafa El-Batouty, Mohammed Aslam; Restor Dent Endod 2021;46(4):e58. Published online October 29, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e58

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Objectives

This study addresses the effect of using nanoparticles (np) on the antimicrobial properties of bioactive glass (BAG) when used in intracanal medicaments against Enterococcus faecalis (E. faecalis) biofilms.

Materials and Methods

E. faecalis biofilms, grown inside 90 root canals for 21 days, were randomly divided into 4 groups according to the antimicrobial regimen followed (n = 20; BAG-np, BAG, calcium hydroxide [CaOH], and saline). After 1 week, residual live bacteria were quantified in terms of colony-forming units (CFU), while dead bacteria were assessed with a confocal laser scanning microscope.

Results

Although there was a statistically significant decrease in the mean CFU value among all groups, the nano-group performed the best. The highest percentage of dead bacteria was detected in the BAG-np group, with a significant difference from the BAG group.

Conclusions

The reduction of particle size and use of a nano-form of BAG improved the antimicrobial properties of the intracanal treatment of E. faecalis biofilms

Citations

Citations to this article as recorded by

Size matters: radiation shielding superiority of borate glasses with nano vs. micro ZnO
Aljawhara H. Almuqrin, M.I. Sayyed, M. Elsafi
Nuclear Engineering and Technology.2025; : 103614. CrossRef
Application of Nanomaterials in Endodontics
Farzaneh Afkhami, Yuan Chen, Laurence J. Walsh, Ove A. Peters, Chun Xu
BME Frontiers.2024;[Epub] CrossRef
Antimicrobial efficacy of newly prepared nano-tricalcium silicate-58s bioactive glass-based endodontic sealer
Nawal Atiya Al-Sabawi, Sawsan Hameed Al-Jubori
Endodontology.2024;[Epub] CrossRef
Antimicrobial Effects of Formulations of Various Nanoparticles and Calcium Hydroxide as Intra-canal Medications Against Enterococcus faecalis: A Systematic Review
Seema H Bukhari, Dax Abraham, Shakila Mahesh
Cureus.2024;[Epub] CrossRef
Effect of nanoparticles on antibacterial efficacy of intracanal medicament: A scoping review
Alpa Gupta, Arundeep Singh, Vivek Aggarwal
Endodontology.2023; 35(4): 283. CrossRef
Physical properties, marginal adaptation and bioactivity of an experimental mineral trioxide aggregate-like cement modified with bioactive materials
Abigailt Flores-Ledesma, Adriana Tejeda-Cruz, María A. Moyaho-Bernal, Ana Wintergerst, Yoshamin A. Moreno-Vargas, Jacqueline A. Rodríguez-Chávez, Carlos E. Cuevas-Suárez, Kenya Gutiérrez-Estrada, Jesús A. Arenas-Alatorre
Journal of Oral Science.2023; 65(2): 141. CrossRef
Nanopartículas antimicrobianas en endodoncia: Revisión narrativa
Gustavo Adolfo Tovar Rangel , Fanny Mildred González Sáenz , Ingrid Ximena Zamora Córdoba , Lina María García Zapata
Revista Estomatología.2023;[Epub] CrossRef

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Biocompatibility and bioactive potential of the NeoMTA Plus endodontic bioceramic-based sealer: Roberto Alameda Hoshino, Mateus Machado Delfino, Guilherme Ferreira da Silva, Juliane Maria Guerreiro-Tanomaru, Mário Tanomaru-Filho, Estela Sasso-Cerri, Paulo Sérgio Cerri; Restor Dent Endod 2021;46(1):e4. Published online December 17, 2020; DOI: https://doi.org/10.5395/rde.2021.46.e4

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Objectives

This study evaluated the biocompatibility and bioactive potential of NeoMTA Plus mixed as a root canal sealer in comparison with MTA Fillapex.

Materials and Methods

Polyethylene tubes filled with NeoMTA Plus (n = 20), MTA Fillapex (n = 20), or nothing (control group, CG; n = 20) were inserted into the connective tissue in the dorsal subcutaneous layer of rats. After 7, 15, 30 and 60 days, the specimens were processed for paraffin embedding. The capsule thickness, collagen content, and number of inflammatory cells (ICs) and interleukin-6 (IL-6) immunolabeled cells were measured. von Kossa-positive structures were evaluated and unstained sections were analyzed under polarized light. Two-way analysis of variance was performed, followed by the post hoc Tukey test (p ≤ 0.05).

