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Original Article Evaluation of Sodium Dichloroisocyanurate as a root canal irrigation solution; Cl- concentration, pH, Cytotoxicity and Antimicrobial effect in vitro
Woo-Cheol Lee, Bong-Sun Kang, Cheol-Ho Kim, Ho-Hyun Son
2003;28(5):-430.
DOI: https://doi.org/10.5395/JKACD.2003.28.5.425
Published online: September 30, 2003

Department of Conservative Dentistry, College of Dentistry, Seoul National University, Korea.

Corresponding author (hhson@snu.ac.kr)

Copyright © 2003 Korean Academy of Conservative Dentistry

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  • The purpose of this study was to evaluate the clinical applications of the Sodium Dichloroisocyanurate effervescent tablet as a routine root canal irrigant by performing several in vitro tests such as Cl- content, cytotoxicity, antimicrobial effect as well as its pH level compared to the equivalent concentration of sodium hypochlorite solution.

    1. Sodium Dichloroisocyanurate demonstrated lower level of Cl- concentation than each dilution of sodium hypochlorite solution. Both solution has increased level of Cl- as the concentration of each solution increased. There was no significant change of Cl- concentration in sodium hypochlorite as time goes by. However, Cl- concentration in Sodium Dichloroisocyanurate was increased.

    2. The antimicrobial effects of both solutions were increased when their concentrations were increased. One day after dilution, antimicrobial effect of Sodium Dichloroisocyanurate was slightly higher than sodium hypochlorite, however, there was no difference in 1 week dilution solution. One month dilution solution of sodium hypochlorite still retain its activity, but antimicrobial effect of Sodium Dichloroisocyanurate was drastically decreased 1 month after dilution.

    3. The cytotoxicity of Sodium Dichloroisocyanurate was rather higher than same concentration of sodium hypochlorite solution until 1 week after dilution. Then in 1 month, cytotoxicity of Sodium Dichloroisocyanurate was decreased than that of 1 week dilution solution, especially 4% Sodium Dichloroisocyanurate solution has almost no toxicity. However, 1% and 2% sodium hypochlorite solution has unchanged moderate degree of cytotoxicity after the dilution. Furthermore, 4% sodium hypochlorite solution showed high level of toxicity.

    4. The pH level of Sodium Dichloroisocyanurate showed that the solution was weak acid (pH5). On the other hand, sodium hypochlorite was revealed as a strong alkaline solution (pH12). There was no change in pH following the dilution of each solution.

    As results, Sodium Dichloroisocyanurate solution fully satisfy the basic requirements as a root canal irrigation solution. However, we strongly recommend to use this solution clinically in low concentration and try to apply into the root canal within 1 week after dilution.
  • Keywords: Root canal irrigant; Sodium dichloroisocyanurate; Cytotoxicity; Antimicrobial effect
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Fig. 1
Cl- concentration in each solution
A : Sodium Dichloroisocyanurate
B : Sodium Hypochlorite
jkacd-28-425-g001.jpg
Fig. 2
Result of antimicrobial test
jkacd-28-425-g002.jpg
Table 1-1
Ingredients of NeoDental®-F
jkacd-28-425-i001.jpg
Table 1-2
Molecule of Sodium Dichloroisocyanuric acid
jkacd-28-425-i002.jpg
Table 2
Cl- concentration(%) in each solution

A : Sodium Dichloroisocyanurate

B : Sodium Hypochlorite

jkacd-28-425-i003.jpg
Table 3
Result of cytotoxicity after 4 hr incubation
jkacd-28-425-i004.jpg
Table 4
pH of each solution
jkacd-28-425-i005.jpg

Tables & Figures

REFERENCES

    Citations

    Citations to this article as recorded by  
    • Evaluation of pH, free available chlorine and tissue dissolution property of solid dosage chlorine releasing agents for root canal irrigation based on contact time – An in vitro study
      S. Aishwarya, Debolina Bishayi, Vinod Rakesh Jathanna, Manuel S. Thomas, Srikant Natarajan, Suchitra Shenoy, Aradhana Marathe
      Endodontology.2025; 37(2): 217.     CrossRef
    • Evaluation of time-dependent antimicrobial effect of sodium dichloroisocyanurate (NaDCC) onEnterococcus faecalisin the root canal
      Hye-Jeong Kim, Se-Hee Park, Kyung-Mo Cho, Jin-Woo Kim
      Journal of Korean Academy of Conservative Dentistry.2007; 32(2): 121.     CrossRef

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      Evaluation of Sodium Dichloroisocyanurate as a root canal irrigation solution; Cl- concentration, pH, Cytotoxicity and Antimicrobial effect in vitro
      J Korean Acad Conserv Dent. 2003;28(5):425-430.   Published online September 30, 2003
      DOI: https://doi.org/10.5395/JKACD.2003.28.5.425
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    Evaluation of Sodium Dichloroisocyanurate as a root canal irrigation solution; Cl- concentration, pH, Cytotoxicity and Antimicrobial effect in vitro
    Image Image
    Fig. 1 Cl- concentration in each solution A : Sodium Dichloroisocyanurate B : Sodium Hypochlorite
    Fig. 2 Result of antimicrobial test

    Fig. 1

    Fig. 2

    Evaluation of Sodium Dichloroisocyanurate as a root canal irrigation solution; Cl- concentration, pH, Cytotoxicity and Antimicrobial effect in vitro

    Ingredients of NeoDental®-F

    Molecule of Sodium Dichloroisocyanuric acid

    Cl- concentration(%) in each solution

    A : Sodium Dichloroisocyanurate

    B : Sodium Hypochlorite

    Result of cytotoxicity after 4 hr incubation

    pH of each solution
    Table 1-1 Ingredients of NeoDental®-F

    Table 1-2 Molecule of Sodium Dichloroisocyanuric acid

    Table 2 Cl- concentration(%) in each solution

    A : Sodium Dichloroisocyanurate

    B : Sodium Hypochlorite

    Table 3 Result of cytotoxicity after 4 hr incubation

    Table 4 pH of each solution

    Table 1-1

    Table 1-2

    Table 2

    Table 3

    Table 4

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