Restorative Dentistry & Endodontics

Research Articles

Effect of combined application of premixed bioceramic paste and diode laser in vital pulp therapy: an immunohistochemical randomized controlled split-mouth in vivo animal experiment: Mo’men A. Salama, Dalia M. Fayyad, Mohamed I. Rabie, Manar A. A. Selim, Mahmoud F. Ahmed; J Korean Acad Conserv Dent ;Published online January 20, 2026; DOI: https://doi.org/10.5395/rde.2026.51.e4 [Epub ahead of print]

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This study aimed to evaluate the effect of premixed bioceramic paste (Well-Root PT; Vericom) compared to mineral trioxide aggregate (MTA) on the expression of the mineralization-related marker dentin sialoprotein (DSP) in dental pulp following direct pulp capping, with or without prior diode laser application.
Methods
Direct pulp exposures were performed in the upper and lower incisors of eight dogs (n = 96 teeth). Cavities (Class V) were created and received pulp capping with either Well-Root PT (n = 32), MTA (n = 32), or no capping material (Teflon disc only) (n = 32), with or without the application of a diode laser. Immunohistochemical analysis of DSP expression was conducted and quantified as the mean area percentage using ImageJ software at 2 and 8 weeks posttreatment.
Results
Both the Well-Root PT and MTA groups showed significantly increased DSP expression compared to the control group at both 2 and 8 weeks (p < 0.05). No significant difference in the mean area percentage of DSP expression was found between the Well-Root PT and MTA groups. The diode laser application did not produce a significant effect on DSP expression. Within-group comparison revealed a significant increase in DSP expression between the 2- and 8-week follow-up periods (p < 0.05).
Conclusions
Well-Root PT demonstrated comparable efficacy to MTA in promoting DSP expression, supporting its use as an effective direct pulp capping material. Diode laser application prior to capping had no effect on DSP expression in this experimental model.

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Resolvin E1 incorporated carboxymethyl chitosan scaffold accelerates repair of dental pulp stem cells under inflammatory conditions: a laboratory investigation: Hemalatha P Balasubramanian, Nandini Suresh, Vishnupriya Koteeswaran, Velmurugan Natanasabapathy; Restor Dent Endod 2025;50(4):e40. Published online November 28, 2025; DOI: https://doi.org/10.5395/rde.2025.50.e40

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This study fabricated and characterized a resolvin E1 (RvE1)-loaded carboxymethyl chitosan (CMC) scaffold and determined its cytotoxicity and mineralization potential on inflamed human dental pulp stem cells (hDPSCs).
Methods
CMC scaffold incorporated with two concentrations of RvE1 (100 and 200 nM) was fabricated and characterized. The scaffolds’ porosity, drug release kinetics, and degradation were assessed. The impact of RvE1 on inflamed hDPSCs proliferation, proinflammatory gene expression (tumor necrosis factor alpha [TNF-α]), alkaline phosphatase activity, and alizarin red S staining was evaluated.
Results
Scanning electron microscopy analysis demonstrated a highly porous interconnected microstructure. Release kinetics showed gradual RvE1 release peaking at day 14. Cumulative degradation of the CMC scaffold at 28 days was 57.35%. Inflamed hDPSCs exposed to 200 nM RvE1-CMC scaffold exhibited significantly improved viability compared to 100 nM. Both RvE1-CMC scaffolds significantly suppressed the expression of TNF-α at 7 days. Alkaline phosphatase activity was enhanced by both RvE1 concentrations on days 7 and 14. Alizarin red staining revealed superior mineralization potential of 200 nM RvE1 on days 14 and 21.
Conclusions
This study concludes 200 nM RvE1-CMC scaffold is a promising therapy for inflamed pulp conditions, enhancing cell proliferation and biomineralization potential in inflamed hDPSCs.

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Comparison of remineralization in caries-affected dentin using calcium silicate, glass ionomer cement, and resin-modified glass ionomer cement: an in vitro study: Kwanchanok Youcharoen, Onwara Akkaratham, Papichaya Intajak, Pipop Saikaew, Sirichan Chiaraputt; Restor Dent Endod 2025;50(4):e37. Published online November 14, 2025; DOI: https://doi.org/10.5395/rde.2025.50.e37

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This study evaluated the ability of calcium silicate cement (CSC) as a remineralizing agent compared with conventional glass ionomer cement (GIC) and resin-modified GIC (RMGIC) to remineralize artificial caries-affected dentin.
Methods
Twenty-five class V cavities were prepared on extracted human third molars. Twenty teeth underwent artificial caries induction. The remaining five teeth with sound dentin serve as the positive control. The twenty demineralized teeth were subdivided into four groups (n = 5): carious dentin without restoration (negative control [NC]), carious dentin restored with CSC (Biodentine, Septodont), carious dentin restored with GI (Fuji IX, GC Corporation), and carious dentin restored with RMGIC (Fuji II LC, GC Corporation). Following restoration, the specimens were stored in artificial saliva for 7 days. The elastic modulus was evaluated by a nanoindentation test. The mineral composition was analyzed by scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDX), and the mineral composition at the dentin-material interface.
Results
CSC had a higher modulus of elasticity compared to GI, RMGI, and NC groups (p < 0.05). Higher calcium and phosphorus content was observed under CSC restorations, as indicated by SEM-EDX examination, which may lead to better remineralization.
Conclusions
Compared to GI and RMGI, CSC showed the best remineralization and mechanical reinforcement in caries-affected dentin, indicating CSC for use in minimally invasive restorative dentistry.

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Stress distribution of restorations in external cervical root resorption under occlusal and traumatic loads: a finite element analysis: Padmapriya Ramanujam, Paul Kevin Abishek Karthikeyan, Vignesh Srinivasan, Selvakarthikeyan Ulaganathan, Velmurugan Natanasabapathy, Nandini Suresh; Restor Dent Endod 2025;50(2):e21. Published online May 21, 2025; DOI: https://doi.org/10.5395/rde.2025.50.e21

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This study analyzed the stress distribution in a maxillary central incisor with external cervical resorptive defect restored with different restorative materials under normal masticatory and traumatic loading conditions using finite element analysis.
Methods
Cone-beam computed tomography of an extracted intact incisor and created resorptive models (Patel’s 3D classification-2Bd and 2Bp) in the maxillary central incisor was performed for finite element models. The 2Bd models were restored either with glass ionomer cement (GIC)/Biodentine (Septodont) or a combination of both with composite resin. 2Bp models were restored externally with a combination technique and internally with root canal treatment. The other model was external restoration with GIC and internal with fiber post. Two masticatory loads were applied at 45˚ to the palatal aspect, and two traumatic loads were applied at 90˚ to the buccal aspect. Maximum von Mises stresses were calculated, and stress distribution patterns were studied.
Results
In 2Bd models, all restorative strategies decreased stress considerably, similar to the control model under all loads. In 2Bp models, the dentin component showed maximum stress at the deepest portion of the resorptive defect, which transfers into the adjacent pulp space. In 2Bp defects, a multilayered restoration externally and root canal treatment internally provides better stress distribution compared to the placement of a fiber post.
Conclusions
Increase in load, proportionally increased von Mises stress, despite the direction or angulation of the load. Multilayered restoration is preferred for 2Bd defects, and using an internal approach of root canal treatment is suggested to restore 2Bp defects.

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Histological evaluation of pulp response to alendronate and Biodentine as pulp capping agents: an animal study: Thangavel Boopathi, Sekar Manimaran, Joseline Charles Kerena, Mathew Sebeena, Kumaravadivel Karthick, Natesan Thangaraj Deepa; Restor Dent Endod 2024;49(4):e39. Published online October 29, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e39

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Objectives

This study aimed to comparatively assess the histological response of the pulp toward alendronate and Biodentine in a direct pulp capping procedure.

Materials and Methods

Twenty-four anterior teeth from 6 New Zealand rabbits were used in this study. Firstly, all rabbits were anesthetized according to their weight. Class V cavities were prepared on the buccal surfaces of anterior teeth. A pin-point exposure of the pulp was then made using a small, sterile round carbide bur and bleeding was arrested with a saline-soaked, sterile cotton pellet. The teeth under study were divided into 2 groups (n = 12). The intentionally exposed pulp was capped with alendronate (Group 1) and Biodentine (Group 2), correspondingly. After 30 days, all rabbits were euthanized; the teeth under study were extracted and taken up for histological analysis.

Results

Biodentine showed an intact, very dense dentin bridge formation with a uniform odontoblast (OD) layer pattern and mild or absent inflammatory response whereas specimens capped with alendronate demonstrated a dense dentin bridge formation with non-uniform OD layer pattern and mild to moderate inflammatory response.

Conclusions

Biodentine showed more biocompatibility than alendronate. However, alendronate can initiate reparative dentin formation and may be used as an alternative pulp capping agent.

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In Vivo Evaluation of NF-κB and TGFβ-1 Modulation by Anadara granosa Shell-Derived Calcium Carbonate Bioceramic in Rat Model
Randy Nugraha Pratama, Nurhayati Natsir, Kezia Rachellea Mustakim, Juni Jekti Nugroho
European Journal of General Dentistry.2026;[Epub] CrossRef

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Effects of a relined fiberglass post with conventional and self-adhesive resin cement: Wilton Lima dos Santos Junior, Marina Rodrigues Santi, Rodrigo Barros Esteves Lins, Luís Roberto Marcondes Martins; Restor Dent Endod 2024;49(2):e18. Published online March 27, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e18

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Objectives

This study was conducted to evaluate the mechanical properties of relined and non-relined fiberglass posts when cemented to root canal dentin using a conventional dual-cure resin cement or a self-adhesive resin cement.

Materials and Methods

Two types of resin cements were utilized: conventional and self-adhesive. Additionally, 2 cementation protocols were employed, involving relined and non-relined fiberglass posts. In total, 72 bovine incisors were cemented and subjected to push-out bond strength testing (n = 10) followed by failure mode analysis. The cross-sectional microhardness (n = 5) was assessed along the root canal, and interface analyses (n = 3) were conducted using scanning electron microscopy (SEM). Data from the push-out bond strength and cross-sectional microhardness tests were analyzed via 3-way analysis of variance and the Bonferroni post-hoc test (α = 0.05).

Results

For non-relined fiberglass posts, conventional resin cement exhibited higher push-out bond strength than self-adhesive cement. Relined fiberglass posts yielded comparable results between the resin cements. Type II failure was the most common failure mode for both resin cements, regardless of cementation protocol. The use of relined fiberglass posts improved the cross-sectional microhardness values for both cements. SEM images revealed voids and bubbles in the incisors with non-relined fiberglass posts.

Conclusions

Mechanical properties were impacted by the cementation protocol. Relined fiberglass posts presented the highest push-out bond strength and cross-sectional microhardness values, regardless of the resin cement used (conventional dual-cure or self-adhesive). Conversely, for non-relined fiberglass posts, the conventional dual-cure resin cement yielded superior results to the self-adhesive resin cement.

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Push-Out Bond Strength of Different Luting Cements Following Post Space Irrigation with 2% Chitosan: An In Vitro Study
Shimaa Rifaat, Ahmed Rahoma, Hind Muneer Alharbi, Sawsan Jamal Kazim, Shrouq Ali Aljuaid, Basmah Omar Alakloby, Faraz A. Farooqi, Noha Taymour
Prosthesis.2025; 7(1): 18. CrossRef

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Single-session associative protocol for dentin hypersensitivity management: a 1-year randomized, blinded clinical study: Thayna Carolina Zeni, Poliana Maria de Faveri Cardoso, Rafael da Silva Vanolli, Márcio José Mendonça, Julio Katuhide Ueda, Veridiana Camilotti; Restor Dent Endod 2024;49(2):e15. Published online March 20, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e15

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Objectives

This study aimed to establish a single-session associative protocol for non-restorative management of dentin hypersensitivity (DH).

Materials and Methods

Twenty-four individuals with DH and a minimum sensitivity level of 4 on the visual analog scale (VAS) were selected. The study was conducted in a split-mouth design, with each participant (n = 20) having at least 1 affected tooth in all quadrants. The management protocols consisted of control group: universal adhesive, Neural Desensitizing Protocol group: 5% potassium nitrate, Mixed Desensitizing Protocol (PAM) group: 5% sodium fluoride and 5% potassium nitrate, Remineralizing Desensitizing Protocol (PDR) group: surface-partially reacted glass technology photopolymerizable varnish. Evaluations were performed immediately after application, at 1 week, 1 month, 2 months, and 12 months using the VAS sensitivity test.

Results

The scores were subjected to statistical analysis using the Friedman test (p < 0.05), Durbin-Conover test (p < 0.05), and Wilcoxon test (p < 0.05). At the 12-month evaluation, all groups showed statistically significant differences compared to the initial assessment. For the evaluation after 12 months, there was a statistically significant difference between the PAM group, the control group, and the PDR group.

Conclusions

It can be concluded that all groups were effective in controlling DH, but there were significant results in the control group and PDR group. The clinical relevance of this study is to demonstrate that the application of single-session desensitizing protocols can be effective in controlling DH for up to 12 months.

Trial Registration

Brazilian Clinical Trials Registry Identifier: RBR-4r63d7s

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In vivo and in situ evaluation of innovative approaches in dentin hypersensitivity treatment
Heba Abd El-Fattah Mohamed, Dina Ezzeldin Mohamed, Elhassan Hassanein, Heba El-din Salah El-din Hamza
BMC Oral Health.2025;[Epub] CrossRef
Publication trends and scientific profile of clinical trials on universal adhesives in dentistry: A metrics-based review
Aurélio de Oliveira Rocha, Lucas Menezes dos Anjos, Michael Willian Favoreto, Michely Cristina Goebel, Bruno Henriques, Alessandra Reis, Alessandro D. Loguercio, Mariane Cardoso
Journal of Dentistry.2025; 161: 105965. CrossRef
EVALUATION OF PUSH-OUT BOND STRENGTH OF GLASS FIBER POSTS USING DIFFERENT LUTING CEMENTS
Jannah Mohammed, Maha Agha
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY.2025; : 274. CrossRef
EVALUATION OF PUSH-OUT BOND STRENGTH OF GLASS FIBER POSTS USING DIFFERENT LUTING CEMENTS
Jannah Mohammed, Jannah Mohammed
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY.2025; : 274. CrossRef
CLINICAL AND BEHAVIORAL DETERMINANTS OF DENTIN SENSITIVITY AMONG DENTAL STUDENTS: AN INSTITUTIONAL CROSS-SECTIONAL STUDY
Giuseppe Eliseo ALLOCCA, Alexandrina MUNTEAN , Cristian Doru OLTEANU , Sorana Maria BUCUR
Medicine and Materials.2025; 5(2): 73. CrossRef
Desensitizing efficacy of a universal dentin adhesive containing mesoporous bioactive glass on dentin hypersensitivity: a randomized clinical trial with a split-mouth model
Hyun-Jung Kim, Soram Oh, Jiyoung Kwon, Kyoung-Kyu Choi, Ji-Hyun Jang, Duck-Su Kim
Scientific Reports.2024;[Epub] CrossRef

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Pomegranate extract on eroded dentin: antioxidant action, bond strength and morphology of the adhesive interface after aging: Thiago Vinícius Cortez, Nathália Mancioppi Cerqueira, Julia Adornes Gallas, Wanderley Pereira Oliveira, Silmara Aparecida Milori Corona, Aline Evangelista Souza-Gabriel; Restor Dent Endod 2024;49(1):e9. Published online January 26, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e9

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Objectives

This study aimed to evaluate the effect of pomegranate solution (Punica granatum) on eroded dentin through antioxidant action, shear bond strength (SBS) and interface morphology.

Materials and Methods

The 10% pomegranate peel extract was prepared by the lyophilization method. Punicalagin polyphenol was confirmed by high-performance liquid chromatography. Antioxidant activity was evaluated by capturing the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. For the SBS, 48 dentin fragments were divided into sound or eroded, and subdivided according to the pretreatment (n = 12): water or P. granatum. The surfaces were restored with self-etch adhesive and a bulk-fill resin (Ecosite; DMG). The SBS was done immediately (24 hours) and after thermal cycling + water storage (12 months). For scanning electron microscopy, 48 dentin fragments (24 sound and 24 eroded) received the same treatments as for SBS (n = 6), and they were analyzed after 24 hours and 12 months.

Results

The P. granatum had antioxidant action similar (p = 0.246) to the phenolic standard antioxidants. After 24 hours, eroded dentin had lower SBS than sound dentin (p < 0.001), regardless of the pretreatment. After 12 months, P. granatum maintained the SBS of sound dentin (13.46 ± 3.42 MPa) and eroded dentin (10.96 ± 1.90 MPa) statistically similar. The lowest values were found on eroded dentin treated with water (5.75 ± 1.65 MPa) (p < 0.001). P. granatum on eroded dentin caused peritubular demineralization and hybrid layer with resin tags.

Conclusions

The pomegranate extract had antioxidant action and preserved the adhesive interface of the eroded dentin.

Citations

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Antibacterial Effects of Ethanolic Extractions of Aloe Vera, Black Tea, Pomegranate and Orange on Streptococcus mutans: An In-vitro Study
Bardia Vadiati Saberi, Soheil Taghavi Namin, Dina Maleki
Nutrition And Food In Health And Disease.2025; 12(2): 29. CrossRef
Protective effect of a novel antioxidant gel containing resveratrol and sodium fluoride on dentin erosion in the presence of acquired salivary pellicle: An in vitro study
Loraine Perez Manzoli, Luan Júlio Ruiz da Silva, George Clay dos Santos Caracas, Kalinca Furtado de Oliveira, Walessa Alana Braganca Aragão, Rafael Rodrigues Lima, Milton Carlos Kuga, Cristiane de Melo Alencar
Archives of Oral Biology.2025; 179: 106395. CrossRef
Effect of pomegranate solution alone or combined with chlorhexidine against oral multispecies biofilm
J. A. Gallas, L. L. Pelozo, S. A. M. Corona, Y. Shen, M. Haapasalo, M. D. Sousa‐Neto, A. E. Souza‐Gabriel
International Endodontic Journal.2024; 57(12): 1819. CrossRef
The effect of resveratrol application on the micro-shear bond strength of adhesive to bleached enamel
Esra Cengiz-Yanardag, Izgen Karakaya
Scientific Reports.2024;[Epub] CrossRef

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Effect of dentin roughening and type of composite material on the restoration of non-carious cervical lesions: an in vivo study with 18 months of follow-up: Sanjana Verma, Rakesh Singla, Gurdeep Singh Gill, Namita Jain; Restor Dent Endod 2023;48(4):e35. Published online October 17, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e35

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Objectives

The purpose of this study was to evaluate the impact of dentin roughening and the type of composite resin used (either bulk-fill flowable or nanohybrid) on the restoration of non-carious cervical lesions (NCCLs) with an 18-month follow-up period.

Materials and Methods

This prospective split-mouth study included 36 patients, each with a minimum of 4 NCCLs. For each patient, 4 types of restorations were performed: unroughened dentin with nanohybrid composite, unroughened dentin with bulk-fill flowable composite, roughened dentin with nanohybrid composite, and roughened dentin with bulk-fill flowable composite. A universal bonding agent (Tetric N Bond Universal) was applied in self-etch mode for all groups. The restorations were subsequently evaluated at 6, 12, and 18 months in accordance with the criteria set by the FDI World Dental Federation. Inferential statistics were computed using the Friedman test, with the level of statistical significance established at 0.05.

Results

The 4 groups exhibited no significant differences in relation to fracture and retention, marginal staining, marginal adaptation, postoperative hypersensitivity, or the recurrence of caries at any follow-up point.

Conclusions

Within the limitations of the present study, over an 18-month follow-up period, no significant difference was present in the clinical performance of bulk-fill flowable and nanohybrid composite restorations of non-carious cervical lesions. This held true regardless of whether dentin roughening was performed.

Citations

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The challenges of composite restorations of non-carious cervical lesions
Zakaria Karimi
Dental Update.2025; 52(5): 340. CrossRef
Clinical performance of preheating thermoviscous composite resin for non-carious cervical lesions restoration: A 24-month randomized clinical trial
Michael Willian Favoreto, Taynara de Souza Carneiro, Romina Ñaupari-Villasante, Deisy Cristina Cordeiro, Gabriel David Cochinski, Thais Vilalba Paniagua Machado do Nascimento, Thalita de Paris Matos, Matheus Coelho Bandeca, Alessandra Reis, Alessandro D.
Journal of Dentistry.2024; 144: 104930. CrossRef
Die Zahnhalsfüllung
Roland Frankenberger
Der Freie Zahnarzt.2024; 68(7-8): 70. CrossRef

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Review Article

Stem cell-derived exosomes for dentin-pulp complex regeneration: a mini-review: Dina A. Hammouda, Alaa M Mansour, Mahmoud A. Saeed, Ahmed R. Zaher, Mohammed E. Grawish; Restor Dent Endod 2023;48(2):e20. Published online May 3, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e20

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This mini-review was conducted to present an overview of the use of exosomes in regenerating the dentin-pulp complex (DPC). The PubMed and Scopus databases were searched for relevant articles published between January 1, 2013 and January 1, 2023. The findings of basic in vitro studies indicated that exosomes enhance the proliferation and migration of mesenchymal cells, as human dental pulp stem cells, via mitogen-activated protein kinases and Wingless-Int signaling pathways. In addition, they possess proangiogenic potential and contribute to neovascularization and capillary tube formation by promoting endothelial cell proliferation and migration of human umbilical vein endothelial cells. Likewise, they regulate the migration and differentiation of Schwann cells, facilitate the conversion of M1 pro-inflammatory macrophages to M2 anti-inflammatory phenotypes, and mediate immune suppression as they promote regulatory T cell conversion. Basic in vivo studies have indicated that exosomes triggered the regeneration of dentin-pulp–like tissue, and exosomes isolated under odontogenic circumstances are particularly strong inducers of tissue regeneration and stem cell differentiation. Exosomes are a promising regenerative tool for DPC in cases of small pulp exposure or for whole-pulp tissue regeneration.