Results

At 7 days, the capsules around NeoMTA Plus and MTA Fillapex had more ICs and IL-6-immunostained cells than the CG. However, at 60 days, there was no significant difference in the IC number between NeoMTA Plus and the CG (p = 0.1137) or the MTA Fillapex group (p = 0.4062), although a greater number of IL-6-immunostained cells was observed in the MTA Fillapex group (p = 0.0353). From 7 to 60 days, the capsule thickness of the NeoMTA Plus and MTA Fillapex specimens significantly decreased, concomitantly with an increase in the collagen content. The capsules around root canal sealers showed positivity to the von Kossa stain and birefringent structures.

Conclusions

The NeoMTA Plus root canal sealer is biocompatible and exhibits bioactive potential.

Citations

Citations to this article as recorded by

The osteoinductive potential of different root-end filling materials in a rat femur model
Seçkin Aksu, Ebru Delikan, Ayşe Özcan Küçük, Zehra Demiray Asoğlu, Şakir Necat Yılmaz
Scientific Reports.2024;[Epub] CrossRef
Clinical outcomes of nonsurgical root canal treatment using NeoSealer Flo and Endosequence BC Sealer: A retrospective analysis with short-term follow-up
Christian Lepure, Ryan M. Walsh, Sayeed Attar, Casey L. Turner, Joshua Crawford, Poorya Jalali
Clinical Oral Investigations.2024;[Epub] CrossRef
Biocompatibility and bioactive potential of NeoPUTTY calcium silicate‐based cement: An in vivo study in rats
Evelin Carine Alves Silva, Jéssica Arielli Pradelli, Guilherme Ferreira da Silva, Paulo Sérgio Cerri, Mario Tanomaru‐Filho, Juliane Maria Guerreiro‐Tanomaru
International Endodontic Journal.2024; 57(6): 713. CrossRef
Carbon Nanotubes Induce Mineralization of Human Cementoblasts
Ting-Hsuan Wang, Kiyoko Watanabe, Koichiro Muromachi, Nobushiro Hamada, Nobuyuki Tani-Ishii
Journal of Endodontics.2024; 50(8): 1117. CrossRef
Tissue repair capacity of bioceramic endodontic sealers in rat subcutaneous tissue
George Sampaio Bonates dos Santos, Ceci Nunes Carvalho, Rudys Rodolfo de Jesus Tavares, Paulo Goberlânio de Barros Silva, George Táccio de Miranda Candeiro, Etevaldo Matos Maia Filho
Brazilian Dental Journal.2023; 34(3): 25. CrossRef
Participation of fibroblast growth factor‐1 and interleukin‐10 in connective tissue repair following subcutaneous implantation of bioceramic materials in rats
Mateus Machado Delfino, José Leandro de Abreu Jampani, Camila Soares Lopes, Juliane Maria Guerreiro‐Tanomaru, Mário Tanomaru‐Filho, Estela Sasso‐Cerri, Paulo Sérgio Cerri
International Endodontic Journal.2023; 56(3): 385. CrossRef
Biocompatibility and bioactive potential of an experimental tricalcium silicate‐based cement in comparison with Bio‐C repair and MTA Repair HP materials
Marcela Borsatto Queiroz, Rafaela N. H. Inada, José Leandro de Abreu Jampani, Juliane Maria Guerreiro‐Tanomaru, Estela Sasso‐Cerri, Mário Tanomaru‐Filho, Paulo Sérgio Cerri
International Endodontic Journal.2023; 56(2): 259. CrossRef
Calcium Silicate-Based Sealer Dentinal Tubule Penetration—A Systematic Review of In Vitro Studies
Israa Ashkar, José Luis Sanz, Leopoldo Forner, María Melo
Materials.2023; 16(7): 2734. CrossRef
Bioactivity Potential of Bioceramic-Based Root Canal Sealers: A Scoping Review
Mauro Schmitz Estivalet, Lucas Peixoto de Araújo, Felipe Immich, Adriana Fernandes da Silva, Nadia de Souza Ferreira, Wellington Luiz de Oliveira da Rosa, Evandro Piva
Life.2022; 12(11): 1853. CrossRef
Tricalcium silicate cement sealers
Anita Aminoshariae, Carolyn Primus, James C. Kulild
The Journal of the American Dental Association.2022; 153(8): 750. CrossRef
Bioactive potential of Bio‐C Pulpo is evidenced by presence of birefringent calcite and osteocalcin immunoexpression in the rat subcutaneous tissue
Marcela Borsatto Queiroz, Rafaela Nanami Handa Inada, Camila Soares Lopes, Juliane Maria Guerreiro‐Tanomaru, Estela Sasso‐Cerri, Mário Tanomaru‐Filho, Paulo Sérgio Cerri
Journal of Biomedical Materials Research Part B: Applied Biomaterials.2022; 110(10): 2369. CrossRef
An Updated Review on Properties and Indications of Calcium Silicate-Based Cements in Endodontic Therapy
Fateme Eskandari, Alireza Razavian, Rozhina Hamidi, Khadije Yousefi, Susan Borzou, Zohaib Khurshid
International Journal of Dentistry.2022; 2022: 1. CrossRef

