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Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion


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Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion

Article information

Restor Dent Endod. 2012;37(1):2-8
Publication date (electronic) : 2012 March 02
doi : https://doi.org/10.5395/rde.2012.37.1.2
Jung-Hyun Lee, DDS1, Juhea Chang, DDS, PhD2, Ho-Hyun Son, DDS, PhD1
1Department of Conservative Dentistry, Seoul National University School of Dentistry, Seoul, Korea.
2Clinic for Persons with Disabilities, Seoul National University Dental Hospital, Seoul, Korea.
Correspondence to Ho-Hyun Son, DDS, PhD. Professor, Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute, 101 Daehag-ro, Jongro-gu, Seoul, Korea 110-749. TEL, +82-2-2072-2652; Fax, +82-2-2072-3859; hhson@snu.ac.kr
Received 2011 September 06; Revised 2011 November 18; Accepted 2011 November 18.

Abstract

The limited durability of resin-dentin bonds severely compromises the longevity of composite resin restorations. Resin-dentin bond degradation might occur via degradation of water-rich and resin sparse collagen matrices by host-derived matrix metalloproteinases (MMPs). This review article provides overview of current knowledge of the role of MMPs in dentin matrix degradation and four experimental strategies for extending the longevity of resin-dentin bonds. They include: (1) the use of broad-spectrum inhibitors of MMPs, (2) the use of cross-linking agents for silencing the activities of MMPs, (3) ethanol wet-bonding with hydrophobic resin, (4) biomimetic remineralization of water-filled collagen matrix. A combination of these strategies will be able to overcome the limitations in resin-dentin adhesion.

Keywords: Biomimetic remineralization; Chlorhexidine; Cross-linking agent; Dentin bonding; Ethanol wet-bonding; Matrix metalloproteinase

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