Restorative Dentistry & Endodontics

Research Articles

Success rates comparison of endodontic microsurgery and single implants with comprehensive and explicit criteria: a systematic review and meta-analysis: Min Jung Ko, Ju Hyun Park, Na Rae Lee, Joon-Ho Yoon, Young-Taek Kim, Sin-Yeon Cho; Restor Dent Endod 2025;50(1):e8. Published online February 19, 2025; DOI: https://doi.org/10.5395/rde.2025.50.e8

Abstract PDF Supplementary Material PubReader ePub: Objectives
While the success criteria of endodontic microsurgery (EMS) have been consistently defined and widely accepted, the success criteria of dental implants are outdated and focus only on the implant fixture and surrounding bone. This study aimed to evaluate the outcomes of EMS and single implants (SIs) with explicit criteria.
Methods
We searched for articles published from January 2010 to February 2022 and discussed them and consulted with a clinical advisory committee composed of four dental specialists and one epidemiologist during article selection and data extraction.
Results
Twenty-two EMS studies and six SI studies were included in the meta-analysis. Teeth treated using EMS had a pooled success rate of 89% (90% at <5-year follow-up and 80% at ≥5-year follow-up) and the pooled success rate of SI was 78%.
Conclusions
The success rates of the two procedures with similar follow-up periods were comparable. Subgroup analysis found no other variable that significantly influenced study heterogeneity. Considering the treatment sequence and the similar success rates, it would be advantageous to consider EMS, rather than implants, first in a situation where both procedures are applicable.

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Fracture resistance and failure modes of endodontically-treated permanent teeth restored with Ribbond posts vs other post systems: a systematic review and meta-analysis of in vitro studies: Meghana Aditya Vartak, Vibha Rahul Hegde, Sanitra Rahul Hegde, Ushaina Fanibunda; Restor Dent Endod 2025;50(1):e5. Published online February 17, 2025; DOI: https://doi.org/10.5395/rde.2025.50.e5

Abstract PDF PubReader ePub: Objectives
This systematic review aimed to investigate the fracture resistance and mode of failure of endodontically-treated permanent teeth restored with Ribbond posts (Ribbond, Inc.) compared with endodontically-treated permanent teeth restored with other post systems.
Methods
A comprehensive, systematic literature search was carried out using several electronic databases: MEDLINE/PubMed, Google Scholar, and Cochrane Library. Two separate researchers were appointed to identify the studies meeting the eligibility criteria, and to perform the data extraction, risk of bias, and quality assessment.
Results
Twelve studies were included in the quantitative analysis. Meta-analysis was performed with 11 of the 12 included articles. The meta-analysis showed that Ribbond posts have a fracture strength less than prefabricated metal posts, cast metal posts, and prefabricated fiber posts and greater than custom e-glass fiber posts. Mode of failure analysis revealed that Ribbond posts have the most favorable non-catastrophic fractures.
Conclusions
Although Ribbond posts have lower fracture resistance, their favorable mode of failure makes them potentially the most biomimetic post system.

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Review Article

Effect of endodontic sealer on postoperative pain: a network meta-analysis: Cynthia Maria Chaves Monteiro, Ana Cristina Rodrigues Martins, Alessandra Reis, Juliana Larocca de Geus; Restor Dent Endod 2023;48(1):e5. Published online December 29, 2022; DOI: https://doi.org/10.5395/rde.2023.48.e5

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This systematic review and network meta-analysis aimed to answer the following focused research question: “Does the type of endodontic sealer affect the postoperative pain in patients who received endodontic treatment?” Different databases and grey literature were surveyed. Only one randomized controlled trial were included. The risk of bias in the studies was evaluated by using the Cochrane Collaboration’s tool. A random-effects meta-analysis was conducted to compare the risk and intensity of postoperative pain. The quality of the body of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Out of 11,601 studies, 15 remained for qualitative analyses and 12 for meta-analysis. Seven studies were classified at high risk of bias, and 8 studies raised some concerns. No significant differences between the endodontic materials were observed in the direct comparisons, both in risk and in intensity of postoperative pain (pairwise comparisons with 2 studies: I² = 0%; p > 0.05 and 8 studies: I² = 23%; p > 0.05, respectively). The certainty of the evidence was graded as low or moderate. There was no difference in the risk and intensity of postoperative pain after filling with different endodontic sealers. Further systematic reviews should be conducted.

