Restorative Dentistry & Endodontics

Research Articles

Evaluation of at-home bleaching protocol with application on different surfaces: bleaching efficacy and hydrogen peroxide permeability: Heloisa Forville, Michael Willian Favoreto, Michel Wendlinger, Roberta Micheten Dias, Christiane Philippini Ferreira Borges, Alessandra Reis, Alessandro D. Loguercio; Restor Dent Endod 2023;48(4):e33. Published online October 6, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e33

Objectives

This study aimed to evaluate the bleaching efficacy and hydrogen peroxide permeability in the pulp chamber by the at-home bleaching gel in protocols applied on different dental surfaces.

Materials and Methods

Forty premolars were randomly into 4 groups: control group no bleaching, only application on the buccal surface (OB), only application on the lingual surface (OL) and application in buccal and lingual surfaces, simultaneously (BL). At-home bleaching gel (White Class 7.5%) was used for the procedure. The bleaching efficacy was evaluated with a digital spectrophotometer (color change in CIELAB [ΔE _ab] and CIEDE 2000 [ΔE ₀₀] systems and Whitening Index for Dentistry [ΔWI_D]). The hydrogen peroxide permeability in the pulp chamber (µg/mL) was assessed using UV-Vis spectrophotometry and data were analyzed for a 1-way analysis of variance and Tukey’s test (α = 0.05).

Results

All groups submitted to bleaching procedure showed bleaching efficacy when measured with ΔE _ab and ΔE ₀₀ (p > 0.05). Therefore, when analyzed by ΔWI_D, a higher bleaching efficacy were observed for the application on the groups OB and BL (p = 0.00003). Similar hydrogen peroxide permeability was found in the pulp chambers of the teeth undergoing different protocols (p > 0.05).

Conclusions

The application of bleaching gel exclusively on the OB is sufficient to achieve bleaching efficacy, when compared to BL. Although the OL protocol demonstrated lower bleaching efficacy based on the ΔWI_D values, it may still be of interest and relevant in certain clinical scenarios based on individual needs, requiring clinical trials to better understand its specificities.

Citations

Citations to this article as recorded by

Effect of whitening pens on hydrogen peroxide permeability in the pulp chamber, color change and surface morphology
Laryssa Mylenna Madruga Barbosa, Gabrielle Gomes Centenaro, Deisy Cristina Ferreira Cordeiro, Maria Alice de Matos Rodrigues, Letícia Condolo, Michael Willian Favoreto, Alessandra Reis, Alessandro D. Loguercio
Journal of Dentistry.2025; 154: 105595. CrossRef
Efficacy of a buccal and lingual at‐home bleaching protocol—A randomized, split‐mouth, single‐blind controlled trial
Heloisa Forville, Laís Giacomini Bernardi, Michael Willian Favoreto, Felipe Coppla, Taynara de Souza Carneiro, Fabiana Madalozzo Coppla, Alessandro D. Loguercio, Alessandra Reis
Journal of Esthetic and Restorative Dentistry.2024; 36(9): 1301. CrossRef
REANATOMIZAÇÃO DE DENTE CONOIDE ASSOCIADA A ESTÉTICA VERMELHA: RELATO DE CASO
Ana Karolayne Sousa de Morais, Daniele Fernanda Sousa Barros, Daniel Messias Limeira, Rhana Leticia de Oliveira Faria, Roberta Furtado Carvalho, Sandna Nolêto de Araújo, Laura Barbosa Santos Di Milhomem
Revista Contemporânea.2024; 4(10): e6299. CrossRef
Effect of the reduction in the exposure time to at-home bleaching gel on color change and tooth sensitivity: A systematic review and meta-analysis
Priscila Borges Gobbo de Melo, Letícia Vasconcelos Silva Souza, Lucianne Cople Maia, Guido Artemio Marañón-Vásquez, Matheus Kury, Vanessa Cavalli
Clinical Oral Investigations.2024;[Epub] CrossRef

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Effect of medium or high concentrations of in-office dental bleaching gel on the human pulp response in the mandibular incisors: Douglas Augusto Roderjan, Rodrigo Stanislawczuk, Diana Gabriela Soares, Carlos Alberto de Souza Costa, Michael Willian Favoreto, Alessandra Reis, Alessandro D. Loguercio; Restor Dent Endod 2023;48(2):e12. Published online March 8, 2023; DOI: https://doi.org/10.5395/rde.2023.48.e12

Abstract PDF PubReader ePub

Objectives

The present study evaluated the pulp response of human mandibular incisors subjected to in-office dental bleaching using gels with medium or high concentrations of hydrogen peroxide (HP).

