Citations

Citations to this article as recorded by  

• Comparative evaluation of compressive strength and morphological interface of carbonated hydroxyapatite with other pulp capping materials: An in vitro analysis
  S. Swathi Priyadharshini, Chinnasamy Ragavendran, I. Anand Sherwood, Ramanaramya Jeyapalan
  Endodontology.2025; 37(1): 90.     CrossRef

Citations

Citations to this article as recorded by  

• Biodegradable Zn‐5Dy Alloy with Enhanced Osteo/Angio‐Genic Activity and Osteointegration Effect via Regulation of SIRT4‐Dependent Mitochondrial Function
  Yue Han, Xian Tong, Runqi Zhou, Yilin Wang, Yuge Chen, Liang Chen, Xinhua Hong, Linmei Wu, Zhiqiang Lin, Yichi Zhang, Xuejia Zhang, Chaoming Hu, Bin Li, Yifan Ping, Zelin Cao, Zhou Ye, Zhongchen Song, Yuncang Li, Cuie Wen, Yongsheng Zhou, Jixing Lin, Shen
  Advanced Science.2024;[Epub]     CrossRef
• The Role of Histone Acetylation Modification in Dental Tissue-Derived Mesenchymal Stem Cells and Odontogenesis
  Haoling Chen, Zijing Huang, Chuxiao Chen
  Cellular Reprogramming.2023; 25(1): 11.     CrossRef
• Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells
  Haiyun Luo, Yachuan Zhou, Wenjing Liu, Jun Wang
  Stem Cells International.2022; 2022: 1.     CrossRef
• SIRT4 regulates rat dental papilla cell differentiation by promoting mitochondrial functions
  Haoling Chen, Jun Kang, Fuping Zhang, Tong Yan, Wenguo Fan, Hongwen He, Fang Huang
  The International Journal of Biochemistry & Cell Biology.2021; 134: 105962.     CrossRef
• Sirtuins as Interesting Players in the Course of HIV Infection and Comorbidities
  Karolina Jurkowska, Beata Szymańska, Brygida Knysz, Amadeusz Kuźniarski, Agnieszka Piwowar
  Cells.2021; 10(10): 2739.     CrossRef
• Robust expression of SIRT6 inhibits pulpitis via activation of the TRPV1 channel
  Jia Hu, Weiran Chen, Zailing Qiu, Hongbing Lv
  Cell Biochemistry and Function.2020; 38(5): 676.     CrossRef
• Downregulation of microRNA‐143‐5p is required for the promotion of odontoblasts differentiation of human dental pulp stem cells through the activation of the mitogen‐activated protein kinases 14‐dependent p38 mitogen‐activated protein kinases signaling pa
  Bao‐Liang Wang, Zhi Wang, Xi Nan, Qing‐Cai Zhang, Wei Liu
  Journal of Cellular Physiology.2019; 234(4): 4840.     CrossRef
• A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis
  H. Kudo, O. Takeichi, K. Hatori, K. Makino, K. Himi, B. Ogiso
  International Endodontic Journal.2018; 51(7): 747.     CrossRef
• Overexpressed Sirt1 in MSCs Promotes Dentin Formation in Bmi1-Deficient Mice
  H. Wang, C. Lv, Y. Gu, Q. Li, L. Xie, H. Zhang, D. Miao, W. Sun
  Journal of Dental Research.2018; 97(12): 1365.     CrossRef
• Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas
  Hiroshi Kudo, Osamu Takeichi, Kosuke Makino, Keisuke Hatori, Bunnai Ogiso
  Journal of Oral Science.2018; 60(3): 411.     CrossRef
• TET1 knockdown inhibits the odontogenic differentiation potential of human dental pulp cells
  Li-Jia Rao, Bai-Cheng Yi, Qi-Meng Li, Qiong Xu
  International Journal of Oral Science.2016; 8(2): 110.     CrossRef