Citations

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Extracellular vesicles derived from dental mesenchymal stem cells for regenerative medicine: a scoping review
Maria Emília Mota, Márcia Martins Marques, Thaís Gimenez, Suely Kunimi Kubo Ariga, Tiago Góss dos Santos, Fábio Abreu Alves, Maria Stella Moreira
Molecular Biology Reports.2026;[Epub] CrossRef
Cell Homing Strategies in Regenerative Endodontic Therapy
David Kim, Sahng G. Kim
Cells.2025; 14(3): 201. CrossRef
Impact of dental pulp cells-derived small extracellular vesicles on the properties and behavior of dental pulp cells: an in-vitro study
Dina A. Hammouda, Alaa M. Mansour, Ahmed R. Zaher, Mohammed E. Grawish
BMC Oral Health.2025;[Epub] CrossRef
Methodological Approaches for Economic Comparison of Mesenchymal Stem Cell and Exosome-based Therapies with Conventional Endodontic Treatments in Regenerative Endodontics
Madina A. Kurmanalina Kurmanalina, Nadiar M. Mussin, Aigul M. Sumanova, Violetta R. Detochkina, Maryam Mardani, Nader Tanideh, Amin Tamadon
West Kazakhstan Medical Journal.2025; 67(2): 188. CrossRef
Exosomal circ_0003057 promotes osteo/odontogenic differentiation of hDPSCs by binding with EIF4A3 through upregulated parental gene ANKH
Bingtao Wang, Yuanyuan Kong, Huixian Dong, Feng Lai, Zixin Guo, Liecong Lin, Jingyi Xu, Jingkun Zhang, Yiguo Jiang, Qianzhou Jiang
International Endodontic Journal.2025; 58(9): 1433. CrossRef
Mechanistic insights into dental stem cells‐derived exosomes in regenerative endodontics
Paras Ahmad, Nathan Estrin, Nima Farshidfar, Yufeng Zhang, Richard J. Miron
International Endodontic Journal.2025; 58(9): 1384. CrossRef
Development and characterization of an exosome-loaded biomimetic hydroxyapatite/gelatin scaffold for enhanced dental pulp regeneration
Yuen-Shan Tsai, Shih-Jung Cheng, Tsao-Li Chuang, Shu-Fang Chang, Feng-Huei Lin, Chun-Pin Lin
Journal of Dental Sciences.2025;[Epub] CrossRef
Exosomes as Promising Therapeutic Tools for Regenerative Endodontic Therapy
Qingyue Kong, Yujie Wang, Nan Jiang, Yifan Wang, Rui Wang, Xiaohan Hu, Jing Mao, Xin Shi
Biomolecules.2024; 14(3): 330. CrossRef
Role and Molecular Mechanism of miR-586 in the Differentiation of Dental Pulp Stem Cells into Odontoblast-like Cells
Gang Pan, Qianwen Zhou, Chenhua Pan, Yingxue Zhang
Cell Biochemistry and Biophysics.2024; 83(1): 507. CrossRef

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Research Articles

Effect of an aluminum chloride hemostatic agent on the dentin shear bond strength of a universal adhesive: Sujin Kim, Yoorina Choi, Sujung Park; Restor Dent Endod 2023;48(2):e14. Published online March 22, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e14

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Objectives

This study investigated the effect of an aluminum chloride hemostatic agent on the shear bond strength (SBS) of a universal adhesive to dentin.

Materials and Methods

Eighty extracted human molars were trimmed at the occlusal dentin surfaces and divided mesiodistally. According to hemostatic agent application, specimens were randomly allocated into control (C) and hemostatic agent (Traxodent; H) groups. Each group was divided into 4 subgroups according to the adhesive system (n = 20): Scotchbond Multi-Purpose (SBER), Clearfil SE Bond (CLSE), All-Bond Universal etch-and-rinse mode (ALER), and All-Bond Universal self-etch mode (ALSE). SBS was measured for half of the specimens at 24 hours, and the other half were thermocycled in water baths (group T). Fracture surfaces were examined to determine the failure mode. The SBS was measured, and data were analyzed using 1-way analysis of variance, the Student’s t-test, and the Tukey honestly significant difference test (p = 0.05).

Results

No significant differences in SBS were found between groups C and H for any adhesive system at 24 hours. After thermocycling, a statistically significant difference was observed between CT+ALSE and HT+ALSE (p < 0.05). When All-Bond Universal was applied to hemostatic agent-contaminated dentin, the SBS of H+ALSE was significantly lower than that of H+ALER (p < 0.05). The SBER subgroups showed no significant differences in SBS regardless of treatment and thermocycling.

Conclusions

When exposed dentin was contaminated by an aluminum chloride hemostatic agent before dentin adhesive treatment, application of All-Bond Universal in etch-and-rinse mode was superior to self-etch mode.

Citations

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Nature-driven blue-emissive N, S-CDs: Harnessing sequential "switch-off-on" fluorescence signals for detection of chrysin and Al³⁺ along with cellular imaging versatility
Maha Mohammad Abdel-Monem, Mohamed I. Walash, Asmaa Kamal El-Deen
Talanta Open.2025; : 100466. CrossRef
Comparative Evaluation of the Shear Bond Strength of Self-Adhesive and Glass Ionomer Cement to Dentin After Removal of Hemostatic Agents Using Different Cleansing Protocols: An In Vitro Study
Hemashree Namburajan, Mathew Chalakuzhiyil Abraham, Vidhyasankari N, Rajkumar K, Abhinayaa Suthagar, Vishnupriya Venkatasubramanian, Sindhuja Nagarajan
Cureus.2025;[Epub] CrossRef
Emalje- og dentinadhesiver: Avgjørende faser i klinisk behandling
Torgils Lægreid, Tom Paulseth, Arne Lund
Den norske tannlegeforenings Tidende.2024; 134(8): 604. CrossRef

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Epigallocatechin-3-gallate prior to composite resin in abfraction lesions: a split-mouth randomized clinical trial: Luísa Valente Gotardo Lara Alves, Lisiane Martins Fracasso, Thiago Vinicius Cortez, Aline Evangelista Souza-Gabriel, Silmara Aparecida Milori Corona; Restor Dent Endod 2023;48(2):e13. Published online March 20, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e13

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Objectives

Natural extracts have been investigated as a biomimetic strategy to mechanically strengthen the collagen network and control the biodegradation of extracellular matrix. This study evaluated the effect of epigallocatechin-3-gallate (EGCG) on abfraction lesions prior to the composite resin.

Materials and Methods

The sample consisted of 30 patients (aged between 28 and 60 years) with abfraction lesions located in 2 homologous premolars. The teeth were randomly assigned according to dentin treatment: 0.02% EGCG solution or distilled water (control). After enamel acid etching, the solutions were applied immediately for 1 minute. The teeth were restored with Universal Adhesive (3M) and Filtek Z350 XT (3M). Analyzes were done by 2 independent examiners using modified USPHS (retention, secondary caries, marginal adaptation, and postoperative sensitivity) and photographic (color, marginal pigmentation, and anatomical form) criteria at baseline (7 days) and final (18 months). The data analysis used Friedman and Wilcoxon signed-rank tests (α = 0.05).

Results

At baseline, all restorations were evaluated as alpha for all criteria. After 18 months, restorations were evaluated as alpha for secondary caries, color, and marginal pigmentation. There was significant difference between baseline and 18 months (p = 0.009) for marginal adaptation and postoperative sensitivity (p = 0.029), but no significant difference were verified between treatments (p = 0.433). The EGCG group had a restoration retention rate of 93.3%, while the control group had 96.7%.

Conclusions

The application of EGCG solution on abfraction lesions did not significantly influence the survival of the restorations based on clinical and photographic criteria.

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Therapeutic potential of flavonoids in erosive tooth wear management: a scoping review
Gabriel Pereira Nunes, Renata de Oliveira Alves, Geórgia Rondó Peres, Priscila Toninatto Alves de Toledo, Aline Rogéria Freire de Castilho
Clinical Oral Investigations.2025;[Epub] CrossRef

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Dentinal tubule penetration of sodium hypochlorite in root canals with and without mechanical preparation and different irrigant activation methods: Renata Aqel de Oliveira, Theodoro Weissheimer, Gabriel Barcelos Só, Ricardo Abreu da Rosa, Matheus Albino Souza, Rodrigo Gonçalves Ribeiro, Marcus Vinicius Reis Só; Restor Dent Endod 2023;48(1):e1. Published online December 1, 2022; DOI: https://doi.org/10.5395/rde.2023.48.e1

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Objectives

This study evaluated the dentinal penetration depth of 2.5% sodium hypochlorite (NaOCl) in root canals with and without preparation and different irrigant activation protocols.

Materials and Methods

Sixty-three bovine mandibular incisors were randomly allocated to 6 groups (n = 10): G1, preparation + conventional needle irrigation (CNI); G2, preparation + passive ultrasonic irrigation (PUI); G3, preparation + Odous Clean (OC); G4, no preparation + CNI; G5, no preparation + PUI; G6, no preparation + OC; and CG (negative control; n = 3). Samples were filled with crystal violet for 72 hours. Irrigant activation was performed. Samples were sectioned perpendicularly along the long axis, 3 mm and 7 mm from the apex. Images of the root thirds of each block were captured with a stereomicroscope and analyzed with an image analysis software. One-way analysis of variance, followed by the Tukey post hoc test, and the Student’s t-test were used for data analysis, with a significance level of 5%.

Results

The NaOCl penetration depth was similar when preparation was performed, regardless of the method of irrigation activation (p > 0.05). In the groups without preparation, G6 showed greater NaOCl penetration depth (p < 0.05). The groups without preparation had a greater NaOCl penetration depth than those with preparation (p = 0.0019).

Conclusions

The NaOCl penetration depth was similar in groups with root canal preparation. Without root canal preparation, OC allowed deeper NaOCl penetration. The groups without preparation had greater NaOCl penetration than those undergoing root canal preparation.

Citations

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Novel approaches involving curcumin in endodontic and periodontal diseases: a scoping review
Yuxi Xing, Yanbing Zhu, Yukai Shen, Yuou Xu, Ziman Xu, Mengxue Wang, Xudong Ma, Lehua Liu, Shu Chen
BMC Oral Health.2026;[Epub] CrossRef
Influence of passive ultrasonic irrigation cycles on the penetration depth of sodium hypochlorite into root dentin
Hüseyin Gündüz, Esin Özlek, Züleyha Baş
Scientific Reports.2025;[Epub] CrossRef
Evaluating the Effects of Various Antioxidants on Dentinal Tubule Penetrability of a Resin-Based Sealer: A Confocal Laser Microscopic Study
Sanjeev Srivastava, Shijita Sinha, Abhishek Singh, Aditya Singh, Pragyan Paliwal, Syed H Mehdii
Cureus.2025;[Epub] CrossRef
Impact of different activation procedures on sodium hypochlorite penetration into dentinal tubules after endodontic retreatment via confocal laser scanning microscopy
Betul Gunes, Kübra Yeşildal Yeter, Yasin Altay
BMC Oral Health.2024;[Epub] CrossRef
Debridement ability of the WaveOne Gold and TruNatomy systems in the apical third of root canals: ex vivo assessment
Sara Carvalho Avelar de Oliveira, Carlos Eduardo da Silveira Bueno, Rina Andréa Pelegrine, Carlos Eduardo Fontana, Alexandre Sigrist de Martin, Carolina Pessoa Stringheta
Brazilian Dental Journal.2024;[Epub] CrossRef
Combined effect of electrical energy and graphene oxide on Enterococcus faecalis biofilms
Myung-Jin LEE, Mi-Ah KIM, Kyung-San MIN
Dental Materials Journal.2023; 42(6): 844. CrossRef

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Resin infiltrant protects deproteinized dentin against erosive and abrasive wear: Ana Theresa Queiroz de Albuquerque, Bruna Oliveira Bezerra, Isabelly de Carvalho Leal, Maria Denise Rodrigues de Moraes, Mary Anne S. Melo, Vanara Florêncio Passos; Restor Dent Endod 2022;47(3):e29. Published online July 1, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e29

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Objectives

This study aimed to investigate the anti-erosive/abrasive effect of resin infiltration of previous deproteinized dentin.

Materials and Methods

Dentin slabs were randomly assigned to 3 groups (n = 15): Control (no deproteinization; no resin infiltrant applied), RI (no deproteinization; resin infiltrant applied), and DRI (deproteinization; resin infiltrant applied). After undergoing the assigned treatment, all slabs were subjected to an in vitro cycling model for 5 days. The specimens were immersed in citric acid (0.05 M, pH = 3.75; 60 seconds; 3 times/day) and brushed (150 strokes). Between the challenges, the specimens were exposed to a remineralizing solution (60 minutes). The morphological alterations were analyzed by mechanical profilometry (µm) and scanning electron microscopy (SEM). Data were submitted to one-way analysis of variance (ANOVA) and Tukey tests (p < 0.05).

Results

Control and RI groups presented mineral wear and did not significantly differ from each other (p = 0.063). DRI maintained a protective layer preserving the dentin (p < 0.001). After erosive/abrasive cycles, it was observed that in group RI, only 25% of the slabs partially evidenced the presence of the infiltrating, while, in the DRI group, 80% of the slabs presented the treated surface entirely covered by a resin-component layer protecting the dentin surface as observed in SEM images.

Conclusions

The removal of the organic content allows the resin infiltrant to efficiently protect the dentin surface against erosive/abrasive lesions.

Citations

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Acidic/abrasive challenges on simulated non-carious cervical lesions development and morphology
Giovanna C. Denucci, Ian Towle, Cecilia P. Turssi, George J. Eckert, Anderson T. Hara
Archives of Oral Biology.2025; 169: 106120. CrossRef
Physio‐Mechanic and Microscopic Analyses of Bioactive Glass‐Based Resin Infiltrants
Syed Zubairuddin Ahmed, Abdul Samad Khan, Wejdan Waleed Nasser, Methayel Abdulrahman Alrushaid, Zahrah Mohammed Alfaraj, Moayad Mohammed Aljeshi, Asma Tufail Shah, Budi Aslinie Md Sabri, Sultan Akhtar, Mohamed Ibrahim Abu Hassan
Microscopy Research and Technique.2025; 88(2): 595. CrossRef
Resin Infiltration Treatment of Developmental Enamel Defects in a Patient With Hydrocephalus and Cerebral Palsy: A Case Report on the Impact on the Maternal Caregiver
Eduarda Martins Fontes Cantarella de Almeida, Anna Luísa Araujo Pimenta, Francisco Wanderley Garcia de Paula‐Silva, Fabricio Kitazono de Carvalho, Laurindo Borelli‐Neto, Susanne Effenberger, Fernanda de Carvalho Panzeri, Silmara Aparecida Milori Corona, K
Special Care in Dentistry.2025;[Epub] CrossRef

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Chitosan-induced biomodification on demineralized dentin to improve the adhesive interface: Isabella Rodrigues Ziotti, Vitória Leite Paschoini, Silmara Aparecida Milori Corona, Aline Evangelista Souza-Gabriel; Restor Dent Endod 2022;47(3):e28. Published online June 15, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e28

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Objectives

Metalloproteinase-inhibiting agents, such as chitosan, can prevent collagen degradation in demineralized dental substrates, thereby improving the adhesive interface. This study evaluated the bond strength (BS) and chemical and morphological characterization of the adhesive interface after applying chitosan solution to demineralized dentin.

Materials and Methods

The 80 third molars were selected. Forty teeth underwent caries induction using the pH cycling method. The teeth were divided according to the treatment: distilled water (control) and 2.5% chitosan solution. The surfaces were restored using adhesive and composite resins. Half of the specimens in each group were aged, and the other half underwent immediate analyses. The teeth were sectioned and underwent the microtensile bond strength test (µTBS), and chemical and morphological analyses using energy-dispersive spectroscopy and scanning electron microscopy, respectively. Data analysis was performed using 3-way analysis of variance.

Results

For µTBS, sound dentin was superior to demineralized dentin (p < 0.001), chitosan-treated specimens had higher bond strength than the untreated ones (p < 0.001), and those that underwent immediate analysis had higher values than the aged specimens (p = 0.019). No significant differences were observed in the chemical or morphological compositions.

Conclusions

Chitosan treatment improved bond strength both immediately and after aging, even in demineralized dentin.

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Recent advances in medical applications of chitosan-based biomaterials
Dinesh Kumar Sharma
International Journal of Polymeric Materials and Polymeric Biomaterials.2025; 74(11): 1027. CrossRef
Push-Out Bond Strength of Different Luting Cements Following Post Space Irrigation with 2% Chitosan: An In Vitro Study
Shimaa Rifaat, Ahmed Rahoma, Hind Muneer Alharbi, Sawsan Jamal Kazim, Shrouq Ali Aljuaid, Basmah Omar Alakloby, Faraz A. Farooqi, Noha Taymour
Prosthesis.2025; 7(1): 18. CrossRef
Bioinspired Dentin Biomodification: Current Evidence and Emerging Approaches
Priyanka S R, Sharath Pare
International Journal of Innovative Science and Research Technology.2025; : 219. CrossRef
A synergistic approach to tooth remineralization using nano-chitosan, fluoride, and pulsed magnetic field
Alaa M. Khalil, Samar A. Abbassy, Mona Mohy ElDin, Sherif Kandil, Ahmed M. El-Khatib
Scientific Reports.2025;[Epub] CrossRef
Chitosan-based Nano/Biomaterials in Bone Tissue Engineering and Regenerative Medicine: Recent Progress and Advances
Taha Jafari, Seyed Morteza Naghib, M. R. Mozafari
Current Organic Synthesis.2025; 22(4): 457. CrossRef
Influence of Non-Staining Chitosan-Based Nano-Silver Fluoride on Shear Bond Strengths of Dental Restorations
Bennett T. Amaechi, Sima Abdollahi, Tejal Gohil, Amos C. Obiefuna, Temitayo Omoniyi, Temitope O. Omosebi, Thais S. Phillips, Noha Elhabashi
Journal of Composites Science.2025; 9(10): 518. CrossRef
Does dentin pretreatment with chitosan improve the bond strength of restorative material? A systematic review and meta-analysis of in vitro studies
Luísa Valente Gotardo Lara Alves, Nathália Mancioppi Cerqueira, Amanda Pelegrin Candemil, André Luis Faria-e-Silva, Manoel Damião Sousa-Neto, Aline Evangelista Souza-Gabriel
International Journal of Adhesion and Adhesives.2024; 128: 103553. CrossRef
Comparative Evaluation of Apical Leakage in Root Canal Obturation Using AH Plus Sealer, Bioceramic Sealer, and Bioceramic Sealer Incorporated With Chitosan Nanoparticles: An In Vitro Study
Sushmita Rane, Varsha Pandit, Sanpreet S Sachdev, Shivani Chauhan, Rishabh Mistry, Barun Kumar
Cureus.2024;[Epub] CrossRef
Aesthetic impact of resin infiltration and its mechanical effect on ceramic bonding for white spot lesions
Jiaen Shu, Yijia Huang, Xueying Ma, Zhonghua Duan, Pei Wu, Sijing Chu, Yuqiong Wu, Yuhua Wang
BMC Oral Health.2024;[Epub] CrossRef
Effect of Incorporating Chitosan to Resin Modified Glass Ionomer Cement on Shear Bond Strength to Dentin (An In vitro Comparative Study)
Aya Tahseen Khudhair, Muna Saleem Khalaf
Journal of International Society of Preventive and Community Dentistry.2024; 14(3): 225. CrossRef
Biomodification of eroded and abraded dentin with epigallocatechin-3-gallate (EGCG)
Bruna Dantas Abreu, Renata Siqueira Scatolin, Silmara Aparecida Milori Corona, Fabiana Almeida Curylofo Zotti
Journal of the Mechanical Behavior of Biomedical Materials.2023; 147: 106158. CrossRef
Chitosan-Based Biomaterials for Tissue Regeneration
Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kamila Raziyeva, Laura Tabyldiyeva, Kamila Berikova, Dias Zhumagul, Kamila Temirkhanova, Arman Saparov
Pharmaceutics.2023; 15(3): 807. CrossRef
Er:YAG laser in selective caries removal and dentin treatment with chitosan: a randomized clinical trial in primary molars
Rai Matheus Carvalho Santos, Renata Siqueira Scatolin, Sérgio Luiz de Souza Salvador, Aline Evangelista Souza-Gabriel, Silmara Aparecida Milori Corona
Lasers in Medical Science.2023;[Epub] CrossRef
Effect of Dentin Surface Pretreatment With Chitosan Nanoparticles on Immediate and Prolonged Shear Bond Strength of Resin Composite: An in Vitro Study
Shaymaa Ali Abdul-Razzaq, Muna Saleem Khalaf
Dental Hypotheses.2023; 14(3): 84. CrossRef
MODERN TRENDS AND PERSPECTIVES OF THE DEVELOPMENT OF ADHESIVE DENTISTRY. INNOVATIVE TECHNIQUES FOR THE APPLICATION OF ADHESIVE SYSTEMS
Oleksandr O. Pompii, Viktor A. Tkachenko, Tetiana M. Kerimova, Elina S. Pompii
Wiadomości Lekarskie.2023; 76(12): 2721. CrossRef

2,207 View
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Is dentin biomodification with collagen cross-linking agents effective for improving dentin adhesion? A systematic review and meta-analysis: Julianne Coelho Silva, Edson Luiz Cetira Filho, Paulo Goberlânio de Barros Silva, Fábio Wildson Gurgel Costa, Vicente de Paulo Aragão Saboia; Restor Dent Endod 2022;47(2):e23. Published online May 6, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e23

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Objectives

The aim of this investigation was to evaluate the effectiveness of collagen cross-linking agents (CCLAs) used in combination with the adhesive technique in restorative procedures.

Materials and Methods

In this systematic review, the authors followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. An electronic search was performed using PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and DOSS, up to October 2020. The gray literature was also researched. Only randomized clinical trials were selected.

