Restorative Dentistry & Endodontics

Research Articles

Do universal adhesives promote bonding to dentin? A systematic review and meta-analysis: Ali A. Elkaffas, Hamdi H. H. Hamama, Salah H. Mahmoud; Restor Dent Endod 2018;43(3):e29. Published online June 18, 2018; DOI: https://doi.org/10.5395/rde.2018.43.e29

Objectives

The aims of this study were to conduct a systematic review of the microtensile bond strength (µTBS) of multi-mode adhesives to dentin and to perform a meta-analysis to assess the significance of differences in the µTBS of one of the most commonly used universal adhesives (Scotchbond Universal, 3M ESPE) depending on whether the etch-and-rinse or self-etch mode was used.

Materials and Methods

An electronic search was performed of MEDLINE/PubMed, ScienceDirect, and EBSCOhost. Laboratory studies that evaluated the µTBS of multi-mode adhesives to dentin using either the etch-and-rinse or self-etch mode were selected. A meta-analysis was conducted of the reviewed studies to quantify the differences in the µTBS of Scotchbond Universal adhesive.

Results

Only 10 studies fulfilled the inclusion criteria for the systematic review. Extensive variation was found in the restorative materials, testing methodologies, and failure mode in the reviewed articles. Furthermore, variation was also observed in the dimensions of the microtensile testing beams. The meta-analysis showed no statistically significant difference between the etch-and-rinse and self-etch modes for Scotchbond Universal adhesive (p > 0.05).

Conclusions

Multi-mode ‘universal’ adhesives can achieve substantial bonding to dentin, regardless of the used modes (either etch-and-rinse or self-etch).