Genetic information such as DNA sequences has been limited to fully explain mechanisms of gene regulation and disease process. Epigenetic mechanisms, which include DNA methylation, histone modification and non-coding RNAs, can regulate gene expression and affect progression of disease. Although studies focused on epigenetics are being actively investigated in the field of medicine and biology, epigenetics in dental research is at the early stages. However, studies on epigenetics in dentistry deserve attention because epigenetic mechanisms play important roles in gene expression during tooth development and may affect oral diseases. In addition, understanding of epigenetic alteration is important for developing new therapeutic methods. This review article aims to outline the general features of epigenetic mechanisms and describe its future implications in the field of dentistry.

Citations

Citations to this article as recorded by  

• Conversation between skin microbiota and the host: from early life to adulthood
  Jimin Cha, Tae-Gyun Kim, Ji-Hwan Ryu
  Experimental & Molecular Medicine.2025;[Epub]     CrossRef
• Effect of Long Non-coding RNA and DNA Methylation on Gene Expression in Dental Fluorosis
  Xiaoyan Hu, Huiru Li, Minzhi Yang, Yujiong Chen, Ailin Zeng, Jiayuan Wu, Jian Zhang, Yuan Tian, Jing Tang, Shengyan Qian, Mingsong Wu
  Biological Trace Element Research.2024; 202(1): 221.     CrossRef
• MicroRNAs: Mighty Mite RNAs in Oral Diseases
  Devapriya Appukuttan, P. S. G. Prakash
  Journal of Interdisciplinary Dentistry.2024; 14(3): 145.     CrossRef
• Role of epigenetics in OSCC: an understanding above genetics
  Priyanka P. Vatsa, Yogita Jindal, Janhavi Bhadwalkar, Ambika Chamoli, Vinal Upadhyay, Amit Mandoli
  Medical Oncology.2023;[Epub]     CrossRef
• Downregulation of miRNA‐26 in chronic periodontitis interferes with innate immune responses and cell migration by targeting phospholipase C beta 1
  Juhi R. Uttamani, Afsar R. Naqvi, Araceli Maria Valverde Estepa, Varun Kulkarni, Maria F. Brambila, Gloria Martínez, Gabriela Chapa, Christine D. Wu, Wei Li, Sona Rivas‐Tumanyan, Salvador Nares
  Journal of Clinical Periodontology.2023; 50(1): 102.     CrossRef
• The Potential Role of Epigenetic Modifications on Different Facets in the Periodontal Pathogenesis
  Samuel Laberge, Daniel Akoum, Piotr Wlodarczyk, Jean-Daniel Massé, Dominique Fournier, Abdelhabib Semlali
  Genes.2023; 14(6): 1202.     CrossRef
• The Role of Histone Acetylation Modification in Dental Tissue-Derived Mesenchymal Stem Cells and Odontogenesis
  Haoling Chen, Zijing Huang, Chuxiao Chen
  Cellular Reprogramming.2023; 25(1): 11.     CrossRef
• Your health is in your mouth: A comprehensive view to promote general wellness
  Antonia Barranca-Enríquez, Tania Romo-González
  Frontiers in Oral Health.2022;[Epub]     CrossRef
• A Brief Landscape of Epigenetic Mechanisms in Dental Pathologies
  Wojciech Tynior, Joanna Katarzyna Strzelczyk
  Cytology and Genetics.2022; 56(5): 475.     CrossRef
• Influence of epigenetics on periodontitis and peri‐implantitis pathogenesis
  Lena Larsson, Nolan M. Kavanagh, Trang V. N. Nguyen, Rogerio M. Castilho, Tord Berglundh, William V. Giannobile
  Periodontology 2000.2022; 90(1): 125.     CrossRef
• DNA methylation alterations and their potential influence on macrophage in periodontitis
  Yiyang Jiang, Jingfei Fu, Juan Du, Zhenhua Luo, Lijia Guo, Junji Xu, Yi Liu
