This review aimed to answer the following question “Does photobiomodulation treatment of the root surface decrease the occurrence of root resorption in reimplanted teeth?” Electronic searches were performed in the MEDLINE/PubMed, Cochrane Library, Scopus, Web of Science, Embase, and Grey Literature Report databases. Risk of bias was evaluated using SYRCLE Risk of Bias tool. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) tool was used to assess the certainty of evidence. In total, 6 studies were included. Five studies reported a reduced occurrence of root resorption in teeth that received photobiomodulation treatment of the root surface prior to replantation. Only 1 study reported contradictory results. The photobiomodulation parameters varied widely among studies. GRADE assessment showed a low certainty of evidence. It can be inferred that photobiomodulation treatment of the root surface prior to replantation of teeth can reduce the occurrence of root resorption. Nonetheless, further clinical studies are needed.

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• Feasibility and Outcomes of Cell-based Regenerative Endodontic Therapy in Postautogenous Transplantation of a Mature Tooth: A Case Report
  Noriaki Yoshihashi
  Journal of Endodontics.2025; 51(1): 85.     CrossRef
• Photobiomodulation Literature Watch September 2023
  James D. Carroll
  Photobiomodulation, Photomedicine, and Laser Surgery.2024; 42(7): 498.     CrossRef

Calcium hydroxide (CH) is the gold-standard intracanal dressing for teeth subjected to traumatic avulsion. A common complication after the replantation of avulsed teeth is root resorption (RR). The current review was conducted to compare the effect of CH with that of other intracanal medications and filling materials on inflammatory RR and replacement RR (ankylosis) in replanted teeth. The PubMed and Scopus databases were searched through June 2018 using specific keywords related to the title of the present article. The materials that were compared to CH were in 2 categories: 1) mineral trioxide aggregate (MTA) and endodontic sealers as permanent filling materials for single-visit treatment, and 2) Ledermix, bisphosphonates, acetazolamide, indomethacin, gallium nitrate, and enamel matrix-derived protein (Emdogain) as intracanal medicaments for multiple-visit management of avulsed teeth prior to the final obturation. MTA can be used as a single-visit root filling material; however, there are limited data on its efficacy due to a lack of clinical trials. Ledermix and acetazolamide were comparable to CH in reducing RR. Emdogain seems to be an interesting material, but the data supporting its use as an intracanal medication remain very limited. The conclusions drawn in this study were limited by the insufficiency of clinical trials.

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• Efficacy of Simvastatin in Inhibiting Bone Resorption and Promoting Healing in Delayed Tooth Avulsion: A Case Series
  Rajesh Kumar, Supraja N Atluri, Alekhya Achanta, Chittaranjan Bogishetty, Tejaswini R Chunduri, Tejaswini PSS, Ramakrishna Ravi
  Cureus.2025;[Epub]     CrossRef
• Bioactive potential of Bio-C Temp demonstrated by systemic mineralization markers and immunoexpression of bone proteins in the rat connective tissue
  Camila Soares Lopes, Mateus Machado Delfino, Mário Tanomaru-Filho, Estela Sasso-Cerri, Juliane Maria Guerreiro-Tanomaru, Paulo Sérgio Cerri
  Journal of Materials Science: Materials in Medicine.2024;[Epub]     CrossRef
• The use of mineral trioxide aggregate for treatment of children with complications of dental trauma
  L.Yu. Kharkova, M.V. Korolenkova
  Stomatology.2024; 103(4): 59.     CrossRef
• Instant Re-Implantation of Avulsed Teeth
  Smita Paul, Sambarta Das, Nirmal Debbarma, Barun Dasgupta, Bidyut Seal, Ayesha Satapathy
  Journal of Pharmacy and Bioallied Sciences.2024; 16(Suppl 4): S3461.     CrossRef
• Interpretation by literature review of the use of calcium hydroxide as an intra-ductal medication
  María Belén Muñoz Padilla, Verónica Alicia Vega Martínez, Camila Alejandra Villafuerte Moya
  Salud, Ciencia y Tecnología.2024; 4: 924.     CrossRef
• Evaluation of the physicochemical properties of intracanal medications used in traumatized teeth
  Patricia Almeida da Silva de Macedo, Walbert de Andrade Vieira, Paulo Henrique Gabriel, Karla de Faria Vasconcelos, Francisco Haiter Neto, Ana Carolina Correia Laurindo de Cerqueira Neto, Brenda Paula Figueiredo de Almeida Gomes, Marcos Roberto dos Santo
  Brazilian Journal of Oral Sciences.2024; 23: e242997.     CrossRef
• Treatment of Teeth with Root Resorptions: A Case Report and Systematic Review
  Damla Erkal, Abdullah Başoğlu, Damla Kırıcı, Nezahat Arzu Kayar, Simay Koç, Kürşat Er
  Galician Medical Journal.2023;[Epub]     CrossRef
• Successful outcome of permanent maxillary incisor reimplanted after 30 hours of extra‐oral time—a case report with 5‐year follow‐up
  Ibadat Preet Kaur, Ashok Kumar, Mukul Kumar, Kanistika Jha
  Clinical Case Reports.2023;[Epub]     CrossRef
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  Nishad Kadulkar, Rubi Kataki, Adrija Deka, Salouno Thonai
  Cureus.2023;[Epub]     CrossRef
• Avulsion of Permanent Mandibular Incisors: A Report of Two Cases with Pertinent Literature
  Ibadat Preet Kaur, Jitendra Sharan, Pallawi Sinha, Ashok Kumar, Anand Marya, Leandro Napier de Souza
  Case Reports in Dentistry.2023; 2023: 1.     CrossRef
• The Impact of Autologous Platelet Concentrates on the Periapical Tissues and Root Development of Replanted Teeth: A Systematic Review
  Zohaib Khurshid, Faris Yahya I. Asiri, Shariq Najeeb, Jithendra Ratnayake
  Materials.2022; 15(8): 2776.     CrossRef

The objective of this study was to observe the histology of dental pulp healing after tooth replantation in rats. The maxillary right first molars of 4-week-old rat were extracted, and then the teeth were repositioned in the original socket. At 3 days after replantation, there was localized inflammatory reaction. But, pulp revasculization and healing had already begun in the root area. At 5 days after replantation, odontoblast-like cells were observed. Tertiary dentin deposition was observed beneath the pulp-dentin border from 1 week after replantation. And tertiary dentin was increased at 2 weeks after replantation. The presence of odontoblast-like cells and the formation of tertiary dentin were continued to 4 weeks after replantation. At 4 weeks after replantation, the deposition of bone-like tissues and cementum-like tissues was observed. This results show that there is a possibility of pulp healing after tooth replantation in rats and the mineralization of tooth can progress. The mineralization of tooth after replantation was initially occurred by the deposition of tertiary dentin, but as time passed, the deposition of bone-like tissues and cementum-like tissues was begun and increased.

Citations

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• Doxycycline-Loaded Nitric Oxide-Releasing Nanomatrix Gel in Replanted Rat Molar on Pulp Regeneration
  Kwan-Hee Yun, Mi-Ja Ko, Yong-Kown Chae, Koeun Lee, Ok-Hyung Nam, Hyo-Seol Lee, Kyounga Cheon, Sung-Chul Choi
  Applied Sciences.2021; 11(13): 6041.     CrossRef
• Bio-Photonic Detection and Quantitative Evaluation Method for the Progression of Dental Caries Using Optical Frequency-Domain Imaging Method
  Ruchire Wijesinghe, Nam Cho, Kibeom Park, Mansik Jeon, Jeehyun Kim
  Sensors.2016; 16(12): 2076.     CrossRef