Citations

Citations to this article as recorded by

Influence of Proximal-Cervical Undermined Enamel Areas on Marginal Quality and Enamel Integrity of Laboratory and CAD/CAM Ceramic Inlays and Partial Crowns
Roland Frankenberger, Katharina Friedrich, Marie-Christine Dudek, Julia Winter, Norbert Krämer, Matthias J. Roggendorf
Journal of Functional Biomaterials.2025; 16(3): 82. CrossRef
Improving Bonding Protocols: The Effect of Selective Dentin Etching with Two Different Universal Adhesives—An In Vitro Study
Sandro Ferreira, Tiago Rodrigues, Mariana Nunes, Ana Mano Azul, José João Mendes, Ana Filipa Chasqueira, Joana Costa
Polymers.2025; 17(9): 1215. CrossRef
Effect of surface treatment on glass ionomers in sandwich restorations: a systematic review and meta-analysis of laboratory studies
Hoda S. Ismail, Ashraf Ibrahim Ali, Franklin Garcia-Godoy
Restorative Dentistry & Endodontics.2025; 50(2): e13. CrossRef
Wet vs. Dry Dentin Bonding: A Systematic Review and Meta-Analysis of Adhesive Performance and Hybrid Layer Integrity
Mircea Popescu, Mădălina Malița, Andrei Vorovenci, Andreea Angela Ștețiu, Viorel Ștefan Perieanu, Radu Cătălin Costea, Mihai David, Raluca Mariana Costea, Maria Antonia Ștețiu, Andi Ciprian Drăguș, Cristina Maria Șerbănescu, Andrei Burlibașa, Oana Eftene,
Oral.2025; 5(3): 63. CrossRef
The Effect of Different Multimode Adhesives On Microleakage of Class V Composite Restorations in Three Etching Modes
Fatma Yılmaz, Sevgi Kurşun, Zeliha Öztürk
ADO Klinik Bilimler Dergisi.2025; 14(3): 177. CrossRef
Controversies about refrigeration of dental adhesives: a review
Omar Abd El-Maksoud, Hamdi Hosni Hamdan Hamama, Ramy Ahmed Wafaie, Salah Hasab Mahmoud
BDJ Open.2025;[Epub] CrossRef
Tooth-composite bond failure with a universal and an etch-and-rinse adhesive depending on mode and frequency of application
Ellen Schulz-Kornas, Mathilde Tittel, Hartmut Schneider, Maximilian Bemmann, Marco Pellino, Tobias Meissner, Florian Fuchs, Christian Hannig, Florian Tetschke, Kyung-Jin Park, Michaela Strumpski, Rainer Haak
Dental Materials.2024; 40(2): 359. CrossRef
Comparison of postoperative hypersensitivity between Total-etch and Universal adhesive system: a randomized clinical trial
Kiran Javed, Nouman Noor, Muhammad Zubair Nasir, Manzoor Ahmed Manzoor
Scientific Reports.2024;[Epub] CrossRef
Adhesion and sealing of different universal adhesive systems associated with bulk‐fill resins after using endodontic irrigation solutions: An in vitro study
Érika Mayumi Omoto, Anderson Catelan, Paulo Henrique dos Santos, Luciano Tavares Angelo Cintra, Fernanda de Souza e Silva Ramos, Caio César Pavani, André Luiz Fraga Briso, Ticiane Cestari Fagundes
Australian Endodontic Journal.2024; 50(2): 309. CrossRef
Evaluation of the effects of combined application of dimethylaminohexadecyl methacrylate and MDP on dentin bonding and antimicrobial properties
Jiadi Shen, Ming Ma, Yun Huang, Haochen Miao, Xin Wei
Journal of Materials Science.2023; 58(31): 12685. CrossRef
Efficacy of adhesive strategies for restorative dentistry: A systematic review and network meta-analysis of double-blind randomized controlled trials over 12 months of follow-up
Kevin Sheng-Kai Ma, Li-Tzu Wang, Markus B. Blatz
Journal of Prosthodontic Research.2023; 67(1): 35. CrossRef
Impact of Preceded Tumor Therapeutic Irradiation on the Microtensile Bond Strength of Universal Adhesives Applied in Self-Etch Mode to Human Dentin In Vitro
Sina Broscheit, Dirk Vordermark, Reinhard Gerlach, Christian Ralf Gernhardt
Applied Sciences.2023; 13(13): 7873. CrossRef
Effect of the Adhesive Strategy on Clinical Performance and Marginal Integrity of a Universal Adhesive in Non-Carious Cervical Lesions in a Randomized 36-Month Study
Rainer Haak, Gesa Stache, Hartmut Schneider, Matthias Häfer, Gerhard Schmalz, Ellen Schulz-Kornas
Journal of Clinical Medicine.2023; 12(18): 5776. CrossRef
Universal Adhesives in Clinical Dentistry
Fusun Ozer, Shilpa Patnaikuni
Science, Art and Religion.2023; 2(1--2): 6. CrossRef
Deep proximal margin rebuilding with direct esthetic restorations: a systematic review of marginal adaptation and bond strength
Hoda S. Ismail, Ashraf I. Ali, Rabab El. Mehesen, Jelena Juloski, Franklin Garcia-Godoy, Salah H. Mahmoud