  Oral Diseases.2022; 28(2): 249.     CrossRef
• Stabilizing and Anti-Repressor Elements Effectively Increases Transgene Expression in Transfected CHO Cells
  Qin Li, Rui-Fang Yan, Yong-Xiao Yang, Chun-liu Mi, Yan-long Jia, Tian-Yun Wang
  Frontiers in Bioengineering and Biotechnology.2022;[Epub]     CrossRef
• Synthesis and Anticancer Potential of New Hydroxamic Acid Derivatives as Chemotherapeutic Agents
  Işıl Nihan Korkmaz, Hasan Özdemir
  Applied Biochemistry and Biotechnology.2022; 194(12): 6349.     CrossRef
• Impact of Epigenetic Alterations in the Development of Oral Diseases
  Rodopi Emfietzoglou, Evangelos Pachymanolis, Christina Piperi
  Current Medicinal Chemistry.2021; 28(6): 1091.     CrossRef
• Basics of Epigenetics and Role of Epigenetics in Diabetic Complications
  Andamuthu Yamunadevi, Ramani Pratibha, Muthusamy Rajmohan, Sengottaiyan Mahendraperumal, Nalliappan Ganapathy
  Journal of Pharmacy and Bioallied Sciences.2021; 13(Suppl 1): S336.     CrossRef
• Effects of Epigenetic Regulation on Cancer
  Muhammet Mesut Nezir ENGİN, Esra ÖZEN ENGİN, Recep ERÖZ, Gorkem DULGER, Hüseyin YÜCE
  Journal of Biotechnology and Strategic Health Research.2021; 5(1): 1.     CrossRef
• Photobiomodulation therapy improves human dental pulp stem cell viability and migration in vitro associated to upregulation of histone acetylation
  Ivana M. Zaccara, Letícia B. Mestieri, Emily F. S. Pilar, Maria S. Moreira, Fabiana S. Grecca, Manoela D. Martins, Patrícia Maria Poli Kopper
  Lasers in Medical Science.2020; 35(3): 741.     CrossRef
• The Biology of Social Adversity Applied to Oral Health
  N. Gomaa, H. Tenenbaum, M. Glogauer, C. Quiñonez
  Journal of Dental Research.2019; 98(13): 1442.     CrossRef
• The effect of DNA methylation on the miRNA expression pattern in lipopolysaccharide-induced inflammatory responses in human dental pulp cells
  Zehuan Mo, Qimeng Li, Luhui Cai, Minkang Zhan, Qiong Xu
  Molecular Immunology.2019; 111: 11.     CrossRef
• One-Carbon Metabolism Links Nutrition Intake to Embryonic Development via Epigenetic Mechanisms
  Si Wu, Jun Zhang, Feifei Li, Wei Du, Xin Zhou, Mian Wan, Yi Fan, Xin Xu, Xuedong Zhou, Liwei Zheng, Yachuan Zhou
  Stem Cells International.2019; 2019: 1.     CrossRef
• Epigenetic regulation in dental pulp inflammation
  T Hui, C Wang, D Chen, L Zheng, D Huang, L Ye
  Oral Diseases.2017; 23(1): 22.     CrossRef
• Current Concepts of Epigenetics and Its Role in Periodontitis
  Lena Larsson
  Current Oral Health Reports.2017; 4(4): 286.     CrossRef
• The periodontal war: microbes and immunity
  Jeffrey L. Ebersole, Dolph Dawson, Pinar Emecen‐Huja, Radhakrishnan Nagarajan, Katherine Howard, Martha E. Grady, Katherine Thompson, Rebecca Peyyala, Ahmad Al‐Attar, Kathryn Lethbridge, Sreenatha Kirakodu, Octavio A. Gonzalez
  Periodontology 2000.2017; 75(1): 52.     CrossRef
• Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells
  Niamh Harraghy, David Calabrese, Igor Fisch, Pierre‐Alain Girod, Valérie LeFourn, Alexandre Regamey, Nicolas Mermod
  Biotechnology Journal.2015; 10(7): 967.     CrossRef
• Protocol for assessing maternal, environmental and epigenetic risk factors for dental caries in children
  Surani Fernando, David J. Speicher, Mahmoud M. Bakr, Miles C. Benton, Rodney A. Lea, Paul A. Scuffham, Gabor Mihala, Newell W. Johnson
  BMC Oral Health.2015;[Epub]     CrossRef