Results

The selection process yielded 3 studies from the 838 retrieved. The addition of CCLAs in the retention of restorations increased the number of events. The postoperative sensitivity scores and marginal adaptation scores showed no significant difference between the CCLA and control groups, and the marginal pigmentation scores showed a significant increase in the CCLA group. There were no caries events in any group throughout the evaluation period.

Conclusions

This systematic review showed that there is no clinical efficacy to justify the use of CCLAs in the protocols performed.

Citations

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Riboflavin-ultraviolet-A collagen crosslinking treatments in improving dentin bonding and resistance to enzymatic digestion
Yung-Show Chiang, Ping-Ju Chen, Chun-Chan Ting, Yuh-Ling Chen, Shu-Fen Chuang
Journal of Dental Sciences.2025; 20(1): 109. CrossRef
Effect of dentin bio modifications and matrix metalloproteinase activity on bond strength – A systematic review and meta-analysis
D. Agarwal, S. R. Srinidhi, S. D. Aggarwal, P. Ingle, S. Tandon
Endodontics Today.2025; 23(1): 71. CrossRef
O USO DE ADESIVO AUTOCONDICIONANTE E RESINA FLOW COMO INTERFACE ADESIVA PROTETORA DA DENTINA FRENTE À IRRIGAÇÃO COM NaClO NO TRATAMENTO ENDODÔNTICO: ESTUDO IN-VITRO
Luís Daniel Ramos de Oliveira, Leandro Botelho Hanna, José Augusto Rodrigues
RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218.2025; 6(12): e6127063. CrossRef
Stability of dentin matrix treated with caffeic acid phenethyl ester at different concentrations
Aline Honorato Damázio, Rosanna Tarkany Basting, Enrico Coser Bridi, Fabiana Mantovani Gomes França, Flávia Lucisano Botelho do Amaral, Cecilia Pedroso Turssi, Waldemir Francisco Vieira Junior, Roberta Tarkany Basting
Brazilian Journal of Oral Sciences.2024; 23: e244006. CrossRef
Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis
Louis Hardan, Umer Daood, Rim Bourgi, Carlos Enrique Cuevas-Suárez, Walter Devoto, Maciej Zarow, Natalia Jakubowicz, Juan Eliezer Zamarripa-Calderón, Mateusz Radwanski, Giovana Orsini, Monika Lukomska-Szymanska
Cells.2022; 11(15): 2417. CrossRef

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Bonding effects of cleaning protocols and time-point of acid etching on dentin impregnated with endodontic sealer: Tatiane Miranda Manzoli, Joissi Ferrari Zaniboni, João Felipe Besegato, Flávia Angélica Guiotti, Andréa Abi Rached Dantas, Milton Carlos Kuga; Restor Dent Endod 2022;47(2):e21. Published online April 6, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e21

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Objectives

This study aimed to investigate the bonding effects of cleaning protocols on dentin impregnated with endodontic sealer residues using ethanol (E) or xylol (X). The effects of dentin acid etching immediately (I) or 7 days (P) after cleaning were also evaluated. For bonding to dentin, universal adhesive (Scotchbond Universal; 3M ESPE) was used. The persistence of sealer residues, hybrid layer formation and microshear bond strength were the performed analysis.

Materials and Methods

One hundred and twenty bovine dentin specimens were allocated into 4 groups (n = 10): G1 (E+I); G2 (X+I); G3 (E+P); and G4 (X+P). The persistence of sealer residues was evaluated by SEM. Confocal laser scanning microscopy images were taken to measure the formed hybrid layer using the Image J program. For microshear bond strength, 4 resin composite cylinders were placed over the dentin after the cleaning protocols. ANOVA followed by Tukey test and Kruskal-Wallis followed by Dunn test were used for parametric and non-parametric data, respectively (α = 5%).

Results

G2 and G4 groups showed a lower persistence of residues (p < 0.05) and thicker hybrid layer than the other groups (p < 0.05). No bond strength differences among all groups were observed (p > 0.05).

Conclusions

Dentin cleaning using xylol, regardless of the time-point of acid etching, provided lower persistence of residues over the surface and thicker hybrid layer. However, the bond strength of the universal adhesive system in etch-and-rinse strategy was not influenced by the cleaning protocols or time-point of acid etching.

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Efficacy of Post-Endodontic Access Cavity Cleaning Techniques: A Randomized Clinical Study
Ayse Karadayi, Elif Irem Altintas, Ezgi Tüter Bayraktar, Bora Korkut
Journal of Endodontics.2025;[Epub] CrossRef
Does cleaning of post space before cementation of fiber reinforced post affect the push-out bond strength to resin cement?
Maher S. Hajjaj, Khalid A. Alghamdi, Abdulrahman A. Alshehri, Hassan A. Almusallam, Nabeel M. Munshi, Osamah A. Alsulimani, Naseeba H. Khouja, Yousef A. Alnowailaty, Saeed J. Alzahrani
BMC Oral Health.2025;[Epub] CrossRef
Influence of the Use of a Mixed Solution of Equal Amounts of Amyl Acetate, Acetone, and Ethanol on the Cleaning of Endodontic Sealer Residues on the Bond Strength of the Fiber Post Cementation System: A Laboratory Investigation
Antonia Patricia Oliveira Barros, Ana Paula Aparecida Raimundo Alves Freitas, Frederico Guilherme Otto Kokol, Elizangela Maria Pereira de Souza, Adirson Jorge Junior, Cristiane de Melo Alencar, Marcelo Ferrarezi de Andrade, Milton Carlos Kuga
The Open Dentistry Journal.2024;[Epub] CrossRef
Effects of the application protocol and bonding strategy of the universal adhesive on dentin previously impregnated with bioceramic sealer
Antonia Patricia Oliveira Barros, Joatan Lucas de Sousa Gomes Costa, Jardel Camilo do Carmo Monteiro, Lucas David Galvani, Marcelo Ferrarezi de Andrade, José Roberto Cury Saad, Milton Carlos Kuga
International Journal of Adhesion and Adhesives.2024; 134: 103765. CrossRef
Influência do protocolo de remoção de resíduos de cimentos à base de resina epóxi sobre a interface de adesão com o adesivo universal, utilizado na estratégia condiciona-e-lava
Paulo Firmino Da Costa Neto, Mariana Bena Gelio, Elisângela Maria Pereira De Souza, Jardel Camilo do Carmo Monteiro, Adirson Jorge Júnior, Thais Piragine Leandrin, José Roberto Cury Saad, Milton Carlos Kuga
Cuadernos de Educación y Desarrollo.2023; 15(5): 4802. CrossRef

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Review Article

Deep proximal margin rebuilding with direct esthetic restorations: a systematic review of marginal adaptation and bond strength: Hoda S. Ismail, Ashraf I. Ali, Rabab El. Mehesen, Jelena Juloski, Franklin Garcia-Godoy, Salah H. Mahmoud; Restor Dent Endod 2022;47(2):e15. Published online March 4, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e15

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This review aimed to characterize the effect of direct restorative material types and adhesive protocols on marginal adaptation and the bond strength of the interface between the material and the proximal dentin/cementum. An electronic search of 3 databases (the National Library of Medicine [MEDLINE/PubMed], Scopus, and ScienceDirect) was conducted. Studies were included if they evaluated marginal adaptation or bond strength tests for proximal restorations under the cementoenamel junction. Only 16 studies met the inclusion criteria and were included in this review. These studies presented a high degree of heterogeneity in terms of the materials used and the methodologies and evaluation criteria of each test; therefore, only a descriptive analysis could be conducted. The included studies were individually evaluated for the risk of bias following predetermined criteria. To summarize the results of the included studies, the type of restorative material affected the test results, whereas the use of different adhesive protocols had an insignificant effect on the results. It could be concluded that various categories of resin-based composites could be a suitable choice for clinicians to elevate proximal dentin/cementum margins, rather than the open sandwich technique with resin-modified glass ionomers. Despite challenges in bonding to proximal dentin/cementum margins, different adhesive protocols provided comparable outcomes.

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Girija S Sajjan, Naveena Ponnada, Praveen Dalavai, Madhu Varma Kanumuri, Venkata Karteek Varma Penmatsa, B V Sindhuja
World Journal of Dentistry.2025; 15(9): 749. CrossRef
Effect of Cervical Margin Relocation With Different Injectable Restorative Materials on Fracture Resistance of Molars Received MOD CAD/CAM Onlay Restorations
Basema N. Roshdy, Radwa I. Eltoukhy, Ashraf I. Ali, Salah Hasab Mahmoud
Journal of Esthetic and Restorative Dentistry.2025; 37(6): 1522. CrossRef
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Hoda Saleh Ismail, Hanan Ahmed Nabil Soliman
BMC Oral Health.2025;[Epub] CrossRef
Awareness and Practice of Deep Margin Elevation among Dental Practitioners in India: A Cross-Sectional Survey
Mythri Padaru, Preethesh Shetty, Namith Rai, Raksha Bhat
Pesquisa Brasileira em Odontopediatria e Clínica Integrada.2025;[Epub] CrossRef
Effect of surface treatment on glass ionomers in sandwich restorations: a systematic review and meta-analysis of laboratory studies
Hoda S. Ismail, Ashraf Ibrahim Ali, Franklin Garcia-Godoy
Restorative Dentistry & Endodontics.2025; 50(2): e13. CrossRef
Do irrigation solutions effect bond strength of composite resin to deep margin elevation material? An in-vitro study
Şeref Nur Mutlu, Yasemin Derya Fidancıoğlu, Hatice Büyüközer Özkan, Hayriye Esra Ülker
BMC Oral Health.2025;[Epub] CrossRef
Two-year evaluation of periodontal parameters following deep-margin-elevation and CAD/CAM partial lithium disilicate restorations – a prospective controlled clinical trial
Tim Hausdörfer, Philipp Kanzow, Tina Rödig, Annette Wiegand, Clemens Lechte
Journal of Dentistry.2025; 160: 105901. CrossRef
Deep Margin Elevation: Current Evidence and a Critical Approach to Clinical Protocols—A Narrative Review
Athanasios Karageorgiou, Maria Fostiropoulou, Maria Antoniadou, Eftychia Pappa
Adhesives.2025; 1(3): 10. CrossRef
Comparative Micro-CT Analysis of Internal Adaptation and Closed Porosity of Conventional Layered and Thermoviscous Bulk-Fill Resin Composites Using Total-Etch or Universal Adhesives
Dóra Jordáki, Virág Veress, Tamás Kiss, József Szalma, Márk Fráter, Edina Lempel
Polymers.2025; 17(15): 2049. CrossRef
Effect of different restorative systems and aging on marginal adaptation of resin composites to deep proximal margins
Hoda S. Ismail, Ashraf I. Ali
Journal of Esthetic and Restorative Dentistry.2024; 36(2): 346. CrossRef
Management of subgingival proximal defects
Jagruti Mutalikdesai, K. C. Dhaniba, Supriya Choudhary, Promila Verma, Rhythm Bains
Asian Journal of Oral Health and Allied Sciences.2024; 14: 15. CrossRef
Effect of Deep Margin Elevation on the Pulpal and Periodontal Health of Teeth: A Systematic Review
S Srirama, S Jain, B Arul, K Prabakar, V Natanasabapathy
Operative Dentistry.2024; 49(4): 388. CrossRef
Alternative Direct Restorative Materials for Dental Amalgam: A Concise Review Based on an FDI Policy Statement
Gottfried Schmalz, Falk Schwendicke, Reinhard Hickel, Jeffrey A. Platt
International Dental Journal.2024; 74(4): 661. CrossRef
Comparison of the stress distribution in base materials and thicknesses in composite resin restorations
Min-Kwan Jung, Mi-Jeong Jeon, Jae-Hoon Kim, Sung-Ae Son, Jeong-Kil Park, Deog-Gyu Seo
Heliyon.2024; 10(3): e25040. CrossRef
Influence of curing mode and aging on the bonding performance of universal adhesives in coronal and root dentin
Hoda Saleh Ismail, Ashraf Ibrahim Ali, Mohamed Elshirbeny Elawsya
BMC Oral Health.2024;[Epub] CrossRef
CLINICAL ASSESSMENT OF THE EFFECTIVENESS OF ESTHETIC RESTORATION OF ANTERIOR TEETH
Lyudmila Tatintsyan, Minas Poghosyan, Armen Shaginyan, Hovhannes Gevorgyan, Biayna Hoveyan, Tatevik Margaryan, Arsen Kupelyan
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY.2023; : 16. CrossRef
Deep margin elevation—Present status and future directions
Florin Eggmann, Jose M. Ayub, Julián Conejo, Markus B. Blatz
Journal of Esthetic and Restorative Dentistry.2023; 35(1): 26. CrossRef

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Research Articles

Effects of dentin surface preparations on bonding of self-etching adhesives under simulated pulpal pressure: Chantima Siriporananon, Pisol Senawongse, Vanthana Sattabanasuk, Natchalee Srimaneekarn, Hidehiko Sano, Pipop Saikaew; Restor Dent Endod 2022;47(1):e4. Published online December 28, 2021; DOI: https://doi.org/10.5395/rde.2022.47.e4

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Objectives

This study evaluated the effects of different smear layer preparations on the dentin permeability and microtensile bond strength (µTBS) of 2 self-etching adhesives (Clearfil SE Bond [CSE] and Clearfil Tri-S Bond Universal [CTS]) under dynamic pulpal pressure.

Materials and Methods

Human third molars were cut into crown segments. The dentin surfaces were prepared using 4 armamentaria: 600-grit SiC paper, coarse diamond burs, superfine diamond burs, and carbide burs. The pulp chamber of each crown segment was connected to a dynamic intra-pulpal pressure simulation apparatus, and the permeability test was done under a pressure of 15 cmH₂O. The relative permeability (%P) was evaluated on the smear layer-covered and bonded dentin surfaces. The teeth were bonded to either of the adhesives under pulpal pressure simulation, and cut into sticks after 24 hours water storage for the µTBS test. The resin-dentin interface and nanoleakage observations were performed using a scanning electron microscope. Statistical comparisons were done using analysis of variance and post hoc tests.

Results

Only the method of surface preparation had a significant effect on permeability (p < 0.05). The smear layers created by the carbide and superfine diamond burs yielded the lowest permeability. CSE demonstrated a higher µTBS, with these values in the superfine diamond and carbide bur groups being the highest. Microscopic evaluation of the resin-dentin interface revealed nanoleakage in the coarse diamond bur and SiC paper groups for both adhesives.

Conclusions

Superfine diamond and carbide burs can be recommended for dentin preparation with the use of 2-step CSE.

Citations

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The effect of different adhesive strategies and diamond burs on dentin bond strength of universal resin cements
Chavakorn Atsavathavornset, Pipop Saikaew, Choltacha Harnirattisai, Hidehiko Sano
Clinical Oral Investigations.2025;[Epub] CrossRef
Universal adhesive systems in dentistry: A narrative review
Svetlana N. Razumova, Anzhela S. Brago, Oxana R. Ruda, Zoya A. Guryeva, Elvira V. Adzhieva
Russian Journal of Dentistry.2024; 28(5): 512. CrossRef
Delayed light activation of resin composite affects the bond strength of adhesives under dynamic simulated pulpal pressure
Nattaporn Sukprasert, Choltacha Harnirattisai, Pisol Senawongse, Hidehiko Sano, Pipop Saikaew
Clinical Oral Investigations.2022; 26(11): 6743. CrossRef

2,900 View
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Comparative analysis of bond strength to root dentin and compression of bioceramic cements used in regenerative endodontic procedures: Maykely Naara Morais Rodrigues, Kely Firmino Bruno, Ana Helena Gonçalves de Alencar, Julyana Dumas Santos Silva, Patrícia Correia de Siqueira, Daniel de Almeida Decurcio, Carlos Estrela; Restor Dent Endod 2021;46(4):e59. Published online November 9, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e59

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Objectives

This study compared the Biodentine, MTA Repair HP, and Bio-C Repair bioceramics in terms of bond strength to dentin, failure mode, and compression.

Materials and Methods

Fifty-four slices obtained from the cervical third of 18 single-rooted human mandibular premolars were randomly distributed (n = 18). After insertion of the bioceramic materials, the push-out test was performed. The failure mode was analyzed using stereomicroscopy. Another set of cylindrically-shaped bioceramic samples (n = 10) was prepared for compressive strength testing. The normality of data distribution was analyzed using the Shapiro-Wilk test. The Kruskal-Wallis and Friedman tests were used for the push-out test data, while compressive strength was analyzed with analysis of variance and the Tukey test, considering a significance level of 0.05.

Results

Biodentine presented a higher median bond strength value (14.79 MPa) than MTA Repair HP (8.84 MPa) and Bio-C Repair (3.48 MPa), with a significant difference only between Biodentine and Bio-C Repair. In the Biodentine group, the most frequent failure mode was mixed (61%), while in the MTA Repair HP and Bio-C Repair groups, it was adhesive (94% and 72%, respectively). Biodentine showed greater resistance to compression (29.59 ± 8.47 MPa) than MTA Repair HP (18.68 ± 7.40 MPa) and Bio-C Repair (19.96 ± 3.96 MPa) (p < 0.05).

Conclusions

Biodentine showed greater compressive strength than MTA Repair HP and Bio-C Repair, and greater bond strength than Bio-C Repair. The most frequent failure mode of Biodentine was mixed, while that of MTA Repair HP and Bio-C Repair was adhesive.

Citations

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Comparación de la resistencia compresiva entre el Agregado Trióxido Mineral y BiodentineTM en perforaciones de furca de molares inferiores permanentes
Jheymy Gerardo Huatuco-Granda, John Paul Torres-Navarro, Rosa Josefina Roncal-Espinoza
Revista Facultad de Odontología.2024;[Epub] CrossRef
Effects of different calcium-silicate based materials on fracture resistance of immature permanent teeth with replacement root resorption and osteoclastogenesis
Gabriela Leite de Souza, Gabrielle Alves Nunes Freitas, Maria Tereza Hordones Ribeiro, Nelly Xiomara Alvarado Lemus, Carlos José Soares, Camilla Christian Gomes Moura
Restorative Dentistry & Endodontics.2023;[Epub] CrossRef
Evaluation the Marginal Adaptation for the Bio C Repair and Other Root end Filling Material by Using Scanning Electron Microscope (A Comparative In Vitro Study)
Fatimah HAMADHİ, Zainab M.
Cumhuriyet Dental Journal.2023; 26(3): 261. CrossRef
Dentin Bond Strength of Calcium Silicate-Based Materials: A Systematic Review of In Vitro Studies
Natalia Radulica, José Luis Sanz, Adrián Lozano
Applied Sciences.2023; 14(1): 104. CrossRef
Evaluation Of The Push-out Bond Strength Of The Bio-C Repair And Compare It With The Mineral Trioxide Aggregate And Amalgam When Used As Root-end Filling Material
Fatimah R. Hammadi, Zainab M Abdul-Ameer
Dental Hypotheses.2023; 14(2): 62. CrossRef
Effect of different root canal irrigants on push-out bond strength of two novel root-end filling materials
Nada Omar, Rasha M. Abdelraouf, Tamer M. Hamdy
BMC Oral Health.2023;[Epub] CrossRef
Effect of irrigation systems on the bond strength of calcium-silicate-based cement used as pulp barrier in regenerative endodontic treatment
Cihan Hascizmeci, Burak Buldur
Journal of Adhesion Science and Technology.2023; 37(23): 3393. CrossRef

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Adhesive systems applied to dentin substrate under electric current: systematic review: Carolina Menezes Maciel, Tatiane Cristina Vieira Souto, Bárbara de Almeida Pinto, Laís Regiane Silva-Concilio, Kusai Baroudi, Rafael Pino Vitti; Restor Dent Endod 2021;46(4):e55. Published online November 5, 2021; DOI: https://doi.org/10.5395/rde.2021.46.e55

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Objectives

The purpose of this systematic review was to collect and discuss the technique of adhesive systems application on dentin substrate under electric current.

Materials and Methods

The first search strategy was based on data available at PubMed, LILACS, Scielo, Scopus, and Cochrane Library, using a combination of descriptors such as “dentin bond agents OR adhesive system AND electric current OR electrobond” or “dentin bonding agents OR dentin bonding agent application OR adhesive system AND electric current OR electrobond”, with no limit regarding the publication year. The second search strategy was based on the articles' references found previously. An additional search strategy was applied that concerned the proposed theme in the SBU-UNICAMP (Unicamp's Library System Institutional Repository).

Results

Twelve studies published between 2006 and 2020 were found. The analyses of the selected studies showed that the use of electric current during adhesive systems application on dentin, whether conventional or self-conditioning, increases resinous monomer infiltration in the dentin substrate, which improves the hybridization processes and the bond strength of the restorative material to dentin.

Conclusions

Despite the favorable results related to the use of this technique, there is still no specific protocol for the application of adhesive systems under electric current.

Citations

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Advances in Resin-Dentin Bonding: Evaluating Pre-Treatment Techniques for Improved Adhesion
Rim Bourgi
Journal of Dental Health and Oral Research.2025; : 1. CrossRef
Iontophoresis effects of two-step self-etch and total-etch systems on dentin permeability and sealing of composite restoration under simulated pulpal pressure
Orapin Ajcharanukul, Peeraya Santikulluk, Palat Sasingha, Sirithorn Sabpawat, Kanokporn Sukyanan
BMC Oral Health.2022;[Epub] CrossRef

1,877 View
14 Download
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Biomineralization of three calcium silicate-based cements after implantation in rat subcutaneous tissue: Ranjdar Mahmood Talabani, Balkees Taha Garib, Reza Masaeli, Kavosh Zandsalimi, Farinaz Ketabat; Restor Dent Endod 2021;46(1):e1. Published online December 2, 2020; DOI: https://doi.org/10.5395/rde.2021.46.e1

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Objectives

The aim of this study was to evaluate the dystrophic mineralization deposits from 3 calcium silicate-based cements (Micro-Mega mineral trioxide aggregate [MM-MTA], Biodentine [BD], and EndoSequence Root Repair Material [ESRRM] putty) over time after subcutaneous implantation into rats.

