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Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry
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Jia Kim, Young-Sang Song, Kyung-San Min, Sun-Hun Kim, Jeong-Tae Koh, Bin-Na Lee, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Yun-Chan Hwang
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Restor Dent Endod 2016;41(1):29-36. Published online January 4, 2016
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DOI: https://doi.org/10.5395/rde.2016.41.1.29
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Abstract
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- Objectives
The purpose of this study was to assess the ability of two new calcium silicate-based pulp-capping materials (Biodentine and BioAggregate) to induce healing in a rat pulp injury model and to compare them with mineral trioxide aggregate (MTA). Materials and MethodsEighteen rats were anesthetized, cavities were prepared and the pulp was capped with either of ProRoot MTA, Biodentine, or BioAggregate. The specimens were scanned using a high-resolution micro-computed tomography (micro-CT) system and were prepared and evaluated histologically and immunohistochemically using dentin sialoprotein (DSP). ResultsOn micro-CT analysis, the ProRoot MTA and Biodentine groups showed significantly thicker hard tissue formation (p < 0.05). On H&E staining, ProRoot MTA showed complete dentin bridge formation with normal pulpal histology. In the Biodentine and BioAggregate groups, a thick, homogeneous hard tissue barrier was observed. The ProRoot MTA specimens showed strong immunopositive reaction for DSP. ConclusionsOur results suggest that calcium silicate-based pulp-capping materials induce favorable effects on reparative processes during vital pulp therapy and that both Biodentine and BioAggregate could be considered as alternatives to ProRoot MTA.
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Citations
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- Clinical applications and classification of calcium silicate-based cements based on their history and evolution: a narrative review
Kenta Tsuchiya, Salvatore Sauro, Hidehiko Sano, Jukka P. Matinlinna, Monica Yamauti, Shuhei Hoshika, Yu Toida, Rafiqul Islam, Atsushi Tomokiyo Clinical Oral Investigations.2025;[Epub] CrossRef - Histological evaluation of pulp response to alendronate and Biodentine as pulp capping agents: an animal study
Thangavel Boopathi, Sekar Manimaran, Joseline Charles Kerena, Mathew Sebeena, Kumaravadivel Karthick, Natesan Thangaraj Deepa Restorative Dentistry & Endodontics.2024;[Epub] CrossRef - Comparative Clinical and Radiographic Success Rate of Bioceramic Premix vs Biosilicate-based Medicament as Indirect Pulp Treatment Materials in Primary Molars: A Double-blind Randomized Trial with a Follow-up of 12 Months
Aditi Mathur, Meenakshi Nankar, Sunnypriyatham Tirupathi, Payal Kothari, Rashmi Chauhan, Ashrita Suvarna International Journal of Clinical Pediatric Dentistry.2024; 17(7): 748. CrossRef - Effects of mineral trioxide aggregate and methyl sulfonyl methane on pulp exposure via RUNX2 and RANKL pathways
Altar Ateş, Ayca Kurt, Tolga Mercantepe Odontology.2024; 112(3): 895. CrossRef - Evaluation of biocompatibility and bioactive potential of Well-Root PT by comparison with ProRoot MTA and Biodentine
Yong Kwon Chae, Ju Ri Ye, Ok Hyung Nam Journal of Dental Sciences.2024; 19(4): 2218. CrossRef - Dentine Remineralisation Induced by “Bioactive” Materials through Mineral Deposition: An In Vitro Study
Marta Kunert, Ireneusz Piwonski, Louis Hardan, Rim Bourgi, Salvatore Sauro, Francesco Inchingolo, Monika Lukomska-Szymanska Nanomaterials.2024; 14(3): 274. CrossRef - Different pulp capping agents and their effect on pulp inflammatory response: A narrative review