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Dentin moisture conditions strongly influence its interactions with bioactive root canal sealers: Esin Ozlek, Hüseyin Gündüz, Elif Akkol, Prasanna Neelakantan; Restor Dent Endod 2020;45(2):e24. Published online March 24, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e24

Abstract PDF PubReader ePub

Objectives

It is known that bioactive materials interact with the dentin to undergo biomineralization. The exact role of moisture in this interaction is unknown. Here, we investigate the effects of dentin moisture conditions on the dislocation resistance of two bioactive root canal sealers (MTA Fillapex [Angelus Solucoes Odontologicas] and GuttaFlow BioSeal [Colténe/Whaledent AG]) at 3 weeks and 3 months after obturation.

Materials and Methods

Mandibular premolars (n = 120) were prepared and randomly divided into 3 groups based on the dentin condition: group 1, dry dentin; group 2, moist dentin; group 3, wet dentin. Each group was divided into 2 subgroups for root canal filling: MTA Fillapex and GuttaFlow BioSeal. Dislocation resistance was evaluated by measuring the push-out bond strength at 3 weeks and 3 months. Failure modes were examined under a stereomicroscope. Data were statistically analyzed by Kruskal-Wallis test with a significance level of 5%.

Results

Moist dentin resulted in higher bond strength values for both materials at both time points. This was significantly higher than wet and dry dentin for both the sealers at the 3 months (p < 0.05), while at 3 weeks it was significant only for GuttaFlow Bioseal. The different moisture conditions demonstrated similar trends in their effects on the dislocation resistance of the 2 root canal sealers.

Conclusions

The dentin moisture conditions had a significant impact on its interaction with the bioactive materials tested. Maintaining moist dentin, but not dry or wet dentin, may be advantageous before the filling root canals with bioactive sealers.