Trial Registration

PROSPERO Identifier: CRD42020215314

Citations

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Comparative evaluation of postoperative pain and periapical healing after root canal treatment using three different endodontic sealers: A randomized controlled clinical trial
Ruchika Pandey, Nitin Kararia, Deepak Kumar Sharma, Vishal Rathod, Anand Vilas Bansod, Dhaval Desai
Journal of Conservative Dentistry and Endodontics.2024; 27(9): 962. CrossRef
Effect of bioceramic-based and resin-based sealers on postoperative discomfort following root canal therapy: a systematic review and meta-analysis
Mansi Supare, Ajinkya M. Pawar, Kashmira Sawant, Dian Agustin Wahjuningrum, Suraj Arora, Firas Elmsmari, Mohmed Isaqali Karobari, Bhagyashree Thakur
PeerJ.2024; 12: e18198. CrossRef
Comparative Evaluation of Incidences of Post Operative Pain in Patient Treated in Single Visit Root Canal Treatment by Using Different Sealers: - An in-Vivo Study
Sadashiv Daokar, Aishwarya Ranjalkar, Kalpana Pawar, Komal Potfode, Dhanashri Padwal, Sana Khan
International Journal of Innovative Science and Research Technology (IJISRT).2024; : 2743. CrossRef

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Research Articles

Anesthetic efficacy in vital asymptomatic teeth using different local anesthetics: a systematic review with network meta-analysis: Amy Kia Cheen Liew, Yi-Chun Yeh, Dalia Abdullah, Yu-Kang Tu; Restor Dent Endod 2021;46(3):e41. Published online July 21, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e41

Abstract PDF Supplementary Material PubReader ePub

Objectives

This study aimed to evaluate the efficacy of various local anesthesia (LA) in vital asymptomatic teeth.

Materials and Methods

Randomized controlled trials comparing pulpal anesthesia of various LA on vital asymptomatic teeth were included in this review. Searches were conducted in the Cochrane CENTRAL, MEDLINE (via PubMed), EMBASE, ClinicalTrials.gov, Google Scholar and 3 field-specific journals from inception to May 3, 2019. Study selection, data extraction, and risk of bias assessment using Cochrane Risk of Bias Tool were done by 2 independent reviewers in duplicate. Network meta-analysis (NMA) was performed within the frequentist setting using STATA 15.0. The LA was ranked, and the surface under the cumulative ranking (SUCRA) line was plotted. The confidence of the NMA estimates was assessed using the CINeMA web application.

Results

The literature search yielded 1,678 potentially eligible reports, but only 42 were included in this review. For maxillary buccal infiltration, articaine 4% with epinephrine 1:100,000 was more efficacious than lidocaine 2% with epinephrine 1:100,000 (odds ratio, 2.11; 95% confidence interval, 1.14–3.89). For mandibular buccal infiltration, articaine 4% with epinephrine 1:100,000 was more efficacious than various lidocaine solutions. The SUCRA ranking was highest for articaine 4% with epinephrine when used as maxillary and mandibular buccal infiltrations, and lidocaine 2% with epinephrine 1:80,000 when used as inferior alveolar nerve block. Inconsistency and imprecision were detected in some of the NMA estimates.

Conclusions

Articaine 4% with epinephrine is superior when maxillary or mandibular infiltration is required in vital asymptomatic teeth.

Citations

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Adrenaline in pulp capping treatment of reversible pulpitis
Si-Yun Yang, Jin-Zhu Wang, Hao Fan, Min Chen
World Journal of Clinical Cases.2024; 12(22): 5024. CrossRef
Effect of 810 nm Diode Laser Irradiation on the Time of Initiation and Depth of Anesthesia for Endodontic Treatment of Mandibular First Molars with Symptomatic Irreversible Pulpitis: A Clinical Trial
Elham Khoshbin, Leila Ghasemi, Rooholah Behroozi, Zahra Khosravi, Afsaneh Rahmati, Loghman Rezaeisoufi, Hamed Karkehabadi
Photobiomodulation, Photomedicine, and Laser Surgery.2023; 41(9): 475. CrossRef
The potential of articaine as new generation of local anesthesia in dental clinics: A review
Wen Luo, Kaiyue Zheng, Huifang Kuang, Zhixin Li, Jinrong Wang, Jie Mei
Medicine.2022; 101(48): e32089. CrossRef