Mustafa Tariq Mutar, Anas F Mahdee The Saudi Dental Journal.2024; 36(10): 1295. CrossRef - Clinical application of calcium silicate-based bioceramics in endodontics
Xinyuan Wang, Yizhi Xiao, Wencheng Song, Lanxiang Ye, Chen Yang, Yuzhen Xing, Zhenglin Yuan Journal of Translational Medicine.2023;[Epub] CrossRef - Evaluation of the pulp response following direct pulp capping with exogenous nitric oxide and Mineral Trioxide Aggregate (MTA) a histologic study
Amirah Alnour, Ghassan Almohammad, Anas Abdo, Kinda Layous Heliyon.2023; 9(7): e17458. CrossRef - Histological evaluation of dental pulp response to Biodentine, enamel matrix derivative (Emdogain), and mineral trioxide aggregate as direct pulp-capping agents – A randomized clinical trial
Takhellambam Premlata Devi, Amandeep Kaur, Shamurailatpam Priyadarshini, B. S. Deepak, Sumita Banerjee, Ngairangbam Sanjeeta Journal of Medical Society.2023; 37(3): 107. CrossRef - Effect of Intracoronal Sealing Biomaterials on the Histological Outcome of Endodontic Revitalisation in Immature Sheep Teeth—A Pilot Study
Elanagai Rathinam, Sivaprakash Rajasekharan, Heidi Declercq, Christian Vanhove, Peter De Coster, Luc Martens Journal of Functional Biomaterials.2023; 14(4): 214. CrossRef - Restorative management of the posterior tooth that has undergone a pulpotomy
Nicholas N Longridge, James S Hyde, Fadi Jarad, Sondos Albadri Dental Update.2023; 50(11): 932. CrossRef - Direct pulp capping procedures – Evidence and practice
Rafiqul Islam, Md Refat Readul Islam, Toru Tanaka, Mohammad Khursheed Alam, Hany Mohamed Aly Ahmed, Hidehiko Sano Japanese Dental Science Review.2023; 59: 48. CrossRef - A novel analysis of the formation and resorption changes in dental hard tissue using longitudinal in vivo micro computed tomography
Yeon-Jee YOO, Joonil HWANG, So-Hyun PARK, Jaehong HWANG, Seungryong CHO, Sun-Young KIM Dental Materials Journal.2023; 42(5): 708. CrossRef - Evaluation of pH and Calcium Ion Diffusion from Intracanal MTA and Bioaggregate to Simulated External Resorption Cavities Through Dentinal Tubules
Umut AKSOY, Kaan POLATOĞLU, Feridun ŞAKLAR European Annals of Dental Sciences.2022; 49(3): 108. CrossRef - Pulpa Kuafajı ve Kuafaj Materyallerine Güncel Bir Bakış: Derleme
Dilek AKIN, Çiğdem ATALAYIN ÖZKAYA Selcuk Dental Journal.2022; 9(2): 617. CrossRef - The Influence of New Bioactive Materials on Pulp–Dentin Complex Regeneration in the Assessment of Cone Bone Computed Tomography (CBCT) and Computed Micro-Tomography (Micro-CT) from a Present and Future Perspective—A Systematic Review
Mirona Paula Palczewska-Komsa, Bartosz Gapiński, Alicja Nowicka Journal of Clinical Medicine.2022; 11(11): 3091. CrossRef - Evaluation of shear bond strength of e-mineral trioxide aggregate and biodentine with glass ionomer cement
Hemalatha Hiremath, Aishwarya Singh Solanki, Shivangi Trivedi, Devansh Verma Endodontology.2022; 34(2): 127. CrossRef - Multiple growth factors accommodated degradable submicron calcium sulfate hemihydrate/porous hydroxyapatite for dentin-pulp regeneration
Chih-Wen Chi, Bharathi Priya Lohanathan, Ching-Ching Wong, Che-Lun Chen, Hsun-Chang Lin, Yu-Chih Chiang Biomaterials Advances.2022; 140: 213045. CrossRef - THE EFFECT OF BLOOD CONTAMINATION ON SHEAR BOND STRENGTH OF CALCIUM SILICATE-BASED PULP CAPPING MATERIALS
Hasan Fatih YAVUZ, Güneş BULUT EYÜBOĞLU Cumhuriyet Dental Journal.2022; 24(4): 371. CrossRef - Comparison of Four Dental Pulp-Capping Agents by Cone-Beam Computed Tomography and Histological Techniques—A Split-Mouth Design Ex Vivo Study
Jayanandan Muruganandhan, Govindarajan Sujatha, Saravanan Poorni, Manali Ramakrishnan Srinivasan, Nezar Boreak, Ahmed Al-Kahtani, Mohammed Mashyakhy, Hitesh Chohan, Shilpa Bhandi, A. Thirumal Raj, Alessio Zanza, Luca Testarelli, Shankargouda Patil Applied Sciences.2021; 11(7): 3045. CrossRef - Effect of Naturally Occurring Biogenic Materials on Human Dental Pulp Stem Cells (hDPSC): an In Vitro Study.
