Restorative Dentistry & Endodontics

Jayakumar Jayaraman

2 Articles

Effect of QMix irrigant in removal of smear layer in root canal system: a systematic review of in vitro studies: Margaret Soo Yee Chia, Abhishek Parolia, Benjamin Syek Hur Lim, Jayakumar Jayaraman, Isabel Cristina Celerino de Moraes Porto; Restor Dent Endod 2020;45(3):e28. Published online May 21, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e28

Objectives

To evaluate the outcome of in vitro studies comparing the effectiveness of QMix irrigant in removing the smear layer in the root canal system compared with other irrigants.

Materials and Methods

The research question was developed by using Population, Intervention, Comparison, Outcome and Study design framework. Literature search was performed using 3 electronic databases PubMed, Scopus, and EBSCOhost until October 2019. Two reviewers were independently involved in the selection of the articles and data extraction process. Risk of bias of the studies was independently appraised using revised Cochrane Risk of Bias tool (RoB 2.0) based on 5 domains.

Results

Thirteen studies fulfilled the selection criteria. The overall risk of bias was moderate. QMix was found to have better smear layer removal ability than mixture of tetracycline isonomer, an acid and a detergent (MTAD), sodium hypochlorite (NaOCl), and phytic acid. The efficacy was less effective than 7% maleic acid and 10% citric acid. No conclusive results could be drawn between QMix and 17% ethylenediaminetetraacetic acid due to conflicting results. QMix was more effective when used for 3 minutes than 1 minute.

Conclusions

QMix has better smear layer removal ability compared to MTAD, NaOCl, Tubulicid Plus, and Phytic acid. In order to remove the smear layer more effectively with QMix, it is recommended to use it for a longer duration.

Citations

Citations to this article as recorded by

Biological and chemical properties of new multi-functional root canal irrigants
Nidambur Vasudev Ballal, Rajkumar Narkedamalli, Padmaja A Shenoy, Shubhankar Das, Saravana Karthikeyan Balasubramanian, Jothi Varghese, Herman Sunil Dsouza, Kevin Epps, Theodroe Ravenel, Franklin R. Tay
Journal of Dentistry.2025; 153: 105551. CrossRef
Chitosan’s Ability to Remove the Smear Layer—A Systematic Review of Ex Vivo Studies
Ana Ferreira-Reguera, Inês Ferreira, Irene Pina-Vaz, Benjamín Martín-Biedma, José Martín-Cruces
Medicina.2025; 61(1): 114. CrossRef
The advancement in irrigation solution within the field of endodontics, A Review
Fatima Fahad , Raghad A Al-Hashimi , Munther J Hussain
Journal of Baghdad College of Dentistry.2024; 36(1): 54. CrossRef
The effect of final irrigation with different solutions on smear layer removal and dentin erosion: A scanning electron microscope study
Mohammed AlBatati, Ammar AbuMostafa, Miriam Fatima Zaccaro Scelza
PLOS ONE.2024; 19(8): e0308606. CrossRef
Effect of QMix as final irrigation protocol on periapical healing after single‐visit root canal treatment: A randomised controlled clinical trial
Cemre Sapmaz Ucan, Aysin Dumani, Ilker Unal, Sehnaz Yilmaz, Oguz Yoldas
Australian Endodontic Journal.2023; 49(S1): 113. CrossRef
Effectiveness of Different Final Irrigation Procedures on Enterococcus faecalis Infected Root Canals: An In Vitro Evaluation
Sanda Ileana Cîmpean, Ioana-Sofia Pop-Ciutrila, Sebastian-Roberto Matei, Ioana Alina Colosi, Carmen Costache, Gheorghe Zsolt Nicula, Iulia Clara Badea, Loredana Colceriu Burtea
Materials.2022; 15(19): 6688. CrossRef
Evaluation of a Novel Tool for Apical Plug Formation during Apexification of Immature Teeth
Yasser Alsayed Tolibah, Line Droubi, Saleh Alkurdi, Mohammad Tamer Abbara, Nada Bshara, Thuraya Lazkani, Chaza Kouchaji, Ibrahim Ali Ahmad, Ziad D. Baghdadi
International Journal of Environmental Research and Public Health.2022; 19(9): 5304. CrossRef
Influence of chelating solutions on tubular dentin sealer penetration: A systematic review with network meta‐analysis
Felipe de Souza Matos, Camila Maria Peres de Rosatto, Thaís Christina Cunha, Maria Tereza Campos Vidigal, Cauane Blumenberg, Luiz Renato Paranhos, Camilla Christian Gomes Moura
Australian Endodontic Journal.2021; 47(3): 715. CrossRef

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Antimicrobial efficacy of QMix on Enterococcus faecalis infected root canals: a systematic review of in vitro studies: Benjamin Syek Hur Lim, Abhishek Parolia, Margaret Soo Yee Chia, Jayakumar Jayaraman, Venkateshbabu Nagendrababu; Restor Dent Endod 2020;45(2):e23. Published online March 11, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e23

Abstract PDF PubReader ePub

Objectives

This study aimed to summarize the outcome of in vitro studies comparing the antibacterial effectiveness of QMix with other irrigants against Enterococcus faecalis.