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• iPSC-derived cranial neural crest-like cells can replicate dental pulp tissue with the aid of angiogenic hydrogel
  Yoshifumi Kobayashi, Julie Nouet, Erdenechimeg Baljinnyam, Zain Siddiqui, Daniel H. Fine, Diego Fraidenraich, Vivek A. Kumar, Emi Shimizu
  Bioactive Materials.2022; 14: 290.     CrossRef
• The role of sclerostin and dickkopf-1 in oral tissues – A review from the perspective of the dental disciplines
  Mohammad Samiei, Klara Janjić, Barbara Cvikl, Andreas Moritz, Hermann Agis
  F1000Research.2019; 8: 128.     CrossRef
• The Influence of Pro-Inflammatory Factors on Sclerostin and Dickkopf-1 Production in Human Dental Pulp Cells Under Hypoxic Conditions
  Klara Janjić, Mohammad Samiei, Andreas Moritz, Hermann Agis
  Frontiers in Bioengineering and Biotechnology.2019;[Epub]     CrossRef
• Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures
  Klara Janjić, Barbara Cvikl, Christoph Kurzmann, Andreas Moritz, Hermann Agis
  BMC Oral Health.2018;[Epub]     CrossRef
• The effects of dexamethasone on the apoptosis and osteogenic differentiation of human periodontal ligament cells
  Sung-Mi Kim, Yong-Gun Kim, Jin-Woo Park, Jae-Mok Lee, Jo-Young Suh
  Journal of Periodontal & Implant Science.2013; 43(4): 168.     CrossRef

Citations

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• Analysis of gene expression during odontogenic differentiation of cultured human dental pulp cells
  Min-Seock Seo, Kyung-Gyun Hwang, Hyongbum Kim, Seung-Ho Baek
  Restorative Dentistry & Endodontics.2012; 37(3): 142.     CrossRef

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• Evaluation of bioactivity, biocompatibility, and antibacterial properties of tricalcium silicate bone cement modified with wollastonite/ fluorapatite glass and glass-ceramic
  H.K. Abd El-Hamid, A.M. Fayad, R.L. Elwan
  Ceramics International.2024; 50(14): 25322.     CrossRef
• Influence of insulin on the healing of exposed dental pulp after pulp capping: An experimental study in a dog model
  Mokhtar A. Al‐Anesi, Ashraf M. Abu‐Seida, Salma H. El Ashry, Abeer H. Mahran, Ehab S. Abd‐Elhamid
  Special Care in Dentistry.2021; 41(1): 49.     CrossRef
• ROOT END FILLING MATERIALS – A REVIEW
  Bynagari Chandra Shekar, Veerendra Uppin, Madhu Pujar
  GLOBAL JOURNAL FOR RESEARCH ANALYSIS.2021; : 5.     CrossRef
• Effects of two fast-setting calcium-silicate cements on cell viability and angiogenic factor release in human pulp-derived cells
  Chooryung J. Chung, Euiseong Kim, Minju Song, Jeong-Won Park, Su-Jung Shin
  Odontology.2016; 104(2): 143.     CrossRef
• Cytotoxicity and physical properties of tricalcium silicate-based endodontic materials
  Young-Eun Jang, Bin-Na Lee, Jeong-Tae Koh, Yeong-Joon Park, Nam-Eok Joo, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Yun-Chan Hwang
  Restorative Dentistry & Endodontics.2014; 39(2): 89.     CrossRef
• Biocompatibility of root-end filling materials: recent update
  Payal Saxena, Saurabh Kumar Gupta, Vilas Newaskar
  Restorative Dentistry & Endodontics.2013; 38(3): 119.     CrossRef