Restorative Dentistry & Endodontics.2022;[Epub] CrossRef
Improving Properties of an Experimental Universal Adhesive by Adding a Multifunctional Dendrimer (G-IEMA): Bond Strength and Nanoleakage Evaluation
Joana Vasconcelos e Cruz, António H. S. Delgado, Samuel Félix, José Brito, Luísa Gonçalves, Mário Polido
Polymers.2022; 14(7): 1462. CrossRef
Scoping review of trials evaluating adhesive strategies in pediatric dentistry: where do simplified strategies lie?
António H. S. Delgado, Hasan Jamal, Anne Young, Paul Ashley
BMC Oral Health.2021;[Epub] CrossRef
Does acid etching prior to applying universal adhesives affect the bond strength of glass fiber post to root dentin?
Helder Callegaro Velho, Eduardo Trindade Dalence, Pablo Soares Machado, Marília Pivetta Rippe, Jovito Adiel Skupien, Vinícius Felipe Wandscher
International Journal of Adhesion and Adhesives.2021; 105: 102795. CrossRef
Does Adhesive Layer Thickness and Tag Length Influence Short/Long-Term Bond Strength of Universal Adhesive Systems? An In-Vitro Study
Naji Kharouf, Tarek Ashi, Ammar Eid, Levi Maguina, Jihed Zghal, Nairy Sekayan, Rim Bourgi, Louis Hardan, Salvatore Sauro, Youssef Haikel, Davide Mancino
Applied Sciences.2021; 11(6): 2635. CrossRef
Chronological history and current advancements of dental adhesive systems development: a narrative review
Maicon Sebold, Carolina Bosso André, Beatriz Ometto Sahadi, Lorenzo Breschi, Marcelo Giannini
Journal of Adhesion Science and Technology.2021; 35(18): 1941. CrossRef
Laboratory methods for measuring adhesive bond strength between restoration materials and hard tooth tissues
I.Ya. Poyurovskaya, A.P. Polikarpova, F.S. Rusanov
Stomatologiya.2021; 100(5): 88. CrossRef
Effect of Curcumin Suspension and Vitamin C on Dentin Shear Bond Strength and Durability. A Pilot Study
Dalia A. Abuelenain, Ensanya A. Abou Neel, Tariq S. Abuhaimed, Amal M. Alamri, Hanan S. Ammar, Sahar M. N. Bukhary
The Open Dentistry Journal.2021; 15(1): 540. CrossRef
Effect of 9.3 μm CO2 and 2.94 μm Er:YAG Laser vs. Bur Preparations on Marginal Adaptation in Enamel and Dentin of Mixed Class V Cavities Restored With Different Restorative Systems
Clara Isabel Anton y Otero, Enrico Di Bella, Ivo Krejci, Tissiana Bortolotto
Frontiers in Dental Medicine.2021;[Epub] CrossRef
Adhesion strategy and curing mode of a universal adhesive influence the bonding of dual-cured core build-up resin composite to dentin
Ahmed Eid Elsayed, Mohamed Amr Kamel, Farid Sabry El-Askary
Journal of Adhesion Science and Technology.2021; 35(1): 52. CrossRef
Influence of etching mode and composite resin type on bond strength to dentin using universal adhesive system
Stefan Dačić, Milan Miljković, Aleksandar Mitić, Goran Radenković, Marija Anđelković‐Apostolović, Milica Jovanović
Microscopy Research and Technique.2021; 84(6): 1212. CrossRef
Universal adhesives - a new direction in the development of adhesive systems
A. Tichý, K. Hosaka, J. Tagami
Česká stomatologie a praktické zubní lékařství.2020; 120(1): 4. CrossRef
Effect of Over-Etching and Prolonged Application Time of a Universal Adhesive on Dentin Bond Strength
Phoebe Burrer, Hoang Dang, Matej Par, Thomas Attin, Tobias T. Tauböck
Polymers.2020; 12(12): 2902. CrossRef
Profile of a 10-MDP-based universal adhesive system associated with chlorhexidine: Dentin bond strength and in situ zymography performance
Marina Ciccone Giacomini, Polliana Mendes Candia Scaffa, Rafael Simões Gonçalves, Giovanna Speranza Zabeu, Cristina de Mattos Pimenta Vidal, Marcela Rocha de Oliveira Carrilho, Heitor Marques Honório, Linda Wang
Journal of the Mechanical Behavior of Biomedical Materials.2020; 110: 103925. CrossRef
Universal dental adhesives: Current status, laboratory testing, and clinical performance
Sanket Nagarkar, Nicole Theis‐Mahon, Jorge Perdigão
Journal of Biomedical Materials Research Part B: Applied Biomaterials.2019; 107(6): 2121. CrossRef
Modifying Adhesive Materials to Improve the Longevity of Resinous Restorations
Wen Zhou, Shiyu Liu, Xuedong Zhou, Matthias Hannig, Stefan Rupf, Jin Feng, Xian Peng, Lei Cheng
International Journal of Molecular Sciences.2019; 20(3): 723. CrossRef

