Restorative Dentistry & Endodontics

Marcelo Rocha Marques

1 Article

Antioxidant therapy enhances pulpal healing in bleached teeth: Adriano Fonseca Lima, Marcelo Rocha Marques, Diana Gabriela Soares, Josimeri Hebling, Giselle Maria Marchi, Carlos Alberto de Souza Costa; Restor Dent Endod 2016;41(1):44-54. Published online February 1, 2016; DOI: https://doi.org/10.5395/rde.2016.41.1.44

Objectives

The purpose of this study was to evaluate the histopathological effects of an antioxidant therapy on the pulp tissue of rat teeth exposed to a bleaching gel with 35% hydrogen peroxide.

Materials and Methods

Forty rats were subjected to oral ingestion by gavage of distilled water (DW) or ascorbic acid (AA) 90 min before the bleaching therapy. For the bleaching treatment, the agent was applied twice for 5 min each to buccal surfaces of the first right mandibular molars. Then, the animals were sacrificed at 6 hr, 24 hr, 3 day, or 7 day post-bleaching, and the teeth were processed for microscopic evaluation of the pulp tissue.

Results

At 6 hr, the pulp tissue showed moderate inflammatory reactions in all teeth of both groups. In the DW and AA groups, 100% and 80% of teeth exhibited pulp tissue with significant necrosis and intense tissue disorganization, respectively. At 24 hr, the AA-treated group demonstrated a greater regenerative capability than the DW group, with less intense inflammatory reaction and new odontoblast layer formation in 60% of the teeth. For up to the 7 day period, the areas of pulpal necrosis were replaced by viable connective tissue, and the dentin was underlined by differentiated odontoblast-like cells in most teeth of both groups.

Conclusions

A slight reduction in initial pulpal damage during post-bleaching was promoted by AA therapy. However, the pulp tissue of AA-treated animals featured faster regenerative potential over time.

Citations

Citations to this article as recorded by

Influence of dental bleaching on the pulp tissue: A systematic review of in vivo studies
Mariana Viana Donato, Alexandre Henrique dos Reis‐Prado, Lucas Guimarães Abreu, Lara Cancella de Arantes, Juliana Goto, Hebertt Gonzaga dos Santos Chaves, Luciano Tavares Angelo Cintra, André Luiz Fraga Briso, Isabella Faria da Cunha Peixoto, Francine Ben
International Endodontic Journal.2024; 57(6): 630. CrossRef
ANALYSIS OF THE INFLUENCE OF THE TEETH WHITENING PROCEDURE ON THE GUM AND CYTOKINE PROFILE OF ORAL FLUID (LITERATURE REVIEW)
S. S. Bozhik, N. V. Hasyuk, V. B. Radchuk
Bulletin of Problems Biology and Medicine.2024; 1(3): 17. CrossRef
Assessing the Viability of Laser-Activated Dental Bleaching Compared to Conventional In-Office Bleaching Methods: A Systematic Review of Clinical and In Vitro Studies
Eugenia Anagnostaki, Valina Mylona, Steven Parker, Mark Cronshaw, Martin Grootveld
Applied Sciences.2023; 13(22): 12459. CrossRef
Effects of the application of sodium ascorbate after in-office bleaching on the penetration of hydrogen peroxide, color change, and microtensile bond strength
Alexandra Mena-Serrano, María G. Granda-Albuja, Jenny Naranjo, Eliana Aldás Fierro, Michael Willian Favoreto, Alessandro D. Loguercio, Alessandra Reis
Brazilian Dental Journal.2023; 34(5): 87. CrossRef
Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research
Letícia Aparecida Silva Batista, Alexandre Henrique dos Reis-Prado, Hebertt Gonzaga dos Santos Chaves, Lara Cancella de Arantes, Luís Fernando Santos Alves Morgan, Carolina Bosso André, Thaís Yumi Suzuki, Francine Benetti
Restorative Dentistry & Endodontics.2023;[Epub] CrossRef
Design of a thermosensitive ibuprofen-loaded nanogel as smart material applied as anti-inflammatory in tooth bleaching: An in vivo study
Samara K.S.C.F. Moura, Milena L.V. dos Santos, Lucas A. do Nascimento, Mariana F.A. da Silva, Glória M. de França, Lucas M. da Costa, Aldo C. Medeiros, Raimundo F. Araújo-Júnior, Aurigena A. de Araújo, Cláudia N. Oliveira, André L. Dorini, Rejane A. de Ca
Journal of Drug Delivery Science and Technology.2022; 68: 103123. CrossRef
Effect of bleaching gel volume on color change and postoperative sensitivity: a randomized clinical study
Lara Maria Bueno Esteves, Paulo Henrique dos Santos, Ticiane Cestari Fagundes, Marjorie de Oliveira Gallinari, Giulia Bessa de Mello Antonaccio, Luciano Tavares Ângelo Cintra, André Luiz Fraga Briso
Clinical Oral Investigations.2022; 26(3): 2527. CrossRef
Human Dental Pulp Stem Cells Exhibit Different Biological Behaviours in Response to Commercial Bleaching Products
Carmen Llena, Mar Collado-González, Christopher Joseph Tomás-Catalá, David García-Bernal, Ricardo Elías Oñate-Sánchez, Francisco Javier Rodríguez-Lozano, Leopoldo Forner
Materials.2018; 11(7): 1098. CrossRef
Concentration‐dependent effect of bleaching agents on the immunolabelling of interleukin‐6, interleukin‐17 and CD5‐positive cells in the dental pulp
F. Benetti, J. E. Gomes‐Filho, L. L. Ferreira, G. Sivieri‐Araújo, E. Ervolino, A. L. F. Briso, L. T. A. Cintra
International Endodontic Journal.2018; 51(7): 789. CrossRef

166 View
0 Download
9 Crossref

Author index