Materials and Methods

Forty-five silicon tubes containing the tested materials and 15 empty tubes (serving as a control group) were subcutaneously implanted into the backs of 15 Wistar rats. At 1, 4, and 8 weeks after implantation, the animals were euthanized (n = 5 animals/group), and the silicon tubes were removed with the surrounding tissues. Histopathological tissue sections were stained with von Kossa stain to assess mineralization. Scanning electron microscopy and energy-dispersive X-ray spectroscopy (SEM/EDX) were also used to assess the chemical components of the surface precipitates deposited on the implant and the pattern of calcium and phosphorus distribution at the material-tissue interface. The calcium-to-phosphorus ratios were compared using the non-parametric Kruskal-Wallis test at a significance level of 5%.

Results

The von Kossa staining showed that both BD and ESRRM putty induced mineralization starting at week 1; this mineralization increased further until the end of the study. In contrast, MM-MTA induced dystrophic calcification later, from 4 weeks onward. SEM/EDX showed no statistically significant differences in the calcium- and phosphorus-rich areas among the 3 materials at any time point (p > 0.05).

Conclusions

After subcutaneous implantation, biomineralization of the 3-calcium silicate-based cements started early and increased over time, and all 3 tested cements generated calcium- and phosphorus-containing surface precipitates.

Citations

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Evaluating Retrieval-Augmented Large Language Models on External Cervical Resorption: A Comparative Study of Gemini and NotebookLM
Marc Garcia-Font, Nicolás Dufey-Portilla, Fernando Durán-Sindreu, José Antonio González Sánchez, Gustavo Rodríguez Millán, Venkateshbabu Nagendrababu, Paul M.H. Dummer, Francesc Abella Sans
Journal of Endodontics.2025;[Epub] CrossRef
Antibacterial, biocompatible, and mineralization‐inducing properties of calcium silicate‐based cements
Taimy Cruz Hondares, Xiaoxiao Hao, Yanfang Zhao, Yuyin Lin, Dobrawa Napierala, Janice G. Jackson, Ping Zhang
International Journal of Paediatric Dentistry.2024; 34(6): 843. CrossRef
Bioactive potential of Bio‐C Pulpo is evidenced by presence of birefringent calcite and osteocalcin immunoexpression in the rat subcutaneous tissue
Marcela Borsatto Queiroz, Rafaela Nanami Handa Inada, Camila Soares Lopes, Juliane Maria Guerreiro‐Tanomaru, Estela Sasso‐Cerri, Mário Tanomaru‐Filho, Paulo Sérgio Cerri
Journal of Biomedical Materials Research Part B: Applied Biomaterials.2022; 110(10): 2369. CrossRef

2,284 View
19 Download
3 Web of Science
3 Crossref

Effect of post space preparation drills on the incidence of root dentin defects: Thaíse Ayres Bezerra Zuli, Orlando Aguirre Guedes, Gislaine Figueiredo Zarza Arguello Gonçalves, Aurélio Rosa da Silva Júnior, Álvaro Henrique Borges, Andreza Maria Fábio Aranha; Restor Dent Endod 2020;45(4):e53. Published online October 16, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e53

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Objectives

This study investigated the incidence of root dentin defects after the use of different post space preparation (PSP) drills.

Materials and Methods

Seventy-two bovine incisors were selected and obtained 14-mm-long root sections. Twelve roots served as controls with no intervention (G1). The 60 root canals remaining were instrumented using the crown-down technique with the ProTaper Next system and obturated using the lateral condensation technique. Specimens were randomly distributed into 5 groups (n = 12) according to the operative steps performed: G2, root canal instrumentation and filling (I+F); G3, I+F and PSP with Gates-Glidden drills; G4, I+F and PSP with Largo-Peeso reamers; G5, I+F and PSP with Exacto drill; and G6, I+F and PSP with WhitePost drill. Roots were sectioned at 3, 6, 9, and 12 mm from the apex, and digital images were captured. The presence of root dentin defects was recorded. Data were analyzed by the χ² test, with p < 0.05 considered to indicate statistical significance.

Results

Root dentin defects were observed in 39.6% of the root sections. No defects were observed in G1. G5 had significantly more cracks and craze lines than G1, G2, and G3 (p < 0.05), and more fractures than G1, G2, G3, and G4 (p < 0.05). When all root sections were analyzed together, significantly more defects were observed at the 12-mm level than at the 3-mm level (p < 0.05).

Conclusions

PSP drills caused defects in the root dentin. Gates-Glidden drills caused fewer root defects than Largo-Peeso reamers and Exacto drills.

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Evaluation of dentinal crack formation during post space preparation using different fiber post systems with micro-computed tomography
Ayşe Nur Kuşuçar, Damla Kırıcı
BMC Oral Health.2025;[Epub] CrossRef
Fracture and Crack Behavior of Weakened Incisors Restored With Fiber Posts, Polyethylene Reinforcement, or 3D-Printed Endocrowns
Diana Codas-Duarte, Laís L Pelozo, Jardel F Mazzi-Chaves, Fabiane C Lopes-Olhê, Manoel D Sousa-Neto, Aline E Souza-Gabriel
Cureus.2025;[Epub] CrossRef
Selecting drill size for post space preparation based on final endodontic radiographs: An in vitro study
Farzaneh Farid, Julfikar Haider, Marjan Sadeghpour Shahab, Nika Rezaeikalantari
Technology and Health Care.2024; 32(4): 2575. CrossRef
Cone Beam Computed Tomography Analysis of Post Space in Bifurcated Premolars Using ParaPost and Peeso Reamer Drills
Abdulaziz Saleh Alqahtani, Omar Nasser Almonabhi, Abdulmajeed Moh. Almutairi, Reem R. Alnatsha
The Open Dentistry Journal.2024;[Epub] CrossRef
A Comparative Evaluation of Real-Time Guided Dynamic Navigation and Conventional Techniques for Post Space Preparation During Post Endodontic Management: An In Vitro Study
Sherifa Shervani, Sihivahanan Dhanasekaran, Vijay Venkatesh
Cureus.2024;[Epub] CrossRef
The effect of ultrasonic vibration protocols for cast post removal on the incidence of root dentin defects
Giulliano C. Serpa, Orlando A. Guedes, Neurinelma S. S. Freitas, Julio A. Silva, Carlos Estrela, Daniel A. Decurcio
Journal of Oral Science.2023; 65(3): 190. CrossRef

2,553 View
33 Download
6 Crossref

Physicochemical properties, cytotoxicity and penetration into dentinal tubules of sodium hypochlorite with and without surfactants: Hernán Coaguila-Llerena, Isadora Barbieri, Mário Tanomaru-Filho, Renato de Toledo Leonardo, Ana Paula Ramos, Gisele Faria; Restor Dent Endod 2020;45(4):e47. Published online September 10, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e47

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Objectives

The aim of this study was to assess the physicochemical properties, cytotoxicity and penetration into dentinal tubules of ChlorCid™ Surf (3% sodium hypochlorite [NaOCl] with surfactant) in comparison to ChlorCid™ (3% NaOCl without surfactant).

Materials and Methods

The physicochemical properties evaluated were pH, surface tension, free available chlorine (FAC) and contact angle. Cytotoxicity was evaluated in L929 fibroblasts exposed to the solutions by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and neutral red assays. Assessment of penetration into dentinal tubules was performed by staining single-rooted permanent human teeth with crystal violet (n = 9), which were irrigated with the solutions and analyzed in cervical, middle and apical segments. Data were analyzed by one-way analysis of variance (ANOVA) and Tukey's post-test, 2-way ANOVA and Bonferroni's post-test or t-test (α = 0.05).

Results

ChlorCid™ Surf and ChlorCid™ FAC values were close to those indicated by the manufacturer. ChlorCid™ Surf showed lower surface tension and contact angle on dentin, and higher pH than ChlorCid™ (p < 0.05). The penetration of ChlorCid™ Surf was higher in cervical and middle segments, compared with ChlorCid™ (p < 0.05). There was no difference in irrigant cytotoxicity (p > 0.05).

Conclusions

ChlorCid™ Surf showed lower surface tension, lower contact angle on root canal dentin, higher penetration into dentinal tubules and more alkaline pH, compared with ChlorCid™. However, both solutions showed similar cytotoxicity and FAC content.

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Effects of penetration enhancers on the performance of irrigants for root canal disinfection
Yi Luo, Runze Liu, Pei Liu, Mengting Duan, Wei Fan, Bing Fan
Clinical Oral Investigations.2025;[Epub] CrossRef
Physicochemical and Biological Properties of the “All-In-One” Endodontic Irrigant Triton
Jesus Aranda, Elda Olivia Nobre de Souza, Arturo Javier Aranda Garcia, Renato de Toledo Leonardo, Ana Paula Ramos, Giampiero Rossi-Fedele, Gisele Faria
Journal of Endodontics.2025;[Epub] CrossRef
Influence of post space disinfection protocols on the push-out bond strength of fiber posts luted with self-adhesive cement
Satheesh B. Haralur, Salem Ali Alqahtani, Khalid Salem Alqahtani, Mohammed A. Al-Qarni, Saeed M. AlQahtani
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Hernán Coaguila-Llerena, Luana Raphael da Silva, Gisele Faria
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Preety Sehrawat
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Yanhuang Wang, Lishan Lei, Jing Huang, Zhiyu Cai, Xiaojing Huang
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Shubhashini N, Krithika D, Akhilesh Gowda , Shruthi Nagaraja , Rhea S Mathew, Nivaskumar G A, Vinaychandra R
Cureus.2024;[Epub] CrossRef
Antibacterial efficacy of silver nanoparticles, sodium hypochlorite, chlorhexidine, and hypochlorous acid on dentinal surfaces infected with Enterococcus faecalis
Aysenur Oncu, Berkan Celikten, Betül Aydın, Gulin Amasya, Erkan Tuncay, Gamze Guney Eskiler, Leyla Açık, Fatma Semra Sevimay
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Chen Cai, Xuan Chen, Yang Li, Qianzhou Jiang, Yeliz Guven
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Joatan Lucas de Sousa Gomes COSTA, Tatiane Miranda MANZOLI, João Felipe BESEGATO, Joissi Ferrari ZANIBONI, Eliane Cristina Gulin DE OLIVEIRA, Lucas David GALVANI, Andréa Abi Rached DANTAS, Luis Geraldo VAZ, Milton Carlos KUGA
Dental Materials Journal.2023; 42(6): 878. CrossRef
Physicochemical properties and penetration into dentinal tubules of calcium hypochlorite with surfactants
Hernán Coaguila-Llerena, Julia da Silva Toledo, Ana Paula Ramos, Gisele Faria
Brazilian Dental Journal.2022; 33(2): 1. CrossRef

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Invited Review Article

The effect of root canal irrigants on dentin: a focused review: Priti Pragati Rath, Cynthia Kar Yung Yiu, Jukka Pekka Matinlinna, Anil Kishen, Prasanna Neelakantan; Restor Dent Endod 2020;45(3):e39. Published online June 30, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e39

Abstract PDF PubReader ePub

Despite the vast literature on the effects of root canal irrigants on the dentin characteristics, the precise effects of clinically relevant irrigation sequences remain unclear. In this review, we systematically dissect the role of different sequential irrigation approaches that are used in clinical endodontics. Using a systematic search strategy, we attempt to answer the question: ‘Which irrigating sequence has the most deleterious effects on dentin structure and properties?’ The effect of irrigants on the dentin composition and mechanical properties have been reviewed. A wide variety of concentrations, duration and techniques have been employed to characterize the effects of chemicals on dentin properties, thus making it impossible to draw guidelines or recommendations of irrigant sequences to be followed clinically. It was apparent that all the studied irrigation sequences potentially result in some deleterious effects on dentin such as decrease in the flexural strength, microhardness, modulus of elasticity and inorganic content and organic-inorganic ratio of the dentin. However, the literature still lacks comprehensive investigations to compare the deleterious effect of different irrigation sequences, using a wide variety of qualitative and quantitative methods. Such investigations are essential to make clinical recommendations and strategize efforts to minimize chemically-induced damage to dentin characteristics.

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Research Article

Bonding of a resin-modified glass ionomer cement to dentin using universal adhesives: Muhittin Ugurlu; Restor Dent Endod 2020;45(3):e36. Published online June 15, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e36

Abstract PDF PubReader ePub

Objectives

This study aims to assess the effect of universal adhesives pretreatment on the bond strength of resin-modified glass ionomer cement to dentin.

Materials and Methods

Fifty caries-free human third molars were employed. The teeth were randomly assigned into five groups (n = 10) based on dentin surface pretreatments: Single Bond Universal (3M Oral Care), Gluma Bond Universal (Heraeus Kulzer), Prime&Bond Elect (Dentsply), Cavity Conditioner (GC) and control (no surface treatment). After Fuji II LC (GC) was bonded to the dentin surfaces, the specimens were stored for 7 days at 37°C. The specimens were segmented into microspecimens, and the microspecimens were subjugated to microtensile bond strength testing (1.0 mm/min). The modes of failure analyzed using a stereomicroscope and scanning electron microscopy. Data were statistically analyzed with one-way analysis of variance and Duncan tests (p = 0.05).

Results

The surface pretreatments with the universal adhesives and conditioner increased the bond strength of Fuji II LC to dentin (p < 0.05). Single Bond Universal and Gluma Bond Universal provided higher bond strength to Fuji II LC than Cavity Conditioner (p < 0.05). The bond strengths obtained from Prime&Bond Elect and Cavity Conditioner were not statistically different (p > 0.05).

Conclusions

The universal adhesives and polyacrylic acid conditioner could increase the bond strength of resin-modified glass ionomer cement (RMGIC) to dentin. The use of universal adhesives before the application of RMGIC may be more beneficial in improving bond strength.

Citations

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Reham Hendam, Rania Mosallam, Dina Kamal
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Review Article

Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion: Izadora Quintela Souza de Moraes, Ticiano Gomes do Nascimento, Antonio Thomás da Silva, Lilian Maria Santos Silva de Lira, Abhishek Parolia, Isabel Cristina Celerino de Moraes Porto; Restor Dent Endod 2020;45(3):e31. Published online May 22, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e31

Abstract PDF PubReader ePub

Matrix metalloproteinases (MMPs) are enzymes that can degrade collagen in hybrid layer and reduce the longevity of adhesive restorations. As scientific understanding of the MMPs has advanced, useful strategies focusing on preventing these enzymes' actions by MMP inhibitors have quickly developed in many medical fields. However, in restorative dentistry, it is still not well established. This paper is an overview of the strategies to inhibit MMPs that can achieve a long-lasting material-tooth adhesion. Literature search was performed comprehensively using the electronic databases: PubMed, ScienceDirect and Scopus including articles from May 2007 to December 2019 and the main search terms were “matrix metalloproteinases”, “collagen”, and “dentin” and “hybrid layer”. MMPs typical structure consists of several distinct domains. MMP inhibitors can be divided into 2 main groups: synthetic (synthetic-peptides, non-peptide molecules and compounds, tetracyclines, metallic ions, and others) and natural bioactive inhibitors mainly flavonoids. Selective inhibitors of MMPs promise to be the future for specific targeting of preventing dentin proteolysis. The knowledge about MMPs functionality should be considered to synthesize drugs capable to efficiently and selectively block MMPs chemical routes targeting their inactivation in order to overcome the current limitations of the therapeutic use of MMPs inhibitors, i.e., easy clinical application and long-lasting effect.

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Research Article

Dentin moisture conditions strongly influence its interactions with bioactive root canal sealers: Esin Ozlek, Hüseyin Gündüz, Elif Akkol, Prasanna Neelakantan; Restor Dent Endod 2020;45(2):e24. Published online March 24, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e24

Abstract PDF PubReader ePub

Objectives

It is known that bioactive materials interact with the dentin to undergo biomineralization. The exact role of moisture in this interaction is unknown. Here, we investigate the effects of dentin moisture conditions on the dislocation resistance of two bioactive root canal sealers (MTA Fillapex [Angelus Solucoes Odontologicas] and GuttaFlow BioSeal [Colténe/Whaledent AG]) at 3 weeks and 3 months after obturation.

Materials and Methods

Mandibular premolars (n = 120) were prepared and randomly divided into 3 groups based on the dentin condition: group 1, dry dentin; group 2, moist dentin; group 3, wet dentin. Each group was divided into 2 subgroups for root canal filling: MTA Fillapex and GuttaFlow BioSeal. Dislocation resistance was evaluated by measuring the push-out bond strength at 3 weeks and 3 months. Failure modes were examined under a stereomicroscope. Data were statistically analyzed by Kruskal-Wallis test with a significance level of 5%.

Results

Moist dentin resulted in higher bond strength values for both materials at both time points. This was significantly higher than wet and dry dentin for both the sealers at the 3 months (p < 0.05), while at 3 weeks it was significant only for GuttaFlow Bioseal. The different moisture conditions demonstrated similar trends in their effects on the dislocation resistance of the 2 root canal sealers.

Conclusions

The dentin moisture conditions had a significant impact on its interaction with the bioactive materials tested. Maintaining moist dentin, but not dry or wet dentin, may be advantageous before the filling root canals with bioactive sealers.

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Ahmadreza Sarrafan, Ali Soleymani, Tasnim Bagheri Chenari, Seyedali Seyedmajidi
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T. B. M. Antunes, A. C. P. Janini, L. E. Pelepenko, G. F. Abuna, E. M. Paiva, M. A. C. Sinhoreti, I. M. Raimundo, B. P. F. A. Gomes, A. de‐Jesus‐Soares, M. A. Marciano
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Mi-Ah Kim, Vinicius Rosa, Prasanna Neelakantan, Yun-Chan Hwang, Kyung-San Min
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Review Article

Age-dependent root canal instrumentation techniques: a comprehensive narrative review: Michael Solomonov, Hyeon-Cheol Kim, Avi Hadad, Dan Henry Levy, Joe Ben Itzhak, Oleg Levinson, Hadas Azizi; Restor Dent Endod 2020;45(2):e21. Published online March 4, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e21

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The aim of this article was to review age-dependent clinical recommendations for appropriate root canal instrumentation techniques. A comprehensive narrative review of canal morphology, the structural characteristics of dentin, and endodontic outcomes at different ages was undertaken instead of a systematic review. An electronic literature search was carried out, including the Medline (Ovid), PubMed, and Web of Science databases. The searches used controlled vocabulary and free-text terms, as follows: ‘age-related root canal treatment,’ ‘age-related instrumentation,’ ‘age-related chemo-mechanical preparation,’ ‘age-related endodontic clinical recommendations,’ ‘root canal instrumentation at different ages,’ ‘geriatric root canal treatment,’ and ‘pediatric root canal treatment.’ Due to the lack of literature with practical age-based clinical recommendations for an appropriate root canal instrumentation technique, a narrative review was conducted to suggest a clinical algorithm for choosing the most appropriate instrumentation technique during root canal treatment. Based on the evidence found through the narrative review, an age-related clinical algorithm for choosing appropriate instrumentation during root canal treatment was proposed. Age affects the morphology of the root canal system and the structural characteristics of dentin. The clinician’s awareness of root canal morphology and dentin characteristics can influence the choice of instruments for root canal treatment.

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Cross-Sectional Analysis of the Challenges Faced by Undergraduate Dental Students During Root Canal Treatment (RCT) and the Oral Health-Related Quality of Life in Patients After RCT
Mubashir Baig Mirza, Abdullah Bajran Almuteb, Abdulaziz Tariq Alsheddi, Qamar Hashem, Mohammed Ali Abuelqomsan, Ahmed AlMokhatieb, Shahad AlBader, Abdullah AlShehri
Medicina.2025; 61(2): 215. CrossRef
OUTCOMES OF COMBINED ENDODONTIC TREATMENT AND APICAL SURGERY IN MANAGING LARGE PERIAPICAL CYSTS: A CLINICAL STUDY
Sapna Pandey, P Nihar, Amit Kumar, Nitin Bhagat, Vikram Karande, Zameer Pasha, Anukriti Kumari
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY.2025; : 329. CrossRef
El Uso del hipoclorito de sodio en endodoncia: concentración, temperatura y activación
Ábilson Josue Fabiani Ticona, Fernanda Camargo Espejo
Revista de investigación e información en salud.2025;[Epub] CrossRef
Assessment of Anatomical Dentin Thickness in Mandibular First Molar: An In Vivo Cone‐Beam Computed Tomographic Study
Sahil Choudhari, Kavalipurapu Venkata Teja, Sindhu Ramesh, Jerry Jose, Mariangela Cernera, Parisa Soltani, Emmanuel João Nogueira Leal da Silva, Gianrico Spagnuolo, Ricardo Danil Guiraldo
International Journal of Dentistry.2024;[Epub] CrossRef
Oral Health Concerns of the ‘Sunset Age’
Pradnya V. Kakodkar, Amandeep Kaur, Shivasakthy Manivasakan, Sounyala Rayannavar, Revati Deshmukh, Smita Athavale
Journal of Medical Evidence.2023; 4(2): 141. CrossRef
Root canal treatment of a six-canal first mandibular molar with extensive periapical lesion: A case report
Xin Li, Shuyu Sun, Tengyi Zheng
Medicine.2023; 102(30): e34336. CrossRef
Endodontic Dentistry: Analysis of Dentinal Stress and Strain Development during Shaping of Curved Root Canals
Laura Iosif, Bogdan Dimitriu, Dan Florin Niţoi, Oana Amza
Healthcare.2023; 11(22): 2918. CrossRef
Mechanisms of age-related changes in the morphology of the pulp system of the first lower molars
N.B. Petrukhina, O.A. Zorina, V.A. Venediktova
Stomatologiya.2022; 101(2): 19. CrossRef

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Research Articles

Comparative evaluation of the bond strength of self-adhering and bulk-fill flowable composites to MTA Plus, Dycal, Biodentine, and TheraCal: an in vitro study: Aakrati Raina, Asheesh Sawhny, Saurav Paul, Sridevi Nandamuri; Restor Dent Endod 2020;45(1):e10. Published online January 8, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e10

Abstract PDF PubReader ePub

Objectives

This study aimed to compare the shear bond strength (SBS) of a self-adhering flowable composite (Dyad Flow) and a bulk-fill flowable composite (Smart Dentin Replacement [SDR]) to several pulp-capping materials, including MTA Plus, Dycal, Biodentine, and TheraCal.