This study investigated the changes in gene expression when mineral trioxide aggregate (MTA) was applied in vitro to human dental pulp cells (HDPCs). MTA in a teflon tube (diameter 10 mm, height 2 mm) was applied to HDPCs. Empty tube-applied HDPCs were used as negative control. For microarray analysis, total RNA was extracted at 6, 24, and 72 hrs after MTA application. The results were confirmed selectively by performing reverse transcriptase polymerase chain reaction for genes that showed changes of more than two-fold or less than half. Of the 24,546 genes, 109 genes were up-regulated greater than two-fold (e.g., FOSB, THBS1, BHLHB2, EDN1, IL11, FN1, COL10A1, and TUFT1) and 69 genes were down-regulated below 50% (e.g., SMAD6 and DCN). These results suggest that MTA, rather than being a bio-inert material, may have potential to affect the proliferation and differentiation of pulp cells in various ways.

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• Analysis of gene expression during odontogenic differentiation of cultured human dental pulp cells
  Min-Seock Seo, Kyung-Gyun Hwang, Hyongbum Kim, Seung-Ho Baek
  Restorative Dentistry & Endodontics.2012; 37(3): 142.     CrossRef
• Comparison of gene expression profiles of human dental pulp cells treated with mineral trioxide aggregate and calcium hydroxide
  Yong-Beom Kim, Won-Jun Shon, Woocheol Lee, Kee-Yeon Kum, Seung-Ho Baek, Kwang-Shik Bae
  Journal of Korean Academy of Conservative Dentistry.2011; 36(5): 397.     CrossRef

The purpose of this study was to characterize functional distinction between human dental pulp cells(PC) and periodontal ligament cells(PDLC) using cDNA microarray assay and to confirm the results of the microarray assay using RT-PCR. 3 genes out of 51 genes which were found to be more expressed(>2 fold) in PC were selected, and 3 genes out of 19 genes which were found to be more expressed(>2 fold) in PDLC were selected for RT-PCR as well.

According to this study, the results were as follows:

1. From the microarray assay, 51 genes were more expressed (2 fold) from PC than PDLC.

2. RT-PCR confirmed that ITGA4 and TGF β2 were more expressed in PC than in PDLC.

3. From the microarray assay, 19 genes were more expressed (2 fold) from PDLC than PC.

4. RT-PCR confirmed that LUM, WISP1, and MMP1 were more expressed in PDLC than in PC.

From the present study, different expression of the genes between the PC and PDLC were characterized to show the genes which play an important role in dentinogenesis were more expressed from PC than PDLC, while the genes which were related with collagen synthesis were more expressed from PDLC than PC.

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• Gene expression profiling in human dental pulp cells treated with mineral trioxide aggregate
  Yong-Beom Kim, Won-Jun Shon, WooCheol Lee, Kee-Yeon Kum, Seung-Ho Baek, Kwang-Shik Bae
  Journal of Korean Academy of Conservative Dentistry.2010; 35(3): 152.     CrossRef

The purpose of this study is to investigate the response of human pulp cell on Portland cement mixed with β-glycerophosphate. To investigate the effect of β-glycerophosphate and/or dexamethasone on human pulp cell, ALP activity on various concentration of β-glycerophosphate and dexamethasone was measured and mineral nodule of human pulp cell was stained with Alizarin red S. MTS assay and ALP activity of human pulp cell on Portland cement mixed with various concentration of β-glycerophosphate (10 mM, 100mM, 1M) was measured and the specimens were examined under SEM.

Addition of β-glycerophosphate or dexamethasone alone had no effect however, the addition of 5 mM β-glycerophosphate and 100 nM dexamethasone had the largest increasement in ALP activity. There was no toxicity in all samples and the data showed that Portland cement mixed with 10 mM β-glycerophosphate had more increase in ALP activity compared with control.

