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Research Article
Concentrated growth factor scaffold-based pulpotomy of permanent molars with symptomatic irreversible pulpitis
Arthi K. Harith, Vishnupriya Koteeswaran, Dinesh Kowsky, Natanasabapathy Velmurugan, Suresh Nandini
Restor Dent Endod 2025;50(1):e1.   Published online January 17, 2025
DOI: https://doi.org/10.5395/rde.2025.50.e1
AbstractAbstract PDFPubReaderePub
Objectives
Pulpotomy is a minimally invasive procedure that aims to retain the vitality of the radicular pulp by removing the inflamed coronal pulp tissue. This case series presents the successful management of symptomatic irreversible pulpitis by pulpotomy with concentrated growth factor (CGF) scaffolds.
Methods
Six permanent mandibular molars with a diagnosis of symptomatic irreversible pulpitis were included. Under Local anesthesia and rubber dam isolation, caries were excavated using high-speed bur under coolant. Full coronal pulpotomy was done and hemostasis was achieved. CGF membrane was prepared and placed over the radicular pulp and layered with Biodentine (Septodont). Final restoration of type IX glass ionomer cement and bulk fill composite resin was placed. Patients were assessed for various clinical and radiographic parameters at intervals of 1 week and 3, 6, and 12 months. Five patients fulfilled the success criteria at the end of 1 year.
Results
Pulpotomy is considered an alternative treatment modality for root canal treatment in symptomatic irreversible pulpitis aiming at alleviating symptoms and maintaining vitality. CGF scaffold when used as a capping material acts as a reservoir for growth factors with anti-inflammatory properties and enhances healing.
Conclusions
Scaffold-based pulpotomy can be considered a biological approach to healing inflamed pulp.
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Original Article
The effect of mineral trioxide aggregate on the production of growth factors and cytokine by human periodontal ligament fibroblasts
Ji-Yoon Kwon, Sung-Sam Lim, Seung-Ho Baek, Kwang-Shik Bae, Myung-Hoe Kang, Woocheol Lee
J Korean Acad Conserv Dent 2007;32(3):191-197.   Published online May 31, 2007
DOI: https://doi.org/10.5395/JKACD.2007.32.3.191
AbstractAbstract PDFPubReaderePub

Mineral trioxide aggregate (MTA) would influence healing of periapical tissues by modulating the production of growth factors and cytokines from PDL fibroblasts, however, the studies are insufficient. Therefore, the purpose of this study was to monitor the expression of transforming growth factor-beta1 (TGF-β1), fibroblast growth factor-2 (FGF-2), and interleukin-6 (IL-6) from PDL fibroblasts in the presence of MTA. The human PDL fibroblasts were seeded onto the set MTA or IRM at a level of 1 × 105 cells per unit well, and further incubated for 6, 12, 24, and 48 hours. The levels of TGF-β1, FGF-2, and IL-6 from the supernatant were measured by enzyme-linked immunosorbent assay (ELISA). The data were analyzed using one-way ANOVA. The level of TGF-β1 was down-regulated when the cells were grown in the presence of MTA except at 6 hours. The levels of FGF-2 release were significantly suppressed when PDL fibroblasts were grown in the presence of MTA or IRM at all time intervals (p < 0.05). The expressions of IL-6 from MTA treated cells were comparable to those of untreated control cells throughout the observation periods. We presume that this material inhibits the stimulatory function of growth factors on granulation tissue formation and in turn, it promotes the healing process modulated by other bone-remodeling cells.

Citations

Citations to this article as recorded by  
  • Osteo/odontogenic Differentiation of Human Mesenchymal Stem Cells with Platelet-rich Plasma and Mineral Trioxide Aggregate
    Shanthi Vanka, Amit Vanka, Sandeep Kumar Vishwakarma, Manohar K Bhat, Othman Wali, Aleem A Khan
    The Journal of Contemporary Dental Practice.2019; 20(10): 1171.     CrossRef
  • The effect of several root-end filling materials on MG63 osteoblast-like cells
    Jeong-Ho Lee, Won-Jun Shon, WooCheol Lee, Seung-Ho Baek
    Journal of Korean Academy of Conservative Dentistry.2010; 35(3): 222.     CrossRef
  • Biocompatibility of experimental mixture of mineral trioxide aggregate and glass ionomer cement
    Min-Jae Oh, Yu-Na Jeong, In-Ho Bae, So-Young Yang, Bum-Jun Park, Jeong-Tae Koh, Yun-Chan Hwang, In-Nam Hwang, Won-Mann Oh
    Journal of Korean Academy of Conservative Dentistry.2010; 35(5): 359.     CrossRef
  • Biocompatibility of bioaggregate cement on human pulp and periodontal ligament (PDL) derived cells
    Choo-Ryung Chung, Euiseong Kim, Su-Jung Shin
    Journal of Korean Academy of Conservative Dentistry.2010; 35(6): 473.     CrossRef
  • Effects of condensation techniques and canal sizes on the microleakage of orthograde MTA apical plug in simulated canals
    Deuk-Lim Nam, Jeong-Kil Park, Bock Hur, Hyeon-Cheol Kim
    Journal of Korean Academy of Conservative Dentistry.2009; 34(3): 208.     CrossRef
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