Materials and Methods

Eighty acrylic blocks with 2-mm-deep central holes that were 4 mm in diameter were prepared and divided into 2 groups (n = 40 each) according to the composite used (Dyad Flow or SDR). They were further divided into 4 sub-groups (n = 10 each) according to the pulp-capping agent used. SBS was tested using a universal testing machine at a crosshead speed of 1 mm/min. Data were analyzed using 2-way analysis of variance. A p value of < 0.05 was considered to indicate statistical significance.

Results

A statistically significant difference (p = 0.040) was found between Dyad Flow and SDR in terms of bond strength to MTA Plus, Dycal, Biodentine, and TheraCal.

Conclusions

Among the 8 sub-groups, the combination of TheraCal and SDR exhibited the highest SBS.

Citations

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Shear Bond Strength of Liner Materials to Caries-Free and Caries-Affected Dentin
ZK Greene, NR Smith, T Gomes, NC Lawson
Operative Dentistry.2025; 50(3): 324. CrossRef
Shear Bond Strength of Biointeractive Restorative Materials to NeoMTA Plus and Biodentine
Zübeyde Uçar Gündoğar, Gül Keskin, Merve Yaman Küçükersen
Polymers.2025; 17(22): 3070. CrossRef
Hygroscopic bioactive light-cured composite promoting dentine bridge formation
Yunzi Long, Guibin Huang, Siyi Liu, Liju Xu, Ailing Li, Dong Qiu, Yanmei Dong
Regenerative Biomaterials.2024;[Epub] CrossRef
Comparative evaluation of shear bond strength and modes of failure of five different reinforced glass ionomer restorative cements to TheraCal LC: An in vitro study
Kalyani Gajanan Umale, Vandana Jaykumar Gade, Ambar W. Raut
Journal of Conservative Dentistry and Endodontics.2024; 27(2): 200. CrossRef
Evaluation of the Effect of Chitosan-Based Irrigation Solutions on the Bond Strength of Mineral Trioxide Aggregate to Bulk-Fill Composite
Arzu Şahin Mantı, Bağdagül Helvacıoğlu Kıvanç
Journal of Functional Biomaterials.2024; 15(12): 370. CrossRef
Radiopacity evaluations of the novel calcium-silicate and glass-Ionomer-based materials
Yeşim Şeşen Uslu, Elif Çelebi, Meriç Berkman
Journal of Health Sciences and Medicine.2024; 7(2): 192. CrossRef
Effect of Er Cr YSGG laser etching procedure on the bond strength of different calcium silicate cements
Yesim Sesen Uslu, Hakan Yasin Gönder, Pinar Sesen, Gizem Gunduz Bektaş
Lasers in Dental Science.2024;[Epub] CrossRef
The micro‐shear bond strength of new endodontic tricalcium silicate‐based putty: An in vitro study
Merve Yeniçeri Özata, Seda Falakaloğlu, Gianluca Plotino, Özkan Adıgüzel
Australian Endodontic Journal.2023; 49(1): 124. CrossRef
Analysis of the bond strength between conventional, putty or resin‐modified calcium silicate cement and bulk fill composites
İ Ipek, B Karaağaç Eskibağlar, Ş Yildiz, O Ataş, M Ünal
Australian Dental Journal.2023; 68(4): 265. CrossRef
Effect of Different Adhesive Strategies on the Microshear Bond Strength of Calcium-Silicate-Based Materials
Aliye Tuğçe Gürcan, Soner Şişmanoğlu, Görkem Sengez
Journal of Advanced Oral Research.2022; 13(2): 191. CrossRef
BULK FİLL KOMPOZİT REZİN RESTORATİF MATERYALLER
Merve NEZİR, Suat ÖZCAN
Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi.2022; : 1. CrossRef
Effect of Bioinductive Cavity Liners on Shear Bond Strength of Dental Composite to Dentin
Saba Tohidkhah, Elham Ahmadi, Mahdi Abbasi, Reza Morvaridi Farimani, Ladan Ranjbar Omrani, Victor Feitosa
BioMed Research International.2022;[Epub] CrossRef
Bond Strength of Adhesive Systems to Calcium Silicate-Based Materials: A Systematic Review and Meta-Analysis of In Vitro Studies
Louis Hardan, Davide Mancino, Rim Bourgi, Alejandra Alvarado-Orozco, Laura Emma Rodríguez-Vilchis, Abigailt Flores-Ledesma, Carlos Enrique Cuevas-Suárez, Monika Lukomska-Szymanska, Ammar Eid, Maya-Line Danhache, Maryline Minoux, Youssef Haïkel, Naji Kharo
Gels.2022; 8(5): 311. CrossRef
How do imaging protocols affect the assessment of root-end fillings?
Fernanda Ferrari Esteves Torres, Reinhilde Jacobs, Mostafa EzEldeen, Karla de Faria-Vasconcelos, Juliane Maria Guerreiro-Tanomaru, Bernardo Camargo dos Santos, Mário Tanomaru-Filho
Restorative Dentistry & Endodontics.2022;[Epub] CrossRef
Evaluation of Shear Bond Strength of Resin‐Based Composites to Biodentine with Three Types of Seventh‐Generation Bonding Agents: An In Vitro Study
Huda Abbas Abdullah, Zahraa Abdulaali Al-Ibraheemi, Zanbaq Azeez Hanoon, Julfikar Haider, Boonlert Kukiattrakoon
International Journal of Dentistry.2022;[Epub] CrossRef
Evaluation of the Bond Strength of Different Pulp Capping Materials to Dental Adhesive Systems: An In Vitro Study
Sema Yazici Akbiyik, Elif Pınar Bakir, S¸eyhmus Bakir
Journal of Advanced Oral Research.2021; 12(2): 286. CrossRef
Differential Gene Expression Changes in Human Primary Dental Pulp Cells Treated with Biodentine and TheraCal LC Compared to MTA
Ok Hyung Nam, Ho Sun Lee, Jae-Hwan Kim, Yong Kwon Chae, Seoung-Jin Hong, Sang Wook Kang, Hyo-Seol Lee, Sung Chul Choi, Young Kim
Biomedicines.2020; 8(11): 445. CrossRef

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A micro-computed tomography evaluation of voids using calcium silicate-based materials in teeth with simulated internal root resorption: Vildan Tek, Sevinç Aktemur Türker; Restor Dent Endod 2020;45(1):e5. Published online November 29, 2019; DOI: https://doi.org/10.5395/rde.2020.45.e5

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Objectives

The obturation quality of MTA, Biodentine, Total Fill BC root canal sealer (RCS), and warm gutta-percha (WGP) in teeth with simulated internal root resorption (IRR) was evaluated by using micro-computed tomography.

Materials and Methods

Standardized IRR cavities were created using 40 extracted maxillary central incisor teeth and randomly assigned into 4 groups (n = 10). IRR cavities were filled with MTA, Biodentine, Total Fill BC RCS (bulk-fill form) and WGP + Total Fill BC RCS. Percentage of voids between resorptive cavity walls and obturation material (external void), and inside the filling materials (internal voids) were measured.

Results

Total Fill BC sealer in the bulk-fill form presented significantly highest values of external and internal void percentages (p < 0.05). Biodentine showed a significantly lowest external void percentage (p < 0.05). WGP + Total Fill BC RCS presented significantly lower values of internal void percentages than all groups (p < 0.05), except Biodentine (p > 0.05).

Conclusion

None of the filling materials were created void-free obturation in resorption cavities. Biodentine may favor its application in teeth with IRR over Angelus MTA and bulk-fill form of Total Fill BC.

Citations

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Removal of AH Plus Bioceramic Sealer from Artificial Internal Resorption Cavities Using Different Irrigation Activation Systems
Mine Büker, Meltem Sümbüllü, Emine Şimşek, Fadime Sena Sezer
Cumhuriyet Dental Journal.2025; 28(3): 383. CrossRef
Functional and Bioactive Performance of Premixed Bioceramic Sealers with Warm Obturation: A Scoping Review
Patryk Wiśniewski, Stanisław Krokosz, Małgorzata Pietruska, Anna Zalewska
Gels.2025; 11(11): 932. CrossRef
Evaluation of the effectiveness of different supplemental cleaning techniques in the retreatment of roots with small simulated internal resorption cavities: an in vitro comparative study
Sine Güngör Us, Özgür Uzun, Nazlı Merve Güngör
BMC Oral Health.2025;[Epub] CrossRef
Evaluation of Different Techniques and Materials for Filling in 3-dimensional Printed Teeth Replicas with Perforating Internal Resorption by Means of Micro–Computed Tomography
Angelo J.S. Torres-Carrillo, Helena C. Assis, Rodrigo E. Salazar-Gamarra, Leonardo Moreira Teodosio, Alice C. Silva-Sousa, Jardel F. Mazzi-Chaves, Priscila B. Ferreira-Soares, Manoel D. Sousa-Neto, Fabiane C. Lopes-Olhê
Journal of Endodontics.2024; 50(2): 205. CrossRef
Three-Dimensional Measurement of Obturation Quality of Bioceramic Materials in Filling Artificial Internal Root Resorption Cavities Using Different Obturation Techniques: An In Vitro Comparative Study
Ammar M. Sharki, Ahmed H. Ali
Journal of Endodontics.2024; 50(7): 997. CrossRef
Evaluation of calcium hydroxide root canal filling materials by cone beam computed tomography and three-dimensional modeling
Asel Usdat Ozturk, Ekin Dogan, Venus Seyedoskuyi, Berk Senguler, Asli Topaloglu-Ak
Folia Medica.2024; 66(2): 250. CrossRef
Clinical applications of calcium silicate‐based materials: a narrative review
S Küçükkaya Eren
Australian Dental Journal.2023;[Epub] CrossRef
A critical analysis of research methods and experimental models to study root canal fillings
Gustavo De‐Deus, Erick Miranda Souza, Emmanuel João Nogueira Leal Silva, Felipe Gonçalves Belladonna, Marco Simões‐Carvalho, Daniele Moreira Cavalcante, Marco Aurélio Versiani
International Endodontic Journal.2022; 55(S2): 384. CrossRef
An Updated Review on Properties and Indications of Calcium Silicate‐Based Cements in Endodontic Therapy
Fateme Eskandari, Alireza Razavian, Rozhina Hamidi, Khadije Yousefi, Susan Borzou, Zohaib Khurshid
International Journal of Dentistry.2022;[Epub] CrossRef
Efficacy Of Calcium Silicate-Based Sealers In Root Canal Treatment: A Systematic Review
Hattan Mohammed Omar Baismail, Mohammed Ghazi Moiser Albalawi, Alaa Mofareh Thoilek Alanazi, Muhannad Atallah Saleem Alatawi, Badr Soliman Alhussain
Annals of Dental Specialty.2021; 9(1): 87. CrossRef

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The effect of individualization of fiberglass posts using bulk-fill resin-based composites on cementation: an in vitro study: Rodrigo Barros Esteves Lins, Jairo Matozinho Cordeiro, Carolina Perez Rangel, Thiago Bessa Marconato Antunes, Luís Roberto Marcondes Martins; Restor Dent Endod 2019;44(4):e37. Published online October 18, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e37

Abstract PDF PubReader ePub

Objectives

This study evaluated the bond strength of various fiberglass post cementation techniques using different resin-based composites.

Materials and Methods

The roots from a total of 100 bovine incisors were randomly assigned to 5 treatment groups: G1, post + Scotchbond Multi-Purpose (SBMP) + RelyX ARC luting agent; G2, relined post (Filtek Z250) + SBMP + RelyX ARC; G3, individualized post (Filtek Z250) + SBMP; G4, individualized post (Filtek Bulk-Fill) + SBMP; G5, individualized post (Filtek Bulk-Fill Flow) + SBMP. The samples were subjected to the push-out (n = 10) and pull-out (n = 10) bond strength tests. Data from the push-out bond strength test were analyzed using 2-way analysis of variance (ANOVA) with the Bonferroni post hoc test, and data from the pull-out bond strength test were analyzed using 1-way ANOVA.

Results

The data for push-out bond strength presented higher values for G2 and G5, mainly in the cervical and middle thirds, and the data from the apical third showed a lower mean push-out bond strength in all groups. No significant difference was noted for pull-out bond strength among all groups. The most frequent failure modes observed were adhesive failure between dentine and resin and mixed failure.

Conclusions

Fiberglass post cementation using restorative and flowable bulk-fill composites with the individualization technique may be a promising alternative to existing methods of post cementation.

Citations

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EVALUATION OF PUSH-OUT BOND STRENGTH OF GLASS FIBER POSTS USING DIFFERENT LUTING CEMENTS
Jannah Mohammed, Maha Agha
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY.2025; : 274. CrossRef
Effects of a relined fiberglass post with conventional and self-adhesive resin cement
Wilton Lima dos Santos Junior, Marina Rodrigues Santi, Rodrigo Barros Esteves Lins, Luís Roberto Marcondes Martins
Restorative Dentistry & Endodontics.2024;[Epub] CrossRef
Fracture resistance of weakened roots restored with relined or milled CAD-CAM glass fiber posts
Belizane das Graças Oliveira MAIA, Thais da Silva Alves SANTOS, Cláudio Antonio Talge CARVALHO, Francielle Silvestre VERNER, Rafael Binato JUNQUEIRA
Dental Materials Journal.2023; 42(1): 92. CrossRef
Evaluation of pretreatments on intra‐radicular dentin bond strength of self‐adhesive resin cements
Marina Rodrigues Santi, Rodrigo Barros Esteves Lins, Beatriz Ometto Sahadi, Luís Roberto Marcondes Martins, Jorge Rodrigo Soto‐Montero
Journal of Esthetic and Restorative Dentistry.2022; 34(7): 1051. CrossRef
Comparison of the Mechanical Properties and Push-out Bond Strength of Self-adhesive and Conventional Resin Cements on Fiber Post Cementation
MR Santi, RBE Lins, BO Sahadi, JR Soto-Montero, LRM Martins
Operative Dentistry.2022; 47(3): 346. CrossRef
Glass fiber posts
Renata Pereira, Rodrigo Barros Esteves Lins, Victória Castelan Rodrigues, Débora Alves Nunes Leite Lima, Luís Roberto Marcondes Martins, Flávio Henrique Baggio Aguiar
Brazilian Journal of Oral Sciences.2020; 19: e207508. CrossRef

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Dentinal defects induced by 6 different endodontic files when used for oval root canals: an in vitro comparative study: Ajinkya M Pawar, Bhagyashree Thakur, Anda Kfir, Hyeon-Cheol Kim; Restor Dent Endod 2019;44(3):e31. Published online July 29, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e31

Abstract PDF PubReader ePub

Objectives

To compare the formation of dentinal defects using stainless-steel hand K-files (HFs), rotary files, reciprocating files, and Self-Adjusting File (SAF), when used for oval root canals.

Materials and Methods

One hundred and forty extracted human mandibular premolar with single root and oval canal were selected for this study. Oval canals were confirmed by exposing to mesio-distal and bucco-lingual radiographs. Teeth with open apices or anatomic irregularities were excluded. All selected teeth were de-coronated perpendicular to the long axis of the tooth, leaving roots segments approximately of 16 mm in length. Twenty teeth were left unprepared (control), and the remaining 120 teeth were divided into 6 groups (n = 20) and instrumented using HF (size 40/0.02), Revo-S (RS; size 40/0.06), ProTaper NEXT (PTN; size 40/0.06), WaveOne (WO; size 40/0.09), RECIPROC (RC; size 40/0.06), and the SAF (2 mm). Roots were then sectioned 3, 6, and 9 mm from the apex, and observed under stereomicroscope, for presence of dentinal defects. “No defect” was defined as root dentin that presented with no visible microcracks or fractures. “Defect” was defined by microcracks or fractures in the root dentin.

Results

The control, HF, and SAF did not exhibit any dentinal defects. In roots instrumented by RS, PTN, WO, and RC files exhibited microcracks (incomplete or complete) in 40%, 30%, 55%, and 50%, respectively.

Conclusions

The motor-driven root canal instrumentation with rotary and reciprocating files may create microcracks in radicular dentine, whereas the stainless-steel hand file instrumentation, and the SAF produce minimal or less cracks.

Citations

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Ayşe Nur Kuşuçar, Damla Kırıcı
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Jianning Li, Kerstin Bitter, Anh Duc Nguyen, Hagay Shemesh, Paul Zaslansky, Stefan Zachow
Dentistry Journal.2025; 13(12): 579. CrossRef
Comparative evaluation of incidence of dentinal defects after root canal preparation using three different endodontic retreatment systems – An in vitro study
S. Aarthi, J. S. Sivakumar, A. Andamuthu Sivakumar, J. Saravanapriyan Soundappan, M. Chittrarasu, G. Jayanthi
Journal of Conservative Dentistry and Endodontics.2024; 27(3): 262. CrossRef
Evaluation of Dentin Cracks by Stereomicroscope after Preparation of Mesiobuccal Canal of Maxillary First Molars Using Edge Taper Platinum and ProTaper Gold Rotary Files: A Laboratory Study
Narjes Hoshyari, Seyedali Seyedmajidi, Anahita Lotfizadeh, Eghlima Malakan, Abolfazl Hosseinnataj, Azam Haddadi Kohsar
Avicenna Journal of Dental Research.2023; 15(4): 167. CrossRef
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Harakh Chand Branawal, Neelam Mittal, Prachi Rani, Aiyman Ayubi, Silviya Samad
Indian Journal of Dental Research.2023; 34(4): 433. CrossRef
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Debanjan Das, Sudipto Barai, Rohit Kumar, Sourav Bhattacharyya, AsimB Maity, Pushpa Shankarappa
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R. S. Emara, S. I. Gawdat, H. M. M. El‐Far
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Baby James, A Devadathan, Manuja Nair, Ashitha T Kulangara, Jose Jacob
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Márk Fráter, András Jakab, Gábor Braunitzer, Zsolt Tóth, Katalin Nagy, Andrej M. Kielbassa
PLOS ONE.2020; 15(9): e0238790. CrossRef

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The push-out bond strength of BIOfactor mineral trioxide aggregate, a novel root repair material: Makbule Bilge Akbulut, Durmus Alperen Bozkurt, Arslan Terlemez, Melek Akman; Restor Dent Endod 2019;44(1):e5. Published online January 28, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e5

Abstract PDF PubReader ePub

Objectives

The aim of this in vitro study was to evaluate the push-out bond strength of a novel calcium silicate-based root repair material-BIOfactor MTA to root canal dentin in comparison with white MTA-Angelus (Angelus) and Biodentine (Septodont).

Materials and Methods

The coronal parts of 12 central incisors were removed and the roots were embedded in acrylic resin blocks. Midroot dentin of each sample was horizontally sectioned into 1.1 mm slices and 3 slices were obtained from each root. Three canal-like standardized holes having 1 mm in diameter were created parallel to the root canal on each dentin slice with a diamond bur. The holes were filled with MTA-Angelus, Biodentine, or BIOfactor MTA. Wet gauze was placed over the specimens and samples were stored in an incubator at 37°C for 7 days to allow complete setting. Then samples were subjected to the push-out test method using a universal test machine with the loading speed of 1 mm/min. Data was statistically analyzed using Friedman test and post hoc Wilcoxon signed rank test with Bonferroni correction.

Results

There were no significant differences among the push-out bond strength values of MTA-Angelus, Biodentine, and BIOfactor MTA (p > 0.017). Most of the specimens exhibited cohesive failure in all groups, with the highest rate found in Biodentine group.

Conclusions

Based on the results of this study, MTA-Angelus, Biodentine, and BIOfactor MTA showed similar resistances to the push-out testing.

