Restorative Dentistry & Endodontics

Moon-Hwan Lee

2 Articles

Involvement of TRPA1 in the cinnamaldehyde-induced pulpal blood flow change in the feline dental pulp: Dokyung Kim, Moon-Hwan Lee, Sung Kyo Kim; Restor Dent Endod 2016;41(3):202-209. Published online July 29, 2016; DOI: https://doi.org/10.5395/rde.2016.41.3.202

Objectives

The purpose of this study was to investigate the involvement of TRPA1 in the cinnamaldehyde-induced pulpal blood flow (PBF) change in the feline dental pulp.

Materials and Methods

Mandibles of eight cats were immobilized and PBF was monitored with a laser Doppler flowmetry at the mandibular canine tooth. To evaluate the effect of cinnamaldehyde on PBF, cinnamaldehyde was injected into the pulp through the lingual artery at a constant rate for 60 seconds. As a control, a mixture of 70% ethanol and 30% dimethyl sulfoxide (DMSO, vehicle) was used. To evaluate the involvement of transient receptor potential ankyrin 1 (TRPA1) in PBF change, AP18, a specific TRPA1 antagonist, was applied into the pulp through the Class V dentinal cavity followed by cinnamaldehyde-administration 3 minutes later. The paired variables of experimental data were statistically analyzed using paired t-test. A p value of less than 0.05 was considered as statistically significant.

Results

Administration of cinnamaldehyde (0.5 mg/kg, intra-arterial [i.a.]) induced significant increases in PBF (p < 0.05). While administration of a TRPA1 antagonist, AP18 (2.5 - 3.0 mM, into the dentinal cavity [i.c.]) caused insignificant change of PBF (p > 0.05), administration of cinnamaldehyde (0.5 mg/kg, i.a.) following the application of AP18 (2.5 - 3.0 mM, i.c.) resulted in an attenuation of PBF increase from the control level (p < 0.05). As a result, a TRPA1 antagonist, AP18 effectively inhibited the vasodilative effect of cinnamaldehyde (p < 0.05).

Conclusions

The result of the present study provided a functional evidence that TRPA1 is involved in the mechanism of cinnamaldehyde-induced vasodilation in the feline dental pulp.

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A simple model for the assessment of the agonistic activity of dibenzazepine derivatives by molecular moieties
Mohammad Hossein Keshavarz, Hossein Fakhraian, Norollah Saedi
Medicinal Chemistry Research.2021; 30(1): 215. CrossRef

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Endodontic treatment of maxillary lateral incisors with anatomical variations: Moon-Hwan Lee, Jung-Hong Ha, Myoung-Uk Jin, Young-Kyung Kim, Sung-Kyo Kim; Restor Dent Endod 2013;38(4):253-257. Published online November 12, 2013; DOI: https://doi.org/10.5395/rde.2013.38.4.253

Abstract PDF PubReader ePub

Maxillary lateral incisors usually exhibit a single root with a single canal. However, maxillary lateral incisor teeth with unusual morphology of root canal system are frequently reported. These cases of variable root canal anatomy can be treated well by nonsurgical endodontic methods. A detailed description of root canal morphology is fundamental for successful endodontic treatment. Treatment using an operating microscope, radiographs from different angles, and cone-beam computerized tomography (CBCT) can produce more predictable endodontic outcomes.

Citations

Citations to this article as recorded by

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World Journal of Clinical Cases.2022; 10(33): 12240. CrossRef
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