Restorative Dentistry & Endodontics

Hyunjung Ko

4 Articles

Effects of the cathepsin K inhibitor with mineral trioxide aggregate cements on osteoclastic activity: Hee-Sun Kim, Soojung Kim, Hyunjung Ko, Minju Song, Miri Kim; Restor Dent Endod 2019;44(2):e17. Published online April 23, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e17

Objectives

Root resorption is an unexpected complication after replantation procedures. Combining anti-osteoclastic medicaments with retrograde root filling materials may avert this resorptive activity. The purpose of this study was to assess effects of a cathepsin K inhibitor with calcium silicate-based cements on osteoclastic activity.

Methods

MC3T3-E1 cells were cultured for biocompatibility analyses. RAW 264.7 cells were cultured in the presence of the receptor activator of nuclear factor-kappa B and lipopolysaccharide, followed by treatment with Biodentine (BIOD) or ProRoot MTA with or without medicaments (Odanacatib [ODN], a cathepsin inhibitor and alendronate, a bisphosphonate). After drug treatment, the cell counting kit-8 assay and Alizarin red staining were performed to evaluate biocompatibility in MC3T3-E1 cells. Reverse-transcription polymerase chain reaction, tartrate-resistant acid phosphatase (TRAP) staining and enzyme-linked immunosorbent assays were performed in RAW 264.7 cells to determine the expression levels of inflammatory cytokines, interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2). Data were analyzed by one-way analysis of variance and Tukey's post hoc test (p < 0.05).

Results

Biocompatibility results showed that there were no significant differences among any of the groups. RAW 264.7 cells treated with BIOD and ODN showed the lowest levels of TNF-α and PGE2. Treatments with BIOD + ODN were more potent suppressors of inflammatory cytokine expression (p < 0.05).

Conclusion

The cathepsin K inhibitor with calcium silicate-based cement inhibits osteoclastic activity. This may have clinical application in preventing inflammatory root resorption in replanted teeth.

Citations

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Root-filling materials for endodontic surgery: biological and clinical aspects
Andreas Koutroulis, Vasileios Kapralos, Dag Ørstavik, Pia Titterud Sunde
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Effect of intra‐alveolar delivery of Frondoside A on inflammatory response of delayed tooth replantation
Lar Herr, Ju Ri Ye, Sang Wook Kang, Sang Tae Ro, Yong Kwon Chae, Ko Eun Lee, Mi Sun Kim, Myeong Kwan Jih, Chunui Lee, Sung Chul Choi, Ok Hyung Nam
Dental Traumatology.2024; 40(2): 178. CrossRef
Bone-targeting PLGA derived lipid drug delivery system ameliorates bone loss in osteoporotic ovariectomized rats
Youyun Zeng, Yiding Shen, Shuyi Wu, Lei Cai, Zhen Wang, Kexin Cai, Jiating Shen, Kendrick Hii Ru Yie, Hualin Zhang, Lihua Xu, Jinsong Liu
Materials & Design.2022; 221: 110967. CrossRef

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Cytotoxicity and biocompatibility of Zirconia (Y-TZP) posts with various dental cements: Hyeongsoon Shin, Hyunjung Ko, Miri Kim; Restor Dent Endod 2016;41(3):167-175. Published online May 30, 2016; DOI: https://doi.org/10.5395/rde.2016.41.3.167

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Objectives

Endodontically treated teeth with insufficient tooth structure are often restored with esthetic restorations. This study evaluated the cytotoxicity and biological effects of yttria partially stabilized zirconia (Y-TZP) blocks in combination with several dental cements.

Materials and Methods

Pairs of zirconia cylinders with medium alone or cemented with three types of dental cement including RelyX U200 (3M ESPE), FujiCEM 2 (GC), and Panavia F 2.0 (Kuraray) were incubated in medium for 14 days. The cytotoxicity of each supernatant was determined using 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays on L929 fibroblasts and MC3T3-E1 osteoblasts. The levels of interleukin-6 (IL-6) mRNA were evaluated by reverse transcription polymerase chain reaction (RT-PCR), and IL-6 protein was evaluated by enzyme-linked immunosorbent assays (ELISA). The data were analyzed using one-way ANOVA and Tukey post-hoc tests. A p < 0.05 was considered statistically significant.

Results

The MTT assays showed that MC3T3-E1 osteoblasts were more susceptible to dental cements than L929 fibroblasts. The resin based dental cements increased IL-6 expression in L929 cells, but reduced IL-6 expression in MC3T3-E1 cells.

Conclusions

Zirconia alone or blocks cemented with dental cement showed acceptable biocompatibilities. The results showed resin-modified glass-ionomer based cement less produced inflammatory cytokines than other self-adhesive resin-based cements. Furthermore, osteoblasts were more susceptible than fibroblasts to the biological effects of dental cement.