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Comparison of bond strengths of ceramic brackets bonded to zirconia surfaces using different zirconia primers and a universal adhesive: Ji-Yeon Lee, Jaechan Ahn, Sang In An, Jeong-won Park; Restor Dent Endod 2018;43(1):e7. Published online January 22, 2018; DOI: https://doi.org/10.5395/rde.2018.43.e7

Abstract PDF PubReader ePub

Objectives

The aim of this study is to compare the shear bond strengths of ceramic brackets bonded to zirconia surfaces using different zirconia primers and universal adhesive.

Materials and Methods

Fifty zirconia blocks (15 × 15 × 10 mm, Zpex, Tosoh Corporation) were polished with 1,000 grit sand paper and air-abraded with 50 µm Al₂O₃ for 10 seconds (40 psi). They were divided into 5 groups: control (CO), Metal/Zirconia primer (MZ, Ivoclar Vivadent), Z-PRIME Plus (ZP, Bisco), Zirconia Liner (ZL, Sun Medical), and Scotchbond Universal adhesive (SU, 3M ESPE). Transbond XT Primer (used for CO, MZ, ZP, and ZL) and Transbond XT Paste was used for bracket bonding (Gemini clear ceramic brackets, 3M Unitek). After 24 hours at 37°C storage, specimens underwent 2,000 thermocycles, and then, shear bond strengths were measured (1 mm/min). An adhesive remnant index (ARI) score was calculated. The data were analyzed using one-way analysis of variance and the Bonferroni test (p = 0.05).

Results

Surface treatment with primers resulted in increased shear bond strength. The SU group showed the highest shear bond strength followed by the ZP, ZL, MZ, and CO groups, in that order. The median ARI scores were as follows: CO = 0, MZ = 0, ZP = 0, ZL = 0, and SU = 3 (p < 0.05).

Conclusions

Within this experiment, zirconia primer can increase the shear bond strength of bracket bonding. The highest shear bond strength is observed in SU group, even when no primer is used.

