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Is dentin biomodification with collagen cross-linking agents effective for improving dentin adhesion? A systematic review and meta-analysis
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Julianne Coelho Silva, Edson Luiz Cetira Filho, Paulo Goberlânio de Barros Silva, Fábio Wildson Gurgel Costa, Vicente de Paulo Aragão Saboia
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Restor Dent Endod 2022;47(2):e23. Published online May 6, 2022
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DOI: https://doi.org/10.5395/rde.2022.47.e23
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 Abstract
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- Objectives
The aim of this investigation was to evaluate the effectiveness of collagen cross-linking agents (CCLAs) used in combination with the adhesive technique in restorative procedures. Materials and MethodsIn this systematic review, the authors followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. An electronic search was performed using PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and DOSS, up to October 2020. The gray literature was also researched. Only randomized clinical trials were selected. ResultsThe selection process yielded 3 studies from the 838 retrieved. The addition of CCLAs in the retention of restorations increased the number of events. The postoperative sensitivity scores and marginal adaptation scores showed no significant difference between the CCLA and control groups, and the marginal pigmentation scores showed a significant increase in the CCLA group. There were no caries events in any group throughout the evaluation period. ConclusionsThis systematic review showed that there is no clinical efficacy to justify the use of CCLAs in the protocols performed.
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Citations
Citations to this article as recorded by  - Riboflavin-ultraviolet-A collagen crosslinking treatments in improving dentin bonding and resistance to enzymatic digestion
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Aline Honorato Damázio, Rosanna Tarkany Basting, Enrico Coser Bridi, Fabiana Mantovani Gomes França, Flávia Lucisano Botelho do Amaral, Cecilia Pedroso Turssi, Waldemir Francisco Vieira Junior, Roberta Tarkany Basting
Brazilian Journal of Oral Sciences.2024; 23: e244006. CrossRef - Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis
Louis Hardan, Umer Daood, Rim Bourgi, Carlos Enrique Cuevas-Suárez, Walter Devoto, Maciej Zarow, Natalia Jakubowicz, Juan Eliezer Zamarripa-Calderón, Mateusz Radwanski, Giovana Orsini, Monika Lukomska-Szymanska
Cells.2022; 11(15): 2417. CrossRef
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