Citations

Citations to this article as recorded by

The effect of moisture conditions and canal morphologies on the filling quality of iRoot SP with single-cone technique in root canals: an ex-vivo study
Jing Yang, Xiran Xu, Jian Zhang, Kehua Que
Frontiers in Dental Medicine.2025;[Epub] CrossRef
Bond Strength and Adhesive Interface Quality of New Pre‐Mixed Bioceramic Root Canal Sealer
Gustavo Creazzo, Bruna Monteiro de Barros Ciribelli Alves, Helena Cristina de Assis, Karen Gisselle Garay Villamayor, Manoel Damião de Sousa‐Neto, Jardel Francisco Mazzi‐Chaves, Fabiane Carneiro Lopes‐Olhê
Microscopy Research and Technique.2025;[Epub] CrossRef
Evaluation of apical seal and tubular penetration of a novel bioactive glass sealer, bioceramic sealer and resin–based sealer: an In-Vitro study
M. Bilal, S. Pasha, S. Kumar, S. Arif, S. Taj, A. Saleem
Endodontics Today.2025; 23(1): 39. CrossRef
Preparation and characterization of novel nano-tricalcium silicate-58s bioactive glass-based root canal sealer
Nawal Atiya Al-Sabawi, Sawsan Hameed Al-Jubori
Saudi Endodontic Journal.2024; 14(1): 90. CrossRef
The flow behavior and sealing ability of calcium silicate root canal cement containing dimethyl sulfoxide: An in vitro study
Bokyung Shin, Ji-Hwan Seo, Wonjung Kim, Yu Jin Ahn, Ho-Young Kim, Won-Jun Shon
Journal of the Mechanical Behavior of Biomedical Materials.2024; 150: 106156. CrossRef
Nanoleakage of apical sealing using a calcium silicate-based sealer according to canal drying methods
Yoon-Joo Lee, Kyung-Mo Cho, Se-Hee Park, Yoon Lee, Jin-Woo Kim
Restorative Dentistry & Endodontics.2024;[Epub] CrossRef
Effect of operators’ proficiency level and patients’ related factors on possible complications, using a high frequency polyamide sonic intracanal irrigation device: A prospective clinical cohort study
Tobias Hahn, David W. Christofzik, Karim Fawzy El-Sayed, Sandra Freitag-Wolf, Jonas Conrad, Christian Graetz, Birte Größner-Schreiber, Christof Dörfer, Artak Heboyan
PLOS ONE.2023; 18(5): e0285492. CrossRef
Physical-chemical properties and acellular bioactivity of newly prepared nano-tricalcium silicate-58s bioactive glass-based endodontic sealer
Nawal A. Al-Sabawi, Sawsan Hameed Al-Jubori
Journal of Oral Biosciences.2023; 65(4): 305. CrossRef
Biocompatibility analysis in subcutaneous tissue and physico-chemical analysis of pre-mixed calcium silicate–based sealers
Ana Cristina Padilha Janini, Lauter Eston Pelepenko, Juliana Minto Boldieri, Victor Augusto Benedicto dos Santos, Nilvan Alves da Silva, Ivo Milton Raimundo, Brenda P. F. A. Gomes, Marina Angélica Marciano
Clinical Oral Investigations.2023; 27(5): 2221. CrossRef
Canal Drying Protocols to Use with Calcium Silicate–based Sealer: Effect on Bond Strength and Adhesive Interface
Lais Lima Pelozo, Aline Evangelista Souza-Gabriel, Guilherme Nilson Alves dos Santos, Rafael Verardino Camargo, Fabiane Carneiro Lopes-Olhê, Manoel Damião Sousa-Neto, Jardel Francisco Mazzi-Chaves
Journal of Endodontics.2023; 49(9): 1154. CrossRef
Comparison of push‐out bond strength of endodontic sealers after root canal drying with different techniques
Ahmadreza Sarrafan, Ali Soleymani, Tasnim Bagheri Chenari, Seyedali Seyedmajidi
Clinical and Experimental Dental Research.2023; 9(2): 314. CrossRef
Designing Calcium Silicate Cements with On-Demand Properties for Precision Endodontics
A. Cahyanto, P. Rath, T.X. Teo, S.S. Tong, R. Malhotra, B.N. Cavalcanti, L.Z. Lim, K.S. Min, D. Ho, W.F. Lu, V. Rosa
Journal of Dental Research.2023; 102(13): 1425. CrossRef
Outcome of root canal treatment using warm vertical compaction with bioceramic and resin‐based sealers: A randomised clinical trial
Jinghao Hu, Yunjie Zhu, Shuli Deng, Zeji Wang, Fuming He
Australian Endodontic Journal.2023; 49(S1): 170. CrossRef
Evaluation of the Sealing Ability and Bond Strength of Two Endodontic Root Canal Sealers: An In Vitro Study
Manuel Marques Ferreira, José Pedro Martinho, Inês Duarte, Diogo Mendonça, Ana Catarina Craveiro, Maria Filomena Botelho, Eunice Carrilho, Carlos Miguel Marto, Ana Coelho, Anabela Paula, Siri Paulo, Nuno Chichorro, Ana Margarida Abrantes
Dentistry Journal.2022; 10(11): 201. CrossRef
How do imaging protocols affect the assessment of root-end fillings?
Fernanda Ferrari Esteves Torres, Reinhilde Jacobs, Mostafa EzEldeen, Karla de Faria-Vasconcelos, Juliane Maria Guerreiro-Tanomaru, Bernardo Camargo dos Santos, Mário Tanomaru-Filho
Restorative Dentistry & Endodontics.2022;[Epub] CrossRef
Effect of using calcium-silicate and silicone based root canal sealers in bulk or with main core material on bond strength
Gizem Kadı, Esin Özlek, Yousef Saed
Journal of Dental Research, Dental Clinics, Dental Prospects.2022; 16(4): 229. CrossRef
Physico-chemical properties of calcium silicate-based sealers in powder/liquid and ready-to-use forms
Ana C P Janini, Lauter E Pelepenko, Brenda P F A Gomes, Marina A Marciano
Brazilian Dental Journal.2022; 33(5): 18. CrossRef
Influence of dentin moisture conditions on the wetting action of different endodontic sealers using Rame-Hart goniometer: An in vitro study
Sivaji Kauravi, ShruthiH Attavar, GyanendraPratap Singh
Journal of International Oral Health.2022; 14(6): 624. CrossRef
Heating stability, physical and chemical analysis of calcium silicate‐based endodontic sealers
T. B. M. Antunes, A. C. P. Janini, L. E. Pelepenko, G. F. Abuna, E. M. Paiva, M. A. C. Sinhoreti, I. M. Raimundo, B. P. F. A. Gomes, A. de‐Jesus‐Soares, M. A. Marciano
International Endodontic Journal.2021; 54(7): 1175. CrossRef
Characterization, Antimicrobial Effects, and Cytocompatibility of a Root Canal Sealer Produced by Pozzolan Reaction between Calcium Hydroxide and Silica
Mi-Ah Kim, Vinicius Rosa, Prasanna Neelakantan, Yun-Chan Hwang, Kyung-San Min
Materials.2021; 14(11): 2863. CrossRef
Main and Accessory Canal Filling Quality of a Premixed Calcium Silicate Endodontic Sealer According to Different Obturation Techniques
Su-Yeon Ko, Hae Won Choi, E-Deun Jeong, Vinicius Rosa, Yun-Chan Hwang, Mi-Kyung Yu, Kyung-San Min
Materials.2020; 13(19): 4389. CrossRef