Citations

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Examination of the Bond Strength of Retrograde Filling in Teeth with Failed Apical Resection After Retreatment
Sevda Tok, Leyla Benan Ayranci
Applied Sciences.2025; 15(7): 3441. CrossRef
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Tanvi Arvind Jagtap, Budhabhushan A. Sonvane, Guruprasad Handal, Jayashri Nimba Bhangare, Kedar Vilas Saraf, Abhishek Mulay
Journal of Pharmacy and Bioallied Sciences.2025; 17(Suppl 1): S608. CrossRef
Influence of Incubation Duration on Bond Strength and Microhardness of Calcium Silicate‐Based Materials
Emine Şimşek, Makbule Bilge Akbulut
Australian Endodontic Journal.2025; 51(2): 438. CrossRef
Comparative evaluation of push-out bond strength after root perforation repair using recently introduced bioceramic and calcium silicate-based materials – An in vitro study
Gurinder Kaur, Deepak Kurup, Deepyanti Dubey, Ajit Hindlekar, Ganesh Ranganath Jadhav, Priya Mittal, Siddharth Shinde
Endodontology.2025; 37(2): 194. CrossRef
Comparative Evaluation of Push-out Bond Strength of Conventional Mineral Trioxide Aggregate, Biodentine, and Two Novel Antibacterial-enhanced Mineral Trioxide Aggregates
Sanjeev Khanagar, Suman Panda, Prabhadevi C Maganur, Ganesh Jeevanandan, Satish Vishwanathaiah, Ather A Syed, Sara Kalagi, Arokia RS Merlin, Vignesh Ravindran, Aram AlShehri
The Journal of Contemporary Dental Practice.2024; 25(2): 168. CrossRef
Influence of Phase Composition and Morphology on the Calcium Ion Release of Several Classical and Hybrid Endodontic Cements
Ivanka Dimitrova, Galia Gentscheva, Ivanka Spassova, Daniela Kovacheva
Materials.2024; 17(22): 5568. CrossRef
The Effect of Two Different MTA (Mineral Trioxide Aggregate) On Thermal Insulation
Gizem Akkus, Ecem Salmaz, Didem Oner Ozdas
The Open Dentistry Journal.2024;[Epub] CrossRef
Comparison of push‐out bond strength and apical microleakage of different calcium silicate‐based cements after using EDTA, chitosan and phytic acid irrigations
Tutku Koçak Şahin, Murat Ünal
Microscopy Research and Technique.2024; 87(9): 2072. CrossRef
In vitro evaluation of the physical characteristics and push-out bond strength of new experimental nano-MTA
Nada Omar, Yousra Aly, Haidy N. Salem
Bulletin of the National Research Centre.2024;[Epub] CrossRef
Interfacial characteristics of BIOfactor MTA and Biodentine with dentin
Makbule Bilge Akbulut, Şeref Nur Mutlu, Mehmet Ali Soylu, Emine Şimşek
Microscopy Research and Technique.2023; 86(2): 258. CrossRef
Systemic effect of calcium silicate-based cements with different radiopacifiers-histopathological analysis in rats
Osman Ataş, Kubra Bılge, Semsettin Yıldız, Serkan Dundar, Ilknur Calik, Asime Gezer Ataş, Alihan Bozoglan
PeerJ.2023; 11: e15376. CrossRef
The push-out bond strength of three root canal materials used in primary teeth: in vitro study
Hazal Özer, Merve Abaklı İnci, Sevcihan Açar Tuzluca
Frontiers in Dental Medicine.2023;[Epub] CrossRef
Effects of different irrigation protocols on push-out bond strength of pre-mixed calcium silicate-based cements
Sabiha Ceren İlisulu, Aliye Tugce Gürcan, Soner Sismanoglu
Journal of the Australian Ceramic Society.2023; 59(5): 1381. CrossRef
Micro-Computed Tomographic Evaluation of the Sealing Quality and Bond Strength of Different MTA Apical Plugs
Taibe Tokgöz Kaplan, Murat Selim Botsalı
European Journal of Therapeutics.2023; 30(1): 29. CrossRef
Kan kontaminasyonunun farklı kök ucu dolgu materyallerinin dentine bağlanma dayanımına etkisi
Şeyma Nur GERÇEKCİOĞLU, Melike BAYRAM, Emre BAYRAM
Acta Odontologica Turcica.2023; 40(1): 9. CrossRef
Tooth Discoloration Effect of BIOfactor Mineral Trioxide Aggregate: A 6-Month In Vitro Study
Şeref Nur Mutlu, Makbule Bilge Akbulut
Applied Sciences.2023; 13(15): 8914. CrossRef
Comparative Evaluation of the Push-Out Bond Strength of Root-End Filling Materials by Using Different Condensation Methods
Pelin Tüfenkçi, Sevinç Sevgi, Ayşenur Öncü, Fatma Semra Sevimay, Berkan Çelikten
Cyprus Journal of Medical Sciences.2022; 7(7): 115. CrossRef
Effect of Different Adhesive Strategies on the Microshear Bond Strength of Calcium-Silicate-Based Materials
Aliye Tuğçe Gürcan, Soner Şişmanoğlu, Görkem Sengez
Journal of Advanced Oral Research.2022; 13(2): 191. CrossRef
BIOfactor MTA’nın Radyoopasitesinin Dijital Radyografi ile Değerlendirilmesi
Şeref Nur MUTLU, Makbule Bilge AKBULUT
Selcuk Dental Journal.2022; 9(2): 520. CrossRef
Morphological and Chemical Analysis of Different Types of Calcium Silicate‐Based Cements
Okba Mahmoud, Nashwan Abdullah Al-Afifi, Mohideen Salihu Farook, Maysara Adnan Ibrahim, Saaid Al Shehadat, Mohammed Amjed Alsaegh, Sandrine Bittencourt Berger
International Journal of Dentistry.2022;[Epub] CrossRef
Influence of Blood Contamination on Push-Out Bond Strength of Three Calcium Silicate-Based Materials to Root Dentin
Cristina Rodrigues Paulo, Joana A. Marques, Diana B. Sequeira, Patrícia Diogo, Rui Paiva, Paulo J. Palma, João Miguel Santos
Applied Sciences.2021; 11(15): 6849. CrossRef
An In vitro comparative evaluation of effect of novel irrigant Qmix and 17% ethylenediaminetetraacetic acid on the push-out bond strength of biodentine and endosequence bioceramic root repair material
VandanaJ Gade, Aparajita Gangrade, JaykumarR Gade, Neelam Rahul
Journal of the International Clinical Dental Research Organization.2021; 13(2): 124. CrossRef
A micro-computed tomographic study using a novel test model to assess the filling ability and volumetric changes of bioceramic root repair materials
Fernanda Ferrari Esteves Torres, Jader Camilo Pinto, Gabriella Oliveira Figueira, Juliane Maria Guerreiro-Tanomaru, Mario Tanomaru-Filho
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Micro-computed tomographic evaluation of the flow and filling ability of endodontic materials using different test models
Fernanda Ferrari Esteves Torres, Juliane Maria Guerreiro-Tanomaru, Gisselle Moraima Chavez-Andrade, Jader Camilo Pinto, Fábio Luiz Camargo Villela Berbert, Mario Tanomaru-Filho
Restorative Dentistry & Endodontics.2020;[Epub] CrossRef

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Effects of the exposure site on histological pulpal responses after direct capping with 2 calcium-silicate based cements in a rat model: Panruethai Trongkij, Supachai Sutimuntanakul, Puangwan Lapthanasupkul, Chitpol Chaimanakarn, Rebecca Wong, Danuchit Banomyong; Restor Dent Endod 2018;43(4):e36. Published online August 22, 2018; DOI: https://doi.org/10.5395/rde.2018.43.e36

Abstract PDF PubReader ePub

Objectives

Direct pulp capping is a treatment for mechanically exposed pulp in which a biocompatible capping material is used to preserve pulpal vitality. Biocompatibility tests in animal studies have used a variety of experimental protocols, particularly with regard to the exposure site. In this study, pulp exposure on the occlusal and mesial surfaces of molar teeth was investigated in a rat model.

Materials and Methods

A total of 58 maxillary first molars of Wistar rats were used. Forty molars were mechanically exposed and randomly assigned according to 3 factors: 1) the exposure site (occlusal or mesial), 2) the pulp-capping material (ProRoot White MTA or Bio-MA), and 3) 2 follow-up periods (1 day or 7 days) (n = 5 each). The pulp of 6 intact molars served as negative controls. The pulp of 12 molars was exposed without a capping material (n = 3 per exposure site for each period) and served as positive controls. Inflammatory cell infiltration and reparative dentin formation were histologically evaluated at 1 and 7 days using grading scores.

Results

At 1 day, localized mild inflammation was detected in most teeth in all experimental groups. At 7 days, continuous/discontinuous calcified bridges were formed at exposure sites with no or few inflammatory cells. No significant differences in pulpal response according to the exposure site or calcium-silicate cement were observed.

Conclusions

The location of the exposure site had no effect on rat pulpal healing. However, mesial exposures could be performed easily, with more consistent results. The pulpal responses were not significantly different between the 2 capping materials.

Citations

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Bioactivity and biocompatibility of bioceramic-based pulp capping materials in laboratory and animal models
Rafiqul Islam, Md. Refat Readul Islam, Kenta Tsuchiya, Yu Toida, Hidehiko Sano, Monica Yamauti, Hany Mohamed Aly Ahmed, Atsushi Tomokiyo
Journal of Materials Science: Materials in Medicine.2025;[Epub] CrossRef
The road map to proper dental pulp experiments in animal models
Nuha A Elmubarak
International Dental Journal of Student's Research.2024; 11(4): 163. CrossRef
Treatment outcomes of root perforations repaired by calcium silicate-based cements with or without an accelerator: A randomized controlled trial
Kanyarat Tungputsa, Danuchit Banomyong, Sittichoke Osiri, Supachai Sutimuntanakul
Endodontology.2024; 36(4): 315. CrossRef
Biological evaluation of novel phosphorylated pullulan‐based calcium hydroxide formulations as direct pulp capping materials: An in vivo study on a rat model
Md Refat Readul Islam, Rafiqul Islam, Yunqing Liu, Yu Toida, Yasuhiro Yoshida, Hidehiko Sano, Hany Mohamed Aly Ahmed, Atsushi Tomokiyo
International Endodontic Journal.2024; 57(9): 1247. CrossRef
3D-printed microgels supplemented with dentin matrix molecules as a novel biomaterial for direct pulp capping
Diana Cunha, Nayara Souza, Manuela Moreira, Nara Rodrigues, Paulo Silva, Cristiane Franca, Sivaporn Horsophonphong, Ashley Sercia, Ramesh Subbiah, Anthony Tahayeri, Jack Ferracane, Pamela Yelick, Vicente Saboia, Luiz Bertassoni
Clinical Oral Investigations.2022; 27(3): 1215. CrossRef
Calcium silicate and calcium aluminate cements for dentistry reviewed
Carolyn Primus, James L. Gutmann, Franklin R. Tay, Anna B. Fuks
Journal of the American Ceramic Society.2022; 105(3): 1841. CrossRef
Pulpal response to mineral trioxide aggregate containing phosphorylated pullulan-based capping material
Yu TOIDA, Shimpei KAWANO, Rafiqul ISLAM, Fu JIALE, AFM A CHOWDHURY, Shuhei HOSHIKA, Yasushi SHIMADA, Junji TAGAMI, Masahiro YOSHIYAMA, Satoshi INOUE, Ricardo M. CARVALHO, Yasuhiro YOSHIDA, Hidehiko SANO
Dental Materials Journal.2022; 41(1): 126. CrossRef
The Effect of Calcium-Silicate Cements on Reparative Dentinogenesis Following Direct Pulp Capping on Animal Models
Mihai Andrei, Raluca Paula Vacaru, Anca Coricovac, Radu Ilinca, Andreea Cristiana Didilescu, Ioana Demetrescu
Molecules.2021; 26(9): 2725. CrossRef
Histological evaluation of a novel phosphorylated pullulan‐based pulp capping material: An in vivo study on rat molars
Rafiqul Islam, Yu Toida, Fei Chen, Toru Tanaka, Satoshi Inoue, Tetsuya Kitamura, Yasuhiro Yoshida, Abu Faem Mohammad Almas Chowdhury, Hany Mohamed Aly Ahmed, Hidehiko Sano
International Endodontic Journal.2021; 54(10): 1902. CrossRef
Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review
Ermin Nie, Jiali Yu, Rui Jiang, Xiangzhen Liu, Xiang Li, Rafiqul Islam, Mohammad Khursheed Alam
Materials.2021; 14(22): 6811. CrossRef
A strontium and amorphous calcium phosphate dipped premixed injectable calcium silicate-based ceramic for dental root canal sealing
Huimin Jin, Yuzhu Li, Qingqing Wang, Menglu Dong, Mengmeng Yang, Wendy Chen, Shengrui Wang, Heng Zhang, Shunli Zheng, Chris Ying Cao, Zheng Zhou, Quan-Li Li
Ceramics International.2021; 47(23): 33738. CrossRef
Bioactive tri/dicalcium silicate cements for treatment of pulpal and periapical tissues
Carolyn M. Primus, Franklin R. Tay, Li-na Niu
Acta Biomaterialia.2019; 96: 35. CrossRef

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Do universal adhesives promote bonding to dentin? A systematic review and meta-analysis: Ali A. Elkaffas, Hamdi H. H. Hamama, Salah H. Mahmoud; Restor Dent Endod 2018;43(3):e29. Published online June 18, 2018; DOI: https://doi.org/10.5395/rde.2018.43.e29

Abstract PDF PubReader ePub

Objectives

The aims of this study were to conduct a systematic review of the microtensile bond strength (µTBS) of multi-mode adhesives to dentin and to perform a meta-analysis to assess the significance of differences in the µTBS of one of the most commonly used universal adhesives (Scotchbond Universal, 3M ESPE) depending on whether the etch-and-rinse or self-etch mode was used.

Materials and Methods

An electronic search was performed of MEDLINE/PubMed, ScienceDirect, and EBSCOhost. Laboratory studies that evaluated the µTBS of multi-mode adhesives to dentin using either the etch-and-rinse or self-etch mode were selected. A meta-analysis was conducted of the reviewed studies to quantify the differences in the µTBS of Scotchbond Universal adhesive.

Results

Only 10 studies fulfilled the inclusion criteria for the systematic review. Extensive variation was found in the restorative materials, testing methodologies, and failure mode in the reviewed articles. Furthermore, variation was also observed in the dimensions of the microtensile testing beams. The meta-analysis showed no statistically significant difference between the etch-and-rinse and self-etch modes for Scotchbond Universal adhesive (p > 0.05).

Conclusions

Multi-mode ‘universal’ adhesives can achieve substantial bonding to dentin, regardless of the used modes (either etch-and-rinse or self-etch).

Citations

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Roland Frankenberger, Katharina Friedrich, Marie-Christine Dudek, Julia Winter, Norbert Krämer, Matthias J. Roggendorf
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Sandro Ferreira, Tiago Rodrigues, Mariana Nunes, Ana Mano Azul, José João Mendes, Ana Filipa Chasqueira, Joana Costa
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Hoda S. Ismail, Ashraf Ibrahim Ali, Franklin Garcia-Godoy
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Mircea Popescu, Mădălina Malița, Andrei Vorovenci, Andreea Angela Ștețiu, Viorel Ștefan Perieanu, Radu Cătălin Costea, Mihai David, Raluca Mariana Costea, Maria Antonia Ștețiu, Andi Ciprian Drăguș, Cristina Maria Șerbănescu, Andrei Burlibașa, Oana Eftene,
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Fatma Yılmaz, Sevgi Kurşun, Zeliha Öztürk
ADO Klinik Bilimler Dergisi.2025; 14(3): 177. CrossRef
Controversies about refrigeration of dental adhesives: a review
Omar Abd El-Maksoud, Hamdi Hosni Hamdan Hamama, Ramy Ahmed Wafaie, Salah Hasab Mahmoud
BDJ Open.2025;[Epub] CrossRef
Tooth-composite bond failure with a universal and an etch-and-rinse adhesive depending on mode and frequency of application
Ellen Schulz-Kornas, Mathilde Tittel, Hartmut Schneider, Maximilian Bemmann, Marco Pellino, Tobias Meissner, Florian Fuchs, Christian Hannig, Florian Tetschke, Kyung-Jin Park, Michaela Strumpski, Rainer Haak
Dental Materials.2024; 40(2): 359. CrossRef
Comparison of postoperative hypersensitivity between Total-etch and Universal adhesive system: a randomized clinical trial
Kiran Javed, Nouman Noor, Muhammad Zubair Nasir, Manzoor Ahmed Manzoor
Scientific Reports.2024;[Epub] CrossRef
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Érika Mayumi Omoto, Anderson Catelan, Paulo Henrique dos Santos, Luciano Tavares Angelo Cintra, Fernanda de Souza e Silva Ramos, Caio César Pavani, André Luiz Fraga Briso, Ticiane Cestari Fagundes
Australian Endodontic Journal.2024; 50(2): 309. CrossRef
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Jiadi Shen, Ming Ma, Yun Huang, Haochen Miao, Xin Wei
Journal of Materials Science.2023; 58(31): 12685. CrossRef
Efficacy of adhesive strategies for restorative dentistry: A systematic review and network meta-analysis of double-blind randomized controlled trials over 12 months of follow-up
Kevin Sheng-Kai Ma, Li-Tzu Wang, Markus B. Blatz
Journal of Prosthodontic Research.2023; 67(1): 35. CrossRef
Impact of Preceded Tumor Therapeutic Irradiation on the Microtensile Bond Strength of Universal Adhesives Applied in Self-Etch Mode to Human Dentin In Vitro
Sina Broscheit, Dirk Vordermark, Reinhard Gerlach, Christian Ralf Gernhardt
Applied Sciences.2023; 13(13): 7873. CrossRef
Effect of the Adhesive Strategy on Clinical Performance and Marginal Integrity of a Universal Adhesive in Non-Carious Cervical Lesions in a Randomized 36-Month Study
Rainer Haak, Gesa Stache, Hartmut Schneider, Matthias Häfer, Gerhard Schmalz, Ellen Schulz-Kornas
Journal of Clinical Medicine.2023; 12(18): 5776. CrossRef
Universal Adhesives in Clinical Dentistry
Fusun Ozer, Shilpa Patnaikuni
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Hoda S. Ismail, Ashraf I. Ali, Rabab El. Mehesen, Jelena Juloski, Franklin Garcia-Godoy, Salah H. Mahmoud
Restorative Dentistry & Endodontics.2022;[Epub] CrossRef
Improving Properties of an Experimental Universal Adhesive by Adding a Multifunctional Dendrimer (G-IEMA): Bond Strength and Nanoleakage Evaluation
Joana Vasconcelos e Cruz, António H. S. Delgado, Samuel Félix, José Brito, Luísa Gonçalves, Mário Polido
Polymers.2022; 14(7): 1462. CrossRef
Scoping review of trials evaluating adhesive strategies in pediatric dentistry: where do simplified strategies lie?
António H. S. Delgado, Hasan Jamal, Anne Young, Paul Ashley
BMC Oral Health.2021;[Epub] CrossRef
Does acid etching prior to applying universal adhesives affect the bond strength of glass fiber post to root dentin?
Helder Callegaro Velho, Eduardo Trindade Dalence, Pablo Soares Machado, Marília Pivetta Rippe, Jovito Adiel Skupien, Vinícius Felipe Wandscher
International Journal of Adhesion and Adhesives.2021; 105: 102795. CrossRef
Does Adhesive Layer Thickness and Tag Length Influence Short/Long-Term Bond Strength of Universal Adhesive Systems? An In-Vitro Study
Naji Kharouf, Tarek Ashi, Ammar Eid, Levi Maguina, Jihed Zghal, Nairy Sekayan, Rim Bourgi, Louis Hardan, Salvatore Sauro, Youssef Haikel, Davide Mancino
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Chronological history and current advancements of dental adhesive systems development: a narrative review
Maicon Sebold, Carolina Bosso André, Beatriz Ometto Sahadi, Lorenzo Breschi, Marcelo Giannini
Journal of Adhesion Science and Technology.2021; 35(18): 1941. CrossRef
Laboratory methods for measuring adhesive bond strength between restoration materials and hard tooth tissues
I.Ya. Poyurovskaya, A.P. Polikarpova, F.S. Rusanov
Stomatologiya.2021; 100(5): 88. CrossRef
Effect of Curcumin Suspension and Vitamin C on Dentin Shear Bond Strength and Durability. A Pilot Study
Dalia A. Abuelenain, Ensanya A. Abou Neel, Tariq S. Abuhaimed, Amal M. Alamri, Hanan S. Ammar, Sahar M. N. Bukhary
The Open Dentistry Journal.2021; 15(1): 540. CrossRef
Effect of 9.3 μm CO2 and 2.94 μm Er:YAG Laser vs. Bur Preparations on Marginal Adaptation in Enamel and Dentin of Mixed Class V Cavities Restored With Different Restorative Systems
Clara Isabel Anton y Otero, Enrico Di Bella, Ivo Krejci, Tissiana Bortolotto
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Adhesion strategy and curing mode of a universal adhesive influence the bonding of dual-cured core build-up resin composite to dentin
Ahmed Eid Elsayed, Mohamed Amr Kamel, Farid Sabry El-Askary
Journal of Adhesion Science and Technology.2021; 35(1): 52. CrossRef
Influence of etching mode and composite resin type on bond strength to dentin using universal adhesive system
Stefan Dačić, Milan Miljković, Aleksandar Mitić, Goran Radenković, Marija Anđelković‐Apostolović, Milica Jovanović
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Universal adhesives - a new direction in the development of adhesive systems
A. Tichý, K. Hosaka, J. Tagami
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Effect of Over-Etching and Prolonged Application Time of a Universal Adhesive on Dentin Bond Strength
Phoebe Burrer, Hoang Dang, Matej Par, Thomas Attin, Tobias T. Tauböck
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Profile of a 10-MDP-based universal adhesive system associated with chlorhexidine: Dentin bond strength and in situ zymography performance
Marina Ciccone Giacomini, Polliana Mendes Candia Scaffa, Rafael Simões Gonçalves, Giovanna Speranza Zabeu, Cristina de Mattos Pimenta Vidal, Marcela Rocha de Oliveira Carrilho, Heitor Marques Honório, Linda Wang
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Universal dental adhesives: Current status, laboratory testing, and clinical performance
Sanket Nagarkar, Nicole Theis‐Mahon, Jorge Perdigão
Journal of Biomedical Materials Research Part B: Applied Biomaterials.2019; 107(6): 2121. CrossRef
Modifying Adhesive Materials to Improve the Longevity of Resinous Restorations
Wen Zhou, Shiyu Liu, Xuedong Zhou, Matthias Hannig, Stefan Rupf, Jin Feng, Xian Peng, Lei Cheng
International Journal of Molecular Sciences.2019; 20(3): 723. CrossRef

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Mineral content analysis of root canal dentin using laser-induced breakdown spectroscopy: Selen Küçükkaya Eren, Emel Uzunoğlu, Banu Sezer, Zeliha Yılmaz, İsmail Hakkı Boyacı; Restor Dent Endod 2018;43(1):e11. Published online February 4, 2018; DOI: https://doi.org/10.5395/rde.2018.43.e11

Abstract PDF PubReader ePub

Objectives

This study aimed to introduce the use of laser-induced breakdown spectroscopy (LIBS) for evaluation of the mineral content of root canal dentin, and to assess whether a correlation exists between LIBS and scanning electron microscopy/energy dispersive spectroscopy (SEM/EDS) methods by comparing the effects of irrigation solutions on the mineral content change of root canal dentin.

Materials and Methods

Forty teeth with a single root canal were decoronated and longitudinally sectioned to expose the canals. The root halves were divided into 4 groups (n = 10) according to the solution applied: group NaOCl, 5.25% sodium hypochlorite (NaOCl) for 1 hour; group EDTA, 17% ethylenediaminetetraacetic acid (EDTA) for 2 minutes; group NaOCl+EDTA, 5.25% NaOCl for 1 hour and 17% EDTA for 2 minutes; a control group. Each root half belonging to the same root was evaluated for mineral content with either LIBS or SEM/EDS methods. The data were analyzed statistically.