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Calcium hydroxide intracanal medication effects on pain and flare-up: a systematic review and meta-analysis: Ahmed Mohamed Ibrahim, Siza Yacoub Zakhary, Suzan Abdul Wanees Amin; Restor Dent Endod 2020;45(3):e26. Published online May 22, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e26

Abstract PDF Supplementary Material PubReader ePub

Objectives

This study aimed to systematically review the pain and flare-up effects of calcium hydroxide (CH) as intracanal medication (ICM) in non-vital mature teeth.

Materials and Methods

Electronic-databases searching for published and grey literature and manual searching were conducted. Only randomized clinical trials (RCTs) were included comparing CH to other ICMs in non-vital mature teeth. The risk of bias was assessed using the RoB 2.0 Cochrane tool. The main outcomes were pain and flare-up. Qualitative and quantitative analysis, wherever applicable, was performed. The certainty of evidence (CoE) was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE).

Results

Sixteen articles were included in 6 comparisons at different time points for different outcomes. CH reduced pain risk than no ICM within the 1–14-days interval (p < 0.05) and than triple-antibiotic paste within the first day (p < 0.05) and was similar to corticosteroid/antibiotics combination (p > 0.05). Chlorhexidine (CHX) or CH/CHX, however, reduced pain levels than CH alone (p < 0.05). CH showed higher flare-up risk than CHX (p < 0.05). CoE, however, ranged from very low to moderate.

Conclusion

Most comparisons for different outcomes are based on very few studies, mostly low-powered, with an overall low CoE. Thus, the available evidence is considered insufficient to either support or refute CH effectiveness or to recommend one ICM over another. Therefore, further well-designed, larger RCTs are required.

Trial Registration

PROSPERO database Identifier: CRD42016041953

Citations

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Garre’s osteomyelitis of the mandible managed by nonsurgical re-endodontic treatment
Heegyun Kim, Jiyoung Kwon, Hyun-Jung Kim, Soram Oh, Duck-Su Kim, Ji-Hyun Jang
Restorative Dentistry & Endodontics.2024;[Epub] CrossRef
Interpretation by literature review of the use of calcium hydroxide as an intra-ductal medication
María Belén Muñoz Padilla, Verónica Alicia Vega Martínez, Camila Alejandra Villafuerte Moya
Salud, Ciencia y Tecnología.2024; 4: 924. CrossRef
ProTaper Ultimate: The Evolution of Rotary Systems and Their Clinical Applicability
Mateo-Castillo JF, Siqueira-Sandrin VDS, Moreira RA, Brandelero Junior S, Olano-Dextre TL, Claudia R Pinheiro
Journal of Operative Dentistry & Endodontics.2024; 9(1): 16. CrossRef
Comparative Evaluation of Bacterial Reduction by Laser-Activated Irrigation Technique (LAI) With Conventional Needle Irrigation (CNI) in Single-Rooted Teeth With Pulpal Necrosis: A Single-Blinded Randomized Controlled Trial
Keerthika Rajamanickam, Sandhya Raghu, J Vijayashree Priyadharsini, Delphine Priscilla Antony, Nivedhitha Malli Sureshbabu
Cureus.2023;[Epub] CrossRef
Post-Operative Endodontic Pain Management: An Overview of Systematic Reviews on Post-Operatively Administered Oral Medications and Integrated Evidence-Based Clinical Recommendations
Federica Di Spirito, Giuseppe Scelza, Roberto Fornara, Francesco Giordano, Donato Rosa, Alessandra Amato
Healthcare.2022; 10(5): 760. CrossRef
Management of External Inflammatory Root Resorption following Tooth Autotransplantation Using a Modified Combination of Triple Antibiotics
Saeed Asgary, Ardavan Parhizkar, Paulo J. Palma
Case Reports in Dentistry.2022; 2022: 1. CrossRef
Calcium hydroxide as an intracanal medication for postoperative pain during primary root canal therapy: A systematic review and meta-analysis with trial sequential analysis of randomised controlled trials
Muhammad Zubair Ahmad, Durre Sadaf, Khalid A Merdad, Amani Almohaimeed, Igho J. Onakpoya
Journal of Evidence-Based Dental Practice.2022; 22(1): 101680. CrossRef
Post-operative Pain and Antibacterial Efficacy of Silver Nanoparticles Formulations Intracanal Medication: A Randomized Controlled Clinical Study
Nermine Hassan, Alaa Diab, Geraldine Ahmed
Open Access Macedonian Journal of Medical Sciences.2021; 9(D): 248. CrossRef