Materials and Methods

The following groups were compared: 35% HP (HP35; n = 5) or 20% HP (HP20; n = 4). In the control group (CONT; n = 2), no dental bleaching was performed. The color change (CC) was registered at baseline and after 2 days using the Vita Classical shade guide. Tooth sensitivity (TS) was also recorded for 2 days post-bleaching. The teeth were extracted 2 days after the clinical procedure and subjected to histological analysis. The CC and overall scores for histological evaluation were evaluated by the Kruskal-Wallis and Mann-Whitney tests. The percentage of patients with TS was evaluated by the Fisher exact test (α = 0.05).

Results

The CC and TS of the HP35 group were significantly higher than those of the CONT group (p < 0.05) and the HP20 group showed an intermediate response, without significant differences from either the HP35 or CONT group (p > 0.05). In both experimental groups, the coronal pulp tissue exhibited partial necrosis associated with tertiary dentin deposition. Overall, the subjacent pulp tissue exhibited a mild inflammatory response.

Conclusions

In-office bleaching therapies using bleaching gels with 20% or 35% HP caused similar pulp damage to the mandibular incisors, characterized by partial necrosis, tertiary dentin deposition, and mild inflammation.

Citations

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Can pigments of different natures interfere with the cytotoxicity from in-office bleaching?
Rafael Antonio de Oliveira Ribeiro, Beatriz Voss Martins, Marlon Ferreira Dias, Victória Peruchi, Caroline Anselmi, Igor Paulino Mendes Soares, Josimeri Hebling, Vanessa Cavalli, Carlos Alberto de Souza Costa
Odontology.2025;[Epub] CrossRef
Combined catalytic strategies applied to in-office tooth bleaching: whitening efficacy, cytotoxicity, and gene expression of human dental pulp cells in a 3D culture model
Rafael Antonio de Oliveira Ribeiro, Victória Peruchi, Igor Paulino Mendes Sores, Filipe Koon Wu Mon, Diana Gabriela Soares, Josimeri Hebling, Carlos Alberto de Souza Costa
Clinical Oral Investigations.2024;[Epub] CrossRef
Low and high hydrogen peroxide concentrations of in-office dental bleaching associated with violet light: an in vitro study
Isabela Souza Vardasca, Michael Willian Favoreto, Mylena de Araujo Regis, Taynara de Souza Carneiro, Emanuel Adriano Hul, Christiane Philippini Ferreira Borges, Alessandra Reis, Alessandro D. Loguercio, Carlos Francci
Clinical Oral Investigations.2024;[Epub] CrossRef
Evaluation of hydrogen peroxide permeability, color change, and physical–chemical properties on the in‐office dental bleaching with different mixing tip
Michael Willian Favoreto, Sibelli Olivieri Parreiras, Michel Wendlinger, Taynara De Souza Carneiro, Mariah Ignez Lenhani, Christiane Phillipini Ferreira Borges, Alessandra Reis, Alessandro D. Loguercio
Journal of Esthetic and Restorative Dentistry.2024; 36(3): 460. CrossRef
Catalysis-based approaches with biopolymers and violet LED to improve in-office dental bleaching
Rafael Antonio de Oliveira Ribeiro, Beatriz Voss Martins, Marlon Ferreira Dias, Victória Peruchi, Igor Paulino Mendes Soares, Caroline Anselmi, Josimeri Hebling, Carlos Alberto de Souza Costa
Lasers in Medical Science.2024;[Epub] CrossRef
Feasibility and Safety of Adopting a New Approach in Delivering a 450 nm Blue Laser with a Flattop Beam Profile in Vital Tooth Whitening. A Clinical Case Series with an 8-Month Follow-Up
Reem Hanna, Ioana Cristina Miron, Stefano Benedicenti
Journal of Clinical Medicine.2024; 13(2): 491. CrossRef
Hydrogen Peroxide in the Pulp Chamber and Color Change in Maxillary Anterior Teeth After In-Office Bleaching
Alexandra Mena-Serrano, Sandra Sanchez, María G. Granda-Albuja, Michael Willian Favoreto, Taynara de Souza Carneiro, Deisy Cristina Ferreira Cordeiro, Alessandro D. Loguercio, Alessandra Reis
Brazilian Dental Journal.2024;[Epub] CrossRef
Influence of coating dental enamel with a TiF4-loaded polymeric primer on the adverse effects caused by a bleaching gel with 35% H2O2
Victória Peruchi, Rafael Antonio de Oliveira Ribeiro, Igor Paulino Mendes Soares, Lídia de Oliveira Fernandes, Juliana Rios de Oliveira, Maria Luiza Barucci Araújo Pires, Josimeri Hebling, Diana Gabriela Soares, Carlos Alberto de Souza Costa
Journal of the Mechanical Behavior of Biomedical Materials.2024; 153: 106497. CrossRef