Citations

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The Saudi Dental Journal.2021; 33(6): 322. CrossRef
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Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques.2021; 15(S1): S137. CrossRef
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Cytotoxic effects of different self-adhesive resin cements: Cell viability and induction of apoptosis
Soner Şişmanoğlu, Mustafa Demirci, Helmut Schweikl, Gunes Ozen-Eroglu, Esin Cetin-Aktas, Serap Kuruca, Safa Tuncer, Neslihan Tekce
The Journal of Advanced Prosthodontics.2020; 12(2): 89. CrossRef
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Jiaxue Yang, Mengyuan Liao, Gaoying Hong, Shiqi Dai, Jiadi Shen, Haifeng Xie, Chen Chen
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In Vitro Cytotoxicity of Self-Adhesive Dual-Cured Resin Cement Polymerized Beneath Three Different Cusp Inclinations of Zirconia
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M. Imran, Saira Riaz, Ifra Sanaullah, Usman Khan, Anjum N. Sabri, Shahzad Naseem
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Raquel Galante, Celio G. Figueiredo-Pina, Ana Paula Serro
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Reinforcement of dental resin composite via zirconium hydroxide coating and phosphate ester monomer conditioning of nano-zirconia fillers
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The effects of bone morphogenetic protein-2 and enamel matrix derivative on the bioactivity of mineral trioxide aggregate in MC3T3-E1cells: Youngdan Jeong, Wonkyung Yang, Hyunjung Ko, Miri Kim; Restor Dent Endod 2014;39(3):187-194. Published online June 19, 2014; DOI: https://doi.org/10.5395/rde.2014.39.3.187

Abstract PDF PubReader ePub

Objectives

The effects of bone morphogenetic protein-2 (BMP-2) and enamel matrix derivative (EMD) respectively with mineral trioxide aggregate (MTA) on hard tissue regeneration have been investigated in previous studies. This study aimed to compare the osteogenic effects of MTA/BMP-2 and MTA/EMD treatment in MC3T3-E1 cells.

Materials and Methods

MC3T3-E1 cells were treated with MTA (ProRoot, Dentsply), BMP-2 (R&D Systems), EMD (Emdogain, Straumann) separately and MTA/BMP-2 or MTA/EMD combination. Mineralization was evaluated by staining the calcium deposits with alkaline phosphatase (ALP, Sigma-Aldrich) and Alizarin red (Sigma-Aldrich). The effects on the osteoblast differentiation were evaluated by the expressions of osteogenic markers, including ALP, bone sialoprotein (BSP), osteocalcin (OCN), osteopontin (OPN) and osteonectin (OSN), as determined by reverse-transcription polymerase chain reaction analysis (RT-PCR, AccuPower PCR, Bioneer).

Results

Mineralization increased in the BMP-2 and MTA/BMP-2 groups and increased to a lesser extent in the MTA/EMD group but appeared to decrease in the MTA-only group based on Alizarin red staining. ALP expression largely decreased in the EMD and MTA/EMD groups based on ALP staining. In the MTA/BMP-2 group, mRNA expression of OPN on day 3 and BSP and OCN on day 7 significantly increased. In the MTA/EMD group, OSN and OCN gene expression significantly increased on day 7, whereas ALP expression decreased on days 3 and 7 (p < 0.05).

Conclusions

These results suggest the MTA/BMP-2 combination promoted more rapid differentiation in MC3T3-E1 cells than did MTA/EMD during the early mineralization period.

Citations

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Tissue response of Pro-Root® MTA with rhBMP-2 in pulpotomized rat teeth: Kyungtae Park, Wonkyung Yang, Hyunjung Ko, Miri Kim; J Korean Acad Conserv Dent 2007;32(5):403-410. Published online September 30, 2007; DOI: https://doi.org/10.5395/JKACD.2007.32.5.403

Abstract PDF PubReader ePub

The purpose of this study was to investigate whether rhBMP-2 (BMP2) could induce synergistic effect with Pro-Root® MTA (MTA) in pulpotomized teeth in the rats. Healthy upper first molars from thirty-two, 10 weeks old, Sprague-Dawley rats were used for this investigation. The molars were exposed with round bur, and light pressure was applied with sterilized cotton to control hemorrhage. 1.2 grams of MTA cement was placed in right first molars as a control group. In left first molars, 1 µg of BMP2 was additionally placed on exposed pulps with MTA. All cavities were back-filled with light-cured glass-ionomer cements. The rats were sacrificed after 2 weeks and 7 weeks, respectively. Then histologic sections were made and assessed by light microscopy. Data were statistically analyzed via student t-test with SPSSWIN 12.0 program (p < 0.05).

Inflammation observed in 2 weeks groups were severe compared to the 7 weeks groups. But the differences were not statistically significant. BMP2-addition groups had less inflammation than MTA groups in both periods, though these differences were also not statistically significant. In conclusion, the combination of BMP2 and MTA showed no differences with MTA only for pulpotomy of rat teeth.

Citations

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A bioactivity study of Portland cement mixed with β-glycerophosphosphate on human pulp cell
Young-Hwan Oh, Young-Joo Jang, Yong-Bum Cho
Journal of Korean Academy of Conservative Dentistry.2009; 34(5): 415. CrossRef

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