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Effect of three nanobiomaterials on microhardness of bleached enamel: Maryam Khoroushi, Farinaz Shirban, Sara Kaveh, Samaneh Doustfateme; Restor Dent Endod 2016;41(3):196-201. Published online July 14, 2016; DOI: https://doi.org/10.5395/rde.2016.41.3.196

Abstract PDF PubReader ePub

Objectives

The aim of this in vitro study was to evaluate the effect of incorporating three different nanobiomaterials into bleaching material on microhardness of bleached enamel.

Materials and Methods

The crowns of 24 extracted sound human molars were sectioned. Sixty enamel specimens (2 × 3 × 4 mm) were selected and divided into five groups (n = 12): Group 1 received no bleaching procedure (control); Group 2 underwent bleaching with a 40% hydrogen peroxide (HP) gel; Groups 3, 4, and 5 were bleached with a 40% HP gel modified by incorporation of bioactive glass (BAG), amorphous calcium phosphate (ACP) and hydroxyapatite (HA), respectively. The enamel microhardness was evaluated. The differences in Knoop microhardness data of each group were analyzed by one-way ANOVA, followed by post hoc Tukey tests.

Results

Significant differences were observed between the study groups. The enamel microhardness changes in Groups 1, 3, 4, and 5 were significantly lower than that of Group 2 (p < 0.001).

Conclusions

Within the limitations of this study, it can be concluded that incorporation of each one of the three tested biomaterials as remineralizing agents might be effective in decreasing enamel microhardness changes subsequent to in-office bleaching.

Citations

Citations to this article as recorded by

Effect of strontium fluorophosphate bioactive glass on color, microhardness and surface roughness of bleached enamel
Shiza Yezdani, Monisha Khatri, Sampath Vidhya, Sekar Mahalaxmi
Technology and Health Care.2024; 32(1): 285. CrossRef
In vitro evaluation of the effect of addition of biomaterials to carbamide peroxide on the bleaching efficacy and microhardness of enamel
Sowmya Kavoor, M. A. Ranjini, Naval Abdul Aziz, H. K. Ashok, Roopa R. Nadig
Journal of Conservative Dentistry and Endodontics.2024; 27(3): 310. CrossRef
Effect of hydrogen peroxide and its combination with nano-hydroxyapatite or nano-bioactive glass on the enamel demineralization and tooth color: An in vitro study
Elham Kheradmand, Alirea Daneshkazemi, Abdolrahim Davari, Maede Kave, Solmaz Ghanbarnejad
Dental Research Journal.2023;[Epub] CrossRef
Over‐the‐counter bleaching agents can help with tooth whitening maintenance
Olívia Santana Jorge, Carolina Noronha Ferraz de Arruda, Rafaella Tonani Torrieri, Rocio Geng Vivanco, Fernanda de Carvalho Panzeri Pires‐de‐Souza
Journal of Esthetic and Restorative Dentistry.2022; 34(2): 328. CrossRef
Effect of Indigenously Developed Nano-Hydroxyapatite Crystals from Chicken Egg Shell on the Surface Hardness of Bleached Human Enamel
Divya Kunam, Vidhya Sampath, Sujatha Manimaran, Mahalaxmi Sekar
Contemporary Clinical Dentistry.2019; 10(3): 489. CrossRef
Influence of Time Intervals between Bleaching Procedures on Enamel Microhardness and Surface Roughness
Roberta Pimentel de Oliveira, Juliana Costa Pereira Baia, Mara Eliane Soares Ribeiro, Mario Honorato da Silva e Souza Junior, Sandro Cordeiro Loretto
The Open Dentistry Journal.2018; 12(1): 555. CrossRef

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