Prasanna T. Dahake, Vinod V. Panchal, Yogesh J. Kale, Mahesh V. Dadpe, Shrikant B. Kendre, Vijay M. Kumbar Regenerative Engineering and Translational Medicine.2021; 7(4): 506. CrossRef - Influence of Ultrasonic Activation on the Physicochemical Properties of Calcium Silicate-Based Cements
Fredson Márcio Acris De Carvalho, Yara Teresinha Corrêa Silva-Sousa, Carlos Eduardo Saraiva Miranda, Paulo Henrique Miller Calderon, Ana Flávia Simões Barbosa, Luciana Martins Domingues De Macedo, Fuad Jacob Abi Rached-Junior, Boonlert Kukiattrakoon International Journal of Dentistry.2021; 2021: 1. CrossRef - Tailored 70S30C Bioactive glass induces severe inflammation as pulpotomy agent in primary teeth: an interim analysis of a randomised controlled trial
Yasmine Elhamouly, Rania M. El Backly, Dalia M. Talaat, Samia S. Omar, Maha El Tantawi, Karin M. L. Dowidar Clinical Oral Investigations.2021; 25(6): 3775. CrossRef - Response of dental pulp capped with calcium-silicate based material, calcium hydroxide and adhesive resin in rabbit teeth
Cynthia Kassis, Pierre Khoury, Karim Corbani, Charbel Mansour, Louis Hardan, Ghassan Yared, Carole Chakar Brazilian Journal of Oral Sciences.2021;[Epub] CrossRef - Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review
Ermin Nie, Jiali Yu, Rui Jiang, Xiangzhen Liu, Xiang Li, Rafiqul Islam, Mohammad Khursheed Alam Materials.2021; 14(22): 6811. CrossRef - Immunohistochemical expression of non-collagenous extracellular matrix molecules involved in tertiary dentinogenesis following direct pulp capping: a systematic review
C. Călin, M. Sajin, V.T. Moldovan, C. Coman, S.I. Stratul, A.C. Didilescu Annals of Anatomy - Anatomischer Anzeiger.2021; 235: 151674. CrossRef - Recent Advances in Indirect Pulp Treatment Materials for Primary Teeth: A Literature Review
Omar AES El Meligy, Afnan M Saber, Sumer M Alaki International Journal of Clinical Pediatric Dentistry.2021; 14(6): 795. CrossRef - Chitosan-Based Accelerated Portland Cement Promotes Dentinogenic/Osteogenic Differentiation and Mineralization Activity of SHED
Hasan Subhi, Adam Husein, Dasmawati Mohamad, Nik Rozainah Nik Abdul Ghani, Asma-Abdullah Nurul Polymers.2021; 13(19): 3358. CrossRef - Histological evaluation of the regenerative potential of a novel treated dentin matrix hydrogel in direct pulp capping
Ahmed A. Holiel, Elsayed M. Mahmoud, Wegdan M. Abdel-Fattah, Khadiga Y. Kawana Clinical Oral Investigations.2021; 25(4): 2101. CrossRef - Minimal Intervention in Dentistry: A Literature Review on Biodentine as a Bioactive Pulp Capping Material
Naji Ziad Arandi, Mohammad Thabet, Mona Abbassy BioMed Research International.2021;[Epub] CrossRef - Potential of tailored amorphous multiporous calcium silicate glass for pulp capping regenerative endodontics—A preliminary assessment
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Ahmed A. Holiel, Elsayed M. Mahmoud, Wegdan M. Abdel-Fattah Clinical Oral Investigations.2021; 25(7): 4621. CrossRef - Hard tissue formation after direct pulp capping with osteostatin and MTA in vivo
Ji-Hye Yoon, Sung-Hyeon Choi, Jeong-Tae Koh, Bin-Na Lee, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Yun-Chan Hwang Restorative Dentistry & Endodontics.2021;[Epub] CrossRef - Hydraulic cements for various intra-coronal applications: Part 1
Stephen J Bonsor, Josette Camilleri Dental Update.2021; 48(8): 653. CrossRef - In vivo Biocompatibility and Bioactivity of Calcium Silicate-Based Bioceramics in Endodontics
Wencheng Song, Wei Sun, Lili Chen, Zhenglin Yuan Frontiers in Bioengineering and Biotechnology.2020;[Epub] CrossRef - Evaluation of dentinogenesis inducer biomaterials: an in vivo study
Anabela B. Paula, Mafalda Laranjo, Carlos-Miguel Marto, Siri Paulo, Ana M. Abrantes, Bruno Fernandes, João Casalta-Lopes, Manuel Marques-Ferreira, Maria Filomena Botelho, Eunice Carrilho Journal of Applied Oral Science.2020;[Epub] CrossRef - Micro-computed tomographic evaluation of a new system for root canal filling using calcium silicate-based root canal sealers