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Review Article

Effect of endodontic sealer on postoperative pain: a network meta-analysis: Cynthia Maria Chaves Monteiro, Ana Cristina Rodrigues Martins, Alessandra Reis, Juliana Larocca de Geus; Restor Dent Endod 2023;48(1):e5. Published online December 29, 2022; DOI: https://doi.org/10.5395/rde.2023.48.e5

Abstract PDF PubReader ePub

This systematic review and network meta-analysis aimed to answer the following focused research question: “Does the type of endodontic sealer affect the postoperative pain in patients who received endodontic treatment?” Different databases and grey literature were surveyed. Only one randomized controlled trial were included. The risk of bias in the studies was evaluated by using the Cochrane Collaboration’s tool. A random-effects meta-analysis was conducted to compare the risk and intensity of postoperative pain. The quality of the body of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Out of 11,601 studies, 15 remained for qualitative analyses and 12 for meta-analysis. Seven studies were classified at high risk of bias, and 8 studies raised some concerns. No significant differences between the endodontic materials were observed in the direct comparisons, both in risk and in intensity of postoperative pain (pairwise comparisons with 2 studies: I² = 0%; p > 0.05 and 8 studies: I² = 23%; p > 0.05, respectively). The certainty of the evidence was graded as low or moderate. There was no difference in the risk and intensity of postoperative pain after filling with different endodontic sealers. Further systematic reviews should be conducted.

Trial Registration

PROSPERO Identifier: CRD42020215314

Citations

Citations to this article as recorded by

Comparative evaluation of postoperative pain and periapical healing after root canal treatment using three different endodontic sealers: A randomized controlled clinical trial
Ruchika Pandey, Nitin Kararia, Deepak Kumar Sharma, Vishal Rathod, Anand Vilas Bansod, Dhaval Desai
Journal of Conservative Dentistry and Endodontics.2024; 27(9): 962. CrossRef
Effect of bioceramic-based and resin-based sealers on postoperative discomfort following root canal therapy: a systematic review and meta-analysis
Mansi Supare, Ajinkya M. Pawar, Kashmira Sawant, Dian Agustin Wahjuningrum, Suraj Arora, Firas Elmsmari, Mohmed Isaqali Karobari, Bhagyashree Thakur
PeerJ.2024; 12: e18198. CrossRef
Comparative Evaluation of Incidences of Post Operative Pain in Patient Treated in Single Visit Root Canal Treatment by Using Different Sealers: - An in-Vivo Study
Sadashiv Daokar, Aishwarya Ranjalkar, Kalpana Pawar, Komal Potfode, Dhanashri Padwal, Sana Khan
International Journal of Innovative Science and Research Technology (IJISRT).2024; : 2743. CrossRef

393 View
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