In conclusion, Portland cement mixed with β-glycerophosphate has no toxicity and promotes differentiation and mineralization of pulp cell compared with additive-free Portland cement. This implicated that application of Portland cement mixed with β-glycerophosphate might form more reparative dentin and in turn it would bring direct pulp capping to success.

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• Dentinogenic potential of human adult dental pulp cells during the extended primary culture
  Jin-Hee Min, Seon-Yle Ko, Yong-Bum Cho, Chun-Jeih Ryu, Young-Joo Jang
  Human Cell.2011; 24(1): 43.     CrossRef

Dental pulp is a loose, mesenchymal tissue almost entirely enclosed in the dentin. It consists of cells, ground substance, and neural and vascular supplies. Damage to the dental pulp by mechanical, chemical, thermal, and microbial irritants can provoke various types of inflammatory response. Pulpal inflammation leads to the tissue degradation, which is mediated in part by Matrix metalloproteinase leads to accelerate extracellular matrix degradation with pathological pathway. We have now investigated the induction of MMPs and inflammatory cytokines by Lipopolysaccharide (LPS) control of inflammatory mediators by peroxisome proliferator-activated receptors (PPARs).

Human dental pulp cells exposed to various concentrations of LPS (1-10 µg/ml) revealed elevated levels of MMP-2 and MMP-9 at 24 hrs of culture. LPS also stimulated the production of ICAM-1, VCAM-1, IL-1β, and TNF-α. Adenovirus PPARγ (Ad/PPARγ) and PPARγ agonist rosiglitazone reduced the synthesis of MMPs, adhesion molecules and pro-inflammatory cytokines. The inhibitory effect of Ad/PPARγ was higher than that of PPARγ agonist.

These result offer new insights in regard to the anti-inflammatory potential of PPARγ in human dental pulp cell.

The purpose of this study was to regenerate human dental pulp tissues similar to native pulp tissues. Using the mixture of type I collagen solution, primary cells collected from the different tissues (pulp, gingiva, and skin) and NIH 3T3 (1 × 10⁵ cells/ml/well) were cultured at 12-well plate at 37℃ for 14 days. Standardized photographs were taken with digital camera during 14 days and the diameter of the contracted collagen gel matrix was measured and statistically analyzed with student t-test. As one of the pulp tissue engineering, normal human dental pulp tissue and collagen gel matrix cultured with dental pulp cells for 14 days were fixed and stained with Hematoxyline & Eosin.

According to this study, the results were as follows:

1. The contraction of collagen gel matrix cultured with pulp cells for 14 days was significantly higher than other fibroblasts (gingiva, skin) (p < 0.05).

2. The diameter of collagen gel matrix cultured with pulp cells was reduced to 70.4% after 7 days, and 57.1% after 14 days.

3. The collagen gel without any cells did not contract, whereas the collagen gel cultured with gingiva and skin showed mild contraction after 14 days (88.1% and 87.6% respectively).

4. The contraction of the collagen gel cultured with NIH 3T3 cells after 14 days was higher than those cultured with gingival and skin fibroblasts, but it was not statistically significant (72.1%, p > 0.05).

5. The collagen gel matrix cultured with pulp cells for 14 days showed similar shape with native pulp tissue without blood vessels.

This approach may provide a means of engineering a variety of other oral tissue as well and these cell behaviors may provide information needed to establish pulp tissue engineering protocols.

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• Human amniotic membrane extracellular matrix scaffold for dental pulp regeneration in vitro and in vivo
  Hengameh Bakhtiar, Azin Ashoori, Sarah Rajabi, Mohamad Pezeshki‐Modaress, Alireza Ayati, Mohammad Reza Mousavi, Mohammad Reza Ellini, Amir Kamali, Amir Azarpazhooh, Anil Kishen
  International Endodontic Journal.2022; 55(4): 374.     CrossRef