Mario Tanomaru-Filho, Fernanda Ferrari Esteves Torres, Jader Camilo Pinto, Airton Oliveira Santos-Junior, Karina Ines Medina Carita Tavares, Juliane Maria Guerreiro-Tanomaru Restorative Dentistry & Endodontics.2020;[Epub] CrossRef - Bio-Inductive Materials in Direct and Indirect Pulp Capping—A Review Article
Marta Kunert, Monika Lukomska-Szymanska Materials.2020; 13(5): 1204. CrossRef - Micro-computed tomographic evaluation of the flow and filling ability of endodontic materials using different test models
Fernanda Ferrari Esteves Torres, Juliane Maria Guerreiro-Tanomaru, Gisselle Moraima Chavez-Andrade, Jader Camilo Pinto, Fábio Luiz Camargo Villela Berbert, Mario Tanomaru-Filho Restorative Dentistry & Endodontics.2020;[Epub] CrossRef - Release of Transforming Growth Factor Beta 1 from Human Tooth Dentin after Application of Either ProRoot MTA or Biodentine as a Coronal Barrier
Kunlada Wattanapakkavong, Tanida Srisuwan Journal of Endodontics.2019; 45(6): 701. CrossRef - Effect of Leptin on Odontoblastic Differentiation and Angiogenesis: An In Vivo Study
Sung-Hyeon Choi, Ji-Hyun Jang, Jeong-Tae Koh, Hoon-Sang Chang, Yun-Chan Hwang, In-Nam Hwang, Bin-Na Lee, Won-Mann Oh Journal of Endodontics.2019; 45(11): 1332. CrossRef - Análise da composição química dos cimentos MTA Angelus® branco, cinza e HP Repair® através de Microscopia Eletrônica de Varredura (MEV) acoplada a Espectrômetro de Energia Dispersiva (EDS)
Gabriela Duarte Rocha SARZEDA, Marcelo Santos BAHIA, Paulo Victor Teixeira DORIGUÊTTO, Karina Lopes DEVITO, Anamaria Pessoa Pereira LEITE Revista de Odontologia da UNESP.2019;[Epub] CrossRef - Direct Pulp Capping: Which is the Most Effective Biomaterial? A Retrospective Clinical Study
Anabela Paula, Eunice Carrilho, Mafalda Laranjo, Ana M. Abrantes, João Casalta-Lopes, Maria Filomena Botelho, Carlos Miguel Marto, Manuel M. Ferreira Materials.2019; 12(20): 3382. CrossRef - Characterization of Odontoblast-like Cell Phenotype and Reparative Dentin Formation In Vivo: A Comprehensive Literature Review
Dimitrios Tziafas Journal of Endodontics.2019; 45(3): 241. CrossRef - Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview – part I: vital pulp therapy
M. Parirokh, M. Torabinejad, P. M. H. Dummer International Endodontic Journal.2018; 51(2): 177. CrossRef - Effects of calcium silicate cements on dental pulp cells: A systematic review
Ramy Emara, Karim Elhennawy, Falk Schwendicke Journal of Dentistry.2018; 77: 18. CrossRef - Biodentine™ material characteristics and clinical applications: a 3 year literature review and update
S. Rajasekharan, L. C. Martens, R. G. E. C. Cauwels, R. P. Anthonappa European Archives of Paediatric Dentistry.2018; 19(1): 1. CrossRef - The Relationship of Surface Characteristics and Antimicrobial Performance of Pulp Capping Materials
Cher Farrugia, Christie Y.K. Lung, Pierre Schembri Wismayer, Maria Teresa Arias-Moliz, Josette Camilleri Journal of Endodontics.2018; 44(7): 1115. CrossRef - Effect of iRoot Fast Set root repair material on the proliferation, migration and differentiation of human dental pulp stem cells in vitro
Yan Sun, Tao Luo, Ya Shen, Markus Haapasalo, Ling Zou, Jun Liu, Gianpaolo Papaccio PLOS ONE.2017; 12(10): e0186848. CrossRef - Influence of Biodentine® - A Dentine Substitute - On Collagen Type I Synthesis in Pulp Fibroblasts In Vitro
Frangis Nikfarjam, Kim Beyer, Anke König, Matthias Hofmann, Manuel Butting, Eva Valesky, Stefan Kippenberger, Roland Kaufmann, Detlef Heidemann, August Bernd, Nadja Nicole Zöller, Dimitrios Karamichos PLOS ONE.2016; 11(12): e0167633. CrossRef - Effect of an Experimental Direct Pulp-capping Material on the Properties and Osteogenic Differentiation of Human Dental Pulp Stem Cells
Fan Yu, Yan Dong, Yan-wei Yang, Ping-ting Lin, Hao-han Yu, Xiang Sun, Xue-fei Sun, Huan Zhou, Li Huang, Ji-hua Chen Scientific Reports.2016;[Epub] CrossRef
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