Results

In groups NaOCl and NaOCl+EDTA, the calcium (Ca)/phosphorus (P) ratio decreased while the sodium (Na) level increased compared with the other groups (p < 0.05). The magnesium (Mg) level changes were not significant among the groups. A significant positive correlation was found between the results of LIBS and SEM/EDS analyses (r = 0.84, p < 0.001).

Conclusions

Treatment with NaOCl for 1 hour altered the mineral content of dentin, while EDTA application for 2 minutes had no effect on the elemental composition. The LIBS method proved to be reliable while providing data for the elemental composition of root canal dentin.

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In vitro evaluation of antimicrobial photodynamic therapy with photosensitizers and calcium hydroxide on bond strength, chemical composition, and sealing of glass-fiber posts to root dentin
Thalya Fernanda Horsth Maltarollo, Paulo Henrique dos Santos, Henrique Augusto Banci, Mariana de Oliveira Bachega, Beatriz Melare de Oliveira, Marco Hungaro Antonio Duarte, Índia Olinta de Azevedo Queiroz, Rodrigo Rodrigues Amaral, Luciano Angelo Tavares
Lasers in Medical Science.2025;[Epub] CrossRef
Effect of Using 5% Apple Vinegar Irrigation Solution Adjunct to Diode Laser on Smear Layer Removal and Calcium/Phosphorus Ion Ratio during Root Canal Treatment
Tarek AA Salam, Haythem SA Kader, Elsayed E Abdallah
CODS - Journal of Dentistry.2024; 15(1): 3. CrossRef
Evaluation of chemical composition of root canal dentin between two age groups using different irrigating solutions: An in vitro sem-eds study
Naresh Kumar K, Abhijith Kallu, Surender L.R, Sravani Nirmala, Narender Reddy
International Dental Journal of Student's Research.2024; 12(1): 18. CrossRef
Minimally invasive management of vital teeth requiring root canal therapy
E. Karatas, M. Hadis, W. M. Palin, M. R. Milward, S. A. Kuehne, J. Camilleri
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The Effects of a Novel Nanohydroxyapatite Gel and Er: YAG Laser Treatment on Dentin Hypersensitivity
Demet Sahin, Ceren Deger, Burcu Oglakci, Metehan Demirkol, Bedri Onur Kucukyildirim, Mehtikar Gursel, Evrim Eliguzeloglu Dalkilic
Materials.2023; 16(19): 6522. CrossRef
Chitosan Homogenizing Coffee Ring Effect for Soil Available Potassium Determination Using Laser-Induced Breakdown Spectroscopy
Xiaolong Li, Rongqin Chen, Zhengkai You, Tiantian Pan, Rui Yang, Jing Huang, Hui Fang, Wenwen Kong, Jiyu Peng, Fei Liu
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Light-emitting diode assessment of dentinal defects: the role of presumed extraction forces: Marcelo Santos Coelho, Steven J. Card, Peter Z. Tawil; Restor Dent Endod 2017;42(3):232-239. Published online July 24, 2017; DOI: https://doi.org/10.5395/rde.2017.42.3.232

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Objectives

The evaluation of iatrogenic dentinal defects in extracted teeth may be influenced by extraction forces and prolonged dry times. The purpose of this study was to compare the presence of dentinal defects in freshly extracted, periodontally compromised teeth with those in a group of teeth with uncontrolled extraction forces and storage time.

Materials and Methods

The experimental group consisted of eighteen roots obtained from teeth extracted due to periodontal reasons with class II or III mobility. They were kept in saline and sectioned within 1 hour following extraction. The control group consisted of matched root types obtained from an anonymous tooth collection, consistent with previous dentinal defect studies. The slices were obtained at 3, 6, and 9 mm from the apex. The imaging process exposed all specimens to no more than 60 seconds of dry time. The × 12.8 magnification was used for the 9 mm slices and × 19.2 magnification for the 3 mm and 6 mm slices under light-emitting diode (LED) transillumination. The root canal spaces and periodontal tissues were masked to minimize extraneous factors that might influence the evaluators. Chi-square test was used for statistical analysis.

Results

Dentinal defects were detected in 17% of the experimental group teeth, compared to 61% of control teeth (p = 0.015).

Conclusions

LED transillumination assessment of freshly extracted roots with class II or III mobility showed smaller number of dentinal defects than roots with uncontrolled storage time and extraction forces. The use of freshly extracted roots with mobility should be considered for future dental defect assessment studies.

Citations

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Dentinal microcracks on freshly extracted teeth: the impact of the extraction technique
F. N. Arashiro, G. De‐Deus, F. G. Belladonna, D. M. Cavalcante, M. S. Coelho, E. J. N. L. Silva, K. F. S. Pereira, P. G. da Silva, R. T. Lopes, E. M. Souza
International Endodontic Journal.2020; 53(4): 440. CrossRef
The relationship between the storage methods and the formation of dentinal defects (cracks)
Fábio Nakao ARASHIRO, Michelle Tavares Galotto NANTES, Pedro Gregol da SILVA, Key Fabiano Souza PEREIRA, Muryllo Eduardo Sales dos SANTOS
RGO - Revista Gaúcha de Odontologia.2019;[Epub] CrossRef
Effect of Reciproc blue, XP‐endo shaper, and WaveOne gold instruments on dentinal microcrack formation: A micro‐computed tomographic evaluation
Zeliha Uğur Aydın, Neslihan Büşra Keskin, Taha Özyürek
Microscopy Research and Technique.2019; 82(6): 856. CrossRef
Periapical Microsurgery: Do Root Canal–retreated Teeth Have More Dentinal Defects?
Peter Z. Tawil, Elisa K. Arnarsdottir, Ceib Phillips, Sigurdur R. Saemundsson
Journal of Endodontics.2018; 44(10): 1487. CrossRef
Root-originating dentinal defects: methodological aspects and clinical relevance
Peter Zahi Tawil, Elisa Kristin Arnarsdottir, Marcelo Santos Coelho
Evidence-Based Endodontics.2017;[Epub] CrossRef

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4 Download
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Comparing the effect of a desensitizing material and a self-etch adhesive on dentin sensitivity after periodontal surgery: a randomized clinical trial: Hila Hajizadeh, Atefeh Nemati-Karimooy, Sara Majidinia, Amir Moeintaghavi, Marjaneh Ghavamnasiri; Restor Dent Endod 2017;42(3):168-175. Published online July 21, 2017; DOI: https://doi.org/10.5395/rde.2017.42.3.168

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Objectives

This double-blind randomized placebo-controlled clinical trial evaluated the ability of a desensitizing agent and a self-etch adhesive on cervical dentin sensitivity (CDS) after periodontal surgery.

Materials and Methods

Ninety hypersensitive teeth of 13 subjects were included in the study. After periodontal surgery, the teeth of each posterior sextant treated with one of the following materials: G1: Clearfil S³ Bond (Kuraray Dental), G2: Gluma Desensitizer (Heraeus Kulzer), and G3: placebo (water). The sensitivity was assessed using evaporative stimuli before treatment (baseline, T0), 1 day after treatment (T1), after 1 week (T2), and after 1 month (T3) according to visual analog scale (VAS).

Results

Following the treatment, all the 3 groups showed significant reduction of CDS in T1 compared to T0. Reduction of CDS between T1 and T2 was observed only in G1 but there was no significant difference between T2 and T3 in this group. Although we observed a significant difference in T3 compared to T1 and T2 in G2 and G3, comparison of treatment groups in each assessment time showed a significant difference only in T3. According to paired comparison, this was due to the difference between G2 and G3.

Conclusions

Dentin sensitivity following periodontal surgery will decrease spontaneously over time, but treating the sensitive teeth with Gluma Desensitizer and Clearfil S³ Bond can have some benefits.

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Biomineralization reaction from nanosized calcium silicate: A new method for reducing dentin hypersensitivity
Mi-Jeong Jeon, Yu-Sung Choi, Jeong-Kil Park, Jin-Soo Ahn, Yu-Chih Chiang, Deog-Gyu Seo
Journal of Dental Sciences.2025; 20(1): 428. CrossRef
Effectiveness of Self-etching Adhesive Only Versus in Combination with Gluma Desensitizer for Preventing Post-composite Sensitivity - A Prospective Study
Hemamalini Rath, Shilpa Mahapatra, Sri Priya Narayanan
Indian Journal of Dental Research.2025; 36(1): 32. CrossRef
Efficacy of seventh generation bonding agents as desensitizers in patients with dentin hypersensitivity: a randomized clinical trial
Sumaiya Shabbir, Shahbaz Ahmed, Syed Jaffar Abbas Zaidi, Sania Riaz, Huma Sarwar, Muhammad Taqi, Zia ur Rahman Khan
BMC Oral Health.2024;[Epub] CrossRef
Investigation of the crystal formation from calcium silicate in human dentinal tubules and the effect of phosphate buffer saline concentration
Mi-Jeong Jeon, Jin-Soo Ahn, Jeong-Kil Park, Deog-Gyu Seo
Journal of Dental Sciences.2024; 19(4): 2278. CrossRef
The effect of fluoride iontophoresis on seal ability of self-etch adhesive in human dentin in vitro
Kanittha Kijsamanmith, Parintorn Wallanon, Chanya Pitchayasatit, Poonnapha Kittiratanaviwat
BMC Oral Health.2022;[Epub] CrossRef
The study of toothpaste desensitizing properties
S. B. Ulitovskiy, O. V. Kalinina, A. A. Leontev, O. V. Khabarova, L. I. Pankrateva, E. S. Soloveva, N. K. Fok
Parodontologiya.2022; 27(1): 81. CrossRef
Effectiveness and cytotoxicity of two desensitizing agents: a dentin permeability measurement and dentin barrier testing in vitro study
Ruodan Jiang, Yongxiang Xu, Feilong Wang, Hong Lin
BMC Oral Health.2022;[Epub] CrossRef
A randomized clinical trial of dentin hypersensitivity reduction over one month after a single topical application of comparable materials
Samar Hatem Abuzinadah, Abdulrahman Jafar Alhaddad
Scientific Reports.2021;[Epub] CrossRef
Comparison between effectiveness of dentine desensitizer and one bottle self-etch adhesive on dentine hypersensitivity
Muhammad Zohaib Younus, Muhammad Adeel Ahmed, Azeem Ul Yaqin Syed, Jiand Malik Baloch, Muhammad Ali, Abubakar Sheikh
Technology and Health Care.2021; 29(6): 1153. CrossRef
A long-term evaluation of experimental potassium oxalate concentrations on dentin hypersensitivity reduction: A triple-blind randomized clinical trial
Alexia da Mata Galvão, Livia Fávaro Zeola, Guilherme Faria Moura, Daniela Navarro Ribeiro Teixeira, Ramon Corrêa de Queiroz Gonzaga, Gisele Rodrigues da Silva, Paulo Vinícius Soares
Journal of Dentistry.2019; 89: 103180. CrossRef

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Analysis of the shelf life of chitosan stored in different types of packaging, using colorimetry and dentin microhardness: Antonio Miranda da Cruz-Filho, Angelo Rafael de Vito Bordin, Luis Eduardo Souza-Flamini, Débora Fernandes da Costa Guedes, Paulo César Saquy, Ricardo Gariba Silva, Jesus Djalma Pécora; Restor Dent Endod 2017;42(2):87-94. Published online March 27, 2017; DOI: https://doi.org/10.5395/rde.2017.42.2.87

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Objectives

Chitosan has been widely investigated and used. However, the literature does not refer to the shelf life of this solution. This study evaluated, through the colorimetric titration technique and an analysis of dentin micro-hardness, the shelf life of 0.2% chitosan solution.

Materials and Methods

Thirty human canines were sectioned, and specimens were obtained from the second and third slices, from cemento-enamel junction to the apex. A 0.2% chitosan solution was prepared and distributed in 3 identical glass bottles (v1, v2, and v3) and 3 plastic bottles (p1, p2, and p3). At 0, 7, 15, 30, 45, 60, 90, 120, 150, and 180 days, the specimens were immersed in each solution for 5 minutes (n = 3 each). The chelating effect of the solution was assessed by micro-hardness and colorimetric analysis of the dentin specimens. 17% EDTA and distilled water were used as controls. Data were analyzed statistically by two-way and Tukey-Kramer multiple comparison (α = 0.05).

Results

There was no statistically significant difference among the solutions with respect to the study time (p = 0.113) and micro-hardness/time interaction (p = 0.329). Chitosan solutions and EDTA reduced the micro-hardness in a similar manner and differed significantly from the control group (p < 0.001). Chitosan solutions chelated calcium ions throughout the entire experiment.

Conclusions

Regardless of the storage form, chitosan demonstrates a chelating property for a minimum period of 6 months.

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Chitosan’s Ability to Remove the Smear Layer—A Systematic Review of Ex Vivo Studies
Ana Ferreira-Reguera, Inês Ferreira, Irene Pina-Vaz, Benjamín Martín-Biedma, José Martín-Cruces
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The Utilization of Chitosan and Arduino Interface in Making a Microplastic Filter
Kate Cyrene P. Pineda, Maeven Uriel A. Dela Cruz, Quirsten Daniel R. Repalda, Aldrin Jeynard A. Gonzales, DL Chaturika C. Douglas, Alina Siara D. Hajan, Julie Ann B. Real
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Hoda Raafat Yousri, Abeer Hashem Mahran, Ahmed Abdel Rahman Hashem, Amal A. El-Batouti
Endodontology.2024; 36(4): 383. CrossRef
Influence of Chitosan 0.2% in Various Final Cleaning Methods on the Bond Strength of Fiberglass Post to Intrarradicular Dentin
Naira Geovana Camilo, Alex da Rocha Gonçalves, Larissa Pinzan Flauzino, Cristiane Martins Rodrigues Bernardes, Andreza Maria Fábio Aranha, Priscilla Cardoso Lazari-Carvalho, Marco Aurélio de Carvalho, Helder Fernandes de Oliveira
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Evaluation and comparison of anti-inflammatory properties of ibuprofen using two drug delivery systems after third molar surgery: using chitosan microspheres as a carrier for local drug delivery in to the third molar socket and through the oral route
Karthik KP, Balamurugan R
British Journal of Oral and Maxillofacial Surgery.2021; 59(2): 191. CrossRef
Optimization of chitosan nanoparticle synthesis and its potential application as germination elicitor of Oryza sativa L.
K. Divya, Smitha Vijayan, Sreekumar Janardanan Nair, M.S. Jisha
International Journal of Biological Macromolecules.2019; 124: 1053. CrossRef
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Behrouz Farhadihosseinabadi, Amir Zarebkohan, Mohamad Eftekhary, Mohammad Heiat, Mehrdad Moosazadeh Moghaddam, Mazaher Gholipourmalekabadi
Cellular and Molecular Life Sciences.2019; 76(14): 2697. CrossRef

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Elemental analysis of caries-affected root dentin and artificially demineralized dentin: Young-Hye Sung, Ho-Hyun Son, Keewook Yi, Juhea Chang; Restor Dent Endod 2016;41(4):255-261. Published online August 19, 2016; DOI: https://doi.org/10.5395/rde.2016.41.4.255

Abstract PDF PubReader ePub

Objectives

This study aimed to analyze the mineral composition of naturally- and artificially-produced caries-affected root dentin and to determine the elemental incorporation of resin-modified glass ionomer (RMGI) into the demineralized dentin.

Materials and Methods

Box-formed cavities were prepared on buccal and lingual root surfaces of sound human premolars (n = 15). One cavity was exposed to a microbial caries model using a strain of Streptococcus mutans. The other cavity was subjected to a chemical model under pH cycling. Premolars and molars with root surface caries were used as a natural caries model (n = 15). Outer caries lesion was removed using a carbide bur and a hand excavator under a dyeing technique and restored with RMGI (FujiII LC, GC Corp.). The weight percentages of calcium (Ca), phosphate (P), and strontium (Sr) and the widths of demineralized dentin were determined by electron probe microanalysis and compared among the groups using ANOVA and Tukey test (p < 0.05).

Results

There was a pattern of demineralization in all models, as visualized with scanning electron microscopy. Artificial models induced greater losses of Ca and P and larger widths of demineralized dentin than did a natural caries model (p < 0.05). Sr was diffused into the demineralized dentin layer from RMGI.

Conclusions

Both microbial and chemical caries models produced similar patterns of mineral composition on the caries-affected dentin. However, the artificial lesions had a relatively larger extent of demineralization than did the natural lesions. RMGI was incorporated into the superficial layer of the caries-affected dentin.

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Nathanael Leung, Robert A. Harper, Bin Zhu, Stuart A. Bartlett, Konstantin Ignatyev, Richard M. Shelton, Gabriel Landini, Tan Sui
Journal of Structural Biology.2025; 217(2): 108208. CrossRef
A dynamic microcosm biofilm model for root carious-like lesion development: analysis of demineralization and microbiological characterization
Tamires Timm Maske, Glenda Ávila Marques, Bruna Dalongaro Fritsch, Bruna Moraes Kremer, Maximiliano Sérgio Cenci, Pabulo Henrique Rampelotto, Rodrigo Alex Arthur
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Mostafa A. Abdelshafi, Hanan A.N. Soliman, Dina Abdelaziz
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Grace Yuchan Xu, Irene Shuping Zhao, Christie Ying Kei Lung, Iris Xiaoxue Yin, Edward Chin Man Lo, Chun Hung Chu
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Effects of NaF versus SDF treatment on microhardness of artificial radiation caries at cervical and root areas
Pipop SAIKAEW, Karis KATEKOVIT, Anocha BURANARACHADA, Nattapat SAIMALA, Anussara PRAYONGRAT, Pornpoj FUANGTHARNTHIP
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Therese Schüler, Celine Guder, Franziska Alt, Katrin Lorenz, Torsten Sterzenbach, Christian Hannig, Hans-Peter Wiesmann, Benjamin Kruppke
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Zaid Dohan, Lara T. Friedlander, Paul R. Cooper, Kai-Chun Li, Jithendra T. Ratnayake, May L. Mei
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Effect of fluoride, chlorhexidine or Nd:YAG on the progression of root dentin demineralization after removal of the demineralized organic matrix
Andrea Maselli, Tânia Mara da Silva, Lucélia Lemes Gonçalves, Aline Silva Braga, Eduardo Bresciani, Ana Carolina Magalhães, Sérgio Eduardo de Paiva Gonçalves
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Effect of ionizing radiation and cariogenic biofilm challenge on root-dentin caries
Camila de Carvalho Almança Lopes, Renata Borges Rodrigues, Maximiliano Sérgio Cenci, Juliana Lays Stolfo Uehara, Tamires Timm Maske, Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Veridiana Resende Novais
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Chelsea Mitchell, Andrew J Gross, Peter Milgrom, Lloyd Mancl, David B Prince
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Frontiers in Nutrition.2020;[Epub] CrossRef

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Antifungal effects of synthetic human β-defensin 3-C15 peptide: Sang-Min Lim, Ki-Bum Ahn, Christine Kim, Jong-Won Kum, Hiran Perinpanayagam, Yu Gu, Yeon-Jee Yoo, Seok Woo Chang, Seung Hyun Han, Won-Jun Shon, Woocheol Lee, Seung-Ho Baek, Qiang Zhu, Kee-Yeon Kum; Restor Dent Endod 2016;41(2):91-97. Published online March 17, 2016; DOI: https://doi.org/10.5395/rde.2016.41.2.91

Abstract PDF PubReader ePub

Objectives

The purpose of this ex vivo study was to compare the antifungal activity of a synthetic peptide consisting of 15 amino acids at the C-terminus of human β-defensin 3 (HBD3-C15) with calcium hydroxide (CH) and Nystatin (Nys) against Candida albicans (C. albicans) biofilm.

Materials and Methods

C. albicans were grown on cover glass bottom dishes or human dentin disks for 48 hr, and then treated with HBD3-C15 (0, 12.5, 25, 50, 100, 150, 200, and 300 µg/mL), CH (100 µg/mL), and Nys (20 µg/mL) for 7 days at 37℃. On cover glass, live and dead cells in the biomass were measured by the FilmTracer Biofilm viability assay, and observed by confocal laser scanning microscopy (CLSM). On dentin, normal, diminished and ruptured cells were observed by field-emission scanning electron microscopy (FE-SEM). The results were subjected to a two-tailed t-test, a one way analysis variance and a post hoc test at a significance level of p = 0.05.

Results

C. albicans survival on dentin was inhibited by HBD3-C15 in a dose-dependent manner. There were fewer aggregations of C. albicans in the groups of Nys and HBD3-C15 (≥ 100 µg/mL). CLSM showed C. albicans survival was reduced by HBD3-C15 in a dose dependent manner. Nys and HBD3-C15 (≥ 100 µg/mL) showed significant fungicidal activity compared to CH group (p < 0.05).

Conclusions

Synthetic HBD3-C15 peptide (≥ 100 µg/mL) and Nys exhibited significantly higher antifungal activity than CH against C. albicans by inhibiting cell survival and biofilm.

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Kun Wang, Xuedong Zhou, Wei Li, Linglin Zhang
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Case Report

Fibre reinforcement in a structurally compromised endodontically treated molar: a case report: Renita Soares, Ida de Noronha de Ataide, Marina Fernandes, Rajan Lambor; Restor Dent Endod 2016;41(2):143-147. Published online February 22, 2016; DOI: https://doi.org/10.5395/rde.2016.41.2.143

Abstract PDF PubReader ePub

The reconstruction of structurally compromised posterior teeth is a rather challenging procedure. The tendency of endodontically treated teeth (ETT) to fracture is considerably higher than vital teeth. Although posts and core build-ups followed by conventional crowns have been generally employed for the purpose of reconstruction, this procedure entails sacrificing a considerable amount of residual sound enamel and dentin. This has drawn the attention of researchers to fibre reinforcement. Fibre-reinforced composite (FRC), designed to replace dentin, enables the biomimetic restoration of teeth. Besides improving the strength of the restoration, the incorporation of glass fibres into composite resins leads to favorable fracture patterns because the fibre layer acts as a stress breaker and stops crack propagation. The following case report presents a technique for reinforcing a badly broken-down ETT with biomimetic materials and FRC. The proper utilization of FRC in structurally compromised teeth can be considered to be an economical and practical measure that may obviate the use of extensive prosthetic treatment.