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The effect of preheating resin composites on surface hardness: a systematic review and meta-analysis: Ali A. Elkaffas, Radwa I. Eltoukhy, Salwa A. Elnegoly, Salah H. Mahmoud; Restor Dent Endod 2019;44(4):e41. Published online October 29, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e41

Abstract PDF PubReader ePub

Objectives

This paper presents a systematic review and meta-analysis of the effect of preheating on the hardness of nanofilled, nanoceramic, nanohybrid, and microhybrid resin composites.

Materials and Methods

An electronic search of papers on MEDLINE/PubMed, ScienceDirect, and EBSCOhost was performed. Only in vitro studies were included. Non-English studies, case reports, clinical trials, and review articles were excluded. A meta-analysis of the reviewed studies was conducted to quantify differences in the microhardness of the Z250 microhybrid resin composite using the Comprehensive Meta-Analysis software.

Results

Only 13 studies met the inclusion criteria for this systematic review. The meta-analysis showed that there were significant differences between the non-preheated and preheated modes for both the top and bottom surfaces of the specimens (p < 0.05). The microhardness of the Z250 resin composite on the top surface in the preheated mode (78.1 ± 2.9) was higher than in the non-preheated mode (67.4 ± 4.0; p < 0.001). Moreover, the microhardness of the Z250 resin composite on the bottom surface in the preheated mode (71.8 ± 3.8) was higher than in the non-preheated mode (57.5 ± 5.7, p < 0.001).

Conclusions

Although the results reported in the reviewed studies showed great variability, sufficient scientific evidence was found to support the hypothesis that preheating can improve the hardness of resin composites.