Citations

Citations to this article as recorded by

Effectiveness of universal adhesives for orthodontic bonding to enamel and restorative materials: A systematic review
Claire-Adeline Dantagnan, Maureen Boudrot, Julia Bosco, Gauthier Dot, Ali Nassif, Philippe François, Jean-Pierre Attal
International Orthodontics.2026; 24(2): 101089. CrossRef
State-of-the-Art Zirconia and Glass–Ceramic Materials in Restorative Dentistry: Properties, Clinical Applications, Challenges, and Future Perspectives
Sorin Gheorghe Mihali, Adela Hiller
Applied Sciences.2025; 15(23): 12841. CrossRef
Shear bond strength and ARI scores of metal brackets to glazed glass ceramics and zirconia: an in vitro study investigating surface treatment protocols
Claire Pédemay, Philippe François, Vincent Fouquet, Sarah Abdel-Gawad, Jean-Pierre Attal, Claire-Adeline Dantagnan
BMC Oral Health.2024;[Epub] CrossRef
Impact of different pretreatments and attachment materials on shear bond strength of indirectly bonded brackets using CAD/CAM transfer trays to monolithic zirconia
Rebecca Jungbauer, Christian M. Hammer, Daniel Edelhoff, Peter Proff, Bogna Stawarczyk
Dental Materials.2023; 39(2): 170. CrossRef
Mechanical and chemical surface treatment enhances bond strength between zirconia and orthodontic brackets: an in vitro study
Nareudee Limpuangthip, Atikom Surintanasarn, Ploylada Vitavaspan
BDJ Open.2023;[Epub] CrossRef
Effect of Different Surface Treatments and Orthodontic Bracket Type on Shear Bond Strength of High‐Translucent Zirconia: An In Vitro Study
Yasamin Babaee Hemmati, Hamid Neshandar Asli, Mehran Falahchai, Sina Safary, Sandrine Bittencourt Berger
International Journal of Dentistry.2022;[Epub] CrossRef
Does Surface Treatment With Different Primers Increase The Shear Bond Strength Between Metallic Bracket and Monolithic Zirconia?
Emine Begüm BÜYÜKERKMEN, Ayşe Selenge AKBULUT, Murat KEÇECİ
Selcuk Dental Journal.2022; 9(2): 451. CrossRef
Effect of Different Surface Treatments on the Surface Roughness and Orthodontic Bond Strength of Partially-stabilized Zirconia
Mustafa Borga Dönmez, Betül Ballı Demirel, Münir Demirel, Yasemin Gündoğdu, Hamdi Şükür Kılıç
Meandros Medical and Dental Journal.2022; 23(3): 335. CrossRef
Shear Bond Strength of Polypropylene Fiber in Orthodontic Adhesive on Glazed Monolithic Zirconia
Dhanabhol Riowruangsanggoon, Apiwat Riddhabhaya, Nattisa Niyomtham, Irin Sirisoontorn
Polymers.2022; 14(21): 4627. CrossRef
Effects of Three Novel Bracket Luting Agents Containing Zirconia Primer on Shear Bond Strength of Metal Orthodontic Brackets Attached to Monolithic Zirconia Crowns: A Preliminary In Vitro Study
Milad Shamohammadi Heidari, Mehrnaz Moradinejad, Hamed Tabatabaei, Vahid Rakhshan, Dinesh Rokaya
International Journal of Dentistry.2022;[Epub] CrossRef
Impact of different pretreatments and attachment materials on shear bond strength between monolithic zirconia restorations and metal brackets
Rebecca Jungbauer, Peter Proff, Daniel Edelhoff, Bogna Stawarczyk
Scientific Reports.2022;[Epub] CrossRef
Bracket Bonding to All-Ceramic Materials with Universal Adhesives
Cecilia Goracci, Giuseppe Di Bello, Lorenzo Franchi, Chris Louca, Jelena Juloski, Jovana Juloski, Alessandro Vichi
Materials.2022; 15(3): 1245. CrossRef
Effect of enamel-surface modifications on shear bond strength using different adhesive materials
Bo-wen Zheng, Shan Cao, Majedh Abdo Ali Al-Somairi, Jia He, Yi Liu
BMC Oral Health.2022;[Epub] CrossRef
The effect of various mechanical and chemical surface conditioning on the bonding of orthodontic brackets to all ceramic materials
Dalia A. Abuelenain, Amal I. Linjawi, Ahmed S. Alghamdi, Fahad M. Alsadi
Journal of Dental Sciences.2021; 16(1): 370. CrossRef
The Performance of Universal Adhesives on Orthodontic Bracket Bonding
Muhittin Ugurlu, Muhammed Hilmi Buyukcavus
European Journal of General Dentistry.2021; 10(01): 019. CrossRef
A comparison of shear bond strength of brackets bonded to zirconia
Hannah Knott, Xiaoming Xu, Edwin Kee, Qingzhao Yu, Paul Armbruster, Richard Ballard
Australasian Orthodontic Journal.2021; 37(1): 62. CrossRef
Influence of Surface Treatment and Resin Cements on the Bond Strength between the Y-TZP Zirconia and Composite Resin Interface
Lucas Campagnaro Maciel, Amanda Pádua Proeza, Hélyda Coelho Guimarães Balbino, Marcela Moráo Corteletti, Ricardo Huver De Jesus, Laís Regiane da Silva Concílio
Journal of Health Sciences.2019; 21(5): 477. CrossRef
Effect of Simplified Bonding on Shear Bond Strength between Ceramic Brackets and Dental Zirconia
Ga-Youn Ju, Soram Oh, Bum-Soon Lim, Hyun-Seung Lee, Shin Hye Chung
Materials.2019; 12(10): 1640. CrossRef

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