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Khaled Abid Althaqafi
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Research Articles

Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry: Jia Kim, Young-Sang Song, Kyung-San Min, Sun-Hun Kim, Jeong-Tae Koh, Bin-Na Lee, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Yun-Chan Hwang; Restor Dent Endod 2016;41(1):29-36. Published online January 4, 2016; DOI: https://doi.org/10.5395/rde.2016.41.1.29

Abstract PDF PubReader ePub

Objectives

The purpose of this study was to assess the ability of two new calcium silicate-based pulp-capping materials (Biodentine and BioAggregate) to induce healing in a rat pulp injury model and to compare them with mineral trioxide aggregate (MTA).

Materials and Methods

Eighteen rats were anesthetized, cavities were prepared and the pulp was capped with either of ProRoot MTA, Biodentine, or BioAggregate. The specimens were scanned using a high-resolution micro-computed tomography (micro-CT) system and were prepared and evaluated histologically and immunohistochemically using dentin sialoprotein (DSP).

Results

On micro-CT analysis, the ProRoot MTA and Biodentine groups showed significantly thicker hard tissue formation (p < 0.05). On H&E staining, ProRoot MTA showed complete dentin bridge formation with normal pulpal histology. In the Biodentine and BioAggregate groups, a thick, homogeneous hard tissue barrier was observed. The ProRoot MTA specimens showed strong immunopositive reaction for DSP.

Conclusions

Our results suggest that calcium silicate-based pulp-capping materials induce favorable effects on reparative processes during vital pulp therapy and that both Biodentine and BioAggregate could be considered as alternatives to ProRoot MTA.

Citations

Citations to this article as recorded by

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Clinical and radiographical evaluation of mineral trioxide aggregate, biodentine and propolis as pulpotomy medicaments in primary teeth: Bharti Kusum, Kumar Rakesh, Khanna Richa; Restor Dent Endod 2015;40(4):276-285. Published online September 9, 2015; DOI: https://doi.org/10.5395/rde.2015.40.4.276

Abstract PDF PubReader ePub

Objectives

The purpose of this study was to evaluate the efficacy of mineral trioxide aggregate (MTA), Biodentine and Propolis as pulpotomy medicaments in primary dentition, both clinically and radiographically.

Materials and Methods

A total of 75 healthy 3 to 10 yr old children each having at least one carious primary molar tooth were selected. Random assignment of the pulpotomy medicaments was done as follows: Group I, MTA; Group II, Biodentine; Group III, Propolis. All the pulpotomized teeth were evaluated at 3, 6, and 9 mon clinically and radiographically, based on the scoring criteria system.

Results

The clinical success rates were found to be similar among the three groups at 3 and 6 mon where as a significant decrease in success rate was observed in Group III (84%) compared to both Group I (100%) and Group II (100%) at 9 mon. Radiographic success rates over a period of 9 mon in Groups I, II, and III were 92, 80, and 72%, respectively.

Conclusions

Teeth treated with MTA and Biodentine showed more favorable clinical and radiographic success as compared to Propolis at 9 mon follow-up.

Citations

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The Journal of the American Dental Association.2019; 150(8): 676. CrossRef
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BMC Oral Health.2019;[Epub] CrossRef
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Zahra Jamali, Vajiheh Alavi, Ebrahim Najafpour, Naser Asl Aminabadi, Sajjad Shirazi
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Silvia Caruso, Teresa Dinoi, Giuseppe Marzo, Vincenzo Campanella, Maria Rita Giuca, Roberto Gatto, Marco Pasini
BMC Oral Health.2018;[Epub] CrossRef
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R. Careddu, H. F. Duncan
British Dental Journal.2018; 225(8): 743. CrossRef
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M. Parirokh, M. Torabinejad, P. M. H. Dummer
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Biodentine™ material characteristics and clinical applications: a 3 year literature review and update
S. Rajasekharan, L. C. Martens, R. G. E. C. Cauwels, R. P. Anthonappa
European Archives of Paediatric Dentistry.2018; 19(1): 1. CrossRef
Microleakage and Shear Bond Strength of Biodentine at Different Setting Time
Yong Ho Song, Nanyoung Lee, Sangho Lee, Myeongkwan Jih
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Fouad Ayoub, Hitaf Nasrallah, Balsam El Noueiri, Charles Pilipili
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Influence of a glide path on the dentinal crack formation of ProTaper Next system: Sevinç Aktemur Türker, Emel Uzunoğlu; Restor Dent Endod 2015;40(4):286-289. Published online September 2, 2015; DOI: https://doi.org/10.5395/rde.2015.40.4.286

Abstract PDF PubReader ePub

Objectives

The aim was to evaluate dentinal crack formation after root canal preparation with ProTaper Next system (PTN) with and without a glide path.

Materials and Methods

Forty-five mesial roots of mandibular first molars were selected. Fifteen teeth were left unprepared and served as controls. The experimental groups consist of mesiobuccal and mesiolingual root canals of remaining 30 teeth, which were divided into 2 groups (n = 15): Group PG/PTN, glide path was created with ProGlider (PG) and then canals were shaped with PTN system; Group PTN, glide path was not prepared and canals were shaped with PTN system only. All roots were sectioned perpendicular to the long axis at 1, 2, 3, 4, 6, and 8 mm from the apex, and the sections were observed under a stereomicroscope. The presence/absence of cracks was recorded. Data were analyzed with chi-square tests with Yates correction.

Results

There were no significant differences in crack formation between the PTN with and without glide path preparation. The incidence of cracks observed in PG/PTN and PTN groups was 17.8% and 28.9%, respectively.

Conclusions

The creation of a glide path with ProGlider before ProTaper Next rotary system did not influence dentinal crack formation in root canals.

Citations

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Comparative Evaluation of the Shaping Ability of the Recent, Fifth-generation ProTaper Next and Revo-S NiTi Rotary Endodontic Files Using Three-dimensional Imaging: An Imaging-based Study
Prajna Pattanaik, Akilan Balasubramanian, P. Veeralakshmi, Gautam Singh, Vandana Sadananda, Hina Ahmed, J. Suresh Babu, C. Swarnalatha, Abhishek Singh Nayyar
Journal of Microscopy and Ultrastructure.2025; 13(4): 177. CrossRef
Glide Path in Endodontics: A Literature Review of Current Knowledge
Vlad Mircea Lup, Giulia Malvicini, Carlo Gaeta, Simone Grandini, Gabriela Ciavoi
Dentistry Journal.2024; 12(8): 257. CrossRef
Microscopic Assessment of Dentinal Defects Induced by ProTaper Universal, ProTaper Gold, and Hyflex Electric Discharge Machining Rotary File Systems – An in vitro Study
Takhellambam Premlata Devi, Amandeep Kaur, Shamurailatpam Priyadarshini, B. S. Deepak, Sumita Banerjee, Ng Sanjeeta
Contemporary Clinical Dentistry.2021; 12(3): 230. CrossRef
Influence of Negotiation, Glide Path, and Preflaring Procedures on Root Canal Shaping—Terminology, Basic Concepts, and a Systematic Review
Gianluca Plotino, Venkateshbabu Nagendrababu, Frederic Bukiet, Nicola M. Grande, Sajesh K. Veettil, Gustavo De-Deus, Hany Mohamed Aly Ahmed
Journal of Endodontics.2020; 46(6): 707. CrossRef

1,394 View
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4 Crossref

Changes in SIRT gene expression during odontoblastic differentiation of human dental pulp cells: Young-Eun Jang, Su-Hee Go, Bin-Na Lee, Hoon-Sang Chang, In-Nam Hwang, Won-Mann Oh, Yun-Chan Hwang; Restor Dent Endod 2015;40(3):223-228. Published online July 15, 2015; DOI: https://doi.org/10.5395/rde.2015.40.3.223

Abstract PDF PubReader ePub

Objectives

The aim of this study was to investigate the expression of 7 different sirtuin genes (SIRT1-SIRT7) in human dental pulp cells (HDPCs), and to determine the role of SIRTs in the odontoblastic differentiation potential of HDPCs.

Materials and Methods

HDPCs were isolated from freshly extracted third molar teeth of healthy patients and cultulred in odontoblastic differentiation inducing media. Osteocalcin (OCN) and dentin sialophosphoprotein (DSPP) expression was analyzed to evaluate the odontoblastic differentiation of HDPCs by reverse transcription-polymerase chain reaction (RT-PCR), while alizarin red staining was used for the mineralization assay. To investigate the expression of SIRTs during odontoblastic differentiation of HDPCs, real time PCR was also performed with RT-PCR.

Results

During the culture of HDPCs in the differentiation inducing media, OCN, and DSPP mRNA expressions were increased. Mineralized nodule formation was also increased in the 14 days culture. All seven SIRT genes were expressed during the odontogenic induction period. SIRT4 expression was increased in a time-dependent manner.

Conclusions

Our study identified the expression of seven different SIRT genes in HDPCs, and revealed that SIRT4 could exert an influence on the odontoblast differentiation process. Further studies are needed to determine the effects of other SIRTs on the odontogenic potential of HDPCs.

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Biodegradable Zn‐5Dy Alloy with Enhanced Osteo/Angio‐Genic Activity and Osteointegration Effect via Regulation of SIRT4‐Dependent Mitochondrial Function
Yue Han, Xian Tong, Runqi Zhou, Yilin Wang, Yuge Chen, Liang Chen, Xinhua Hong, Linmei Wu, Zhiqiang Lin, Yichi Zhang, Xuejia Zhang, Chaoming Hu, Bin Li, Yifan Ping, Zelin Cao, Zhou Ye, Zhongchen Song, Yuncang Li, Cuie Wen, Yongsheng Zhou, Jixing Lin, Shen
Advanced Science.2024;[Epub] CrossRef
The Role of Histone Acetylation Modification in Dental Tissue-Derived Mesenchymal Stem Cells and Odontogenesis
Haoling Chen, Zijing Huang, Chuxiao Chen
Cellular Reprogramming.2023; 25(1): 11. CrossRef
Metabolic Remodeling Impacts the Epigenetic Landscape of Dental Mesenchymal Stem Cells
Haiyun Luo, Yachuan Zhou, Wenjing Liu, Jun Wang
Stem Cells International.2022; 2022: 1. CrossRef
SIRT4 regulates rat dental papilla cell differentiation by promoting mitochondrial functions
Haoling Chen, Jun Kang, Fuping Zhang, Tong Yan, Wenguo Fan, Hongwen He, Fang Huang
The International Journal of Biochemistry & Cell Biology.2021; 134: 105962. CrossRef
Sirtuins as Interesting Players in the Course of HIV Infection and Comorbidities
Karolina Jurkowska, Beata Szymańska, Brygida Knysz, Amadeusz Kuźniarski, Agnieszka Piwowar
Cells.2021; 10(10): 2739. CrossRef
Robust expression of SIRT6 inhibits pulpitis via activation of the TRPV1 channel
Jia Hu, Weiran Chen, Zailing Qiu, Hongbing Lv
Cell Biochemistry and Function.2020; 38(5): 676. CrossRef
Downregulation of microRNA‐143‐5p is required for the promotion of odontoblasts differentiation of human dental pulp stem cells through the activation of the mitogen‐activated protein kinases 14‐dependent p38 mitogen‐activated protein kinases signaling pa
Bao‐Liang Wang, Zhi Wang, Xi Nan, Qing‐Cai Zhang, Wei Liu
Journal of Cellular Physiology.2019; 234(4): 4840. CrossRef
A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis
H. Kudo, O. Takeichi, K. Hatori, K. Makino, K. Himi, B. Ogiso
International Endodontic Journal.2018; 51(7): 747. CrossRef
Overexpressed Sirt1 in MSCs Promotes Dentin Formation in Bmi1-Deficient Mice
H. Wang, C. Lv, Y. Gu, Q. Li, L. Xie, H. Zhang, D. Miao, W. Sun
Journal of Dental Research.2018; 97(12): 1365. CrossRef
Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas
Hiroshi Kudo, Osamu Takeichi, Kosuke Makino, Keisuke Hatori, Bunnai Ogiso
Journal of Oral Science.2018; 60(3): 411. CrossRef
TET1 knockdown inhibits the odontogenic differentiation potential of human dental pulp cells
Li-Jia Rao, Bai-Cheng Yi, Qi-Meng Li, Qiong Xu
International Journal of Oral Science.2016; 8(2): 110. CrossRef

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Evaluation of the effects of two novel irrigants on intraradicular dentine erosion, debris and smear layer removal: Melahat Görduysus, Selen Küçükkaya, Nursel Pekel Bayramgil, Mehmet Ömer Görduysus; Restor Dent Endod 2015;40(3):216-222. Published online July 3, 2015; DOI: https://doi.org/10.5395/rde.2015.40.3.216

Abstract PDF PubReader ePub

Objectives

To evaluate the effects of copolymer of acrylic acid and maleic acid (Poly[AA-co-MA]) and calcium hypochlorite (Ca(OCl)₂) on root canal dentin using scanning electron microscope (SEM).

Materials and Methods

Twenty-four single-rooted teeth were instrumented and the apical and coronal thirds of each root were removed, leaving the 5 mm middle thirds, which were then separated into two pieces longitudinally. The specimens were randomly divided into six groups and subjected to each irrigant for 5 min as follows: G1, Ca(OCl)₂; G2, Poly(AA-co-MA); G3, Ca(OCl)₂ + Poly(AA-co-MA); G4, sodium hypochlorite (NaOCl); G5, ethylenediaminetetraacetic acid (EDTA); G6, NaOCl+EDTA. The specimens were prepared for SEM evaluation. Smear layer, debris and erosion scores were recorded by two blinded examiners. One image from G3 was analyzed with energy dispersive spectroscopy (EDS) on suspicion of precipitate formation. Data were analyzed using the Kruskal-Wallis and Dunn tests.

Results

G1 and G4 showed the presence of debris and smear layer and they were statistically different from G2, G3, G5 and G6 where debris and smear layer were totally removed (p < 0.05). In G1 and G4, erosion evaluation could not be done because of debris and smear layer. G2, G3 and G5 showed no erosion, and there was no significant difference between them. G6 showed severe erosion and was statistically different from G2, G3 and G5 (p < 0.05). EDS microanalysis showed the presence of Na, P, and Ca elements on the surface.

Conclusions

Poly(AA-co-MA) is effective in removing the smear layer and debris without causing erosion either alone or with Ca(OCl)₂.

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Effect of Heat and Irrigation Agitation on the Smear Layer Removal Ability of Calcium Hypochlorite: A Scanning Electron Microscope Study
Damla Erkal, Kürşat Er
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Effect of sodium and calcium hypochlorite with or without surfactant on the adhesion of epoxy resin-based endodontic sealer
Guilherme Pauletto, Natália Franco Brum, Israel Bangel Carlotto, Lucas Saldanha da Rosa, Carlos Alexandre Souza Bier
Brazilian Journal of Oral Sciences.2025; 24: e254080. CrossRef
Bonding and Cleaning Effects of Irrigation Protocols Using Calcium Hypochlorite on the Post-space Radicular Dentin
JF Besegato, GR Bravo, JF Zaniboni, LG Belizário, ENM de Almeida, MB Gelio, WG Escalante-Otárola, MC Kuga
Operative Dentistry.2024; 49(6): E1. CrossRef
Effect of sodium hypochlorite and calcium hypochlorite on the apical sealing ability of endodontic sealers
Israel Bangel Carlotto, Natália Franco Brum, Guilherme Pauletto, Lucas Saldanha da Rosa, Carlos Alexandre Souza Bier
Brazilian Journal of Oral Sciences.2024; 23: e242700. CrossRef
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Helen Thomas, D. N. Nirupama, Mohan Thomas Nainan, D. N. Naveen, C. Y. Ranjini, R. Vijay
Journal of Conservative Dentistry and Endodontics.2024; 27(2): 159. CrossRef
Effect of calcium hypochlorite as an irrigant alternative in the removal of methylene blue after photodynamic therapy under the post-space adhesive interface
João Felipe Besegato, Joatan Lucas de Sousa Gomes Costa, Joissi Ferrari Zaniboni, Giovanna Righetti Bravo, Jéssika Mayhara Pereira Morais, Wilfredo Gustavo Escalante-Otárola, Milton Carlos Kuga
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Effectiveness of Different Irrigation Techniques on Post Space Smear Layer Removal: SEM Evaluation
Alfredo Iandolo, Massimo Pisano, Dina Abdellatif, Alessandra Amato, Francesco Giordano, Alessio Buonavoglia, Giuseppe Sangiovanni, Mario Caggiano
Prosthesis.2023; 5(2): 539. CrossRef
The dynamic interplay of dietary acid pH and concentration during early-stage human enamel and dentine erosion
J. Pattem, J. Field, P. J. Waterhouse, M. J. German
Frontiers in Dental Medicine.2022;[Epub] CrossRef
Effect of EDTA, sodium, and calcium hypochlorite on the inorganic component of root canal dentin: A SEM analysis
Luana Roleto Cardoso, Flávia Emi Razera Baldasso, Débora Delai, Francisco Montagner, Patrícia Maria Poli Kopper
Microscopy Research and Technique.2019; 82(2): 128. CrossRef
Comparative Analysis of Manual, Rotary and Reciprocal Systems on Primary Teeth Root Canals: An In Vitro Scanning Electron Microscopy Study
İpek ARSLAN, Sema AYDINOĞLU, Ozgul BAYGIN, Tamer TÜZÜNER, Murat ŞİRİN
Cumhuriyet Dental Journal.2019; 22(3): 299. CrossRef
Regenerating a monoblock to obturate root canalsvia a mineralising strategy
Le Zhang, Quan-Li Li, Ying Cao, Yun Wang
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Aysin Dumani, Hatice Korkmaz Guvenmez, Sehnaz Yilmaz, Oguz Yoldas, Zeliha Gonca Bek Kurklu
BioMed Research International.2016; 2016: 1. CrossRef

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Chelating and antibacterial properties of chitosan nanoparticles on dentin: Aldo del Carpio-Perochena, Clovis Monteiro Bramante, Marco Antonio Hungaro Duarte, Marcia Regina de Moura, Fauze Ahmad Aouada, Anil Kishen; Restor Dent Endod 2015;40(3):195-201. Published online March 30, 2015; DOI: https://doi.org/10.5395/rde.2015.40.3.195

Abstract PDF PubReader ePub

Objectives

The use of chitosan nanoparticles (CNPs) in endodontics is of interest due to their antibiofilm properties. This study was to investigate the ability of bioactive CNPs to remove the smear layer and inhibit bacterial recolonization on dentin.

Materials and Methods

One hundred bovine dentin sections were divided into five groups (n = 20 per group) according to the treatment. The irrigating solutions used were 2.5% sodium hypochlorite (NaOCl) for 20 min, 17% ethylenediaminetetraacetic acid (EDTA) for 3 min and 1.29 mg/mL CNPs for 3 min. The samples were irrigated with either distilled water (control), NaOCl, NaOCl-EDTA, NaOCl-EDTA-CNPs or NaOCl-CNPs. After the treatment, half of the samples (n = 50) were used to assess the chelating effect of the solutions using portable scanning electronic microscopy, while the other half (n = 50) were infected intra-orally to examine the post-treatment bacterial biofilm forming capacity. The biovolume and cellular viability of the biofilms were analysed under confocal laser scanning microscopy. The Kappa test was performed for examiner calibration, and the non-parametric Kruskal-Wallis and Dunn tests (p < 0.05) were used for comparisons among the groups.

Results

The smear layer was significantly reduced in all of the groups except the control and NaOCl groups (p < 0.05). The CNPs-treated samples were able to resist biofilm formation significantly better than other treatment groups (p < 0.05).

Conclusions

CNPs could be used as a final irrigant during root canal treatment with the dual benefit of removing the smear layer and inhibiting bacterial recolonization on root dentin.

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Effects of solvent volatilization time on the bond strength of etch-and-rinse adhesive to dentin using conventional or deproteinization bonding techniques: José Aginaldo de Sousa Júnior, Márcia Luciana Carregosa Santana, Fabricio Eneas Diniz de Figueiredo, André Luis Faria-e-Silva; Restor Dent Endod 2015;40(3):202-208. Published online March 17, 2015; DOI: https://doi.org/10.5395/rde.2015.40.3.202

Abstract PDF PubReader ePub

Objectives

This study determined the effect of the air-stream application time and the bonding technique on the dentin bond strength of adhesives with different solvents. Furthermore, the content and volatilization rate of the solvents contained in the adhesives were also evaluated.

Materials and Methods

Three adhesive systems with different solvents (Stae, SDI, acetone; XP Bond, Dentsply De Trey, butanol; Ambar, FGM, ethanol) were evaluated. The concentrations and evaporation rates of each adhesive were measured using an analytical balance. After acid-etching and rinsing, medium occlusal dentin surfaces of human molars were kept moist (conventional) or were treated with 10% sodium hypochlorite for deproteinization. After applying adhesives over the dentin, slight air-stream was applied for 10, 30 or 60 sec. Composite cylinders were built up and submitted to shear testing. The data were submitted to ANOVA and Tukey's test (α = 0.05).

Results

Stae showed the highest solvent content and Ambar the lowest. Acetone presented the highest evaporation rate, followed by butanol. Shear bond strengths were significantly affected only by the factors of 'adhesive' and 'bonding technique' (p < 0.05), while the factor 'duration of air-stream' was not significant. Deproteinization of dentin increased the bond strength (p < 0.05). Stae showed the lowest bond strength values (p < 0.05), while no significant difference was observed between XP Bond and Ambar.

Conclusions

Despite the differences in content and evaporation rate of the solvents, the duration of air-stream application did not affect the bond strength to dentin irrespective of the bonding technique.

Citations

Citations to this article as recorded by

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