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Evaluation of blood clot, platelet-rich plasma, and platelet-rich fibrin–mediated regenerative endodontic procedures in teeth with periapical pathology: a CBCT study
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Swati Markandey, Haridas Das Adhikari
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Restor Dent Endod 2022;47(4):e41. Published online October 21, 2022
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DOI: https://doi.org/10.5395/rde.2022.47.e41
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Abstract
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- Objectives
This study compared the clinical and radiological outcomes of regenerative endodontic procedures (REPs) using blood clots (BCs), platelet-rich plasma (PRP), and platelet-rich fibrin (PRF) through intraoral periapical radiography (IOPAR) and cone-beam computed tomography (CBCT). Materials and MethodsForty-five single-rooted necrotic teeth with periapical pathology were randomly allocated to receive BC, PRP, or PRF as an individual scaffold. Outcomes were evaluated in 35 teeth in 23 patients with a follow-up period of 12–24 months through qualitative IOPAR scoring and quantitative CBCT measurements. Healing of periapical lesions and in immature teeth, changes in the apical foramen diameter (AFD), root wall thickness (RWT), and root length (RL) were assessed. A p value less than 0.05 was considered to indicate statistical significance. ResultsAll teeth were asymptomatic except 1 in the PRP group. Periapical lesion healing was seen in all except 2 teeth in the BC group and 3 in the PRP group. Both IOPAR and CBCT revealed no significant differences in bone healing or changes in AFD, RWT, and RL among the 3 groups. A positive pulp sensibility response to the cold test was seen in 2 teeth in the BC group, but none to the electric pulp test. Intracanal calcification (ICC) was evident in more teeth in the BC group than in the PRP and PRF groups, and was also significantly higher in immature teeth. ConclusionsOur results revealed that BC, PRP, and PRF have similar potential as scaffolds in REPs, and ICC may be a concern for long-term outcomes.
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Citations
Citations to this article as recorded by 
- Regenerative potential of concentrated growth factor compared to platelet-rich fibrin in treatment of necrotic mature teeth: a randomized clinical trial
Taghreed Salah, Wael Hussein, Heba Abdelkafy BDJ Open.2025;[Epub] CrossRef - Biomimetic pulp scaffolds prepared from extracellular matrix derived from stem cells from human exfoliated deciduous teeth promote pulp–dentine complex regeneration
Ning Yang, Rou Shen, Wenxiao Yang, Shengcai Zhang, Tianxing Gong, Yao Liu International Endodontic Journal.2024; 57(9): 1279. CrossRef - Arrest and Repair of Inflammatory Root Resorption After an Endodontic Regeneration Procedure – A Hypothesis and Case Report
Arieh Y. Kaufman, Bill Kahler Journal of Endodontics.2024; 50(12): 1743. CrossRef - Effect of Platelet Rich Plasma in Regenerative Endodontic Treatment: A Review of Clinical Trials
Hojat Rezazadeh, Mehrnaz Okhovatfard Research Journal of Pharmacy and Technology.2023; : 5562. CrossRef
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