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Research Article
- Involvement of TRPA1 in the cinnamaldehyde-induced pulpal blood flow change in the feline dental pulp
- Dokyung Kim, Moon-Hwan Lee, Sung Kyo Kim
- Restor Dent Endod 2016;41(3):202-209. Published online July 29, 2016
- DOI: https://doi.org/10.5395/rde.2016.41.3.202
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Abstract
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ePub Objectives The purpose of this study was to investigate the involvement of TRPA1 in the cinnamaldehyde-induced pulpal blood flow (PBF) change in the feline dental pulp.
Materials and Methods Mandibles of eight cats were immobilized and PBF was monitored with a laser Doppler flowmetry at the mandibular canine tooth. To evaluate the effect of cinnamaldehyde on PBF, cinnamaldehyde was injected into the pulp through the lingual artery at a constant rate for 60 seconds. As a control, a mixture of 70% ethanol and 30% dimethyl sulfoxide (DMSO, vehicle) was used. To evaluate the involvement of transient receptor potential ankyrin 1 (TRPA1) in PBF change, AP18, a specific TRPA1 antagonist, was applied into the pulp through the Class V dentinal cavity followed by cinnamaldehyde-administration 3 minutes later. The paired variables of experimental data were statistically analyzed using paired
t -test. Ap value of less than 0.05 was considered as statistically significant.Results Administration of cinnamaldehyde (0.5 mg/kg, intra-arterial [i.a.]) induced significant increases in PBF (
p < 0.05). While administration of a TRPA1 antagonist, AP18 (2.5 - 3.0 mM, into the dentinal cavity [i.c.]) caused insignificant change of PBF (p > 0.05), administration of cinnamaldehyde (0.5 mg/kg, i.a.) following the application of AP18 (2.5 - 3.0 mM, i.c.) resulted in an attenuation of PBF increase from the control level (p < 0.05). As a result, a TRPA1 antagonist, AP18 effectively inhibited the vasodilative effect of cinnamaldehyde (p < 0.05).Conclusions The result of the present study provided a functional evidence that TRPA1 is involved in the mechanism of cinnamaldehyde-induced vasodilation in the feline dental pulp.
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Citations
Citations to this article as recorded by
- A simple model for the assessment of the agonistic activity of dibenzazepine derivatives by molecular moieties
Mohammad Hossein Keshavarz, Hossein Fakhraian, Norollah Saedi
Medicinal Chemistry Research.2021; 30(1): 215. CrossRef
- A simple model for the assessment of the agonistic activity of dibenzazepine derivatives by molecular moieties
- 210 View
- 1 Download
- 1 Crossref
Case Report
- Endodontic treatment of maxillary lateral incisors with anatomical variations
- Moon-Hwan Lee, Jung-Hong Ha, Myoung-Uk Jin, Young-Kyung Kim, Sung-Kyo Kim
- Restor Dent Endod 2013;38(4):253-257. Published online November 12, 2013
- DOI: https://doi.org/10.5395/rde.2013.38.4.253
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Abstract
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Maxillary lateral incisors usually exhibit a single root with a single canal. However, maxillary lateral incisor teeth with unusual morphology of root canal system are frequently reported. These cases of variable root canal anatomy can be treated well by nonsurgical endodontic methods. A detailed description of root canal morphology is fundamental for successful endodontic treatment. Treatment using an operating microscope, radiographs from different angles, and cone-beam computerized tomography (CBCT) can produce more predictable endodontic outcomes.
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Citations
Citations to this article as recorded by- Endodnontic Management of a Maxillary Lateral Incisor with Two Roots
Pujan Kranti Kayastha, Merina Shakya, Laxman Poudel
Journal of Interdisciplinary Dentistry.2022; 12(1): 32. CrossRef - Non-surgical management of dens invaginatus type IIIB in maxillary lateral incisor with three root canals and 6-year follow-up: A case report and review of literature
Suraj Arora, Gurdeep Singh Gill, Shahabe Abullais Saquib, Priyanka Saluja, Suheel M Baba, Shafait Ullah Khateeb, Anshad M Abdulla, Shashit Shetty Bavabeedu, Ahmed Babiker Mohamed Ali, Mohamed Fadul A Elagib
World Journal of Clinical Cases.2022; 10(33): 12240. CrossRef - Endodontic management and follow-up of two rooted maxillary lateral incisor with open apex – A case report
R AnithaKumari, Sneha Jeetendra, Siddharth Rai, Sudhanva Eregowda
IP Indian Journal of Conservative and Endodontics.2020; 5(4): 200. CrossRef - Geminated Maxillary Lateral Incisor with Two Root Canals
Nayara Romano, Luis Eduardo Souza-Flamini, Isabela Lima Mendonça, Ricardo Gariba Silva, Antonio Miranda Cruz-Filho
Case Reports in Dentistry.2016; 2016: 1. CrossRef - Surgical management with intentional replantation on a tooth with palato-radicular groove
Jorge Forero-López, Luis Gamboa-Martínez, Laura Pico-Porras, Javier Laureano Niño-Barrera
Restorative Dentistry & Endodontics.2015; 40(2): 166. CrossRef - Use of cone-beam computed tomography and three-dimensional modeling for assessment of anomalous pulp canal configuration: a case report
Alper Sinanoglu, Dilek Helvacioglu-Yigit, Ibrahim Mutlu
Restorative Dentistry & Endodontics.2015; 40(2): 161. CrossRef - Endodontic management of a mandibular second molar with radix entomolaris: a case report
Rosaline Hannah, Deivanayagam Kandaswamy, Nachimuthu Jayaprakash
Restorative Dentistry & Endodontics.2014; 39(2): 132. CrossRef
- Endodnontic Management of a Maxillary Lateral Incisor with Two Roots
- 508 View
- 14 Download
- 7 Crossref
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