Materials and Methods

The research question was developed by using population, intervention, comparison, outcome, and study design framework. The literature search was performed using 3 electronic databases: PubMed, Scopus, and EBSCOhost until October 2019. The additional hand search was performed from the reference list of the eligible studies. The risk of bias of the studies was independently appraised using the revised Cochrane Risk of Bias tool (RoB 2.0).

Results

Fourteen studies were included in this systematic review. The overall risk of bias for the selected studies was moderate. QMix was found to have a higher antimicrobial activity compared to 2% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA), 2% chlorhexidine (CHX), mixture of tetracycline isonomer, an acid and a detergent (MTAD), 0.2% Cetrimide, SilverSol/H2O2, HYBENX, and grape seed extract (GSE). QMix had higher antibacterial efficacy compared to NaOCl, only when used for a longer time (10 minutes) and with higher volume (above 3 mL).

Conclusions

QMix has higher antibacterial activity than 17% EDTA, 2% CHX, MTAD, 0.2% Cetrimide, SilverSol/H2O2, HYBENX, GSE and NaOCl with lower concentration. To improve the effectiveness, QMix is to use for a longer time and at a higher volume.

Trial Registration

PROSPERO International prospective register of systematic reviews Identifier: CRD42018096763

Citations

Citations to this article as recorded by

Smear layer removal and antimicrobial efficacy of chitosan as a root canal irrigant: a systematic review of in-vitro studies
Karthikeyan Anbalagan, Amit Jena, Saumyakanta Mohanty, Rashmirekha Mallick, Govind Shashirekha, Priyanka Sarangi
Odontology.2025; 113(1): 61. CrossRef
Limosilactobacillus Fermentun ZS09 Can Improve Antibiotic-Induced Motor Dysfunction in Mice by Regulating the Brain–Gut Functions
Yang Yang, Yuanji Zhao, Huan Lei, Xiaohong Tan
Journal of Inflammation Research.2024; Volume 17: 10093. CrossRef
Regulation of colon injury and improvement of exercise performance in exhausted running mice by Lactobacillus pentosus CQZC02
Limin Cai, Beibei Wang
Frontiers in Physiology.2024;[Epub] CrossRef
A Local Desiccant Antimicrobial Agent as an Alternative to Adjunctive Antibiotics in the Treatment of Periodontitis: A Narrative Review
Iulia C. Micu, Alexandrina Muntean, Alexandra Roman, Ștefan I. Stratul, Emöke Pall, Andreea Ciurea, Andrada Soancă, Marius Negucioiu, Lucian Barbu Tudoran, Ada G. Delean
Antibiotics.2023; 12(3): 456. CrossRef
An in-vitro analysis to evaluate the disinfection effectiveness of Cold Atmospheric Pressure (CAP) plasma jet in Enterococcus faecalis infected root canals
Pravin Kumar, P. Soundharrajan, Ram Prakash, Sarika Prabhakar Kombade, Pankaj Yadav, Ankita Chugh, Arun Kumar Patnana
Biomaterial Investigations in Dentistry.2023;[Epub] CrossRef
Effect of two graphene derivatives on Enterococcus faecalis biofilms and cytotoxicity
Mi-Ah KIM, Vinicius ROSA, Kyung-San MIN
Dental Materials Journal.2023; 42(2): 211. CrossRef
Antibacterial Activity of Endodontic Gutta-Percha—A Systematic Review
Jakub Kowalski, Joanna Rygas, Karolina Homa, Wojciech Dobrzyński, Rafal J. Wiglusz, Jacek Matys, Maciej Dobrzyński
Applied Sciences.2023; 14(1): 388. CrossRef
Evaluation of the Antibacterial Efficacy of QMix and AgNP Solutions in Root Canals of Primary Molars: An In-Vitro Study
Dania Alkhourbotly, Mohamed K Altinawi, Rouaida Abou-Samra, Hasan M Alzoubi, Abedulrahman K Ebrahim
Cureus.2022;[Epub] CrossRef
Microbiological Aspects of Root Canal Infections and Disinfection Strategies: An Update Review on the Current Knowledge and Challenges
Jasmine Wong, Daniel Manoil, Peggy Näsman, Georgios N. Belibasakis, Prasanna Neelakantan
Frontiers in Oral Health.2021;[Epub] CrossRef

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