Citations

Citations to this article as recorded by

Influence of preheating and water storage on the color, whiteness, and translucency of modern resin‐based composites
Corina Mirela Prodan, Cristina Gasparik, Javier Ruiz‐López, Diana Dudea
Journal of Esthetic and Restorative Dentistry.2025; 37(2): 533. CrossRef
Effects of pre-heating on physical–mechanical–chemical properties of contemporary resin composites
Thamires Bueno, Nivien Masoud, Anna Akkus, Italo Silva, Karen McPherson, Adilson Yoshio Furuse, Fabio Rizzante
Odontology.2025; 113(1): 135. CrossRef
Clinical performance of different bulk‐fill composite resin systems in classIIcavities: A 2‐year randomized clinical trial
Badria Goda, Kareem Hamdi, Radwa I. Eltoukhy, Ashraf I. Ali, Salah Hasab Mahmoud
Journal of Esthetic and Restorative Dentistry.2024; 36(8): 1122. CrossRef
Comparative evaluation of microleakage in Class II cavities restored with snowplow technique using flowable or preheated packable bulk-fill composite resin as gingival increment by dye extraction method: An in vitro study
M. A. Ranjini, V. Geetha, B. Vedavathi, H. K. Ashok, Akshata J. Airsang, S. Swathi
Journal of Conservative Dentistry and Endodontics.2024; 27(11): 1158. CrossRef
Influence of Light‐Curing Time and Increment Thickness on the Properties of Bulk Fill Composite Resins With Distinct Application Systems
Carlos Rocha Gomes Torres, Taiana Paola Prado, Daniele Mara da Silva Ávila, Cesar Rogério Pucci, Alessandra Bühler Borges, Heng Bo Jiang
International Journal of Dentistry.2024;[Epub] CrossRef
Last Generation Bis-GMA Free Composite For Indirect Posterior Restorations: A Case Report
M. Delgado
Endodontics Today.2024; 21(4): 305. CrossRef
The clinical performance of dental resin composite repeatedly preheated: A randomized controlled clinical trial
Mahmoud Elkady, Safaa Abdelhakim, Mona Riad
Journal of Dentistry.2024; 144: 104940. CrossRef
Preheating effect on microhardness and depth of cure of three bulk-fill composite resins: An in vitro study
Aashna Sunil Sahetia, Divya Rupesh Jain, Padmaja Panditrao Sirsat, Meenal N. Gulve, Swapnil J. Kolhe, Surbhi P. Patel
Endodontology.2024;[Epub] CrossRef
Evaluation of Shear Bond Strength of Lithium Disilicate Veneers Using Pre-heated Resin Composite With Two Conventional Resin Cements: An In Vitro Study
Ghalia Akyle, Hassan Achour
Cureus.2024;[Epub] CrossRef
Effect of Glass Fiber Reinforcement on Marginal Microleakage in Class II Composite Restorations: An In Vitro Pilot Study
Csaba Dudás, Emánuel Kardos, Melinda Székely, Lea Ádám, Zsuzsanna Bardocz-Veres, Evelyn Szőllősi, Kinga Mária Jánosi, Bernadette Kerekes-Máthé
Dentistry Journal.2024; 12(12): 410. CrossRef
Effect of preheating on the physicochemical properties and bond strength of composite resins utilized as dental cements: An in vitro study
Carolina Carramilo Raposo, Luanna Marinho Sereno Nery, Edilausson Moreno Carvalho, Paulo Vitor Campos Ferreira, Diego Machado Ardenghi, José Bauer, Darlon Martins Lima
The Journal of Prosthetic Dentistry.2023; 129(1): 229.e1. CrossRef
Examining the Impact of Preheating on the Fracture Toughness and Microhardness of Composite Resin: A Systematic Review
Jay Bhopatkar, Anuja Ikhar, Manoj Chandak, Aditya Patel, Paridhi Agrawal
Cureus.2023;[Epub] CrossRef
In Vitro Effect of Mouthrinses on the Microhardness of Three Different Nanohybrid Composite Resins
Jhonn Luis Bernaldo-Faustino, Julissa Amparo Dulanto-Vargas, Kilder Maynor Carranza-Samanez, Carlos A. Munoz-Viveros
International Journal of Dentistry.2023; 2023: 1. CrossRef
Efecto del precalentamiento en la microdureza superficial de seis resinas compuestas
Gloria Cristina Moreno Abello, Kavhas Castro, Paula Alejandra Ovalle Barrera, Paula Bernal, Laura Catalina Lara Hernández
Universitas Odontologica.2023;[Epub] CrossRef
Wear and Color Stability of Preheated Bulk-fill and Conventional Resin Composites
AA Abdulmajeed, AA Suliman, BJ Selivany, A Altitinchi, TA Sulaiman
Operative Dentistry.2022; 47(5): 585. CrossRef
Comparison of Mechanical Properties of a Self-Adhesive Composite Cement and a Heated Composite Material
Anastazja Skapska, Zenon Komorek, Mariusz Cierech, Elzbieta Mierzwinska-Nastalska
Polymers.2022; 14(13): 2686. CrossRef
Effects of ionizing radiation on surface properties of current restorative dental materials
Débora Michelle Gonçalves de Amorim, Aretha Heitor Veríssimo, Anne Kaline Claudino Ribeiro, Rodrigo Othávio de Assunção e Souza, Isauremi Vieira de Assunção, Marilia Regalado Galvão Rabelo Caldas, Boniek Castillo Dutra Borges
Journal of Materials Science: Materials in Medicine.2021;[Epub] CrossRef
Quality assessment tools used in systematic reviews of in vitro studies: A systematic review
Linh Tran, Dao Ngoc Hien Tam, Abdelrahman Elshafay, Thao Dang, Kenji Hirayama, Nguyen Tien Huy
BMC Medical Research Methodology.2021;[Epub] CrossRef
Preheated composite: Innovative approach for aesthetic restoration
Reema N Asani, Vandana J Gade, Kalyani G Umale, Rachana Gawande, Rohit R Amburle, Raksha R Kusumbe, Purva P Kale, Priya R Kosare
Archives of Dental Research.2021; 11(2): 103. CrossRef

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